aristolochic acid i has been researched along with Innate Inflammatory Response in 24 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Then, the pharmacological activities of FJHQT extract with respect to clinical use was investigated with acetic acid-induced writhing response, formalin-induced licking response and carrageenan-induced paw edema." | 3.81 | Anti-nociceptive, anti-inflammatory and toxicological evaluation of Fang-Ji-Huang-Qi-Tang in rodents. ( Chang, CW; Lin, YC; Wu, CR, 2015) |
| "Additionally, we allude to some of the cancer types where there is molecular epidemiological evidence that these agents are aetiological risk factors." | 2.58 | Carcinogens and DNA damage. ( Barnes, JL; John, K; Martin, FL; Poirier, MC; Zubair, M, 2018) |
| " The reduced nitric oxide (NO) bioavailability reported in AAN might contribute to renal function impairment and progression of the disease." | 1.46 | Restored nitric oxide bioavailability reduces the severity of acute-to-chronic transition in a mouse model of aristolochic acid nephropathy. ( Botton, O; Caron, N; Colombaro, V; Declèves, AE; Habsch, I; Jadot, I; Martin, B; Nortier, J, 2017) |
| "To study the accumulated toxic action to bandicoot of aqueous extract of crude and processed Radix Aristolochice and the pharmacodynamic action of aqueous and alcoholic extract of crude and processed Radix Aristolochice." | 1.34 | [Pharmacodynamic and toxicologic comparative study of crude and processed radix aristolochice]. ( Jiang, X; Li, CY; Wang, JH; Wang, ZM; Xue, BY, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 12 (50.00) | 24.3611 |
| 2020's | 5 (20.83) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Taguchi, S | 1 |
| Azushima, K | 1 |
| Yamaji, T | 1 |
| Urate, S | 1 |
| Suzuki, T | 1 |
| Abe, E | 1 |
| Tanaka, S | 1 |
| Tsukamoto, S | 1 |
| Kamimura, D | 1 |
| Kinguchi, S | 1 |
| Yamashita, A | 1 |
| Wakui, H | 1 |
| Tamura, K | 1 |
| Sun, MX | 1 |
| Qiao, FX | 1 |
| Xu, ZR | 1 |
| Liu, YC | 1 |
| Xu, CL | 1 |
| Wang, HL | 2 |
| Qi, ZQ | 1 |
| Liu, Y | 1 |
| Chen, SM | 1 |
| Lin, CE | 1 |
| Chen, HH | 1 |
| Cheng, YF | 1 |
| Cheng, HW | 1 |
| Imai, K | 1 |
| Wang, X | 1 |
| Xue, N | 1 |
| Zhao, S | 1 |
| Shi, Y | 1 |
| Ding, X | 1 |
| Fang, Y | 1 |
| Li, L | 1 |
| Tao, S | 1 |
| Guo, F | 1 |
| Liu, J | 1 |
| Huang, R | 1 |
| Tan, Z | 1 |
| Zeng, X | 1 |
| Ma, L | 1 |
| Fu, P | 1 |
| Jadot, I | 1 |
| Colombaro, V | 1 |
| Martin, B | 1 |
| Habsch, I | 1 |
| Botton, O | 1 |
| Nortier, J | 1 |
| Declèves, AE | 1 |
| Caron, N | 1 |
| Marin, DE | 1 |
| Pistol, GC | 1 |
| Gras, M | 1 |
| Palade, M | 1 |
| Taranu, I | 1 |
| Barnes, JL | 1 |
| Zubair, M | 1 |
| John, K | 1 |
| Poirier, MC | 1 |
| Martin, FL | 1 |
| Wang, L | 1 |
| Liu, N | 1 |
| Xue, X | 1 |
| Zhou, S | 1 |
| Liu, XH | 1 |
| Yang, X | 1 |
| Bai, Y | 3 |
| Lu, H | 2 |
| Hu, L | 1 |
| Hong, D | 1 |
| Ding, L | 1 |
| Chen, B | 2 |
| Lin, YC | 1 |
| Chang, CW | 1 |
| Wu, CR | 1 |
| Zhao, YY | 1 |
| Cheng, XL | 1 |
| Wei, F | 1 |
| Bai, X | 1 |
| Lin, RC | 1 |
| Vaziri, ND | 1 |
| Wu, L | 1 |
| Hong, W | 1 |
| Liang, Y | 1 |
| Ding, YJ | 1 |
| Chen, YH | 1 |
| MOESE, JR | 1 |
| Huang, CC | 1 |
| Chen, PC | 1 |
| Huang, CW | 1 |
| Yu, J | 1 |
| Tilz, GP | 1 |
| Lanzer, G | 1 |
| Lloret, S | 1 |
| Moreno, JJ | 1 |
| Andrioli, G | 1 |
| Lussignoli, S | 1 |
| Gaino, S | 1 |
| Benoni, G | 1 |
| Bellavite, P | 1 |
| Carnevale, KA | 1 |
| Cathcart, MK | 1 |
| Battu, GR | 1 |
| Parimi, R | 1 |
| Chandra Shekar, KB | 1 |
| Wang, JH | 1 |
| Wang, ZM | 1 |
| Jiang, X | 1 |
| Xue, BY | 1 |
| Li, CY | 1 |
2 reviews available for aristolochic acid i and Innate Inflammatory Response
| Article | Year |
|---|---|
Carcinogens and DNA damage.
Topics: Amines; Animals; Aristolochic Acids; Benzo(a)pyrene; Carcinogens; Cross-Linking Reagents; Diet; DNA; | 2018 |
[Aristolochic acid nephropathy: an issue worth more attention].
Topics: Animals; Aristolochic Acids; Autophagy; Drugs, Chinese Herbal; Epithelial-Mesenchymal Transition; Hu | 2013 |
22 other studies available for aristolochic acid i and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Effects of tumor necrosis factor-α inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy.
Topics: Albuminuria; Animals; Aristolochic Acids; Collagen; Disease Models, Animal; Etanercept; Fibrosis; In | 2021 |
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
Topics: Animals; Aristolochic Acids; Fibrosis; Homeostasis; Humans; Inflammasomes; Inflammation; Mice; Mitoc | 2023 |
Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry.
Topics: Animals; Aristolochic Acids; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; F | 2020 |
Upregulation of miR-382 contributes to renal fibrosis secondary to aristolochic acid-induced kidney injury via PTEN signaling pathway.
Topics: Animals; Aristolochic Acids; Base Sequence; Cells, Cultured; Epithelial Cells; Epithelial-Mesenchyma | 2020 |
Genetic and pharmacological inhibition of fatty acid-binding protein 4 alleviated inflammation and early fibrosis after toxin induced kidney injury.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Biphenyl Compounds; Carcinogens; Disease Models, A | 2021 |
Restored nitric oxide bioavailability reduces the severity of acute-to-chronic transition in a mouse model of aristolochic acid nephropathy.
Topics: Animals; Arginine; Aristolochic Acids; Biological Availability; Inflammation; Kidney Diseases; Mice; | 2017 |
A comparison between the effects of ochratoxin A and aristolochic acid on the inflammation and oxidative stress in the liver and kidney of weanling piglets.
Topics: Animals; Animals, Newborn; Aristolochic Acids; Cytokines; Inflammation; Kidney; Liver; Ochratoxins; | 2018 |
The Effect of Overexpression of the Enhancer of Zeste Homolog 1 (EZH1) Gene on Aristolochic Acid-Induced Injury in HK-2 Human Kidney Proximal Tubule Cells In Vitro.
Topics: Acute Kidney Injury; Apoptosis; Aristolochic Acids; Cell Survival; Cells, Cultured; Cytokines; Epith | 2019 |
Effect of Sedum sarmentosum BUNGE extract on aristolochic acid-induced renal tubular epithelial cell injury.
Topics: Animals; Apoptosis; Aristolochic Acids; Cell Proliferation; Cells, Cultured; Drugs, Chinese Herbal; | 2014 |
Anti-nociceptive, anti-inflammatory and toxicological evaluation of Fang-Ji-Huang-Qi-Tang in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aristolochia; Aristolochic Acids; Astrag | 2015 |
Metabolomics analysis reveals the association between lipid abnormalities and oxidative stress, inflammation, fibrosis, and Nrf2 dysfunction in aristolochic acid-induced nephropathy.
Topics: Animals; Aristolochic Acids; Disease Models, Animal; Fibrosis; Inflammation; Kidney; Lipids; Male; M | 2015 |
Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aristolochic Acids; Blotting, West | 2016 |
Developmental nephrotoxicity of aristolochic acid in a zebrafish model.
Topics: Abnormalities, Drug-Induced; Animals; Aristolochic Acids; Dose-Response Relationship, Drug; Embryo, | 2012 |
[ALTERATION OF INFECTION RESISTANCE BY ARISTOLOCHIC ACID].
Topics: Animals; Aristolochic Acids; Communicable Diseases; Drug Resistance; Drug Resistance, Microbial; Inf | 1963 |
Aristolochic Acid induces heart failure in zebrafish embryos that is mediated by inflammation.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aristolochic Acids; Cyclooxygenase 2; Cyclooxygen | 2007 |
[Immunotherapy II: clinical investigations for the induction and activity of interferon (author's transl)].
Topics: Aristolochic Acids; Dioxolanes; Humans; Inflammation; Interferons; Leukemia; Neoplasms; Phenanthrene | 1980 |
Effect of nonapeptide fragments of uteroglobin and lipocortin I on oedema and mast cell degranulation.
Topics: Animals; Annexin A1; Aristolochic Acids; Carrageenan; Cell Degranulation; Chlorpheniramine; Dexameth | 1994 |
Study on paradoxical effects of NSAIDs on platelet activation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 12-Lipoxygenase; Aristolochic Acids; Calcium; | 1997 |
Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1.
Topics: Aminobenzoates; Arachidonic Acid; Arachidonic Acids; Aristolochic Acids; Chemokine CCL2; Chemotaxis, | 2001 |
In vivo and in vitro pharmacological activity of Aristolochia tagala (syn: Aristolochia acuminata) root extracts.
Topics: Acetates; Alkanes; Animals; Anti-Inflammatory Agents; Aristolochia; Calcimycin; Calcium Ionophores; | 2011 |
[Pharmacodynamic and toxicologic comparative study of crude and processed radix aristolochice].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aristolochia; Dose-Response Relationship, Drug; Drug | 2007 |