Page last updated: 2024-08-26

artesunic acid and Breast Neoplasms

artesunic acid has been researched along with Breast Neoplasms in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's16 (80.00)24.3611
2020's4 (20.00)2.80

Authors

AuthorsStudies
Bindra, AK; Chen, X; Guo, Y; He, IW; Jana, D; Liu, J; Qian, C; Wang, D; Wu, Y; Zhang, X; Zhao, Y1
Drif, AI; Efferth, T; Saeed, MEM1
Duarte, D; Nunes, M; Ricardo, S; Vale, N1
Ghafouri, H; Majidi, M; Pirali, M; Taheri, M; Zarei, S1
Edler, L; Efferth, T; Elsässer, M; Goeckenjan, M; Munzinger, J; Osburg, J; Remppis, BA; Schneeweiss, A; Sertel, S; Storch-Hagenlocher, B; Strowitzki, T; von Hagens, C; Walter-Sack, I1
Kim, JO; Nguyen, CN; Nguyen, HT; Tran, BN; Yong, CS1
Chockalingam, S; Ghosh, SS; Ghoshal, A; Raza, A1
Liu, L; Wei, F; Wen, L; Yu, T1
Guo, Y; Guo, Z; Wang, K; Wang, X; Yuan, H; Zhang, S1
Fernando, W; Greenshields, AL; Hoskin, DW1
Edler, L; Efferth, T; Elsässer, M; Goeckenjan, M; Munzinger, J; Remppis, BA; Schneeweiss, A; Sertel, S; Storch-Hagenlocher, B; Strowitzki, T; von Hagens, C; Walter-Sack, I1
Chen, K; Duan, WM; Li, W; Lin, F; Shou, LM; Tao, M; Wu, MY; Xie, X; Xie, YF1
Äbelö, A; Ashton, M; Blank, A; Ericsson, T; von Hagens, C1
Kim, JO; Nguyen, CN; Nguyen, HT; Nguyen, TD; Poudel, BK; Tran, TH; Yong, CS1
Firestone, GL; Hargraves, KG; He, L1
Kim, JO; Nguyen, AN; Nguyen, CN; Tran, TH; Yong, CS1
Baumann, I; Edler, L; Hoth, S; König, M; Sertel, S; von Hagens, C; Walter-Sack, I1
Dalgleish, AG; Gravett, AM; Liu, WM1
Brady, NR; Efferth, T; Eils, R; Hamacher-Brady, A; Jennewein, N; Mora, R; Stein, HA; Toegel, I; Turschner, S1
Bachmeier, B; Efferth, T; Fichtner, I; Killian, PH; Kronski, E; Pfeffer, U1

Trials

4 trial(s) available for artesunic acid and Breast Neoplasms

ArticleYear
Prospective open uncontrolled phase I study to define a well-tolerated dose of oral artesunate as add-on therapy in patients with metastatic breast cancer (ARTIC M33/2).
    Breast cancer research and treatment, 2017, Volume: 164, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Artemisinins; Artesunate; Breast Neoplasms; Drug Administration Schedule; Female; Humans; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Prospective Studies; Treatment Outcome

2017
Long-term add-on therapy (compassionate use) with oral artesunate in patients with metastatic breast cancer after participating in a phase I study (ARTIC M33/2).
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Feb-15, Volume: 54

    Topics: Administration, Oral; Adult; Aged; Artesunate; Breast Neoplasms; Compassionate Use Trials; Creatinine; Female; Humans; Liver; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Treatment Outcome

2019
Population pharmacokinetics of artesunate and dihydroartemisinin during long-term oral administration of artesunate to patients with metastatic breast cancer.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:12

    Topics: Administration, Oral; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Breast Neoplasms; Female; Humans; Intestinal Absorption; Middle Aged; Models, Biological; Saliva

2014
Investigation of ototoxicity of artesunate as add-on therapy in patients with metastatic or locally advanced breast cancer: new audiological results from a prospective, open, uncontrolled, monocentric phase I study.
    Cancer chemotherapy and pharmacology, 2016, Volume: 77, Issue:2

    Topics: Adult; Antimalarials; Artemisinins; Artesunate; Audiometry; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Treatment Outcome; Vertigo

2016

Other Studies

16 other study(ies) available for artesunic acid and Breast Neoplasms

ArticleYear
Missing-Linker-Assisted Artesunate Delivery by Metal-Organic Frameworks for Synergistic Cancer Treatment.
    Angewandte Chemie (International ed. in English), 2021, 12-06, Volume: 60, Issue:50

    Topics: Animals; Antineoplastic Agents; Artesunate; Breast Neoplasms; Cell Proliferation; Cell Survival; Drug Carriers; Drug Screening Assays, Antitumor; Female; Humans; Mammary Neoplasms, Experimental; Metal-Organic Frameworks; Mice; Photosensitizing Agents; Reactive Oxygen Species

2021
Biomarker Profiling Revealed Carcinoembryonic Antigen as a Target of Artesunate in a Ductal Breast Cancer Patient.
    Anticancer research, 2022, Volume: 42, Issue:7

    Topics: Artesunate; Biomarkers, Tumor; Breast Neoplasms; Carcinoembryonic Antigen; Carcinoma, Ductal, Breast; Female; Humans; Molecular Docking Simulation

2022
Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action.
    Biomolecules, 2022, Oct-16, Volume: 12, Issue:10

    Topics: Adenosine Diphosphate; Antimalarials; Antineoplastic Agents; Artesunate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benztropine; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Colonic Neoplasms; Containment of Biohazards; Doxorubicin; Drug Resistance, Neoplasm; Female; Fluorouracil; Fluoxetine; Fluphenazine; Humans; Ki-67 Antigen; MCF-7 Cells; Michigan; NF-kappa B; Paclitaxel; Poly(ADP-ribose) Polymerase Inhibitors; Ribose; Sertraline; Thioridazine

2022
Artesunate, as a HSP70 ATPase activity inhibitor, induces apoptosis in breast cancer cells.
    International journal of biological macromolecules, 2020, Dec-01, Volume: 164

    Topics: Adenosine Triphosphatases; Apoptosis; Artesunate; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 9; Cell Line, Tumor; Female; HSP70 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; MCF-7 Cells; Proto-Oncogene Proteins c-bcl-2

2020
Developing combination of artesunate with paclitaxel loaded into poly-d,l-lactic-co-glycolic acid nanoparticle for systemic delivery to exhibit synergic chemotherapeutic response.
    Drug development and industrial pharmacy, 2017, Volume: 43, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Artemisinins; Artesunate; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Humans; Lactic Acid; Nanoparticles; Paclitaxel; Polyglycolic Acid

2017
Connexin-43 enhances tumor suppressing activity of artesunate via gap junction-dependent as well as independent pathways in human breast cancer cells.
    Scientific reports, 2017, 08-08, Volume: 7, Issue:1

    Topics: Antineoplastic Agents; Artesunate; Breast Neoplasms; Cell Survival; Connexin 43; DNA Damage; Gap Junctions; Humans; Inhibitory Concentration 50; MCF-7 Cells; Models, Biological; Reactive Oxygen Species

2017
Artesunate promotes G2/M cell cycle arrest in MCF7 breast cancer cells through ATM activation.
    Breast cancer (Tokyo, Japan), 2018, Volume: 25, Issue:6

    Topics: Antineoplastic Agents; Artesunate; Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Cell Proliferation; DNA Damage; Dose-Response Relationship, Drug; Female; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Phosphorylation

2018
Towards rational design of RAD51-targeting prodrugs: platinum
    Chemical communications (Cambridge, England), 2018, Oct-16, Volume: 54, Issue:83

    Topics: Antineoplastic Agents; Apoptosis; Artemisinins; Artesunate; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; Drug Design; Female; Humans; Molecular Targeted Therapy; Organoplatinum Compounds; Ovarian Neoplasms; Prodrugs; Rad51 Recombinase

2018
The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells.
    Experimental and molecular pathology, 2019, Volume: 107

    Topics: Antimalarials; Antineoplastic Agents; Apoptosis; Artesunate; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Female; Humans; Receptor, ErbB-2; Triple Negative Breast Neoplasms

2019
Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells.
    Anti-cancer drugs, 2014, Volume: 25, Issue:6

    Topics: Antineoplastic Agents; Apoptosis Regulatory Proteins; Artemisinins; Artesunate; Autophagy; Beclin-1; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Epirubicin; Female; G2 Phase Cell Cycle Checkpoints; Humans; Membrane Proteins

2014
Development and Evaluation of Artesunate-Loaded Chitosan-Coated Lipid Nanocapsule as a Potential Drug Delivery System Against Breast Cancer.
    AAPS PharmSciTech, 2015, Volume: 16, Issue:6

    Topics: Antimalarials; Antineoplastic Agents; Artemisinins; Artesunate; Breast Neoplasms; Cell Line, Tumor; Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Drug Delivery Systems; Drug Stability; Excipients; Female; Humans; Lipids; MCF-7 Cells; Nanocapsules; Nanoparticles; Particle Size; Polymers

2015
Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells.
    Molecular carcinogenesis, 2016, Volume: 55, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Artemisinins; Artesunate; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 4; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Indoles; MCF-7 Cells; MicroRNAs; Tumor Suppressor Protein p53

2016
Enhancing activity of artesunate against breast cancer cells via induced-apoptosis pathway by loading into lipid carriers.
    Artificial cells, nanomedicine, and biotechnology, 2016, Volume: 44, Issue:8

    Topics: Apoptosis; Artemisinins; Artesunate; Breast Neoplasms; Female; Humans; Liposomes; MCF-7 Cells

2016
The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies.
    International journal of cancer, 2011, Mar-15, Volume: 128, Issue:6

    Topics: Antimalarials; Antineoplastic Combined Chemotherapy Protocols; Artemisinins; Artesunate; Blotting, Western; Breast Neoplasms; Cell Proliferation; Colonic Neoplasms; Deoxycytidine; Female; Flow Cytometry; Gemcitabine; Humans; Lenalidomide; Lung Neoplasms; Organoplatinum Compounds; Oxaliplatin; Thalidomide; Tumor Cells, Cultured

2011
Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production.
    The Journal of biological chemistry, 2011, Feb-25, Volume: 286, Issue:8

    Topics: Antimalarials; Apoptosis; Artemisinins; Artesunate; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Enzyme Inhibitors; Female; Humans; Iron; Lysosomes; Macrolides; Mitochondria; Mitochondrial Membranes; Permeability; Reactive Oxygen Species

2011
Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells.
    PloS one, 2011, Volume: 6, Issue:5

    Topics: Animals; Apoptosis; Artemisinins; Artesunate; bcl-2-Associated X Protein; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Electrophoretic Mobility Shift Assay; Female; Humans; Matrix Metalloproteinase 1; Mice; Mice, Nude; NF-kappa B; Transcription Factor AP-1; Xenograft Model Antitumor Assays

2011