aristolochic acid i has been researched along with Cell Transformation, Neoplastic in 6 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To distinguish the component(s) of AA responsible for these varied toxic effects, we administered 2." | 1.34 | Selective toxicity of aristolochic acids I and II. ( Dong, H; Grollman, AP; Miller, F; Shibutani, S; Suzuki, N; Ueda, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, T | 1 |
| Jin, K | 1 |
| Zhu, DY | 1 |
| Li, L | 1 |
| Mao, ZR | 1 |
| Wu, BW | 1 |
| Wang, YF | 1 |
| Pan, ZF | 1 |
| Li, LJ | 1 |
| Xiang, CS | 1 |
| Su, KK | 1 |
| Lou, YJ | 1 |
| Feldmeyer, N | 1 |
| Schmeiser, HH | 2 |
| Muehlbauer, KR | 1 |
| Belharazem, D | 1 |
| Knyazev, Y | 1 |
| Nedelko, T | 1 |
| Hollstein, M | 2 |
| Shibutani, S | 1 |
| Dong, H | 1 |
| Suzuki, N | 1 |
| Ueda, S | 1 |
| Miller, F | 1 |
| Grollman, AP | 1 |
| Arlt, VM | 1 |
| Stiborová, M | 1 |
| vom Brocke, J | 1 |
| Simões, ML | 1 |
| Lord, GM | 1 |
| Nortier, JL | 2 |
| Phillips, DH | 1 |
| Stemmer, K | 1 |
| Ellinger-Ziegelbauer, H | 1 |
| Ahr, HJ | 1 |
| Dietrich, DR | 1 |
| Debelle, FD | 1 |
| Vanherweghem, JL | 1 |
2 reviews available for aristolochic acid i and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.
Topics: Animals; Aristolochic Acids; Balkan Nephropathy; Cell Transformation, Neoplastic; DNA Adducts; Genes | 2007 |
Aristolochic acid nephropathy: a worldwide problem.
Topics: Animals; Aristolochia; Aristolochic Acids; Balkan Nephropathy; Belgium; Cell Transformation, Neoplas | 2008 |
4 other studies available for aristolochic acid i and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure.
Topics: Albumins; alpha-Fetoproteins; Animals; Aristolochic Acids; Biomarkers, Tumor; Cell Dedifferentiation | 2016 |
Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences.
Topics: Animals; Aristolochic Acids; Base Sequence; Cell Line, Transformed; Cell Transformation, Neoplastic; | 2006 |
Selective toxicity of aristolochic acids I and II.
Topics: Animals; Aristolochic Acids; Carcinogens; Cell Transformation, Neoplastic; DNA Adducts; Fibrosis; Ki | 2007 |
Carcinogen-specific gene expression profiles in short-term treated Eker and wild-type rats indicative of pathways involved in renal tumorigenesis.
Topics: Animals; Aristolochic Acids; Carcinogens; Cell Cycle; Cell Growth Processes; Cell Transformation, Ne | 2007 |