aristolochic acid i has been researched along with Chemical and Drug Induced Liver Injury in 9 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aristolochic acid I (AAI) was regarded as the major toxic component of aristolochic acid (AA)." | 1.51 | The Disturbance of Hepatic and Serous Lipids in Aristolochic Acid Ι Induced Rats for Hepatotoxicity Using Lipidomics Approach. ( Bian, B; Si, N; Wang, H; Wei, X; Yang, J; Yang, Y; Zhao, H; Zhou, J; Zhou, Y, 2019) |
| " Pattern recognition analysis indicated that the renal proximal tubule lesion was the main damage induced by AA, and the renal toxicity induced by AA was a progressive course with the accumulation of dosage by monitoring the toxicological processes from onset, development and part-recovery." | 1.33 | NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats. ( Li, X; Liao, P; Ni, J; Pei, F; Wu, H; Zhang, X, 2006) |
| "(1) To study the acute and chronic toxicity of stem of Aristolochia manshuriensis (AMA Guanmuton) which is a Chinese medicinal herb in order to provide basis for safe clinical use." | 1.32 | Studies on the toxicity of Aristolochia manshuriensis (Guanmuton). ( Chan, K; Hu, SL; Mei, QX; Zhang, HQ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 2 |
| Guan, H | 1 |
| Feng, M | 1 |
| Du, C | 1 |
| Zhang, Q | 1 |
| Shou, Y | 1 |
| Qi, G | 1 |
| Yu, D | 1 |
| Jin, Y | 1 |
| Zhou, J | 1 |
| Yang, Y | 1 |
| Wang, H | 1 |
| Bian, B | 1 |
| Yang, J | 1 |
| Wei, X | 1 |
| Zhou, Y | 1 |
| Si, N | 1 |
| Zhao, H | 1 |
| Liu, X | 1 |
| Cheng, M | 1 |
| Xiao, H | 1 |
| Tripatara, P | 1 |
| Onlamul, W | 1 |
| Booranasubkajorn, S | 1 |
| Wattanarangsan, J | 1 |
| Huabprasert, S | 1 |
| Lumlerdkij, N | 1 |
| Akarasereenont, P | 1 |
| Laohapand, T | 1 |
| Wojcikowski, K | 1 |
| Johnson, DW | 1 |
| Gobé, G | 1 |
| Zhang, X | 1 |
| Wu, H | 1 |
| Liao, P | 1 |
| Li, X | 1 |
| Ni, J | 1 |
| Pei, F | 1 |
| Zhang, L | 1 |
| Mu, X | 1 |
| Fu, J | 1 |
| Zhou, Z | 1 |
| Tanaka, A | 1 |
| Nishida, R | 1 |
| Maeda, K | 1 |
| Sugawara, A | 1 |
| Kuwahara, T | 1 |
| Hu, SL | 1 |
| Zhang, HQ | 1 |
| Chan, K | 1 |
| Mei, QX | 1 |
1 review available for aristolochic acid i and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Medicinal herbal extracts -- renal friend or foe? Part one: the toxicities of medicinal herbs.
Topics: Aristolochic Acids; Chemical and Drug Induced Liver Injury; Humans; Metals, Heavy; Phytotherapy; Pla | 2004 |
8 other studies available for aristolochic acid i and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced hepatotoxicity by directly targeting the key bioactivating enzyme NQO1.
Topics: Animals; Aristolochic Acids; Chemical and Drug Induced Liver Injury; Humans; MicroRNAs; NAD(P)H Dehy | 2023 |
The Disturbance of Hepatic and Serous Lipids in Aristolochic Acid Ι Induced Rats for Hepatotoxicity Using Lipidomics Approach.
Topics: Animals; Aristolochic Acids; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Administration | 2019 |
[Application of ultra high performance liquid chromatography-mass spectrometry to metabolomics study of drug-induced hepatotoxicity].
Topics: Acetaminophen; Aristolochic Acids; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced | 2015 |
The safety of Homnawakod herbal formula containing Aristolochia tagala Cham. in Wistar rats.
Topics: Animals; Aristolochia; Aristolochic Acids; Blood Pressure; Chemical and Drug Induced Liver Injury; C | 2012 |
NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats.
Topics: Animals; Aristolochic Acids; Blood Chemical Analysis; Body Weight; Chemical and Drug Induced Liver I | 2006 |
In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney.
Topics: Acetaminophen; Aristolochic Acids; Cadmium Chloride; Cell Line; Cell Survival; Chemical and Drug Ind | 2007 |
Chinese herb nephropathy in Japan presents adult-onset Fanconi syndrome: could different components of aristolochic acids cause a different type of Chinese herb nephropathy?
Topics: Adult; Aristolochic Acids; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Fanconi Sy | 2000 |
Studies on the toxicity of Aristolochia manshuriensis (Guanmuton).
Topics: Animals; Aristolochia; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Dru | 2004 |