aristolochic acid i has been researched along with Nephrosclerosis in 2 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Nephrosclerosis: Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scarpellini, A | 1 |
| Huang, L | 1 |
| Burhan, I | 1 |
| Schroeder, N | 1 |
| Funck, M | 1 |
| Johnson, TS | 1 |
| Verderio, EA | 1 |
| Megyesi, J | 1 |
| Tarcsafalvi, A | 1 |
| Li, S | 1 |
| Hodeify, R | 1 |
| Seng, NS | 1 |
| Portilla, D | 1 |
| Price, PM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of a Diagnostic Kit for Urinary Transglutaminase 2 as a Biomarker for Kidney Allograft Fibrosis[NCT03487861] | 1,000 participants (Anticipated) | Observational | 2017-08-29 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for aristolochic acid i and Nephrosclerosis
| Article | Year |
|---|---|
Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis.
Topics: Animals; Aristolochic Acids; Fibrosis; GTP-Binding Proteins; Male; Mice; Mice, Inbred C57BL; Mice, K | 2014 |
Increased expression of p21WAF1/CIP1 in kidney proximal tubules mediates fibrosis.
Topics: Animals; Aristolochic Acids; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Female; Humans; | 2015 |