aristolochic acid i has been researched along with Liver Neoplasms in 14 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Each hepatocellular carcinoma displays dozens of mutations in driver and passenger genes." | 2.61 | Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid. ( Letouzé, E; Nault, JC, 2019) |
| "Notably, ESRD-associated HAS had a significantly higher TMB (17." | 1.91 | Association between hepatic angiosarcoma and end-stage renal disease: nationwide population-based evidence and enriched mutational signature of aristolochic acid exposure. ( Chang, CJ; Chang, IY; Chen, CC; Chen, KH; Chen, TC; Chuang, HC; Hsieh, TY; Huang, HY; Huang, SC; Lin, IC; Liu, H; Liu, TT; Ng, KF, 2023) |
| " In order to understand the toxicity of aristolochic acids and the carcinogenic risks, as well as guide clinical safe medication, the experts suggested that：①Complete the systematical evaluation of aristolochic acids carcinogenicity as soon as possible." | 1.46 | [Study and opinion on toxicity of aristolochic acid]. ( Gao, Y; Liang, AH; Xiao, XH; Zhang, BL; Zhu, XX, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, SC | 1 |
| Chang, IY | 1 |
| Chang, CJ | 1 |
| Liu, H | 1 |
| Chen, KH | 1 |
| Liu, TT | 1 |
| Hsieh, TY | 1 |
| Chuang, HC | 1 |
| Chen, CC | 1 |
| Lin, IC | 1 |
| Ng, KF | 1 |
| Huang, HY | 1 |
| Chen, TC | 1 |
| Chen, CJ | 1 |
| Yang, YH | 1 |
| Lin, MH | 1 |
| Lee, CP | 1 |
| Tsan, YT | 1 |
| Lai, MN | 1 |
| Yang, HY | 1 |
| Doyle, P | 1 |
| Ho, WC | 1 |
| Chen, PC | 1 |
| Wang, JB | 1 |
| Bai, ZF | 1 |
| Xiao, XH | 2 |
| Lu, ZN | 2 |
| Han, ZG | 2 |
| Luo, Q | 1 |
| Zhao, LN | 1 |
| Shi, Y | 1 |
| Wang, N | 1 |
| Wang, L | 1 |
| Li, Y | 1 |
| Zhu, S | 1 |
| Xue, M | 1 |
| Jing, Y | 1 |
| Liu, X | 1 |
| Cai, D | 1 |
| Zhao, Y | 1 |
| Bian, Y | 1 |
| Zhang, Z | 1 |
| Zhang, L | 1 |
| Zhou, G | 1 |
| Zhao, X | 1 |
| Zhang, HM | 1 |
| Zhao, XH | 1 |
| Sun, ZH | 1 |
| Li, GC | 1 |
| Liu, GC | 1 |
| Sun, LR | 1 |
| Hou, JQ | 1 |
| Zhou, W | 1 |
| Nault, JC | 1 |
| Letouzé, E | 1 |
| Jin, K | 2 |
| Su, KK | 2 |
| Li, T | 2 |
| Zhu, XQ | 1 |
| Wang, Q | 1 |
| Ge, RS | 1 |
| Pan, ZF | 2 |
| Wu, BW | 2 |
| Ge, LJ | 1 |
| Zhang, YH | 1 |
| Wang, YF | 2 |
| Shen, GF | 1 |
| Zhu, DY | 2 |
| Xiang, CS | 2 |
| Li, LJ | 2 |
| Lou, YJ | 2 |
| Li, L | 1 |
| Mao, ZR | 1 |
| Rossiello, MR | 2 |
| Rao, PM | 2 |
| Rajalakshmi, S | 2 |
| Sarma, DS | 2 |
| Laconi, E | 1 |
| Gao, Y | 1 |
| Zhu, XX | 1 |
| Liang, AH | 1 |
| Zhang, BL | 1 |
2 reviews available for aristolochic acid i and Liver Neoplasms
| Article | Year |
|---|---|
Recognition of the toxicity of aristolochic acid.
Topics: Age Factors; Aristolochic Acids; Carcinoma, Hepatocellular; Female; Humans; Kidney Diseases; Liver N | 2019 |
Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid.
Topics: Aristolochic Acids; Carcinogenesis; Carcinoma, Hepatocellular; DNA Adducts; Drugs, Chinese Herbal; H | 2019 |
12 other studies available for aristolochic acid i and Liver Neoplasms
| Article | Year |
|---|---|
Association between hepatic angiosarcoma and end-stage renal disease: nationwide population-based evidence and enriched mutational signature of aristolochic acid exposure.
Topics: Hemangiosarcoma; Humans; Incidence; Kidney Failure, Chronic; Liver Neoplasms; Mutation; Renal Insuff | 2023 |
Herbal Medicine Containing Aristolochic Acid and the Risk of Primary Liver Cancer in Patients with Hepatitis C Virus Infection.
Topics: Aristolochic Acids; Carcinogens; Female; Hepacivirus; Hepatitis C; Herbal Medicine; Humans; Liver Ne | 2019 |
Letter to the Editor: Is Aristolochic Acid the Major Cause of Liver Cancer in China and Asia?
Topics: Animals; Aristolochic Acids; Asia; China; Humans; Liver Neoplasms; Mice | 2020 |
Reply.
Topics: Aristolochic Acids; Asia; China; Humans; Liver Neoplasms | 2020 |
The Mutational Features of Aristolochic Acid-Induced Mouse and Human Liver Cancers.
Topics: Animals; Aristolochic Acids; Bile Duct Neoplasms; Carbon Tetrachloride; Carcinoma, Hepatocellular; C | 2020 |
Aristolochic acid I promotes the invasion and migration of hepatocellular carcinoma cells by activating the C3a/C3aR complement system.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Complement C3a; Epithelial-Mesenchymal T | 2023 |
Carcinogens that induce the A:T > T:A nucleotide substitutions in the genome.
Topics: Aristolochic Acids; Carcinogens; Carcinoma, Hepatocellular; China; Environment; Humans; Liver Neopla | 2018 |
Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines.
Topics: Administration, Oral; Animals; Aristolochia; Aristolochic Acids; Carcinogenesis; Carcinogens; Dogs; | 2016 |
Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure.
Topics: Albumins; alpha-Fetoproteins; Animals; Aristolochic Acids; Biomarkers, Tumor; Cell Dedifferentiation | 2016 |
Similar patterns of hypomethylation in the beta-hydroxy-beta-methylglutaryl coenzyme A reductase gene in hepatic nodules induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Animals; Aristolochic Acids; Carcinogens; Cell Cycle; Dimethylhydrazines; DNA | 1994 |
Induction of hepatic nodules in the rat by aristolochic acid.
Topics: Animals; Aristolochic Acids; Carcinogens; Cell Division; Cocarcinogenesis; Hepatectomy; Liver; Liver | 1993 |
[Study and opinion on toxicity of aristolochic acid].
Topics: Aristolochia; Aristolochic Acids; Drugs, Chinese Herbal; Humans; Liver Neoplasms; Medicine, Chinese | 2017 |