aristolochic acid i has been researched along with Nephritis, Interstitial in 37 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Nephritis, Interstitial: Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Generally, renal aging is accompanied by renal fibrosis, which is the final common pathway of chronic kidney diseases." | 5.62 | Aristolochic Acid Induces Renal Fibrosis and Senescence in Mice. ( Abe, E; Atobe, Y; Azushima, K; Funakoshi, K; Kanaoka, T; Kinguchi, S; Suzuki, T; Taguchi, S; Tamura, K; Tanaka, S; Tsukamoto, S; Uneda, K; Urate, S; Wakui, H; Yamaji, T; Yamashita, A, 2021) |
| "Early renal injury via renal interstitial fibrosis was induced in rats by administration of aristolochic acid I (AAI) solution intragastrically for 8 weeks." | 3.77 | Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats. ( Cheng, XH; Lin, RC; Mao, JR; Sun, WJ; Zhang, L; Zhang, Y; Zhao, YY, 2011) |
| "Renal failure was in progression since Pcreat was 2." | 2.68 | Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis: a pilot study in Chinese herbs nephropathy. ( Abramowicz, D; Depierreux, M; Tielemans, C; Vanherweghem, JL, 1996) |
| " In contrast, the molecular mechanism of renal interstitial fibrosis in humans after chronic administration of AA remains to be explored." | 2.41 | Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. ( Arlt, VM; Schmeiser, HH; Stiborova, M, 2002) |
| "Generally, renal aging is accompanied by renal fibrosis, which is the final common pathway of chronic kidney diseases." | 1.62 | Aristolochic Acid Induces Renal Fibrosis and Senescence in Mice. ( Abe, E; Atobe, Y; Azushima, K; Funakoshi, K; Kanaoka, T; Kinguchi, S; Suzuki, T; Taguchi, S; Tamura, K; Tanaka, S; Tsukamoto, S; Uneda, K; Urate, S; Wakui, H; Yamaji, T; Yamashita, A, 2021) |
| "Treatment with probenecid prevented increased plasma creatinine and tubulointerstitial injuries, and reduced both the extent and the severity of ultrastructural lesions induced by aristolochic acid, such as the loss of brush border, mitochondrial edema, and the disappearance of mitochondrial crests." | 1.38 | Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy. ( Antoine, MH; Arlt, VM; Baudoux, TE; De Prez, EG; Goujon, JM; Nortier, JL; Pozdzik, AA; Quellard, N, 2012) |
| " In the present study, the effects of a chronic intake of AA given as a single drug was evaluated through renal histology and function in rabbits." | 1.31 | Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy? ( Bernard, AM; Cosyns, JP; Dehoux, JP; Goebbels, RM; Guiot, Y; Robert, A; van Ypersele de Strihou, C, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (8.11) | 18.2507 |
| 2000's | 19 (51.35) | 29.6817 |
| 2010's | 12 (32.43) | 24.3611 |
| 2020's | 3 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Urate, S | 1 |
| Wakui, H | 1 |
| Azushima, K | 1 |
| Yamaji, T | 1 |
| Suzuki, T | 1 |
| Abe, E | 1 |
| Tanaka, S | 1 |
| Taguchi, S | 1 |
| Tsukamoto, S | 1 |
| Kinguchi, S | 1 |
| Uneda, K | 1 |
| Kanaoka, T | 1 |
| Atobe, Y | 1 |
| Funakoshi, K | 1 |
| Yamashita, A | 1 |
| Tamura, K | 1 |
| Ren, J | 1 |
| Rudemiller, NP | 1 |
| Wen, Y | 1 |
| Lu, X | 1 |
| Privratsky, JR | 1 |
| Crowley, SD | 1 |
| Zhao, H | 1 |
| Jiang, N | 1 |
| Han, Y | 1 |
| Yang, M | 1 |
| Gao, P | 1 |
| Xiong, X | 1 |
| Xiong, S | 1 |
| Zeng, L | 1 |
| Xiao, Y | 1 |
| Wei, L | 1 |
| Li, L | 3 |
| Li, C | 1 |
| Yang, J | 1 |
| Tang, C | 1 |
| Xiao, L | 1 |
| Liu, F | 1 |
| Liu, Y | 1 |
| Sun, L | 2 |
| Aydin, S | 1 |
| Ambroise, J | 1 |
| Cosyns, JP | 4 |
| Gala, JL | 1 |
| Donadei, C | 1 |
| Angeletti, A | 1 |
| Cantarelli, C | 1 |
| D'Agati, VD | 1 |
| La Manna, G | 1 |
| Fiaccadori, E | 1 |
| Horwitz, JK | 1 |
| Xiong, H | 1 |
| Guglielmo, C | 1 |
| Hartzell, S | 1 |
| Madsen, JC | 1 |
| Maggiore, U | 1 |
| Heeger, PS | 1 |
| Cravedi, P | 1 |
| Scarpellini, A | 1 |
| Huang, L | 1 |
| Burhan, I | 1 |
| Schroeder, N | 1 |
| Funck, M | 1 |
| Johnson, TS | 1 |
| Verderio, EA | 1 |
| Zhao, YY | 3 |
| Wang, HL | 1 |
| Cheng, XL | 1 |
| Wei, F | 1 |
| Bai, X | 2 |
| Lin, RC | 2 |
| Vaziri, ND | 2 |
| Liu, X | 1 |
| Wu, J | 1 |
| Wang, J | 1 |
| Fan, J | 1 |
| Feng, X | 1 |
| Yu, X | 1 |
| Yang, X | 1 |
| Chen, H | 1 |
| Cao, G | 1 |
| Chen, DQ | 1 |
| Wang, M | 1 |
| Zhang, ZH | 1 |
| Mao, JR | 2 |
| Witkowicz, J | 1 |
| Yuan, SY | 1 |
| Yang, CR | 1 |
| Cheng, CL | 1 |
| Hsu, SL | 1 |
| Liao, JW | 1 |
| Lin, CC | 1 |
| Chou, YY | 1 |
| Cheng, YW | 1 |
| Sun, D | 2 |
| Liu, CX | 1 |
| Ma, YY | 1 |
| Zhang, L | 2 |
| Chau, W | 1 |
| Ross, R | 1 |
| Li, JY | 1 |
| Yong, TY | 1 |
| Klebe, S | 1 |
| Barbara, JA | 1 |
| Cheng, XH | 1 |
| Zhang, Y | 1 |
| Sun, WJ | 1 |
| Li, YC | 1 |
| Tsai, SH | 1 |
| Chen, SM | 2 |
| Chang, YM | 1 |
| Huang, TC | 1 |
| Huang, YP | 1 |
| Chang, CT | 1 |
| Lee, JA | 1 |
| Baudoux, TE | 1 |
| Pozdzik, AA | 1 |
| Arlt, VM | 3 |
| De Prez, EG | 1 |
| Antoine, MH | 1 |
| Quellard, N | 1 |
| Goujon, JM | 1 |
| Nortier, JL | 3 |
| Stiborova, M | 1 |
| Schmeiser, HH | 2 |
| Debelle, F | 1 |
| Nortier, J | 1 |
| De Prez, E | 1 |
| Vienne, A | 1 |
| Salmon, I | 1 |
| Phillips, DH | 1 |
| Deschodt-Lanckman, M | 1 |
| Vanherweghem, JL | 5 |
| Isnard Bagnis, C | 1 |
| Deray, G | 1 |
| Baumelou, A | 1 |
| Le Quintrec, M | 1 |
| Kazama, I | 1 |
| Matsubara, M | 1 |
| Michimata, M | 1 |
| Suzuki, M | 1 |
| Hatano, R | 1 |
| Sato, H | 1 |
| Ito, S | 1 |
| Ma, YL | 1 |
| Tang, ZY | 1 |
| Wu, Y | 1 |
| Liu, Z | 1 |
| Hu, W | 1 |
| Fujimura, T | 1 |
| Tamaki, K | 1 |
| Iida, S | 1 |
| Tanaka, H | 1 |
| Ikedou, H | 1 |
| Takamiya, Y | 1 |
| Kato, S | 1 |
| Tanaka, A | 1 |
| Okuda, S | 1 |
| Feng, JM | 1 |
| Dai, C | 1 |
| Jin, T | 1 |
| Wang, ZQ | 1 |
| Ma, JF | 1 |
| Wang, LN | 1 |
| Debelle, FD | 1 |
| Abramowicz, D | 1 |
| Tielemans, C | 1 |
| Depierreux, M | 1 |
| Goebbels, RM | 2 |
| Liberton, V | 1 |
| Bieler, CA | 1 |
| Bernard, AM | 2 |
| Sekita, S | 1 |
| Kamakura, H | 1 |
| Yasuda, I | 1 |
| Hamano, T | 1 |
| Satake, M | 1 |
| Dehoux, JP | 1 |
| Guiot, Y | 1 |
| Robert, A | 1 |
| van Ypersele de Strihou, C | 1 |
| Nishimagi, E | 1 |
| Kawaguchi, Y | 1 |
| Terai, C | 1 |
| Kajiyama, H | 1 |
| Hara, M | 1 |
| Kamatani, N | 1 |
| Zheng, F | 1 |
| Zhang, X | 1 |
| Huang, Q | 1 |
| Chen, W | 1 |
| Chen, Y | 1 |
| Li, A | 1 |
| Cronin, AJ | 1 |
| Maidment, G | 1 |
| Cook, T | 1 |
| Kite, GC | 1 |
| Simmonds, MS | 1 |
| Pusey, CD | 1 |
| Lord, GM | 1 |
| Sato, N | 1 |
| Takahashi, D | 1 |
| Tsuchiya, R | 1 |
| Mukoyama, T | 1 |
| Yamagata, S | 1 |
| Ogawa, M | 1 |
| Yoshida, M | 1 |
| Kondo, S | 1 |
| Satoh, N | 1 |
| Ueda, S | 1 |
| Du, GY | 1 |
| Zhou, SJ | 1 |
| Zhao, Y | 1 |
| Cu, HF | 1 |
| Wang, XR | 1 |
| Xiao, YQ | 1 |
| Cao, CY | 1 |
| Wu, ZL | 1 |
| Gao, SR | 1 |
| He, R | 1 |
| Hui, LQ | 1 |
| Liu, BY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of a Diagnostic Kit for Urinary Transglutaminase 2 as a Biomarker for Kidney Allograft Fibrosis[NCT03487861] | 1,000 participants (Anticipated) | Observational | 2017-08-29 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for aristolochic acid i and Nephritis, Interstitial
| Article | Year |
|---|---|
[Aristolochic acid nephropathy].
Topics: Animals; Anti-Obesity Agents; Aristolochiaceae; Aristolochic Acids; Carcinogens; Drugs, Chinese Herb | 2009 |
Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.
Topics: Animals; Aristolochic Acids; Balkan Nephropathy; Carcinogens; DNA Adducts; Drugs, Chinese Herbal; He | 2002 |
Aristolochic acid and 'Chinese herbs nephropathy': a review of the evidence to date.
Topics: Animals; Anti-Obesity Agents; Aristolochic Acids; Belgium; Drugs, Chinese Herbal; Humans; Nephritis, | 2003 |
Herbs and the kidney.
Topics: Aristolochic Acids; Beverages; Drugs, Chinese Herbal; Fanconi Syndrome; Humans; Hyperkalemia; Hypert | 2004 |
[Case of traditional herbal medicine-induced aristolochic acid nephropathy developing to end-stage renal failure].
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nephr | 2005 |
Aristolochic acid nephropathy: a worldwide problem.
Topics: Animals; Aristolochia; Aristolochic Acids; Balkan Nephropathy; Belgium; Cell Transformation, Neoplas | 2008 |
Progressive interstitial renal fibrosis due to Chinese herbs in a patient with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome.
Topics: Aristolochic Acids; Biopsy; Chromatography, High Pressure Liquid; CREST Syndrome; Disease Progressio | 2001 |
Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi).
Topics: Animals; Aristolochia; Drugs, Chinese Herbal; Female; Humans; Kidney Function Tests; Kidney Tubules, | 2002 |
1 trial available for aristolochic acid i and Nephritis, Interstitial
| Article | Year |
|---|---|
Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis: a pilot study in Chinese herbs nephropathy.
Topics: Aristolochic Acids; Case-Control Studies; Disease Progression; Drugs, Chinese Herbal; Female; Fibros | 1996 |
28 other studies available for aristolochic acid i and Nephritis, Interstitial
| Article | Year |
|---|---|
Aristolochic Acid Induces Renal Fibrosis and Senescence in Mice.
Topics: Aging; Animals; Aristolochic Acids; beta-Galactosidase; Collagen; Cyclin-Dependent Kinase Inhibitor | 2021 |
The transcription factor Twist1 in the distal nephron but not in macrophages propagates aristolochic acid nephropathy.
Topics: Animals; Apoptosis; Aristolochic Acids; Coculture Techniques; Disease Models, Animal; Epithelial Cel | 2020 |
Aristolochic acid induces renal fibrosis by arresting proximal tubular cells in G2/M phase mediated by HIF-1α.
Topics: Animals; Aristolochic Acids; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Epithelial Cells; Fib | 2020 |
TP53 mutations in p53-negative dysplastic urothelial cells from Belgian AAN patients: New evidence for aristolochic acid-induced molecular pathogenesis and carcinogenesis.
Topics: Adult; Aristolochic Acids; Belgium; Carcinogenesis; Female; Humans; Immunohistochemistry; Laser Capt | 2017 |
Erythropoietin inhibits SGK1-dependent TH17 induction and TH17-dependent kidney disease.
Topics: Animals; Aristolochic Acids; Cells, Cultured; Disease Models, Animal; Epoetin Alfa; Erythropoietin; | 2019 |
Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis.
Topics: Animals; Aristolochic Acids; Fibrosis; GTP-Binding Proteins; Male; Mice; Mice, Inbred C57BL; Mice, K | 2014 |
Metabolomics analysis reveals the association between lipid abnormalities and oxidative stress, inflammation, fibrosis, and Nrf2 dysfunction in aristolochic acid-induced nephropathy.
Topics: Animals; Aristolochic Acids; Disease Models, Animal; Fibrosis; Inflammation; Kidney; Lipids; Male; M | 2015 |
Possible role of mitochondrial injury in Caulis Aristolochia manshuriensis-induced chronic aristolochic acid nephropathy.
Topics: Animals; Apoptosis; Aristolochia; Aristolochic Acids; Biomarkers; Disease Models, Animal; Dose-Respo | 2017 |
Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression.
Topics: Adenine; Animals; Aristolochic Acids; Biomarkers; Disease Models, Animal; Disease Progression; Early | 2016 |
Comparative nephrotoxicity of aristolochic acid and tetrandrine in vitro and in vivo.
Topics: Animals; Apoptosis; Aristolochic Acids; Benzylisoquinolines; Cell Proliferation; Cell Survival; Cell | 2011 |
Protective effect of prostaglandin E1 on renal microvascular injury in rats of acute aristolochic acid nephropathy.
Topics: Alprostadil; Animals; Aristolochia; Aristolochic Acids; Blotting, Western; Drug Evaluation, Preclini | 2011 |
Nephropathy associated with use of a Chinese herbal product containing aristolochic acid.
Topics: Aged; Aristolochic Acids; Drugs, Chinese Herbal; Fatal Outcome; Fibrosis; Humans; Kidney Diseases; K | 2011 |
Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Body Weight; Cholestenones; Fibrosis; Kidney; Kidn | 2011 |
Aristolochic acid-induced accumulation of methylglyoxal and Nε-(carboxymethyl)lysine: an important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy.
Topics: Animals; Aristolochic Acids; Creatine; Disease Models, Animal; Female; Kidney; Lysine; Mice; Mice, I | 2012 |
Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy.
Topics: Animals; Aristolochic Acids; Atrophy; Biomarkers; Cell Proliferation; Cell Survival; Creatinine; Cyt | 2012 |
Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy.
Topics: Animals; Aristolochic Acids; Autoradiography; Body Weight; Creatinine; Dexfenfluramine; Disease Mode | 2003 |
Adult onset Fanconi syndrome: extensive tubulo-interstitial lesions and glomerulopathy in the early stage of Chinese herbs nephropathy.
Topics: Adult; Aristolochic Acids; Drugs, Chinese Herbal; Fanconi Syndrome; Female; Glomerulonephritis, Memb | 2004 |
[Clinical and pathological analysis on aristolochi acid induced chronic renal impairement in 16 patients].
Topics: Adult; Aged; Aristolochic Acids; Chronic Disease; Drugs, Chinese Herbal; Female; Humans; Male; Middl | 2004 |
Mast cell infiltration associated with tubulointerstitial fibrosis in chronic Aristolochic Acid Nephropathy.
Topics: Acute Disease; Adult; Aged; Aristolochic Acids; Cell Proliferation; Child; Chronic Disease; Disease | 2005 |
[Influence of hypoxia caused by impairment of peritubular capillary on the progression of chronic aristolochic acid nephropathy].
Topics: Animals; Aristolochic Acids; Capillaries; Cell Hypoxia; DNA-Binding Proteins; Hypoxia-Inducible Fact | 2006 |
Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats.
Topics: Animals; Anti-Obesity Agents; Aristolochic Acids; Carcinogens; Drugs, Chinese Herbal; Female; Fibrin | 1998 |
[Aristolochic acids in herbal medicines].
Topics: Antineoplastic Agents; Aristolochic Acids; Drugs, Chinese Herbal; Female; Humans; Nephritis, Interst | 1998 |
Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy?
Topics: Animals; Aristolochic Acids; Disease Models, Animal; Drugs, Chinese Herbal; Enzyme Inhibitors; Femal | 2001 |
[Establishment of model of aristolochic acid-induced chronic renal interstitial fibrosis in rats].
Topics: Animals; Aristolochic Acids; Blood Urea Nitrogen; Body Weight; Carcinogens; Chronic Disease; Creatin | 2001 |
[The clinical and pathological manifestations of aristolochic acid nephropathy--the report of 58 cases].
Topics: Adult; Aristolochic Acids; Carcinogens; Chronic Disease; Drugs, Chinese Herbal; Female; Humans; Kidn | 2001 |
Aristolochic acid as a causative factor in a case of Chinese herbal nephropathy.
Topics: Aristolochia; Aristolochic Acids; Bone Marrow; Drugs, Chinese Herbal; Humans; Male; Middle Aged; Nep | 2002 |
Acute nephrotoxicity of aristolochic acids in mice.
Topics: Acute Disease; Administration, Oral; Animals; Aristolochia; Aristolochic Acids; Blood Urea Nitrogen; | 2004 |
[Experimental study of chronic renal tubular-interstitial injury induced by Radix Aristolochiae Fangchi Extract in rats].
Topics: Animals; Aristolochia; Aristolochic Acids; Blood Urea Nitrogen; Body Weight; Dose-Response Relations | 2005 |