aristolochic acid i has been researched along with Neoplasms in 24 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Additionally, we allude to some of the cancer types where there is molecular epidemiological evidence that these agents are aetiological risk factors." | 2.58 | Carcinogens and DNA damage. ( Barnes, JL; John, K; Martin, FL; Poirier, MC; Zubair, M, 2018) |
| "The anticancer activity of aristololactam-β-D-glucoside has been thought to be due to its DNA and RNA binding activities among other actions." | 2.58 | Natural Aristolochia Alkaloid Aristololactam-β-D-glucoside: Interaction with Biomacromolecules and Correlation to the Biological Perspectives. ( Das, A; Kumar, GS, 2018) |
| " In contrast, the molecular mechanism of renal interstitial fibrosis in humans after chronic administration of AA remains to be explored." | 2.41 | Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. ( Arlt, VM; Schmeiser, HH; Stiborova, M, 2002) |
| "In two patients, pairs of tumors from different parts of the urinary tract, including the bladder, harbored overlapping mutation patterns, suggesting tumor dissemination via cell seeding." | 1.42 | Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid. ( Ardin, M; Castells, X; Dickman, KG; Dittrich, D; Dolgalev, I; Durand, G; Fernandes, A; Forey, N; Grollman, AP; Heguy, A; Jelaković, B; Karanović, S; Karlović, K; Le Calvez-Kelm, F; McKay, J; Mišić, M; Olivier, M; Shariat, SF; Sidorenko, VS; Tomić, K; Villar, S; Voegele, C; Xylinas, E; Zavadil, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 12 (50.00) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, X | 1 |
| Shao, L | 1 |
| Zhang, H | 1 |
| Wang, S | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Das, S | 1 |
| Thakur, S | 1 |
| Korenjak, M | 1 |
| Sidorenko, VS | 2 |
| Chung, FF | 1 |
| Zavadil, J | 2 |
| Au, CK | 1 |
| Ham, YH | 1 |
| Chan, W | 2 |
| Zhang, J | 1 |
| Chan, CK | 1 |
| Pavlović, NM | 1 |
| Belitskiy, GA | 1 |
| Kirsanov, KI | 1 |
| Lesovaya, EA | 1 |
| Yakubovskaya, MG | 1 |
| Brown, AC | 1 |
| Barnes, JL | 1 |
| Zubair, M | 1 |
| John, K | 1 |
| Poirier, MC | 1 |
| Martin, FL | 1 |
| Poon, SL | 1 |
| Pang, ST | 1 |
| McPherson, JR | 1 |
| Yu, W | 1 |
| Huang, KK | 1 |
| Guan, P | 1 |
| Weng, WH | 1 |
| Siew, EY | 1 |
| Liu, Y | 1 |
| Heng, HL | 1 |
| Chong, SC | 1 |
| Gan, A | 1 |
| Tay, ST | 1 |
| Lim, WK | 1 |
| Cutcutache, I | 1 |
| Huang, D | 1 |
| Ler, LD | 1 |
| Nairismägi, ML | 1 |
| Lee, MH | 1 |
| Chang, YH | 1 |
| Yu, KJ | 1 |
| Chan-On, W | 1 |
| Li, BK | 1 |
| Yuan, YF | 1 |
| Qian, CN | 1 |
| Ng, KF | 1 |
| Wu, CF | 1 |
| Hsu, CL | 1 |
| Bunte, RM | 1 |
| Stratton, MR | 1 |
| Futreal, PA | 1 |
| Sung, WK | 1 |
| Chuang, CK | 1 |
| Ong, CK | 1 |
| Rozen, SG | 1 |
| Tan, P | 1 |
| Teh, BT | 1 |
| Lian, CG | 1 |
| Xu, S | 1 |
| Guo, W | 1 |
| Yan, J | 1 |
| Frank, MY | 1 |
| Liu, R | 1 |
| Liu, C | 1 |
| Chen, Y | 1 |
| Murphy, GF | 1 |
| Chen, T | 1 |
| Castells, X | 1 |
| Karanović, S | 1 |
| Ardin, M | 1 |
| Tomić, K | 1 |
| Xylinas, E | 1 |
| Durand, G | 1 |
| Villar, S | 1 |
| Forey, N | 1 |
| Le Calvez-Kelm, F | 1 |
| Voegele, C | 1 |
| Karlović, K | 1 |
| Mišić, M | 1 |
| Dittrich, D | 1 |
| Dolgalev, I | 1 |
| McKay, J | 1 |
| Shariat, SF | 1 |
| Fernandes, A | 1 |
| Heguy, A | 1 |
| Dickman, KG | 1 |
| Olivier, M | 1 |
| Grollman, AP | 2 |
| Jelaković, B | 1 |
| Kucab, JE | 1 |
| Phillips, DH | 1 |
| Arlt, VM | 2 |
| Stiborova, M | 1 |
| Schmeiser, HH | 1 |
| KUPCHAN, SM | 1 |
| DOSKOTCH, RW | 1 |
| JACKSON, L | 1 |
| KOFMAN, S | 1 |
| WEISS, A | 1 |
| BRODOVSKY, H | 1 |
| Cheng, CL | 1 |
| Chen, KJ | 1 |
| Shih, PH | 1 |
| Lu, LY | 1 |
| Hung, CF | 1 |
| Lin, WC | 1 |
| Yesong Gu, J | 1 |
| Tilz, GP | 1 |
| Lanzer, G | 1 |
| Hagemann, U | 1 |
| Grase, R | 1 |
| Thiele, A | 1 |
| Bass, R | 1 |
| Schönhöfer, PS | 1 |
| Das, A | 1 |
| Kumar, GS | 1 |
| Wang, L | 1 |
| Ding, X | 1 |
| Li, C | 1 |
| Zhao, Y | 1 |
| Yu, C | 1 |
| Yi, Y | 1 |
| Zhang, Y | 1 |
| Gao, Y | 1 |
| Pan, C | 1 |
| Liu, S | 1 |
| Han, J | 1 |
| Tian, J | 1 |
| Liu, J | 1 |
| Deng, N | 1 |
| Li, G | 1 |
| Liang, A | 1 |
| Marcus, DM | 1 |
| Ernst, E | 1 |
| Krell, D | 1 |
| Stebbing, J | 1 |
7 reviews available for aristolochic acid i and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Aristolochic acid-associated cancers: a public health risk in need of global action.
Topics: Aristolochic Acids; Humans; Mutagenesis; Neoplasms; Public Health | 2022 |
Drug-Related Carcinogenesis: Risk Factors and Approaches for Its Prevention.
Topics: Animals; Antineoplastic Agents; Aristolochic Acids; Arsenic; Carcinogenesis; Carcinogens; Diethylsti | 2020 |
Carcinogens and DNA damage.
Topics: Amines; Animals; Aristolochic Acids; Benzo(a)pyrene; Carcinogens; Cross-Linking Reagents; Diet; DNA; | 2018 |
Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model.
Topics: Animals; Aristolochic Acids; Benz(a)Anthracenes; Carcinogens, Environmental; Carcinoma; Environmenta | 2010 |
Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.
Topics: Animals; Aristolochic Acids; Balkan Nephropathy; Carcinogens; DNA Adducts; Drugs, Chinese Herbal; He | 2002 |
Natural Aristolochia Alkaloid Aristololactam-β-D-glucoside: Interaction with Biomacromolecules and Correlation to the Biological Perspectives.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Aristolochia; Aristolochic Acids; Biological | 2018 |
17 other studies available for aristolochic acid i and Neoplasms
| Article | Year |
|---|---|
CHMIS-C: a comprehensive herbal medicine information system for cancer.
Topics: Antineoplastic Agents, Phytogenic; Databases, Factual; Internet; National Institutes of Health (U.S. | 2005 |
Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy.
Topics: Aristolochic Acids; Bioaccumulation; Carcinogens; DNA Adducts; Humans; Kidney Diseases; Neoplasms | 2023 |
Effects of Diet on Aristolochic Acid-DNA Adduct Formation: Implications for Balkan Endemic Nephropathy Etiology.
Topics: Aristolochic Acids; Balkan Nephropathy; Diet; DNA Adducts; Humans; Kidney Diseases; Neoplasms | 2023 |
Cancer Related to Herbs and Dietary Supplements: Online Table of Case Reports. Part 5 of 5.
Topics: Aloe; Animals; Aristolochic Acids; Comfrey; Dietary Supplements; Drugs, Chinese Herbal; Ginkgo bilob | 2018 |
Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.
Topics: Animals; Aristolochic Acids; Carcinogens; Cell Line, Tumor; Genome, Human; Humans; Kidney Diseases; | 2013 |
Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid.
Topics: 5-Methylcytosine; Animals; Aristolochic Acids; Carcinogenesis; Carcinogens; Cytosine; DNA-Binding Pr | 2015 |
Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid.
Topics: Aristolochic Acids; Carcinogens; Exome; Formaldehyde; Humans; Neoplasms; Paraffin Embedding; Sequenc | 2015 |
TUMOR INHIBITORS. I. ARISTOLOCHIC ACID, THE ACTIVE PRINCIPLE OF ARISTOLOCHIA INDICA.
Topics: Adenocarcinoma; Antineoplastic Agents; Aristolochia; Aristolochic Acids; Chemical Phenomena; Chemist | 1962 |
ARISTOLOCHIC ACID (NSC-50413): PHASE I CLINICAL STUDY.
Topics: Antineoplastic Agents; Aristolochic Acids; Child; Drug Therapy; Neoplasms; Phenanthrenes; Research; | 1964 |
Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents.
Topics: Animals; Aristolochic Acids; Creatinine; DNA Adducts; Genes, ras; Kidney; Kidney Failure, Chronic; N | 2006 |
[Immunotherapy II: clinical investigations for the induction and activity of interferon (author's transl)].
Topics: Aristolochic Acids; Dioxolanes; Humans; Inflammation; Interferons; Leukemia; Neoplasms; Phenanthrene | 1980 |
[Problems of drug safety: aristolochic acid].
Topics: Animals; Aristolochic Acids; Consumer Product Safety; Germany, West; Legislation as Topic; Neoplasms | 1982 |
Oral administration of Aristolochia manshuriensis Kom in rats induces tumors in multiple organs.
Topics: Administration, Oral; Anemia; Animals; Aristolochia; Body Weight; Carcinogens; Female; Kidney; Liver | 2018 |
Global hazards of herbal remedies: lessons from Aristolochia: The lesson from the health hazards of Aristolochia should lead to more research into the safety and efficacy of medicinal plants.
Topics: Animals; Aristolochia; Biomedical Research; Carcinogens; Dietary Supplements; Epidemiologic Studies; | 2016 |
Final report on carcinogens background document for aristolochic acids.
Topics: Animals; Aristolochia; Aristolochic Acids; Carcinogens; Humans; Neoplasms; Phytotherapy | 2008 |
Aristolochia, a herbal treatment to die for?
Topics: Aristolochia; Aristolochic Acids; Humans; Neoplasms; Nephritis; Phytotherapy; Plant Extracts | 2012 |
Aristolochia: the malignant truth.
Topics: Aristolochia; Carcinogens; Herbal Medicine; Humans; Medicine, Chinese Traditional; Neoplasms | 2013 |