aristolochic acid i has been researched along with Renal Insufficiency in 17 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal failure was in progression since Pcreat was 2." | 2.68 | Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis: a pilot study in Chinese herbs nephropathy. ( Abramowicz, D; Depierreux, M; Tielemans, C; Vanherweghem, JL, 1996) |
| "Six cases with herb-induced renal failure associated with Fanconi syndrome were clinicopathologically analyzed." | 1.32 | [Chinese herbs-induced renal failure with Fanconi syndrome: a report of 6 cases]. ( Li, H; Yu, Y; Zheng, FL, 2003) |
| "Similarities of CHN to the Balkan endemic nephropathy (BEN) have led to the hypothesis of a common etiological agent for both diseases." | 1.31 | Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy. ( Arlt, VM; Cosyns, J; Pfohl-Leszkowicz, A; Schmeiser, HH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M | 1 |
| Zhao, C | 1 |
| Li, Z | 1 |
| Fan, Q | 1 |
| Lu, S | 1 |
| Tao, X | 1 |
| Lin, Y | 1 |
| Lin, R | 1 |
| Wu, J | 1 |
| Lu, PH | 1 |
| Lee, HY | 1 |
| Liou, YL | 1 |
| Tung, SF | 1 |
| Kuo, KL | 1 |
| Chen, YH | 3 |
| Yang, HY | 1 |
| Chen, PC | 1 |
| Wang, JD | 1 |
| Ding, YJ | 2 |
| Sun, CY | 1 |
| Wen, CC | 1 |
| Hu, X | 1 |
| Shen, J | 1 |
| Pu, X | 1 |
| Zheng, N | 1 |
| Deng, Z | 1 |
| Zhang, Z | 1 |
| Li, H | 2 |
| Kong, PI | 1 |
| Chiu, YW | 1 |
| Kuo, MC | 1 |
| Chen, SC | 1 |
| Chang, JM | 1 |
| Tsai, JC | 1 |
| Hwang, SJ | 1 |
| Chen, HC | 1 |
| Sabbisetti, VS | 1 |
| Ito, K | 1 |
| Wang, C | 1 |
| Yang, L | 1 |
| Mefferd, SC | 1 |
| Bonventre, JV | 1 |
| Kanaan, N | 1 |
| Cosyns, JP | 3 |
| Jadoul, M | 3 |
| Goffin, E | 1 |
| Lee, S | 1 |
| Lee, T | 1 |
| Lee, B | 1 |
| Choi, H | 1 |
| Yang, M | 1 |
| Ihm, CG | 1 |
| Kim, M | 1 |
| Vanherweghem, JL | 1 |
| Abramowicz, D | 1 |
| Tielemans, C | 1 |
| Depierreux, M | 1 |
| Arlt, VM | 2 |
| Pfohl-Leszkowicz, A | 1 |
| Cosyns, J | 1 |
| Schmeiser, HH | 2 |
| Solez, K | 1 |
| Daugirdas, J | 1 |
| Gregory, MC | 1 |
| Frohnert, PP | 1 |
| Bhowmik, DM | 1 |
| Jha, V | 1 |
| Gillerot, G | 1 |
| van Ypersele De Strihou, C | 2 |
| But, PP | 1 |
| Bieler, CA | 1 |
| Yu, Y | 1 |
| Zheng, FL | 1 |
| Sun, L | 1 |
| An, R | 1 |
| Zhuang, W | 1 |
2 reviews available for aristolochic acid i and Renal Insufficiency
| Article | Year |
|---|---|
Chinese herbs containing aristolochic acid associated with renal failure and urothelial carcinoma: a review from epidemiologic observations to causal inference.
Topics: Aristolochic Acids; Carcinogens; Carcinoma; DNA Adducts; Drugs, Chinese Herbal; Female; Humans; Occu | 2014 |
[Renal toxicity of Aristolochia and its prevention].
Topics: Animals; Aristolochia; Aristolochic Acids; Drug Incompatibility; Drugs, Chinese Herbal; Humans; Kidn | 2002 |
1 trial available for aristolochic acid i and Renal Insufficiency
| Article | Year |
|---|---|
Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis: a pilot study in Chinese herbs nephropathy.
Topics: Aristolochic Acids; Case-Control Studies; Disease Progression; Drugs, Chinese Herbal; Female; Fibros | 1996 |
14 other studies available for aristolochic acid i and Renal Insufficiency
| Article | Year |
|---|---|
Investigation of the applicability of the zebrafish model for the evaluation of aristolochic acid-related nephrotoxicity.
Topics: Animals; Aristolochic Acids; Kidney; Phosphatidylinositol 3-Kinases; Renal Insufficiency; Zebrafish | 2023 |
Nephroprotective Role of Zhibai Dihuang Wan in Aristolochic Acid-Intoxicated Zebrafish.
Topics: Animals; Animals, Genetically Modified; Aristolochic Acids; Drugs, Chinese Herbal; Gene Expression P | 2020 |
Nephroprotective role of resveratrol and ursolic Acid in aristolochic Acid intoxicated zebrafish.
Topics: Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Aristolochic Acids; Embryo, Nonmam | 2015 |
Urinary Time- or Dose-Dependent Metabolic Biomarkers of Aristolochic Acid-Induced Nephrotoxicity in Rats.
Topics: Animals; Aristolochic Acids; Biomarkers; Carcinogens; Citric Acid; Creatinine; Dose-Response Relatio | 2017 |
Aristolochic acid nephropathy due to herbal drug intake manifested differently as Fanconi's syndrome and end-stage renal failure--a 7-year follow-up.
Topics: Adult; Aristolochic Acids; Chromatography, High Pressure Liquid; Diagnosis, Differential; Disease Pr | 2008 |
Developmental nephrotoxicity of aristolochic acid in a zebrafish model.
Topics: Abnormalities, Drug-Induced; Animals; Aristolochic Acids; Dose-Response Relationship, Drug; Embryo, | 2012 |
Novel assays for detection of urinary KIM-1 in mouse models of kidney injury.
Topics: Animals; Aristolochic Acids; Biological Assay; Biomarkers; Disease Models, Animal; Hepatitis A Virus | 2013 |
The importance of a histology-based diagnosis of interstitial nephropathy in two patients with renal insufficiency.
Topics: Aged; Aristolochic Acids; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Female; Humans; Kidne | 2003 |
Fanconi's syndrome and subsequent progressive renal failure caused by a Chinese herb containing aristolochic acid.
Topics: Adult; Aristolochic Acids; Disease Progression; Drugs, Chinese Herbal; Fanconi Syndrome; Female; Hum | 2004 |
Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy.
Topics: Adult; Animals; Anti-Obesity Agents; Aristolochic Acids; Balkan Nephropathy; Belgium; DNA Adducts; D | 2001 |
Is "Chinese herbs nephropathy" a prejudicial term?
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Humans; Kidney; Phenanthrenes; Renal Insufficiency; Termi | 2001 |
Aristolochic acid nephropathy in a Chinese patient: time to abandon the term "Chinese herbs nephropathy"?
Topics: Aristolochic Acids; DNA Adducts; Drugs, Chinese Herbal; Female; Humans; Kidney; Middle Aged; Phenant | 2001 |
Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose.
Topics: Aristolochia; Disease Progression; Humans; Medicine, Chinese Traditional; Phytotherapy; Renal Insuff | 2002 |
[Chinese herbs-induced renal failure with Fanconi syndrome: a report of 6 cases].
Topics: Adult; Aristolochia; Drugs, Chinese Herbal; Fanconi Syndrome; Female; Glucocorticoids; Humans; Kidne | 2003 |