aristolochic acid i has been researched along with Kidney Failure, Chronic in 34 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Even tough numerous dilemmas and conflicting opinions regarding BEN etiology are encountered in literature, prevailing theory is that BEN is caused by chronic poisoning with aristolochic acid ingested by food in people with genetic predisposition to this disease." | 3.76 | Early detection of Balkan endemic nephropathy in Bosanska Posavina. ( Mesić, E, 2010) |
| "As most patients progress to ESRD, need for renal replacement therapy, as either dialysis or kidney transplant, usually ensues." | 2.52 | Aristolochic acid nephropathy: epidemiology, clinical presentation, and treatment. ( Luciano, RL; Perazella, MA, 2015) |
| "Notably, ESRD-associated HAS had a significantly higher TMB (17." | 1.91 | Association between hepatic angiosarcoma and end-stage renal disease: nationwide population-based evidence and enriched mutational signature of aristolochic acid exposure. ( Chang, CJ; Chang, IY; Chen, CC; Chen, KH; Chen, TC; Chuang, HC; Hsieh, TY; Huang, HY; Huang, SC; Lin, IC; Liu, H; Liu, TT; Ng, KF, 2023) |
| "The incidence of ESRD was ascertained through cross-referencing with a registry for catastrophic illnesses." | 1.43 | Patients with urothelial carcinoma have poor renal outcome regardless of whether they receive nephrouretectomy. ( Chang, CH; Chung, CJ; Chung, MC; Hung, KY; Hung, PH; Muo, CH; Tsai, HB, 2016) |
| " The correlation of cancer incidence with age, gender, dosage of aristolochic acid (AA), the type of renal replacement therapies, and the polymorphisms of quinone oxidoreductase 1 (NQO1) C609T and cytochrome P450 1A1 (CYP1A1) A4889G was examined." | 1.42 | Analysis of potential risk factors for cancer incidence in patients with aristolochic acid nephropathy from Wenzhou, China. ( Chen, C; Lin, F; Liu, Y; Sun, M; Xu, F; Zhang, J; Zheng, C, 2015) |
| "Both end-stage renal disease (ESRD) and urothelial cancer (UC) are associated with the consumption of Chinese herbal products containing aristolochic acid (AA) by the general population." | 1.40 | Increased risk of urinary tract cancer in ESRD patients associated with usage of Chinese herbal products suspected of containing aristolochic acid. ( Chen, PC; Chen, YY; Lai, MN; Pu, YS; Wang, JD; Wang, SM; Wei, A, 2014) |
| "All incident cases of chronic renal failure reported to the Database of Catastrophic Illness of the National Health Insurance Bureau between 1995 and 2000 were defined as the case group." | 1.37 | Occupational kidney disease among Chinese herbalists exposed to herbs containing aristolochic acids. ( Chen, PC; Lo, TC; Wang, JD; Yang, HY, 2011) |
| " Results revealed that chronic administration of aristolochic acid (AA) resulted in a severe AAN characterized by progressive renal dysfunction and tubulointerstitial fibrosis including epithelial-mesenchymal transition (EMT) in Smad3 WT mice, but not in Smad3 KO mice, suggesting a critical role for Smad3 in the development of AAN." | 1.36 | Mechanism of chronic aristolochic acid nephropathy: role of Smad3. ( Chung, AC; Fu, P; Huang, XR; Lai, KN; Lan, HY; Liu, F; Zhou, L, 2010) |
| "To study the effect of long-term use of low dose Caulis Aristolochiae Manshuriensis (CAM) on the deterioration of chronic renal failure rats." | 1.31 | [Influence of long-term use of low dose caulis Aristolochiae manshuriensis on partial nephrectomized rats]. ( Mei, XB; Xu, J; Ye, ZB, 2002) |
| " Moreover, hypothesizing a linear dose-response relationship, the risk of developing ESRD linearly increased with ST-AF doses." | 1.31 | Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose. ( Martinez, MC; Nortier, J; Vanherweghem, JL; Vereerstraeten, P, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 16 (47.06) | 29.6817 |
| 2010's | 14 (41.18) | 24.3611 |
| 2020's | 2 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, SC | 1 |
| Chang, IY | 1 |
| Chang, CJ | 1 |
| Liu, H | 1 |
| Chen, KH | 1 |
| Liu, TT | 1 |
| Hsieh, TY | 1 |
| Chuang, HC | 1 |
| Chen, CC | 1 |
| Lin, IC | 1 |
| Ng, KF | 1 |
| Huang, HY | 1 |
| Chen, TC | 1 |
| Bennett, WM | 1 |
| Segal, G | 1 |
| Wang, SM | 2 |
| Lai, MN | 2 |
| Wei, A | 1 |
| Chen, YY | 2 |
| Pu, YS | 2 |
| Chen, PC | 3 |
| Wang, JD | 3 |
| Roumeguère, T | 2 |
| Broeders, N | 1 |
| Jayaswal, A | 1 |
| Rorive, S | 2 |
| Quackels, T | 1 |
| Pozdzik, A | 1 |
| Arlt, VM | 4 |
| Schmeiser, HH | 3 |
| Nortier, JL | 4 |
| Luciano, RL | 1 |
| Perazella, MA | 1 |
| Sun, M | 1 |
| Zhang, J | 1 |
| Zheng, C | 1 |
| Liu, Y | 1 |
| Lin, F | 1 |
| Xu, F | 1 |
| Chen, C | 1 |
| Hung, PH | 1 |
| Tsai, HB | 1 |
| Hung, KY | 1 |
| Muo, CH | 1 |
| Chung, MC | 1 |
| Chang, CH | 1 |
| Chung, CJ | 1 |
| Kong, PI | 1 |
| Chiu, YW | 1 |
| Kuo, MC | 1 |
| Chen, SC | 1 |
| Chang, JM | 1 |
| Tsai, JC | 1 |
| Hwang, SJ | 1 |
| Chen, HC | 1 |
| Lai, JN | 1 |
| Tseng, WL | 1 |
| Hwang, JS | 1 |
| Zhou, L | 1 |
| Fu, P | 1 |
| Huang, XR | 1 |
| Liu, F | 1 |
| Chung, AC | 1 |
| Lai, KN | 1 |
| Lan, HY | 1 |
| Eaton, L | 1 |
| Mesić, E | 1 |
| Soderland, P | 1 |
| Lovekar, S | 1 |
| Weiner, DE | 1 |
| Brooks, DR | 1 |
| Kaufman, JS | 1 |
| Yang, HY | 1 |
| Lo, TC | 1 |
| Chau, W | 1 |
| Ross, R | 1 |
| Li, JY | 1 |
| Yong, TY | 1 |
| Klebe, S | 1 |
| Barbara, JA | 1 |
| Chen, D | 1 |
| Tang, Z | 1 |
| Luo, C | 1 |
| Chen, H | 1 |
| Liu, Z | 1 |
| Chen, CH | 1 |
| Dickman, KG | 1 |
| Huang, CY | 1 |
| Moriya, M | 1 |
| Shun, CT | 1 |
| Tai, HC | 1 |
| Huang, KH | 1 |
| Lee, YJ | 1 |
| Grollman, AP | 1 |
| Ye, ZB | 1 |
| Xu, J | 1 |
| Mei, XB | 1 |
| Gillerot, G | 1 |
| Goffin, E | 1 |
| Moulin, P | 1 |
| Phillips, DH | 1 |
| Cosyns, JP | 1 |
| Devuyst, O | 1 |
| Fujimura, T | 1 |
| Tamaki, K | 1 |
| Iida, S | 1 |
| Tanaka, H | 1 |
| Ikedou, H | 1 |
| Takamiya, Y | 1 |
| Kato, S | 1 |
| Tanaka, A | 1 |
| Okuda, S | 1 |
| Cheng, CL | 1 |
| Chen, KJ | 1 |
| Shih, PH | 1 |
| Lu, LY | 1 |
| Hung, CF | 1 |
| Lin, WC | 1 |
| Yesong Gu, J | 1 |
| Lemy, A | 1 |
| Wissing, KM | 1 |
| Zlotta, A | 1 |
| Muniz Martinez, MC | 1 |
| Decaestecker, C | 2 |
| Salmon, I | 1 |
| Abramowicz, D | 2 |
| Vanherweghem, JL | 5 |
| Nortier, J | 2 |
| Pozdzik, AA | 1 |
| Salmon, IJ | 2 |
| Husson, CP | 1 |
| Rogier, E | 1 |
| Bourgeade, MF | 1 |
| Deschodt-Lanckman, MM | 2 |
| Stengel, B | 1 |
| Jones, E | 1 |
| Lord, GM | 2 |
| Tagore, R | 1 |
| Cook, T | 2 |
| Gower, P | 1 |
| Pusey, CD | 2 |
| Martinez, MC | 2 |
| Bieler, CA | 1 |
| Petein, M | 1 |
| Depierreux, MF | 1 |
| De Pauw, L | 1 |
| Vereerstraeten, P | 2 |
| Kessler, DA | 1 |
| Li, YM | 1 |
| Williams, G | 1 |
| Debelle, FD | 1 |
| De Prez, EG | 1 |
| Garbar, CH | 1 |
| Vienne, AR | 1 |
| Lampert, N | 1 |
| Xu, Y | 1 |
| Guitouni, O | 1 |
| Karimi, I | 1 |
| Kazmouhi, L | 1 |
| Berrekchi, FZ | 1 |
| Bekkaoui, S | 1 |
| Benabdellah, N | 1 |
| Elyoubi, R | 1 |
| Souaaid, S | 1 |
| Abda, N | 1 |
| Bentata, Y | 1 |
3 reviews available for aristolochic acid i and Kidney Failure, Chronic
| Article | Year |
|---|---|
Aristolochic acid nephropathy: epidemiology, clinical presentation, and treatment.
Topics: Animals; Aristolochia; Aristolochic Acids; Disease Progression; Glucocorticoids; Humans; Kidney Dise | 2015 |
Chronic kidney disease associated with environmental toxins and exposures.
Topics: Aristolochic Acids; Balkan Nephropathy; Chronic Disease; Drugs, Chinese Herbal; Endemic Diseases; En | 2010 |
[Case of traditional herbal medicine-induced aristolochic acid nephropathy developing to end-stage renal failure].
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nephr | 2005 |
31 other studies available for aristolochic acid i and Kidney Failure, Chronic
| Article | Year |
|---|---|
Association between hepatic angiosarcoma and end-stage renal disease: nationwide population-based evidence and enriched mutational signature of aristolochic acid exposure.
Topics: Hemangiosarcoma; Humans; Incidence; Kidney Failure, Chronic; Liver Neoplasms; Mutation; Renal Insuff | 2023 |
Splenic large B-cell lymphoma 17 years after exposure to aristolochic acid.
Topics: Aristolochic Acids; Chemotherapy, Adjuvant; Drugs, Chinese Herbal; Female; Humans; Immunosuppressive | 2013 |
Increased risk of urinary tract cancer in ESRD patients associated with usage of Chinese herbal products suspected of containing aristolochic acid.
Topics: Aged; Aged, 80 and over; Aristolochic Acids; Cohort Studies; Drugs, Chinese Herbal; Female; Humans; | 2014 |
Bacillus Calmette-Guerin therapy in non-muscle-invasive bladder carcinoma after renal transplantation for end-stage aristolochic acid nephropathy.
Topics: Administration, Intravesical; Adult; Aged; Aristolochic Acids; BCG Vaccine; Female; Follow-Up Studie | 2015 |
Analysis of potential risk factors for cancer incidence in patients with aristolochic acid nephropathy from Wenzhou, China.
Topics: Aged; Aristolochic Acids; Carcinogens; China; Cytochrome P-450 CYP1A1; Female; Hematologic Neoplasms | 2015 |
Patients with urothelial carcinoma have poor renal outcome regardless of whether they receive nephrouretectomy.
Topics: Adult; Aged; Aristolochic Acids; Cohort Studies; Female; Humans; Kidney; Kidney Failure, Chronic; Ma | 2016 |
Aristolochic acid nephropathy due to herbal drug intake manifested differently as Fanconi's syndrome and end-stage renal failure--a 7-year follow-up.
Topics: Adult; Aristolochic Acids; Chromatography, High Pressure Liquid; Diagnosis, Differential; Disease Pr | 2008 |
Increased risks of chronic kidney disease associated with prescribed Chinese herbal products suspected to contain aristolochic acid.
Topics: Adult; Aged; Aristolochic Acids; Chronic Disease; Drugs, Chinese Herbal; Female; Follow-Up Studies; | 2009 |
Mechanism of chronic aristolochic acid nephropathy: role of Smad3.
Topics: Animals; Aristolochic Acids; Cell Line; Collagen; Enzyme-Linked Immunosorbent Assay; Fibrosis; Gene | 2010 |
Traditional Chinese practitioner breaches Medicine Act.
Topics: Aristolochic Acids; Dermatologic Agents; Female; Humans; Kidney Failure, Chronic; Medicine, Chinese | 2010 |
Early detection of Balkan endemic nephropathy in Bosanska Posavina.
Topics: Adolescent; Adult; Aged; Aristolochic Acids; Balkan Nephropathy; Bosnia and Herzegovina; Child; Fema | 2010 |
Occupational kidney disease among Chinese herbalists exposed to herbs containing aristolochic acids.
Topics: Adult; Aged; Aristolochic Acids; Case-Control Studies; Drug Compounding; Drug Contamination; Drugs, | 2011 |
Nephropathy associated with use of a Chinese herbal product containing aristolochic acid.
Topics: Aged; Aristolochic Acids; Drugs, Chinese Herbal; Fatal Outcome; Fibrosis; Humans; Kidney Diseases; K | 2011 |
Clinical and pathological spectrums of aristolochic acid nephropathy.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aristolochic Acids; Biomarkers; Biopsy; Chi-Square Dis | 2012 |
Aristolochic acid-induced upper tract urothelial carcinoma in Taiwan: clinical characteristics and outcomes.
Topics: Adenine; Adult; Age Factors; Aged; Aged, 80 and over; Aristolochic Acids; Carcinogens; Carcinoma, Tr | 2013 |
[Influence of long-term use of low dose caulis Aristolochiae manshuriensis on partial nephrectomized rats].
Topics: Animals; Aristolochia; Aristolochic Acids; Creatinine; Drugs, Chinese Herbal; Kidney Failure, Chroni | 2002 |
Aristolochic acid nephropathy and the peritoneum: Functional, structural, and molecular studies.
Topics: Aged; Anti-Obesity Agents; Aquaporin 1; Aquaporins; Aristolochic Acids; Blood Group Antigens; Blotti | 2003 |
Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents.
Topics: Animals; Aristolochic Acids; Creatinine; DNA Adducts; Genes, ras; Kidney; Kidney Failure, Chronic; N | 2006 |
Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up.
Topics: Administration, Intravesical; Adult; Antibiotics, Antineoplastic; Aristolochic Acids; Carcinogens; D | 2008 |
Patterns of interstitial inflammation during the evolution of renal injury in experimental aristolochic acid nephropathy.
Topics: Animals; Aristolochic Acids; Disease Models, Animal; Fibrosis; Kidney; Kidney Failure, Chronic; Macr | 2008 |
[End-stage renal insufficiency associated with Chinese herbal consumption in France].
Topics: Adult; Aristolochic Acids; Belgium; Drugs, Chinese Herbal; Female; France; Humans; Kidney Failure, C | 1998 |
Nephropathy caused by Chinese herbs in the UK.
Topics: Aristolochic Acids; Biopsy; Drugs, Chinese Herbal; Eczema; Female; Humans; Kidney; Kidney Failure, C | 1999 |
[Renal failure after eczema treatment with Chinese herbal medicine].
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Eczema; Female; Humans; Kidney Failure, Chronic; Middle A | 2000 |
Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)
Topics: Anti-Obesity Agents; Aristolochic Acids; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; | 2000 |
Cancer and herbs.
Topics: Aristolochic Acids; Carcinogens; Dietary Supplements; Drugs, Chinese Herbal; Female; Humans; Kidney | 2000 |
Chinese herbs and urothelial carcinoma.
Topics: Anti-Obesity Agents; Aristolochic Acids; Drugs, Chinese Herbal; Humans; Kidney Failure, Chronic; Phe | 2000 |
Urothelial malignant disease and Chinese herbal nephropathy.
Topics: Aristolochic Acids; Carcinogens; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Female; Humans | 2001 |
Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats.
Topics: Animals; Aristolochic Acids; Body Weight; Carcinoma, Transitional Cell; Dose-Response Relationship, | 2002 |
Chinese herbal nephropathy.
Topics: Aristolochic Acids; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Humans; Kidney Failure, Chr | 2002 |
Consumption of nephrotoxic plants among chronic hemodialysis patients in the Eastern region of Morocco: A multicentric cross-sectional study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aristolochia; Child; Cross-Sectional Studies; Disease Pr | 2022 |
Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose.
Topics: Adult; Anti-Obesity Agents; Aristolochia; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; F | 2002 |