aristolochic acid i has been researched along with Genetic Predisposition in 5 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Even tough numerous dilemmas and conflicting opinions regarding BEN etiology are encountered in literature, prevailing theory is that BEN is caused by chronic poisoning with aristolochic acid ingested by food in people with genetic predisposition to this disease." | 3.76 | Early detection of Balkan endemic nephropathy in Bosanska Posavina. ( Mesić, E, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mesić, E | 1 |
| Jelaković, B | 1 |
| Karanović, S | 1 |
| Vuković-Lela, I | 1 |
| Miller, F | 1 |
| Edwards, KL | 1 |
| Nikolić, J | 1 |
| Tomić, K | 1 |
| Slade, N | 1 |
| Brdar, B | 1 |
| Turesky, RJ | 1 |
| Stipančić, Ž | 1 |
| Dittrich, D | 1 |
| Grollman, AP | 2 |
| Dickman, KG | 1 |
| Chen, B | 1 |
| Bai, Y | 1 |
| Sun, M | 1 |
| Ni, X | 1 |
| Yang, Y | 2 |
| Zheng, S | 1 |
| Xu, F | 1 |
| Dai, S | 1 |
| Xiao, J | 1 |
| Zhu, X | 1 |
| Hao, GY | 1 |
| Zhu, YC | 1 |
| Hou, HJ | 1 |
| Zhang, J | 1 |
| Ma, LL | 1 |
| Tian, Y | 1 |
| Zhang, YH | 1 |
| Rosenquist, TA | 1 |
1 review available for aristolochic acid i and Genetic Predisposition
| Article | Year |
|---|---|
Mutational signature of aristolochic acid: Clue to the recognition of a global disease.
Topics: Alkylating Agents; Aristolochia; Aristolochic Acids; Carcinogens; Carcinoma; DNA Adducts; DNA Damage | 2016 |
4 other studies available for aristolochic acid i and Genetic Predisposition
| Article | Year |
|---|---|
Early detection of Balkan endemic nephropathy in Bosanska Posavina.
Topics: Adolescent; Adult; Aged; Aristolochic Acids; Balkan Nephropathy; Bosnia and Herzegovina; Child; Fema | 2010 |
Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid.
Topics: Adult; Aged; Aged, 80 and over; Aristolochic Acids; Balkan Nephropathy; Biomarkers; Biotransformatio | 2012 |
Glutathione S-transferases T1 null genotype is associated with susceptibility to aristolochic acid nephropathy.
Topics: Adult; Aged; Aristolochic Acids; Asian People; ATP Binding Cassette Transporter, Subfamily B, Member | 2012 |
Association between urothelial carcinoma after kidney transplantation and aristolochic acid exposure: the potential role of aristolochic acid in HRas and TP53 gene mutations.
Topics: Adult; Aged; Aristolochic Acids; Chi-Square Distribution; China; DNA Mutational Analysis; Exons; Fem | 2011 |