aristolochic acid i has been researched along with Proteinuria in 9 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Early renal injury via renal interstitial fibrosis was induced in rats by administration of aristolochic acid I (AAI) solution intragastrically for 8 weeks." | 3.77 | Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats. ( Cheng, XH; Lin, RC; Mao, JR; Sun, WJ; Zhang, L; Zhang, Y; Zhao, YY, 2011) |
| "To analyze the toxic effects of aristolochic acid (AA) on developed kidneys in zebrafish larvae, zebrafish at 3 days postfertilization were treated with various concentrations of AA for 24 h before the status of kidney injury was investigated from several points of view." | 1.43 | Evaluation of nephrotoxic effects of aristolochic acid on zebrafish (Danio rerio) larvae. ( Han, LW; Hou, HR; Hsiao, CD; Liu, KC; Peng, WB; Sun, C; Sun, GJ; Wang, RC; Wang, X; Zhang, Y, 2016) |
| " The nephropathy was induced using intravenous injections of aristolochic acid at a dosage of 10 mg/kg per day for 5 days and was characterized biochemically and histologically." | 1.39 | Urinary d-lactate levels reflect renal function in aristolochic acid-induced nephropathy in mice. ( Chen, SM; Huang, TC; Lee, JA; Li, YC, 2013) |
| "AM and LDXG in experimental dosage can induce renal injury, inflammatory cell infiltration in renal tubulointerstitium and high levels of IL-1beta, IL-6 presumpt that the nephrotoxicity of AM and LDXG refered to the immune mechanism." | 1.34 | [Nephrotoxicity of Aristolochia manshriensis and Longdan Xiegan decoction]. ( Xie, M; Zhang, N, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, TC | 1 |
| Chen, SM | 1 |
| Li, YC | 1 |
| Lee, JA | 1 |
| Tang, Z | 1 |
| Chen, D | 1 |
| Zhang, Y | 3 |
| Chen, Z | 1 |
| Chen, H | 1 |
| Zeng, C | 1 |
| Liu, Z | 1 |
| Wang, X | 1 |
| Liu, KC | 1 |
| Sun, GJ | 1 |
| Han, LW | 1 |
| Wang, RC | 1 |
| Peng, WB | 1 |
| Sun, C | 1 |
| Hsiao, CD | 1 |
| Hou, HR | 1 |
| Zhao, YY | 1 |
| Zhang, L | 1 |
| Mao, JR | 1 |
| Cheng, XH | 1 |
| Lin, RC | 1 |
| Sun, WJ | 1 |
| Chen, M | 1 |
| Su, M | 1 |
| Zhao, L | 1 |
| Jiang, J | 1 |
| Liu, P | 1 |
| Cheng, J | 1 |
| Lai, Y | 1 |
| Liu, Y | 1 |
| Jia, W | 1 |
| Du, GY | 2 |
| Zhou, SJ | 2 |
| Zhao, Y | 2 |
| Cu, HF | 2 |
| Wang, XR | 2 |
| Li, L | 2 |
| Xiao, YQ | 2 |
| Cao, CY | 2 |
| Zhang, CY | 1 |
| Wu, ZL | 2 |
| Gao, SR | 2 |
| He, R | 2 |
| Hui, LQ | 2 |
| Liu, BY | 2 |
| Zhang, N | 2 |
| Xie, M | 2 |
9 other studies available for aristolochic acid i and Proteinuria
| Article | Year |
|---|---|
Urinary d-lactate levels reflect renal function in aristolochic acid-induced nephropathy in mice.
Topics: Acetylglucosaminidase; Animals; Aristolochic Acids; Creatinine; Female; Histocytochemistry; Kidney; | 2013 |
Acute kidney injury induced by aristolochic acid in patients with primary glomerular nephritis.
Topics: Acute Kidney Injury; Adult; Aged; Aristolochic Acids; beta-N-Acetyl-Galactosaminidase; Creatinine; D | 2014 |
Evaluation of nephrotoxic effects of aristolochic acid on zebrafish (Danio rerio) larvae.
Topics: Animals; Aristolochic Acids; Creatinine; Embryo, Nonmammalian; Kidney; Larva; Proteinuria; Reverse T | 2016 |
Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Body Weight; Cholestenones; Fibrosis; Kidney; Kidn | 2011 |
Metabonomic study of aristolochic acid-induced nephrotoxicity in rats.
Topics: Animals; Aristolochic Acids; Body Weight; Chromatography, Liquid; Creatinine; Kidney; Male; Mass Spe | 2006 |
[Experimental study of chronic renal tubular-interstitial injury induced by radix aristolochiae fangchi extract in rats].
Topics: Acetylglucosaminidase; Animals; Aristolochia; Aristolochic Acids; Blood Urea Nitrogen; Body Weight; | 2005 |
[Experimental study of chronic renal tubular-interstitial injury induced by Radix Aristolochiae Fangchi Extract in rats].
Topics: Animals; Aristolochia; Aristolochic Acids; Blood Urea Nitrogen; Body Weight; Dose-Response Relations | 2005 |
[The nephrotoxicity in rats caused by Longdan Xiegan decoction].
Topics: Acetylglucosaminidase; Animals; Aristolochia; beta 2-Microglobulin; Blood Urea Nitrogen; Creatinine; | 2006 |
[Nephrotoxicity of Aristolochia manshriensis and Longdan Xiegan decoction].
Topics: Administration, Oral; Animals; Aristolochia; Blood Urea Nitrogen; Creatinine; Drug Combinations; Dru | 2007 |