aristolochic acid i has been researched along with Diathesis in 3 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Exposure to aristolochic acid I (AAI) is associated with aristolochic acid nephropathy, Balkan endemic nephropathy, and urothelial cancer." | 3.77 | Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice. ( Arlt, VM; Bárta, F; Evans, JD; Frei, E; Levová, K; Nebert, DW; Phillips, DH; Schmeiser, HH; Shi, Z; Stiborová, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arlt, VM | 1 |
| Levová, K | 1 |
| Bárta, F | 1 |
| Shi, Z | 1 |
| Evans, JD | 1 |
| Frei, E | 1 |
| Schmeiser, HH | 1 |
| Nebert, DW | 1 |
| Phillips, DH | 1 |
| Stiborová, M | 1 |
| Sato, N | 1 |
| Takahashi, D | 1 |
| Chen, SM | 1 |
| Tsuchiya, R | 1 |
| Mukoyama, T | 1 |
| Yamagata, S | 1 |
| Ogawa, M | 1 |
| Yoshida, M | 1 |
| Kondo, S | 1 |
| Satoh, N | 1 |
| Ueda, S | 1 |
| Stefanovic, V | 1 |
| Toncheva, D | 1 |
| Atanasova, S | 1 |
| Polenakovic, M | 1 |
1 review available for aristolochic acid i and Diathesis
| Article | Year |
|---|---|
Etiology of Balkan endemic nephropathy and associated urothelial cancer.
Topics: Aristolochia; Balkan Nephropathy; Disease Susceptibility; Environmental Exposure; Genetic Markers; H | 2006 |
2 other studies available for aristolochic acid i and Diathesis
| Article | Year |
|---|---|
Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.
Topics: Animals; Aristolochic Acids; Balkan Nephropathy; Biotransformation; Carcinogens; Cytochrome P-450 CY | 2011 |
Acute nephrotoxicity of aristolochic acids in mice.
Topics: Acute Disease; Administration, Oral; Animals; Aristolochia; Aristolochic Acids; Blood Urea Nitrogen; | 2004 |