aristolochic acid i has been researched along with Kidney Tubular Necrosis, Acute in 16 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Kidney Tubular Necrosis, Acute: Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This report describes an investigation of the pathological mechanism of acute renal failure caused by toxic tubular necrosis after treatment with aristolochic acid I (AAI) in Sprague-Dawley (SD) rats." | 1.39 | Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity. ( Bao, Q; Huang, X; Jiang, Z; Li, H; Sun, L; Wang, T; Zhang, L; Zhang, S, 2013) |
| "Treatment with probenecid prevented increased plasma creatinine and tubulointerstitial injuries, and reduced both the extent and the severity of ultrastructural lesions induced by aristolochic acid, such as the loss of brush border, mitochondrial edema, and the disappearance of mitochondrial crests." | 1.38 | Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy. ( Antoine, MH; Arlt, VM; Baudoux, TE; De Prez, EG; Goujon, JM; Nortier, JL; Pozdzik, AA; Quellard, N, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (56.25) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, L | 1 |
| Fu, P | 1 |
| Huang, XR | 1 |
| Liu, F | 1 |
| Lai, KN | 1 |
| Lan, HY | 1 |
| Hamano, Y | 1 |
| Aoki, T | 1 |
| Shirai, R | 1 |
| Hatano, M | 1 |
| Kimura, R | 1 |
| Ogawa, M | 1 |
| Yokosuka, O | 1 |
| Ueda, S | 1 |
| Cao, J | 1 |
| Yang, XD | 1 |
| Wang, XY | 1 |
| Qu, L | 1 |
| Liu, G | 1 |
| Li, XM | 4 |
| Li, ZH | 1 |
| Wei, M | 1 |
| Ding, GF | 1 |
| Wang, DH | 1 |
| Ding, J | 1 |
| Jiang, Z | 1 |
| Bao, Q | 1 |
| Sun, L | 1 |
| Huang, X | 1 |
| Wang, T | 1 |
| Zhang, S | 1 |
| Li, H | 1 |
| Zhang, L | 1 |
| Baudoux, TE | 1 |
| Pozdzik, AA | 1 |
| Arlt, VM | 1 |
| De Prez, EG | 1 |
| Antoine, MH | 1 |
| Quellard, N | 1 |
| Goujon, JM | 1 |
| Nortier, JL | 1 |
| Wang, HY | 3 |
| Yang, L | 3 |
| Isnard Bagnis, C | 1 |
| Deray, G | 1 |
| Baumelou, A | 1 |
| Le Quintrec, M | 1 |
| Vanherweghem, JL | 1 |
| Li, X | 1 |
| Wang, H | 1 |
| Wang, HL | 1 |
| Zhang, JY | 1 |
| Wang, HT | 1 |
| Wang, YM | 1 |
| Liang, YP | 1 |
| Liu, YJ | 1 |
| Peng, W | 1 |
| Chen, W | 1 |
| Chen, Y | 1 |
| Li, A | 1 |
| Nortier, J | 1 |
| Wang, SX | 1 |
1 review available for aristolochic acid i and Kidney Tubular Necrosis, Acute
| Article | Year |
|---|---|
Herbs and the kidney.
Topics: Aristolochic Acids; Beverages; Drugs, Chinese Herbal; Fanconi Syndrome; Humans; Hyperkalemia; Hypert | 2004 |
15 other studies available for aristolochic acid i and Kidney Tubular Necrosis, Acute
| Article | Year |
|---|---|
Activation of p53 promotes renal injury in acute aristolochic acid nephropathy.
Topics: Animals; Apoptosis; Aristolochic Acids; Benzothiazoles; Cells, Cultured; Disease Models, Animal; Dos | 2010 |
Low-dose darbepoetin alpha attenuates progression of a mouse model of aristolochic acid nephropathy through early tubular protection.
Topics: Animals; Apoptosis; Aristolochic Acids; Cell Proliferation; Darbepoetin alfa; Disease Models, Animal | 2010 |
[Differential changes of intrarenal oxygenation in rat models of acute tubular necrosis caused by aristolochic acid and gentamicin].
Topics: Animals; Aristolochic Acids; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Male; Rats; Rats, | 2010 |
[Clinical characteristics and long-term follow-up analysis of three cases with newborn aristolochic acid nephropathy].
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Female; Follow-Up Studies; Glomerular Filtration Rate; Hu | 2011 |
[Experts comment].
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Female; Follow-Up Studies; Glomerular Filtration Rate; Hu | 2011 |
Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Blood Urea Nitrogen; Creatinine; DNA, Mitochondria | 2013 |
Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy.
Topics: Animals; Aristolochic Acids; Atrophy; Biomarkers; Cell Proliferation; Cell Survival; Creatinine; Cyt | 2012 |
[Provide against possible trouble--on knowledge, prevention and treatment of adverse drug reactions].
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Humans; Kidney Tubular Necrosis, Acute | 2003 |
[A comparative study of manchurian Dutchmanspipe and antibiotics induced acute tubular necrosis in renal cellular biological features].
Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Aristolochia; Aristolochic Acids; Biopsy, Needle; Dru | 2003 |
Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis.
Topics: Actins; Adult; Aristolochic Acids; Biomarkers; Biopsy; Connective Tissue Growth Factor; Disease Prog | 2007 |
[Aristolochic acid induces renal tubular injury and inhibits expression of bone morphogenetic protein-7 mRNA in renal tissue of rats].
Topics: Animals; Aristolochia; Aristolochic Acids; Bone Morphogenetic Protein 7; Kidney; Kidney Tubular Necr | 2008 |
[Wenyang Huoxue Recipe up-regulates the expression of angiopoietin-1 mRNA in rats with chronic aristolochic acid nephropathy].
Topics: Angiopoietin-1; Animals; Aristolochia; Aristolochic Acids; Drugs, Chinese Herbal; Kidney; Kidney Tub | 2008 |
[The clinical and pathological manifestations of aristolochic acid nephropathy--the report of 58 cases].
Topics: Adult; Aristolochic Acids; Carcinogens; Chronic Disease; Drugs, Chinese Herbal; Female; Humans; Kidn | 2001 |
[Renal interstitial fibrosis and urotelial carcinomas after ingestion of a Chinese herb (Aristolochia fangchi)].
Topics: Anti-Obesity Agents; Aristolochia; Aristolochic Acids; Atrophy; Biomarkers; Carcinogens; Carcinoma, | 2002 |
[Peritubular capillary injury in Chinese herb guan-mu-tong-induced acute tubular necrosis].
Topics: Adult; Aristolochia; Basement Membrane; Capillaries; Drugs, Chinese Herbal; Endothelial Cells; Femal | 2005 |