aristolochic acid i has been researched along with Cancer of the Urinary Tract in 44 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Exposure to aristolochic acid I (AAI) is associated with aristolochic acid nephropathy, Balkan endemic nephropathy, and urothelial cancer." | 3.77 | Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice. ( Arlt, VM; Bárta, F; Evans, JD; Frei, E; Levová, K; Nebert, DW; Phillips, DH; Schmeiser, HH; Shi, Z; Stiborová, M, 2011) |
| "To find out whether ochratoxin A (OTA), citrinin (CIT), aristolochic acids (AA) are etiologic agents of Balkan endemic nephropathy (BEN) or Chinese herbal nephrotoxicity, and associated urinary tract tumor (UTT), we have compared (i) in human kidney cell culture, the DNA adduct formation and persistence of OTA/CIT and AA adducts (ii) analyzed DNA adduct in several tumors from human kidney suspected to be exposed to either OTA and CIT, or AAs (iii) analyzed OTA, CIT, and AA in food." | 3.74 | New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor. ( Castegnaro, M; Manderville, R; Peraica, M; Pfohl-Leszkowicz, A; Stefanovic, V; Tozlovanu, M, 2007) |
| "Taiwan has a higher incidence rate of urological cancers than many Asian countries do." | 1.51 | Reduction in the Incidence of Urological Cancers after the Ban on Chinese Herbal Products Containing Aristolochic Acid: An Interrupted Time-Series Analysis. ( Chiang, CJ; Jhuang, JR; Lee, WC; Su, SY; Yang, YW, 2019) |
| " The correlation of cancer incidence with age, gender, dosage of aristolochic acid (AA), the type of renal replacement therapies, and the polymorphisms of quinone oxidoreductase 1 (NQO1) C609T and cytochrome P450 1A1 (CYP1A1) A4889G was examined." | 1.42 | Analysis of potential risk factors for cancer incidence in patients with aristolochic acid nephropathy from Wenzhou, China. ( Chen, C; Lin, F; Liu, Y; Sun, M; Xu, F; Zhang, J; Zheng, C, 2015) |
| "Both end-stage renal disease (ESRD) and urothelial cancer (UC) are associated with the consumption of Chinese herbal products containing aristolochic acid (AA) by the general population." | 1.40 | Increased risk of urinary tract cancer in ESRD patients associated with usage of Chinese herbal products suspected of containing aristolochic acid. ( Chen, PC; Chen, YY; Lai, MN; Pu, YS; Wang, JD; Wang, SM; Wei, A, 2014) |
| "Chinese herbs nephropathy (CHN) and Balkan endemic nephropathy (BEN) are chronic tubulointerstitial renal diseases associated with urothelial carcinoma." | 1.38 | Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy. ( De Broe, ME, 2012) |
| " A statistically significant linear dose-response relationship was observed between the prescribed dose of Mu Tong or the estimated cumulative dose of aristolochic acid and the risk of urinary tract cancer (P < ." | 1.36 | Population-based case-control study of Chinese herbal products containing aristolochic acid and urinary tract cancer risk. ( Chen, PC; Chen, YY; Lai, MN; Wang, JD; Wang, SM, 2010) |
| "AAI and AAII were reacted with human mammary carcinoma (MCF-7) DNA in vitro and the major DNA adducts formed were identified by the (32)P-postlabeling method." | 1.31 | Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR. ( Arlt, VM; Pfeifer, GP; Schmeiser, HH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (36.36) | 29.6817 |
| 2010's | 26 (59.09) | 24.3611 |
| 2020's | 2 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Liao, CI | 1 |
| Fang, HC | 1 |
| Lee, PT | 1 |
| Hsu, CY | 1 |
| Chen, CL | 1 |
| Huang, CW | 1 |
| Chen, XY | 1 |
| Ou, SH | 1 |
| Tsai, CT | 1 |
| Chou, KJ | 1 |
| Jhuang, JR | 1 |
| Chiang, CJ | 1 |
| Su, SY | 1 |
| Yang, YW | 1 |
| Lee, WC | 1 |
| Rebhan, K | 1 |
| Ertl, IE | 1 |
| Shariat, SF | 1 |
| Grollman, AP | 9 |
| Rosenquist, T | 3 |
| Aydin, S | 2 |
| Ambroise, J | 2 |
| Cosyns, JP | 4 |
| Gala, JL | 2 |
| Gökmen, MR | 1 |
| Arlt, VM | 9 |
| Stiborová, M | 7 |
| Phillips, DH | 4 |
| Schmeiser, HH | 10 |
| Simmonds, MS | 1 |
| Cook, HT | 1 |
| Vanherweghem, JL | 3 |
| Nortier, JL | 3 |
| Lord, GM | 1 |
| Poon, SL | 1 |
| Pang, ST | 1 |
| McPherson, JR | 1 |
| Yu, W | 1 |
| Huang, KK | 1 |
| Guan, P | 1 |
| Weng, WH | 1 |
| Siew, EY | 1 |
| Liu, Y | 3 |
| Heng, HL | 1 |
| Chong, SC | 1 |
| Gan, A | 1 |
| Tay, ST | 1 |
| Lim, WK | 1 |
| Cutcutache, I | 1 |
| Huang, D | 1 |
| Ler, LD | 1 |
| Nairismägi, ML | 1 |
| Lee, MH | 1 |
| Chang, YH | 1 |
| Yu, KJ | 1 |
| Chan-On, W | 1 |
| Li, BK | 1 |
| Yuan, YF | 1 |
| Qian, CN | 1 |
| Ng, KF | 1 |
| Wu, CF | 1 |
| Hsu, CL | 1 |
| Bunte, RM | 1 |
| Stratton, MR | 1 |
| Futreal, PA | 1 |
| Sung, WK | 1 |
| Chuang, CK | 1 |
| Ong, CK | 1 |
| Rozen, SG | 1 |
| Tan, P | 1 |
| Teh, BT | 1 |
| Hoang, ML | 1 |
| Chen, CH | 2 |
| Sidorenko, VS | 1 |
| He, J | 1 |
| Dickman, KG | 3 |
| Yun, BH | 1 |
| Moriya, M | 3 |
| Niknafs, N | 1 |
| Douville, C | 1 |
| Karchin, R | 1 |
| Turesky, RJ | 3 |
| Pu, YS | 3 |
| Vogelstein, B | 1 |
| Papadopoulos, N | 1 |
| Kinzler, KW | 1 |
| Rosenquist, TA | 2 |
| Fang, D | 1 |
| Zhang, L | 2 |
| Li, X | 1 |
| Xiong, G | 1 |
| Chen, X | 1 |
| Han, W | 1 |
| He, Z | 1 |
| Zhou, L | 2 |
| Wang, SM | 3 |
| Lai, MN | 2 |
| Wei, A | 1 |
| Chen, YY | 2 |
| Chen, PC | 3 |
| Wang, JD | 3 |
| Dekairelle, AF | 1 |
| Durant, JF | 1 |
| Heusterspreute, M | 1 |
| Guiot, Y | 1 |
| Sun, M | 1 |
| Zhang, J | 2 |
| Zheng, C | 1 |
| Lin, F | 1 |
| Xu, F | 1 |
| Chen, C | 1 |
| Tao, L | 1 |
| Zeng, Y | 1 |
| Wang, J | 1 |
| Liu, Z | 1 |
| Shen, B | 1 |
| Ge, J | 1 |
| Guo, Y | 1 |
| Qiu, J | 1 |
| Nedelko, T | 1 |
| Hollstein, M | 2 |
| Yang, HY | 1 |
| Lo, TC | 1 |
| Yuan, M | 1 |
| Shi, YB | 1 |
| Li, ZH | 1 |
| Xia, M | 1 |
| Ji, GZ | 1 |
| Xu, GX | 1 |
| Han, Y | 1 |
| Stefanovic, V | 3 |
| Polenakovic, M | 2 |
| Toncheva, D | 2 |
| Levová, K | 2 |
| Bárta, F | 2 |
| Shi, Z | 2 |
| Evans, JD | 1 |
| Frei, E | 3 |
| Nebert, DW | 2 |
| Jelaković, B | 3 |
| Karanović, S | 1 |
| Vuković-Lela, I | 1 |
| Miller, F | 2 |
| Edwards, KL | 1 |
| Nikolić, J | 1 |
| Tomić, K | 1 |
| Slade, N | 2 |
| Brdar, B | 2 |
| Stipančić, Ž | 1 |
| Dittrich, D | 1 |
| Xiao, J | 1 |
| Zhu, X | 1 |
| Hao, GY | 1 |
| Zhu, YC | 1 |
| Hou, HJ | 1 |
| Ma, LL | 1 |
| Tian, Y | 1 |
| Zhang, YH | 1 |
| De Broe, ME | 1 |
| Rucevic, M | 1 |
| Breen, L | 1 |
| Cao, L | 1 |
| Clifton, J | 1 |
| Hixson, D | 1 |
| Josic, D | 1 |
| Cao, YL | 1 |
| Li, WG | 1 |
| Fu, FT | 1 |
| Wang, X | 1 |
| Shi, XH | 1 |
| Huang, CY | 1 |
| Shun, CT | 1 |
| Tai, HC | 1 |
| Huang, KH | 1 |
| Lee, YJ | 1 |
| Ferluga, D | 1 |
| Pfohl-Leszkowicz, A | 2 |
| Vukelic, M | 2 |
| Ceovic, S | 1 |
| Shibutani, S | 1 |
| Wu, L | 1 |
| Moll, U | 1 |
| Suzuki, N | 1 |
| Fernandes, A | 1 |
| Medverec, Z | 1 |
| Jakovina, K | 1 |
| Goodenough, AK | 1 |
| Rieger, R | 1 |
| Tozlovanu, M | 1 |
| Manderville, R | 1 |
| Peraica, M | 1 |
| Castegnaro, M | 1 |
| Martinez, MC | 1 |
| Bieler, CA | 1 |
| Petein, M | 1 |
| Depierreux, MF | 1 |
| De Pauw, L | 1 |
| Abramowicz, D | 1 |
| Vereerstraeten, P | 1 |
| Kessler, DA | 1 |
| Pfeifer, GP | 1 |
| Lu, W | 2 |
| Li, YM | 1 |
| Marcus, DM | 1 |
| Hawkes, N | 1 |
| Olivier, M | 1 |
| Straif, K | 1 |
| Wild, CP | 1 |
| Atanasova, S | 1 |
8 reviews available for aristolochic acid i and Cancer of the Urinary Tract
| Article | Year |
|---|---|
The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review.
Topics: Aristolochic Acids; Balkan Nephropathy; Humans; Kidney Diseases; Plant Preparations; Risk Factors; U | 2013 |
Balkan endemic nephropathy: an update on its aetiology.
Topics: Animals; Aristolochia; Aristolochic Acids; Balkan Nephropathy; Carcinogens, Environmental; Confoundi | 2016 |
Urothelial carcinoma associated with Balkan endemic nephropathy. A worldwide disease.
Topics: Aristolochic Acids; Balkan Nephropathy; Carcinoma, Transitional Cell; Diet; DNA Adducts; Endemic Dis | 2011 |
Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease.
Topics: Aristolochic Acids; Balkan Nephropathy; DNA Adducts; Humans; Iatrogenic Disease; Kidney Cortex; Kidn | 2013 |
Mutational signature of aristolochic acid: Clue to the recognition of a global disease.
Topics: Alkylating Agents; Aristolochia; Aristolochic Acids; Carcinogens; Carcinoma; DNA Adducts; DNA Damage | 2016 |
Chemical and molecular basis of the carcinogenicity of Aristolochia plants.
Topics: Animals; Aristolochia; Aristolochic Acids; Carcinogenicity Tests; Carcinogens; DNA Adducts; Humans; | 2009 |
Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi).
Topics: Animals; Aristolochia; Drugs, Chinese Herbal; Female; Humans; Kidney Function Tests; Kidney Tubules, | 2002 |
Etiology of Balkan endemic nephropathy and associated urothelial cancer.
Topics: Aristolochia; Balkan Nephropathy; Disease Susceptibility; Environmental Exposure; Genetic Markers; H | 2006 |
36 other studies available for aristolochic acid i and Cancer of the Urinary Tract
| Article | Year |
|---|---|
Trends in the incidence of urothelial carcinoma in Taiwan after the ban on aristolochic acid-containing Chinese herbal preparations, 2001-2018: a national population-based cohort study.
Topics: Carcinoma, Transitional Cell; Cohort Studies; Humans; Incidence; Taiwan; Urinary Bladder Neoplasms; | 2023 |
Reduction in the Incidence of Urological Cancers after the Ban on Chinese Herbal Products Containing Aristolochic Acid: An Interrupted Time-Series Analysis.
Topics: Aristolochic Acids; Carcinogens; Drugs, Chinese Herbal; Humans; Incidence; Kidney Neoplasms; Kidney | 2019 |
Aristolochic acid and its effect on different cancers in uro-oncology.
Topics: Aristolochic Acids; Balkan Nephropathy; Carcinogens; DNA Adducts; Drugs, Chinese Herbal; Humans; Uri | 2020 |
TP53 mutations in p53-negative dysplastic urothelial cells from Belgian AAN patients: New evidence for aristolochic acid-induced molecular pathogenesis and carcinogenesis.
Topics: Adult; Aristolochic Acids; Belgium; Carcinogenesis; Female; Humans; Immunohistochemistry; Laser Capt | 2017 |
Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.
Topics: Animals; Aristolochic Acids; Carcinogens; Cell Line, Tumor; Genome, Human; Humans; Kidney Diseases; | 2013 |
Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing.
Topics: Aged; Aristolochic Acids; Exome; Female; Humans; Male; Middle Aged; Mutation; Sequence Analysis, DNA | 2013 |
Risk factors and treatment outcomes of new contralateral upper urinary urothelial carcinoma after nephroureterectomy: the experiences of a large Chinese center.
Topics: Aged; Aristolochic Acids; Carcinogens; Carcinoma, Transitional Cell; China; Female; Humans; Kaplan-M | 2014 |
Increased risk of urinary tract cancer in ESRD patients associated with usage of Chinese herbal products suspected of containing aristolochic acid.
Topics: Aged; Aged, 80 and over; Aristolochic Acids; Cohort Studies; Drugs, Chinese Herbal; Female; Humans; | 2014 |
Unambiguous detection of multiple TP53 gene mutations in AAN-associated urothelial cancer in Belgium using laser capture microdissection.
Topics: Adult; Aristolochic Acids; Belgium; Female; Humans; Laser Capture Microdissection; Middle Aged; Poin | 2014 |
Analysis of potential risk factors for cancer incidence in patients with aristolochic acid nephropathy from Wenzhou, China.
Topics: Aged; Aristolochic Acids; Carcinogens; China; Cytochrome P-450 CYP1A1; Female; Hematologic Neoplasms | 2015 |
Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo.
Topics: Aged; Aristolochic Acids; Carcinogens; Female; Gene Expression Profiling; Gene Expression Regulation | 2015 |
TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours.
Topics: Aristolochic Acids; Carcinogens; Codon; DNA Mutational Analysis; DNA, Neoplasm; Exons; Genes, p53; G | 2009 |
Increased mortality risk for cancers of the kidney and other urinary organs among Chinese herbalists.
Topics: Adolescent; Adult; Aristolochic Acids; Asian People; Carcinogens; Cohort Studies; Female; Health Sur | 2009 |
De novo urothelial carcinoma in kidney transplant patients with end-stage aristolochic acid nephropathy in China.
Topics: Adult; Aged; Antiviral Agents; Aristolochic Acids; Cadaver; Carcinoma, Transitional Cell; China; Fem | 2009 |
Population-based case-control study of Chinese herbal products containing aristolochic acid and urinary tract cancer risk.
Topics: Adult; Aged; Aristolochic Acids; Carcinogens; Case-Control Studies; Confounding Factors, Epidemiolog | 2010 |
Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.
Topics: Animals; Aristolochic Acids; Balkan Nephropathy; Biotransformation; Carcinogens; Cytochrome P-450 CY | 2011 |
Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid.
Topics: Adult; Aged; Aged, 80 and over; Aristolochic Acids; Balkan Nephropathy; Biomarkers; Biotransformatio | 2012 |
Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
Topics: Animals; Aristolochic Acids; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP | 2012 |
Association between urothelial carcinoma after kidney transplantation and aristolochic acid exposure: the potential role of aristolochic acid in HRas and TP53 gene mutations.
Topics: Adult; Aged; Aristolochic Acids; Chi-Square Distribution; China; DNA Mutational Analysis; Exons; Fem | 2011 |
Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy.
Topics: Aristolochic Acids; Balkan Nephropathy; Carcinogens, Environmental; Carcinoma; DNA Adducts; Environm | 2012 |
Proteome alterations in response to aristolochic acids in experimental animal model.
Topics: Animals; Aristolochic Acids; Biomarkers, Tumor; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred DB | 2012 |
Transitional cell carcinoma associated with aristolochic acid nephropathy: most common cancer in chronic hemodialysis patients in China.
Topics: Adult; Aged; Aged, 80 and over; Aristolochic Acids; Carcinoma, Transitional Cell; China; Female; Hum | 2012 |
Aristolochic acid-induced upper tract urothelial carcinoma in Taiwan: clinical characteristics and outcomes.
Topics: Adenine; Adult; Age Factors; Aged; Aged, 80 and over; Aristolochic Acids; Carcinogens; Carcinoma, Tr | 2013 |
Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?
Topics: Aged; Aristolochic Acids; Balkan Nephropathy; Carcinogens; DNA Adducts; Female; Humans; Middle Aged; | 2002 |
Aristolochic acid and the etiology of endemic (Balkan) nephropathy.
Topics: Aristolochic Acids; Balkan Nephropathy; Carcinoma, Transitional Cell; DNA Adducts; Female; Humans; K | 2007 |
New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor.
Topics: Aged; Aged, 80 and over; Anti-Obesity Agents; Aristolochic Acids; Balkan Nephropathy; Belgium; Bulga | 2007 |
Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid.
Topics: Animals; Aristolochic Acids; Carcinogens; Inactivation, Metabolic; Kidney Diseases; Liver; Mice; NAD | 2008 |
Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)
Topics: Anti-Obesity Agents; Aristolochic Acids; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; | 2000 |
Cancer and herbs.
Topics: Aristolochic Acids; Carcinogens; Dietary Supplements; Drugs, Chinese Herbal; Female; Humans; Kidney | 2000 |
Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR.
Topics: Aristolochic Acids; Breast Neoplasms; Carcinogens; Chromosome Mapping; DNA; DNA Adducts; DNA Nucleot | 2001 |
Chinese herbs and urothelial carcinoma.
Topics: Acetazolamide; Anti-Obesity Agents; Aristolochic Acids; Drug Interactions; Drugs, Chinese Herbal; Fe | 2000 |
Chinese herbs and urothelial carcinoma.
Topics: Anti-Obesity Agents; Aristolochic Acids; Drugs, Chinese Herbal; Humans; Kidney Failure, Chronic; Phe | 2000 |
Global hazards of herbal remedies: lessons from Aristolochia: The lesson from the health hazards of Aristolochia should lead to more research into the safety and efficacy of medicinal plants.
Topics: Animals; Aristolochia; Biomedical Research; Carcinogens; Dietary Supplements; Epidemiologic Studies; | 2016 |
Herbal medicine might be responsible for high incidence of urinary tract cancer.
Topics: Aristolochia; Biomarkers, Tumor; Body Mass Index; Carcinogens; Carcinoma; China; Drugs, Chinese Herb | 2012 |
Upper urinary tract urothelial cancers: where it is A:T.
Topics: Aristolochia; Humans; Plant Extracts; Plants, Medicinal; Ureteral Neoplasms; Urologic Neoplasms | 2012 |
Role of environmental toxins in endemic (Balkan) nephropathy. October 2006, Zagreb, Croatia.
Topics: Aristolochia; Aristolochic Acids; Balkan Nephropathy; Humans; Toxins, Biological; Urologic Neoplasms | 2007 |