aristolochic acid i has been researched along with Carcinogenesis in 6 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Each hepatocellular carcinoma displays dozens of mutations in driver and passenger genes." | 2.61 | Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid. ( Letouzé, E; Nault, JC, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, R | 1 |
| Zhou, C | 1 |
| Cao, Y | 1 |
| Xi, J | 1 |
| Ohira, T | 1 |
| He, L | 1 |
| Huang, P | 1 |
| You, X | 1 |
| Liu, W | 1 |
| Zhang, X | 1 |
| Ma, S | 1 |
| Xie, T | 1 |
| Chang, Y | 1 |
| Luan, Y | 1 |
| Belitskiy, GA | 1 |
| Kirsanov, KI | 1 |
| Lesovaya, EA | 1 |
| Yakubovskaya, MG | 1 |
| Aydin, S | 1 |
| Ambroise, J | 1 |
| Cosyns, JP | 1 |
| Gala, JL | 1 |
| Nault, JC | 1 |
| Letouzé, E | 1 |
| Lian, CG | 1 |
| Xu, S | 1 |
| Guo, W | 1 |
| Yan, J | 1 |
| Frank, MY | 1 |
| Liu, R | 1 |
| Liu, C | 1 |
| Chen, Y | 1 |
| Murphy, GF | 1 |
| Chen, T | 1 |
| Jin, K | 1 |
| Su, KK | 1 |
| Li, T | 1 |
| Zhu, XQ | 1 |
| Wang, Q | 1 |
| Ge, RS | 1 |
| Pan, ZF | 1 |
| Wu, BW | 1 |
| Ge, LJ | 1 |
| Zhang, YH | 1 |
| Wang, YF | 1 |
| Shen, GF | 1 |
| Zhu, DY | 1 |
| Xiang, CS | 1 |
| Li, LJ | 1 |
| Lou, YJ | 1 |
2 reviews available for aristolochic acid i and Carcinogenesis
| Article | Year |
|---|---|
Drug-Related Carcinogenesis: Risk Factors and Approaches for Its Prevention.
Topics: Animals; Antineoplastic Agents; Aristolochic Acids; Arsenic; Carcinogenesis; Carcinogens; Diethylsti | 2020 |
Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid.
Topics: Aristolochic Acids; Carcinogenesis; Carcinoma, Hepatocellular; DNA Adducts; Drugs, Chinese Herbal; H | 2019 |
4 other studies available for aristolochic acid i and Carcinogenesis
| Article | Year |
|---|---|
Assessment of Pig-a, Micronucleus, and Comet Assay Endpoints in Tg.RasH2 Mice Carcinogenicity Study of Aristolochic Acid I.
Topics: Animals; Aristolochic Acids; Bone Marrow; Carcinogenesis; Carcinogens; Comet Assay; Humans; Male; Mi | 2020 |
TP53 mutations in p53-negative dysplastic urothelial cells from Belgian AAN patients: New evidence for aristolochic acid-induced molecular pathogenesis and carcinogenesis.
Topics: Adult; Aristolochic Acids; Belgium; Carcinogenesis; Female; Humans; Immunohistochemistry; Laser Capt | 2017 |
Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid.
Topics: 5-Methylcytosine; Animals; Aristolochic Acids; Carcinogenesis; Carcinogens; Cytosine; DNA-Binding Pr | 2015 |
Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines.
Topics: Administration, Oral; Animals; Aristolochia; Aristolochic Acids; Carcinogenesis; Carcinogens; Dogs; | 2016 |