aristolochic acid i has been researched along with Hepatocellular Carcinoma in 7 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Each hepatocellular carcinoma displays dozens of mutations in driver and passenger genes." | 2.61 | Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid. ( Letouzé, E; Nault, JC, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, ZN | 1 |
| Luo, Q | 1 |
| Zhao, LN | 1 |
| Shi, Y | 1 |
| Wang, N | 1 |
| Wang, L | 1 |
| Han, ZG | 1 |
| Li, Y | 1 |
| Zhu, S | 1 |
| Xue, M | 1 |
| Jing, Y | 1 |
| Liu, X | 1 |
| Cai, D | 1 |
| Zhao, Y | 1 |
| Bian, Y | 1 |
| Zhang, Z | 1 |
| Zhang, L | 1 |
| Zhou, G | 1 |
| Zhao, X | 1 |
| Zhang, HM | 1 |
| Zhao, XH | 1 |
| Sun, ZH | 1 |
| Li, GC | 1 |
| Liu, GC | 1 |
| Sun, LR | 1 |
| Hou, JQ | 1 |
| Zhou, W | 1 |
| Nault, JC | 1 |
| Letouzé, E | 1 |
| Wu, K | 1 |
| Jiang, L | 1 |
| Cao, J | 1 |
| Yang, G | 1 |
| Geng, C | 1 |
| Zhong, L | 1 |
| Ruffa, MJ | 1 |
| Ferraro, G | 1 |
| Wagner, ML | 1 |
| Calcagno, ML | 1 |
| Campos, RH | 1 |
| Cavallaro, L | 1 |
2 reviews available for aristolochic acid i and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Recognition of the toxicity of aristolochic acid.
Topics: Age Factors; Aristolochic Acids; Carcinoma, Hepatocellular; Female; Humans; Kidney Diseases; Liver N | 2019 |
Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid.
Topics: Aristolochic Acids; Carcinogenesis; Carcinoma, Hepatocellular; DNA Adducts; Drugs, Chinese Herbal; H | 2019 |
5 other studies available for aristolochic acid i and Hepatocellular Carcinoma
| Article | Year |
|---|---|
The Mutational Features of Aristolochic Acid-Induced Mouse and Human Liver Cancers.
Topics: Animals; Aristolochic Acids; Bile Duct Neoplasms; Carbon Tetrachloride; Carcinoma, Hepatocellular; C | 2020 |
Aristolochic acid I promotes the invasion and migration of hepatocellular carcinoma cells by activating the C3a/C3aR complement system.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Complement C3a; Epithelial-Mesenchymal T | 2023 |
Carcinogens that induce the A:T > T:A nucleotide substitutions in the genome.
Topics: Aristolochic Acids; Carcinogens; Carcinoma, Hepatocellular; China; Environment; Humans; Liver Neopla | 2018 |
Genotoxic effect and nitrative DNA damage in HepG2 cells exposed to aristolochic acid.
Topics: Aristolochic Acids; Carcinoma, Hepatocellular; Comet Assay; DNA Damage; Dose-Response Relationship, | 2007 |
Cytotoxic effect of Argentine medicinal plant extracts on human hepatocellular carcinoma cell line.
Topics: Anacardiaceae; Antineoplastic Agents; Argentina; Aristolochia; Carcinoma, Hepatocellular; Chenopodiu | 2002 |