aristolochic acid i has been researched along with Mitochondrial Diseases in 1 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This report describes an investigation of the pathological mechanism of acute renal failure caused by toxic tubular necrosis after treatment with aristolochic acid I (AAI) in Sprague-Dawley (SD) rats." | 1.39 | Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity. ( Bao, Q; Huang, X; Jiang, Z; Li, H; Sun, L; Wang, T; Zhang, L; Zhang, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, Z | 1 |
| Bao, Q | 1 |
| Sun, L | 1 |
| Huang, X | 1 |
| Wang, T | 1 |
| Zhang, S | 1 |
| Li, H | 1 |
| Zhang, L | 1 |
1 other study available for aristolochic acid i and Mitochondrial Diseases
| Article | Year |
|---|---|
Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Blood Urea Nitrogen; Creatinine; DNA, Mitochondria | 2013 |