artepillin-c and Liver-Neoplasms
artepillin-c has been researched along with Liver-Neoplasms* in 2 studies
Other Studies
2 other study(ies) available for artepillin-c and Liver-Neoplasms
Article | Year |
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Antioxidative bioavailability of artepillin C in Brazilian propolis.
Propolis has strong antioxidative activity. We investigated here whether this activity was available in intestinal Caco-2 and hepatic HepG2 cells. Phenolics in Brazilian propolis, extracted with ethyl acetate after the removal of resin and wax with 90% methanol, included artepillin C at 21 mmol/100 g, p-coumaric acid and cinnamic acid relatives 24mmol, kaempferol and its derivatives 9.4 mmol, naringenin 2.8 mmol, isosakuranetin 0.9 mmol, chrysin at 0.8 mmol/100 g, and several minor components. When the extract was added to the apical side of Caco-2 monolayers, artepillin C was specifically incorporated into the cells and released to the basolateral side mostly without conjugation. Then, artepillin C was added to HepG2 cells and exposed to reactive oxygens. Artepillin C prevented oxidative damage dose-dependently, and suppressed lipid peroxidation evaluated with thiobarbituric acid reactive substances by 16% and the formation of 8-hydroxy-2'-deoxyguanosine in DNA by 36% at a concentration of 20microM. Artepillin C is a bioavailable antioxidant. Topics: Anti-Infective Agents; Antioxidants; Biological Availability; Brazil; Caco-2 Cells; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Oxidative Stress; Phenylpropionates; Propolis | 2004 |
[Cell cycle and apoptosis in cancer induced by the artepillin C extracted from Brazilian propolis].
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Humans; Liver Neoplasms; Mice; Phenylpropionates; Propolis; Rats; Tumor Cells, Cultured | 1996 |