Compounds > arsenic trioxide
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arsenic trioxide and Leukemia

arsenic trioxide has been researched along with Leukemia in 90 studies

Research

Studies (90)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (4.44)18.2507
2000's54 (60.00)29.6817
2010's32 (35.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bai, Y; Guo, Q; Liu, W; Wang, L1
Chen, S; Lv, X; Yu, J; Zhang, L1
Watts, G1
Chang, LS; Chen, YJ; Huang, CH; Lee, YC; Shi, YJ; Wang, LJ1
Cai, J; Chen, F; Lang, W; Zhong, J; Zhu, J1
Kudva, A; Kumar, M; Vineetha, R1
Feng, L; Jiang, W; Li, Y; Shan, N; Wang, X1
Cui, J; Lin, S; Yang, H1
Cai, D; Dong, WW; Gao, F; Liu, J; Sun, K; Wang, W; Wang, Y; Zheng, Z1
Liu, Y; Ren, X; Wang, D; Yu, R; Zeng, L1
Diamantidis, MD; Papaioannou, M1
Benbijja, M; Bobé, P; Mellouk, A1
Inomata, T; Sunami, K1
Kong, P; Ma, Y; Shen, Z; Yang, S; Zeng, D; Zhang, X; Zou, Z1
Li, Y; Liu, J; Ma, X; Ye, BC; Zhang, B; Zuo, P1
Fan, J; Guo, K; Li, Y; Li, Z; Weng, G; Wu, J; Xia, P; Zeng, Y; Zheng, R1
Ai, Z; Chen, J; Cheng, J; Lin, L; Liu, Z; Wang, B; Wei, H; Xie, B; Yang, Y; Yi, J; Zhao, H1
Li, H; Sun, H; Zhou, Y1
Dong, J; Jing, Y; Wang, R; Xu, L; Yu, Z1
Aller, P; Amrán, D; de Blas, E; Fernández, C; Sánchez, Y1
Cen, J; Chen, Z; Gu, M; Liu, D; Qi, X1
Chen, T; Fu, YL1
Ahuja, HG; Bailey, HH; Chang, JE; Kahl, BS; Kim, K; Kolesar, JM; Rodriguez, GA; Sanchez, FA; Voorhees, PM; Werndli, J1
Lin, TH; Lu, FJ; Tseng, TH; Yin, YF1
Bowling, B; Doudican, NA; Orlow, SJ1
Chen, B; Guo, D; Jiang, H; Song, W; Wang, X; Wu, C1
Jiang, J; Liu, XS; Peng, CY; Zheng, HT1
Bachleitner-Hofmann, T; Roth, E; Sturlan, S; Wessner, B; Wirtitsch, M1
Essers, MA; Trumpp, A1
Chen, L; Dong, Z; Meng, Q; Peng, Z; Si, J; Xia, Y1
Chung, JG; Huang, WW; Kuo, SC; Lai, IC; Lai, TY; Lin, CC; Lin, JJ; Wen, YF; Yang, JS1
Chen, G; Ho, PC; Liu, J; Shao, Y; Wu, J1
Arkusz, J; Ferlińska, M; Gradecka-Meesters, D; Smok-Pieniążek, A; Stańczyk, M; Stępnik, M1
Tang, X; Wang, C; Xiao, G; Yao, C1
Balayssac, S; Ballot, C; Briand, G; Dammak, A; Dauphin, V; Formstecher, P; Idziorek, T; Jendoubi, M; Joha, S; Jonneaux, A; Kluza, J; Maboudou, P; Malet-Martino, M; Marchetti, P; Quesnel, B1
Aller, P; Boyano-Adánez, Mdel C; Bréard, J; Calviño, E; de Blas, E; Estañ, MC; Sancho, P; Simón, GP1
Kwong, YL1
Liu, J; Liu, Y; Qu, J; Qu, X; Xu, L; Zhang, G; Zhang, Y; Zheng, H1
Chin, A; Ciancaglini, P; de Oliveira, KT; dos Santos, GA; Faça, VM; Falcão, RP; Ferreira, GA; Greene, LJ; Hanash, SM; Izumi, C; Leopoldino, AM; Rego, EM; Scheucher, PS; Simão, AM; Thomé, CH1
Aller, P; Boyano-Adánez, Mdel C; Calviño, E; de Blas, E; Estañ, MC; Gómez-Gómez, M; Mena, ML; Rial, E1
Chen, SY; Li, XM; Liu, SX1
Chang, IY; Hsieh, RK; Huang, MJ; Lin, CP; Liu, HJ1
Bachleitner-Hofmann, T; Baumgartner, M; Roth, E; Sturlan, S1
Stull, DM1
An, S; Bae, IJ; Gwak, HS; Hong, SI; Lee, HC; Lee, SH; Park, IC; Park, MJ; Rhee, CH; Seo, KM; Woo, SH1
Bai, D; Ge, J; Ma, L; Su, H; Wang, B; Wei, H; Yao, X; Zhao, H1
Shen, WL; Zhang, Y1
Lin, MF; Wei, GQ; Zhang, SL; Zou, DB1
Antony, S; Fu, H; Kohlhagen, G; Liao, Z; Liu, H; Pommier, Y; Sordet, O; Stevens, EV1
Billi, AM; Cappellini, A; Cocco, L; Falà, F; Manzoli, L; Martelli, AM; Tabellini, G; Tazzari, PL1
Pan, B; Xu, L; Yang, X1
Ma, H; Wang, C; Wang, XF; Wang, Y1
Chen, G; Chen, L; Chen, S; Li, X; Ni, J; Shen, Z; Tang, W; Wang, Z; Xiong, S; Zhong, H; Zhu, J1
Baccarani, M; Billi, AM; Bortul, R; Evangelisti, C; Grafone, T; Martelli, AM; Martinelli, G; Tabellini, G; Tazzari, PL1
Cahill, S; Meyer, M; O'Dwyer, M; Samali, A; Szegezdi, E1
Chen, GQ; Huang, Y; Jiang, Y; Liu, W; Peng, ZG; Song, LP; Zhao, Q1
Jing, Y; Waxman, S; Wurmbach, E; Xia, L1
Moore, P; Tchounwou, PB; Yedjou, CG1
Meng, L; Meng, R; Sui, XH; Yang, BF; Zhou, J1
Duan, LN; Guo, ZK; Ji, SQ; Wang, HX1
Bauer, N; Bergmann, L; Chow, KU; Glienke, W1
Aller, P; Amrán, D; de Blas, E; Esteban, D; Fernandez, C; Palacios, MA; Ramos, AM1
Chan, R; Chen, D; Jing, Y; Waxman, S1
Seo, T; Ueda, T; Urasaki, Y1
Cui, X; Liu, T; Meng, WT; Xi, YM; Ye, XS1
Li, W; Meng, R; Sui, X; Yang, B; Zhou, J1
Aoki, M; Arai, A; Ichijo, H; Miura, O; Yan, W1
Chen, GQ; Li, D; Liu, W; Wang, Y; Wang, YC; Wu, YL; Yan, H1
Berman, JN; Look, AT1
Czyz, M; Duechler, M; Stańczyk, M; Stepnik, M1
Chen, JP; Cong, YW; Dong, B; Fu, YL; Huang, R; Liang, YG; Liu, ZY; Mao, BZ; Shan, YJ; Wang, SQ; Xiao, H; Yu, ZY; Zhao, QS; Zhao, ZH1
Hampton, T1
Aller, P; Amrán, D; Bréard, J; Calle, C; de Blas, E; Fernández, C; Ramos, AM; Sánchez, Y1
Chen, GQ; Wang, LS; Wu, YL; Yu, Y1
Chen, SJ; Chen, Z; Li, G; Zhou, GB1
Chen, SY; Dong, Y; Guo, WJ; Ma, LH; Wang, ZY1
Cai, YX; Fu, YB; Li, L; Meng, FY; Sun, QX1
Aller, P; Ramos, AM1
Kwong, YL; Todd, D1
Conrad, ME1
Akao, Y; Nakagawa, Y; Yamada, H1
Cheson, BD; McBee, WL; Murgo, AJ1
Dias, S; Lam, G; Lane, WJ; Rafii, S; Roboz, GJ; Soignet, SL; Warrell, RP1
Bhalla, KN; Nguyen, D; Nimmanapalli, R; Perkins, C; Porosnicu, M; Worthington, E1
Bruey, JM; Corcos, L; Garrido, C; Leroy, I; Lizard, G; Miguet, C; Plenchette, S; Rébé, C; Solary, E; Sordet, O1
Barbey, JT1
Singer, JW1
Cai, X; Chen, G; Shen, Y1
Buyukececi, F; Omay, SB; Sanli, UA; Saydam, G; Terzioglu, E; Uslu, R; Yuksel, S1
Chen, GQ; Chen, SJ; Chen, Z; Shen, ZX; Sun, GL; Tong, JH; Wang, ZY1

Reviews

14 review(s) available for arsenic trioxide and Leukemia

ArticleYear
[Research of traditional Chinese medicine in the treatment of leukemia: current status].
    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2008, Volume: 6, Issue:8

    Topics: Arsenic Trioxide; Arsenicals; Diagnosis, Differential; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Humans; Leukemia; Medicine, Chinese Traditional; Oxides; Phytotherapy

2008
Targeting leukemic stem cells by breaking their dormancy.
    Molecular oncology, 2010, Volume: 4, Issue:5

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Drug Resistance, Neoplasm; Granulocyte Colony-Stimulating Factor; Humans; Interferon-alpha; Leukemia; Neoplastic Stem Cells; Oxides

2010
The medicinal use of realgar (As₄S₄) and its recent development as an anticancer agent.
    Journal of ethnopharmacology, 2011, Jun-01, Volume: 135, Issue:3

    Topics: Antineoplastic Agents; Arsenic; Arsenic Trioxide; Arsenicals; History, 16th Century; History, 19th Century; History, 20th Century; History, 21st Century; History, Ancient; History, Medieval; Humans; Leukemia; Medicine, Traditional; Oxides; Sulfides

2011
Pathogenesis and treatment of leukemia: an Asian perspective.
    Expert opinion on therapeutic targets, 2012, Volume: 16 Suppl 1

    Topics: Arsenic Trioxide; Arsenicals; Asian People; Cell Proliferation; Humans; Leukemia; Leukemia, Large Granular Lymphocytic; Leukemia, Promyelocytic, Acute; Oxides; Recurrence; Tretinoin

2012
[A review of the research on malignant hemopathies treated with arsenium-containing Chinese drugs].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2000, Volume: 25, Issue:8

    Topics: Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Humans; Leukemia; Leukemia, Promyelocytic, Acute; Materia Medica; Oxides; Sulfides; Tumor Cells, Cultured

2000
Targeted therapies for the treatment of leukemia.
    Seminars in oncology nursing, 2003, Volume: 19, Issue:2

    Topics: Alemtuzumab; Aminoglycosides; Anti-Bacterial Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Benzamides; Dose-Response Relationship, Drug; Drug Interactions; Gemtuzumab; Humans; Imatinib Mesylate; Leukemia; Nurse-Patient Relations; Nurse's Role; Oncology Nursing; Oxides; Patient Education as Topic; Piperazines; Prognosis; Pyrimidines; Randomized Controlled Trials as Topic; Tretinoin

2003
[Advances in the study on antineoplastic action of realgar].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2004, Volume: 27, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Humans; K562 Cells; Leukemia; Leukemia, Promyelocytic, Acute; Materia Medica; Oxides; Tumor Cells, Cultured

2004
Hypoxia inducible factor-1alpha and leukemic cell differentiation.
    Sheng li xue bao : [Acta physiologica Sinica], 2006, Feb-25, Volume: 58, Issue:1

    Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Transformation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia; Leukemia, Promyelocytic, Acute; Oxides

2006
Targeting transcription factors in acute leukemia in children.
    Current drug targets, 2007, Volume: 8, Issue:6

    Topics: Acute Disease; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Child; DNA Methylation; Drug Delivery Systems; Histone Deacetylase Inhibitors; Humans; Leukemia; Oxides; Transcription Factors; Tretinoin

2007
Leukemia, an effective model for chemical biology and target therapy.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Benzamides; Dasatinib; Growth Inhibitors; Humans; Imatinib Mesylate; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Oxides; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Tretinoin

2007
From dissection of disease pathogenesis to elucidation of mechanisms of targeted therapies: leukemia research in the genomic era.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:9

    Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Benzamides; Disease Models, Animal; Humans; Imatinib Mesylate; Leukemia; Oxides; Piperazines; Pyrimidines; Tretinoin

2007
Arsenic-induced apoptosis in malignant cells in vitro.
    Leukemia & lymphoma, 2000, Volume: 37, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspases; Down-Regulation; Glutathione; Growth Inhibitors; Hematopoietic Stem Cells; Humans; Leukemia; Leukemia, B-Cell; Leukemia, Promyelocytic, Acute; Leukocytes, Mononuclear; Neuroblastoma; Oxides; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured

2000
Cardiac toxicity of arsenic trioxide.
    Blood, 2001, Sep-01, Volume: 98, Issue:5

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Artifacts; Electrocardiography; Electrolytes; Humans; Leukemia; Long QT Syndrome; Oxides; Torsades de Pointes

2001
Expanding the use of arsenic trioxide: leukemias and beyond.
    Seminars in hematology, 2002, Volume: 39, Issue:2 Suppl 1

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Humans; Leukemia; Leukemia, Promyelocytic, Acute; Multiple Myeloma; Neoplasms; Oxides

2002

Trials

2 trial(s) available for arsenic trioxide and Leukemia

ArticleYear
Phase II study of arsenic trioxide and ascorbic acid for relapsed or refractory lymphoid malignancies: a Wisconsin Oncology Network study.
    Hematological oncology, 2009, Volume: 27, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Female; Glutathione; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Male; Middle Aged; Oxides; Safety

2009
Effects of arsenic trioxide administration styles on leukocytosis.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2006, Volume: 21, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Line, Tumor; Humans; Infusions, Intravenous; K562 Cells; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Leukocytosis; Oxides

2006

Other Studies

74 other study(ies) available for arsenic trioxide and Leukemia

ArticleYear
A proteomics research of apoptosis of leukemia cells induced by arsenic trioxide.
    Cellular and molecular biology (Noisy-le-Grand, France), 2017, Mar-31, Volume: 63, Issue:3

    Topics: Amino Acid Sequence; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Shape; HL-60 Cells; Humans; Leukemia; Mass Spectrometry; Neoplasm Proteins; Oxides; Proteomics

2017
HOXA9 is critical in the proliferation, differentiation, and malignancy of leukaemia cells both in vitro and in vivo.
    Cell biochemistry and function, 2017, Volume: 35, Issue:7

    Topics: Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Down-Regulation; HL-60 Cells; Homeodomain Proteins; Humans; Leukemia; Male; Mice; Mice, Nude; MicroRNAs; Oxides; RNA Interference; RNA, Messenger; Transplantation, Heterologous; Tretinoin

2017
Guo-Qiang Chen: haematologist who risked all for research success.
    Lancet (London, England), 2018, 04-14, Volume: 391, Issue:10129

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Biomedical Research; China; Hematology; History, 20th Century; History, 21st Century; Humans; Leukemia; Oxides; Portraits as Topic

2018
The suppressive effect of arsenic trioxide on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 expression induces apoptosis in human leukemia cells.
    Toxicology and applied pharmacology, 2018, 11-01, Volume: 358

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Dioxygenases; DNA-Binding Proteins; Dose-Response Relationship, Drug; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Leukemia; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; src-Family Kinases; U937 Cells

2018
EVI-1 modulates arsenic trioxide induced apoptosis through JNK signalling pathway in leukemia cells.
    Experimental cell research, 2019, 01-01, Volume: 374, Issue:1

    Topics: Animals; Anthracenes; Apoptosis; Arsenic Trioxide; Cell Line, Tumor; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Leukemic; Humans; Leukemia; MAP Kinase Signaling System; MDS1 and EVI1 Complex Locus Protein; Models, Biological; Neoplasm Proteins; RNA, Messenger; Zebrafish

2019
Medication related osteonecrosis of jaw in a leukemia patient undergoing systemic arsenic trioxide therapy: A rare case report.
    Oral oncology, 2019, Volume: 99

    Topics: Adult; Arsenic Trioxide; Bisphosphonate-Associated Osteonecrosis of the Jaw; Female; Humans; Leukemia

2019
Artesunate possesses anti-leukemia properties that can be enhanced by arsenic trioxide.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Artemisinins; Artesunate; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Fas Ligand Protein; fas Receptor; Humans; K562 Cells; Leukemia; Oxides; Proto-Oncogene Proteins c-fos; U937 Cells

2014
Identifying arsenic trioxide (ATO) functions in leukemia cells by using time series gene expression profiles.
    Gene, 2014, Feb-10, Volume: 535, Issue:2

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cluster Analysis; Computational Biology; Databases, Nucleic Acid; Gene Expression Regulation, Leukemic; Humans; K562 Cells; Leukemia; Molecular Sequence Annotation; Oxides; Time Factors; Transcriptome

2014
Investigation of the mechanism involved in the As2O3-regulated decrease in MDR1 expression in leukemia cells.
    Oncology reports, 2014, Volume: 31, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Binding Sites; Cell Line, Tumor; Drug Resistance, Neoplasm; HEK293 Cells; Humans; I-kappa B Kinase; K562 Cells; Leukemia; Molecular Sequence Data; Oxides; Phosphorylases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Sequence Analysis, DNA; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2014
The growth-inhibitory and apoptosis-inducing effect of deferoxamine combined with arsenic trioxide on HL-60 xenografts in nude mice.
    Leukemia research, 2014, Volume: 38, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Proliferation; Deferoxamine; Female; HL-60 Cells; Humans; Leukemia; Mice; Mice, Inbred BALB C; Mice, Nude; Oxides; Xenograft Model Antitumor Assays

2014
Toward adjunctive therapy of acute myeloid leukemia: is it feasible?
    Leukemia research, 2014, Volume: 38, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Proliferation; Deferoxamine; Female; Humans; Leukemia; Oxides

2014
Sensitivity of leukemic T-cell lines to arsenic trioxide cytotoxicity is dependent on the induction of phosphatase B220/CD45R expression at the cell surface.
    Molecular cancer, 2014, Nov-19, Volume: 13

    Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Death; Cell Line, Tumor; Cell Membrane; HSP70 Heat-Shock Proteins; Humans; Jurkat Cells; Leukemia; Leukocyte Common Antigens; Mice; Mice, Inbred MRL lpr; NF-kappa B; Oxides; T-Lymphocytes

2014
[Antileukemic].
    Nihon rinsho. Japanese journal of clinical medicine, 2015, Volume: 73 Suppl 2

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Benzoates; Humans; Leukemia; Oxides; Remission Induction; Tetrahydronaphthalenes; Tretinoin

2015
[Effect of arsenic trioxide on proliferation and apoptosis of human leukemia cell line MV4-11 cells].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2015, Volume: 36, Issue:7

    Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Humans; Leukemia; Oxides

2015
Ultrasensitive and selective assay of glutathione species in arsenic trioxide-treated leukemia HL-60 cell line by molecularly imprinted polymer decorated electrochemical sensors.
    Biosensors & bioelectronics, 2016, Jun-15, Volume: 80

    Topics: Acetylcysteine; Arsenic Trioxide; Arsenicals; Biosensing Techniques; Dielectric Spectroscopy; Glutathione; Glutathione Disulfide; HL-60 Cells; Humans; Leukemia; Molecular Imprinting; Oxides; Polymers

2016
Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells.
    Oncology reports, 2016, Volume: 36, Issue:3

    Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Cell Line, Tumor; Curcumin; Down-Regulation; Drug Synergism; Humans; Inhibitor of Apoptosis Proteins; Leukemia; Myelodysplastic Syndromes; Oxides; Poly(ADP-ribose) Polymerases; RNA, Small Interfering; Stem Cells; Survivin

2016
Differential expression and response to arsenic stress of MRPs and ASAN1 determine sensitivity of classical multidrug-resistant leukemia cells to arsenic trioxide.
    Leukemia research, 2016, Volume: 50

    Topics: Antineoplastic Agents; Arsenic; Arsenic Trioxide; Arsenicals; Arsenite Transporting ATPases; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression; HL-60 Cells; Humans; K562 Cells; Leukemia; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oxides

2016
Cytotoxicity of arsenic trioxide in single leukemia cells by time-resolved ICP-MS together with lanthanide tags.
    Chemical communications (Cambridge, England), 2017, Mar-07, Volume: 53, Issue:20

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Death; Cell Differentiation; Cell Line, Tumor; Cisplatin; HL-60 Cells; Humans; Lanthanoid Series Elements; Leukemia; Mass Spectrometry; Oxides; Single-Cell Analysis; Time Factors

2017
N-(beta-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway.
    Cancer letters, 2008, Sep-28, Volume: 269, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Catalase; Cell Proliferation; Cell Survival; Drug Synergism; HL-60 Cells; Humans; Hydrogen Peroxide; Leukemia; Oxides; Sesquiterpenes; Tryptophan

2008
Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK).
    International journal of cancer, 2008, Sep-01, Volume: 123, Issue:5

    Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Drug Synergism; Electrophoretic Mobility Shift Assay; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genistein; HL-60 Cells; Humans; Immunoblotting; Jurkat Cells; Leukemia; Multienzyme Complexes; Oxidative Stress; Oxides; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Reactive Oxygen Species; U937 Cells

2008
Expression of Dlk1 gene in myelodysplastic syndrome determined by microarray, and its effects on leukemia cells.
    International journal of molecular medicine, 2008, Volume: 22, Issue:1

    Topics: Adult; Aged; Antigens, CD34; Apoptosis; Arsenic Trioxide; Arsenicals; Calcium-Binding Proteins; Cell Cycle; Cell Proliferation; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Intercellular Signaling Peptides and Proteins; K562 Cells; Leukemia; Leukocytes, Mononuclear; Male; Membrane Proteins; Middle Aged; Myelodysplastic Syndromes; Oligonucleotide Array Sequence Analysis; Oxides; Tetradecanoylphorbol Acetate; Up-Regulation

2008
Enhancement of esculetin on arsenic trioxide-provoked apoptosis in human leukemia U937 cells.
    Chemico-biological interactions, 2009, Jun-15, Volume: 180, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Survival; Fluorescent Antibody Technique; Humans; Leukemia; Oxides; U937 Cells; Umbelliferones

2009
Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism.
    Leukemia research, 2010, Volume: 34, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Cell Death; Drug Synergism; Humans; Isothiocyanates; Leukemia; Oxides; Reactive Oxygen Species; Sulfides; Sulfones; Sulfoxides; Thiocyanates; Tumor Cells, Cultured; Vegetables

2010
Effect of colloidal gold nanoparticles on cell interface and their enhanced intracellular uptake of arsenic trioxide in leukemia cancer cells.
    Journal of nanoscience and nanotechnology, 2009, Volume: 9, Issue:8

    Topics: Arsenic Trioxide; Arsenicals; Colloids; Electrochemistry; Gold; Humans; K562 Cells; Leukemia; Metal Nanoparticles; Oxides

2009
Growth-inhibiting effects of arsenic trioxide plus epigenetic therapeutic agents on leukemia cell lines.
    Leukemia & lymphoma, 2010, Volume: 51, Issue:2

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Azacitidine; Cell Proliferation; Cell Survival; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Drug Antagonism; Drug Synergism; Electrophoresis, Capillary; Growth Inhibitors; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; K562 Cells; Leukemia; Oxides; U937 Cells; Valproic Acid

2010
Omega-3 and omega-6 polyunsaturated fatty acids enhance arsenic trioxide efficacy in arsenic trioxide-resistant leukemic and solid tumor cells.
    Oncology research, 2009, Volume: 18, Issue:2-3

    Topics: Antineoplastic Agents; Apoptosis; Arachidonic Acid; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Humans; Leukemia; Lipid Peroxidation; Neoplasms; Oxides; Vitamin E

2009
Nuclear Factor-κB modulates cellular glutathione and prevents oxidative stress in cancer cells.
    Cancer letters, 2010, Dec-18, Volume: 299, Issue:1

    Topics: Animals; Arsenic Trioxide; Arsenicals; Glutathione; Humans; Leukemia; Male; Mice; NF-kappa B; Oxidative Stress; Oxides; Prostatic Neoplasms; Signal Transduction

2010
Arsenic trioxide (As₂O₃) inhibits murine WEHI-3 leukemia in BALB/c mice in vivo.
    Environmental toxicology, 2012, Volume: 27, Issue:6

    Topics: Animals; Antigens, Differentiation; Arsenic Trioxide; Arsenicals; B-Lymphocytes; Cell Differentiation; Cell Line, Tumor; Leukemia; Leukemia, Experimental; Macrophages; Male; Mice; Mice, Inbred BALB C; Oxides; Spleen; Tretinoin

2012
Assessment of the involvement of oxidative stress and Mitogen-Activated Protein Kinase signaling pathways in the cytotoxic effects of arsenic trioxide and its combination with sulindac or its metabolites: sulindac sulfide and sulindac sulfone on human leu
    Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Glutathione; Humans; Leukemia; Mitogen-Activated Protein Kinases; Oxidative Stress; Oxides; Reactive Oxygen Species; Signal Transduction; Sulindac

2012
Potentiation of arsenic trioxide-induced apoptosis by 8-bromo-7-methoxychrysin in human leukemia cells involves depletion of intracellular reduced glutathione.
    Acta biochimica et biophysica Sinica, 2011, Volume: 43, Issue:9

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; Glutathione; HL-60 Cells; Humans; Intracellular Space; Jurkat Cells; Leukemia; Mitochondria; Oxides; Phosphorylation; Proto-Oncogene Proteins c-akt; Time Factors; U937 Cells; X-Linked Inhibitor of Apoptosis Protein

2011
Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.
    PloS one, 2011, Volume: 6, Issue:7

    Topics: Animals; Arsenic Trioxide; Arsenicals; Benzamides; Cell Death; Cell Line, Tumor; Cell Respiration; Drug Resistance, Neoplasm; Electron Transport; Energy Metabolism; Glucose; Imatinib Mesylate; Isothiocyanates; Leukemia; Mice; Mitochondria; Models, Biological; Oxidative Stress; Oxides; Piperazines; Pyrimidines; Reactive Oxygen Species

2011
Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation.
    Biochemical pharmacology, 2011, Dec-01, Volume: 82, Issue:11

    Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Indazoles; Leukemia; Membrane Potential, Mitochondrial; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Stress; Oxides; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases

2011
Cbl-b-dependent degradation of FLIP(L) is involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells.
    FEBS letters, 2012, Sep-21, Volume: 586, Issue:19

    Topics: Adaptor Proteins, Signal Transducing; Arsenic Trioxide; Arsenicals; Autophagy; Base Sequence; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Survival; Humans; Jurkat Cells; K562 Cells; Leukemia; Oxides; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-cbl; RNA, Small Interfering; Signal Transduction; Stomach Neoplasms; Ubiquitin

2012
Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.
    Molecular & cellular proteomics : MCP, 2012, Volume: 11, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Cell Line; Cell Proliferation; Cholesterol; Enzyme Activation; Humans; Leukemia; Membrane Microdomains; Oxides; Phosphatidylinositol 3-Kinases; Phospholipids; Phosphorylcholine; Protein Structure, Tertiary; Proteome; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction

2012
2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways.
    Biochemical pharmacology, 2012, Dec-15, Volume: 84, Issue:12

    Topics: Adenosine Triphosphate; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Division; Cell Line, Tumor; Deoxyglucose; Humans; Leukemia; Mitochondria; Oxidative Stress; Oxides; Protein Kinase Inhibitors; Protein Kinases; Receptor, IGF Type 1; Signal Transduction; TOR Serine-Threonine Kinases

2012
The cytotoxicity of arsenic trioxide to normal hematopoietic progenitors and leukemic cells is dependent on their cell-cycle status.
    Leukemia & lymphoma, 2002, Volume: 43, Issue:11

    Topics: Antigens, CD34; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Division; Drug Resistance; Flow Cytometry; Hematopoietic Stem Cells; HL-60 Cells; Humans; Immunophenotyping; Interphase; Leukemia; Oxides

2002
Docosahexaenoic acid enhances arsenic trioxide-mediated apoptosis in arsenic trioxide-resistant HL-60 cells.
    Blood, 2003, Jun-15, Volume: 101, Issue:12

    Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; Caspase 3; Caspases; Docosahexaenoic Acids; Drug Interactions; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Leukemia; Lipid Peroxidation; Membrane Potentials; Mitochondria; Oleic Acid; Oxides; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Tumor Cells, Cultured; Vitamin E

2003
Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway.
    International journal of oncology, 2003, Volume: 23, Issue:4

    Topics: Apoptosis; Arsenic; Arsenic Trioxide; Arsenicals; Caspase 3; Caspases; Catalase; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Hydrogen Peroxide; Leukemia; Membrane Potentials; Mitochondria; Oxides; Reactive Oxygen Species; Time Factors; U937 Cells

2003
Arsenic trioxide inhibits p-glycoprotein expression in multidrug-resistant human leukemia cells that overexpress the MDR1 gene.
    Chinese medical journal, 2003, Volume: 116, Issue:11

    Topics: Apoptosis; Arsenic Trioxide; Arsenicals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Multiple; Gene Expression; Genes, MDR; Humans; Leukemia; Oxides

2003
Bcl-2 antisense oligodeoxynucleotide increases the sensitivity of leukemic cells to arsenic trioxide.
    Cell biology international, 2003, Volume: 27, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Division; Cell Line, Tumor; DNA; Dose-Response Relationship, Drug; Flow Cytometry; Genetic Therapy; Humans; K562 Cells; Leukemia; Oligonucleotides, Antisense; Oxides; Proto-Oncogene Proteins c-bcl-2; Time Factors

2003
[Cytotoxic effects of arsenic trioxide in combination with chemotherapeutic drugs on acute non-promyelocytic leukemia cells].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2004, Volume: 33, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Child; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Leukemia; Male; Middle Aged; Oxides

2004
Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis.
    The Journal of biological chemistry, 2004, Aug-06, Volume: 279, Issue:32

    Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Buthionine Sulfoximine; Caspase 3; Caspase Inhibitors; Caspases; DNA; DNA Fragmentation; DNA Topoisomerases, Type I; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Gene Expression; Gene Silencing; Humans; Leukemia; Oxides; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Recombinant Proteins; Tumor Cells, Cultured

2004
Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells.
    Journal of cellular physiology, 2005, Volume: 202, Issue:2

    Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspases; Cell Line, Tumor; Chromones; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Morpholines; Mutation; NF-kappa B; NF-kappa B p50 Subunit; Oxides; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Transfection; Tumor Suppressor Proteins; Wortmannin

2005
Simultaneously multi-parameter determination of hematonosis cell apoptosis by two-photon and confocal laser scanning microscopy.
    Journal of clinical laboratory analysis, 2004, Volume: 18, Issue:5

    Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Calcium; Cell Line, Tumor; Cell Nucleus; Dose-Response Relationship, Drug; Flow Cytometry; Hematologic Diseases; Humans; Leukemia; Membrane Potentials; Microscopy, Confocal; Mitochondria; Oxides; Photons

2004
[Effects of arsenic trioxide on the subcellular localization of PML/PML-RARalpha protein in leukemic cells].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 1997, Volume: 18, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; HL-60 Cells; Humans; Intracellular Space; Leukemia; Nuclear Proteins; Oxides; Promyelocytic Leukemia Protein; Protein Transport; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Transcription Factors; Tretinoin; Tumor Suppressor Proteins

1997
Phosphoinositide 3-kinase/Akt inhibition increases arsenic trioxide-induced apoptosis of acute promyelocytic and T-cell leukaemias.
    British journal of haematology, 2005, Volume: 130, Issue:5

    Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Line, Tumor; Flow Cytometry; Humans; In Situ Nick-End Labeling; Jurkat Cells; Leukemia; Leukemia, Promyelocytic, Acute; Leukemia, T-Cell; Oxides; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; RNA, Small Interfering; Signal Transduction; Transfection; Tumor Cells, Cultured

2005
TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt.
    British journal of cancer, 2006, Feb-13, Volume: 94, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Caspase 8; Caspase Inhibitors; Caspases; Cell Line, Tumor; Humans; Leukemia; Membrane Glycoproteins; Oligopeptides; Oncogene Protein v-akt; Oxides; Phosphorylation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

2006
Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis.
    Leukemia, 2006, Volume: 20, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Doxorubicin; Gene Silencing; HL-60 Cells; Humans; Leukemia; Minor Histocompatibility Antigens; Oxides; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Tretinoin; Up-Regulation

2006
Dose- and time-dependent response of human leukemia (HL-60) cells to arsenic trioxide treatment.
    International journal of environmental research and public health, 2006, Volume: 3, Issue:2

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Leukemia; Oxides

2006
Arsenic trioxide-responsive leukemia cutis in a patient with acute promyelocytic leukemia after ATRA treatment.
    Leukemia & lymphoma, 2006, Volume: 47, Issue:7

    Topics: Adolescent; Anthracyclines; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Cytarabine; Female; Humans; Leukemia; Leukemia, Promyelocytic, Acute; Oxides; Risk; Skin; Tretinoin

2006
Down-regulation of wt1 expression in leukemia cell lines as part of apoptotic effect in arsenic treatment using two compounds.
    Leukemia & lymphoma, 2006, Volume: 47, Issue:8

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Arsenites; Carrier Proteins; Co-Repressor Proteins; Cytoskeletal Proteins; Gene Expression Regulation; HL-60 Cells; Humans; K562 Cells; Leukemia; Oxides; Sodium Compounds; WT1 Proteins

2006
Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis.
    Journal of cellular physiology, 2006, Volume: 209, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia; Leukemia, Promyelocytic, Acute; Oxides; Peroxides; Reactive Oxygen Species

2006
Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors.
    Cancer research, 2006, Dec-01, Volume: 66, Issue:23

    Topics: Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Buthionine Sulfoximine; Caspase 3; Caspase Inhibitors; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Glutathione; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia; Lymphoma; Oxides; Receptors, TNF-Related Apoptosis-Inducing Ligand; Time Factors; U937 Cells

2006
Establishment of an arsenic trioxide-resistant human leukemia cell line that shows multidrug resistance.
    International journal of hematology, 2007, Volume: 85, Issue:1

    Topics: Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Clone Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia; Multidrug Resistance-Associated Proteins; Oxides; Vincristine

2007
[Methylation of P15INK4B gene in patients with myelodysplastic syndromes and demethylating effects of drugs].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2007, Volume: 38, Issue:1

    Topics: Arsenic Trioxide; Arsenicals; Azacitidine; Cyclin-Dependent Kinase Inhibitor p15; Decitabine; Disease Progression; DNA Methylation; Genetic Predisposition to Disease; Humans; Leukemia; Myelodysplastic Syndromes; Oxides

2007
Various tolerances to arsenic trioxide between human cortical neurons and leukemic cells.
    Science in China. Series C, Life sciences, 2006, Volume: 49, Issue:6

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Calcium; Cell Line, Tumor; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Leukemia; Neurons; Oxides

2006
ASK1 is activated by arsenic trioxide in leukemic cells through accumulation of reactive oxygen species and may play a negative role in induction of apoptosis.
    Biochemical and biophysical research communications, 2007, Apr-20, Volume: 355, Issue:4

    Topics: Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia; MAP Kinase Kinase Kinase 5; Mice; Oxides; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; RNA, Small Interfering

2007
Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase Cdelta.
    Leukemia, 2007, Volume: 21, Issue:7

    Topics: Adult; Apoptosis; Arsenic Trioxide; Arsenicals; Boronic Acids; Bortezomib; Cell Line, Tumor; Drug Synergism; Enzyme Activation; Humans; Leukemia; Middle Aged; Mitogen-Activated Protein Kinases; Oxides; Protease Inhibitors; Protein Kinase C-delta; Pyrazines; Tumor Cells, Cultured

2007
Potentiation of arsenic trioxide cytotoxicity by Parthenolide and buthionine sulfoximine in murine and human leukemic cells.
    Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:5

    Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; DNA Fragmentation; Drug Synergism; Flow Cytometry; Glutamate-Cysteine Ligase; Glutathione; Humans; Leukemia; Mice; Microscopy, Fluorescence; NF-kappa B; Oxides; Reactive Oxygen Species; Sesquiterpenes

2008
Melissoidesin G, a diterpenoid purified from Isodon melissoides, induces leukemic-cell apoptosis through induction of redox imbalance and exhibits synergy with other anticancer agents.
    International journal of cancer, 2007, Nov-01, Volume: 121, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspases; Cytochromes c; Diterpenes; Glutathione; Humans; Isodon; Leukemia; Mitochondria; Molecular Structure; Oxidation-Reduction; Oxides; Phytotherapy; Tumor Cells, Cultured

2007
Cancer agents show first-line potential.
    JAMA, 2007, Jul-25, Volume: 298, Issue:4

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Bevacizumab; Dasatinib; Humans; Kidney Neoplasms; Leukemia; Oxides; Pyrimidines; Thiazoles

2007
Arsenic trioxide sensitizes promonocytic leukemia cells to TNFalpha-induced apoptosis via p38-MAPK-regulated activation of both receptor-mediated and mitochondrial pathways.
    Biochimica et biophysica acta, 2007, Volume: 1773, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cytokines; Enzyme Activation; Enzyme Inhibitors; Glutathione; Humans; Leukemia; MAP Kinase Signaling System; Mitochondria; Myeloid Cells; NF-kappa B; Oxides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Cell Surface; Tumor Necrosis Factor-alpha

2007
[Effects of arsenic trioxide and ATRA on PLZF-RARalpha-positive U937 leukemic cells].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2007, Volume: 23, Issue:9

    Topics: Antigens, CD; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Cycle; Cell Proliferation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Transcription Factors; Leukemia; Nitroblue Tetrazolium; Oxidation-Reduction; Oxides; Promyelocytic Leukemia Zinc Finger Protein; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Tetracycline; Tretinoin; U937 Cells

2007
[Effect of bortezomib used alone or in combination with arsenic trioxide on HL-60 cell xenograft in nude mice].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2007, Volume: 27, Issue:10

    Topics: Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Boronic Acids; Bortezomib; Cell Proliferation; Disease Models, Animal; HL-60 Cells; Humans; Leukemia; Male; Mice; Mice, Nude; Oxides; Pyrazines; Random Allocation; Xenograft Model Antitumor Assays

2007
Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines.
    Biochemical pharmacology, 2008, May-15, Volume: 75, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; Cell Line, Tumor; Drug Synergism; Flavonoids; Glutathione; Humans; Leukemia; Membrane Potential, Mitochondrial; Oxides; Protein Kinases; Quercetin

2008
Delicious poison: arsenic trioxide for the treatment of leukemia.
    Blood, 1997, May-01, Volume: 89, Issue:9

    Topics: Adult; Antineoplastic Agents; Apoptosis; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Cell Differentiation; Fatal Outcome; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocytosis; Male; Oxides; Splenomegaly

1997
Treatment of acute promyelocytic leukemia with arsenic trioxide.
    The New England journal of medicine, 1999, Apr-01, Volume: 340, Issue:13

    Topics: Antineoplastic Agents; Arsenic; Arsenic Trioxide; Arsenicals; History, 16th Century; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Leukemia; Leukemia, Promyelocytic, Acute; Oxides; Remission Induction

1999
Clinical trials referral resource. Clinical trials with arsenic trioxide.
    Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:2

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Clinical Trials as Topic; Female; Humans; Leukemia; Lymphoma; Multiple Myeloma; Neoplasms; Oxides; Urogenital Neoplasms; Uterine Cervical Neoplasms

2000
Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis.
    Blood, 2000, Aug-15, Volume: 96, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Leukemia; Neovascularization, Pathologic; Oxides; Time Factors

2000
Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Brc-Abl-positive acute leukemia cells.
    Leukemia, 2001, Volume: 15, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Benzamides; Drug Synergism; Fusion Proteins, bcr-abl; Hemoglobins; Humans; Imatinib Mesylate; Leukemia; Macrophage-1 Antigen; Oxides; Piperazines; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein

2001
Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis.
    Blood, 2001, Jun-15, Volume: 97, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspases; Cell Differentiation; Cell-Free System; Drug Resistance; Etoposide; Humans; Indazoles; Leukemia; Mitochondria; Oxides; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; U937 Cells

2001
Cardiac toxicity of arsenic trioxide.
    Blood, 2001, Sep-01, Volume: 98, Issue:5

    Topics: Adverse Drug Reaction Reporting Systems; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Drug Approval; Drug Industry; Drug Labeling; Electrocardiography; Electrolytes; Humans; Leukemia; Long QT Syndrome; Oxides; Practice Guidelines as Topic; Safety; Torsades de Pointes; United States; United States Food and Drug Administration

2001
[Glutathione synthesis inhibitor enhances arsenic trioxide-induced apoptosis].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 1999, Volume: 21, Issue:4

    Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Buthionine Sulfoximine; Glutathione; Humans; Leukemia; Lymphoma; Oxides; Tumor Cells, Cultured

1999
Arsenic trioxide and methylprednisolone use different signal transduction pathways in leukemic differentiation.
    Leukemia research, 2002, Volume: 26, Issue:4

    Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Differentiation; Dose-Response Relationship, Drug; HL-60 Cells; Humans; K562 Cells; Leukemia; Methylprednisolone; Oxides; Phosphoprotein Phosphatases; Signal Transduction

2002