aristolochic acid i has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 1 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This report describes an investigation of the pathological mechanism of acute renal failure caused by toxic tubular necrosis after treatment with aristolochic acid I (AAI) in Sprague-Dawley (SD) rats." | 1.39 | Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity. ( Bao, Q; Huang, X; Jiang, Z; Li, H; Sun, L; Wang, T; Zhang, L; Zhang, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, Z | 1 |
| Bao, Q | 1 |
| Sun, L | 1 |
| Huang, X | 1 |
| Wang, T | 1 |
| Zhang, S | 1 |
| Li, H | 1 |
| Zhang, L | 1 |
1 other study available for aristolochic acid i and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Blood Urea Nitrogen; Creatinine; DNA, Mitochondria | 2013 |