aristolochic acid i has been researched along with Cancer of Kidney in 33 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To find out whether ochratoxin A (OTA), citrinin (CIT), aristolochic acids (AA) are etiologic agents of Balkan endemic nephropathy (BEN) or Chinese herbal nephrotoxicity, and associated urinary tract tumor (UTT), we have compared (i) in human kidney cell culture, the DNA adduct formation and persistence of OTA/CIT and AA adducts (ii) analyzed DNA adduct in several tumors from human kidney suspected to be exposed to either OTA and CIT, or AAs (iii) analyzed OTA, CIT, and AA in food." | 3.74 | New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor. ( Castegnaro, M; Manderville, R; Peraica, M; Pfohl-Leszkowicz, A; Stefanovic, V; Tozlovanu, M, 2007) |
| "Balkan endemic nephropathy is a chronic tubulointerstitial disease with insidious onset, slowly progressing to end-stage renal disease and frequently associated with urothelial carcinoma of the upper urinary tract (UTUC)." | 2.61 | Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid. ( Arlt, VM; Colet, JM; Dika, Ž; Jelaković, B; Nikolić, J; Nortier, JL; Pavlović, NM; Stiborova, M; Vanherweghem, JL, 2019) |
| "UTUC and bladder cancer share some common risk factors, even if they are two different entities regarding practical, biological and clinical characteristics." | 2.55 | Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC). ( Babjuk, M; Chade, DC; Fernández, MI; Fritsche, HM; Grollman, AP; Kassouf, W; Kikuchi, E; Lerner, SP; Lotan, Y; Rink, M; Shariat, SF; Soria, F; Spiess, PE; Thalmann, GN; Ye, D, 2017) |
| "Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity." | 1.56 | Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus. ( Bai, F; Dong, J; Dong, ZH; Ge, LY; George Rozen, S; Li, RY; Lu, M; Lu, Y; Luo, GD; Ma, LL; Ma, RZ; Song, YM; Wang, GL; Wang, SY; Wang, X; Wang, XM; Wu, D; Zhang, SD, 2020) |
| "Taiwan has a higher incidence rate of urological cancers than many Asian countries do." | 1.51 | Reduction in the Incidence of Urological Cancers after the Ban on Chinese Herbal Products Containing Aristolochic Acid: An Interrupted Time-Series Analysis. ( Chiang, CJ; Jhuang, JR; Lee, WC; Su, SY; Yang, YW, 2019) |
| " These results differ from previous reports in that tumours originating from both epithelial and mesenchymal tissues were found, which may be attributed to the duration of treatment and the dosage of the drug." | 1.33 | Tumour induction in rats following exposure to short-term high dose aristolochic acid I. ( Cui, M; Li, H; Li, LS; Liu, ZH; Qiu, Q, 2005) |
| "(1) At month 0, 1 and 3, the occurrence of renal tumor or tumor-like proliferation was not observed; (2) At month 6, the occurrence of renal tumor-like proliferation in all the three AM dosage groups (50 g/kg, 30 g/kg and 20 g/kg) was 100." | 1.31 | [Experimental study on oncogenicity of Aristolochia manshuriensis in rats]. ( Liu, ZH; Qiu, Q; Yin, HL, 2001) |
| "1) Administration of large dosage of Aristolochia manshuriensis Kom induces acute renal failure in rats." | 1.31 | Long-term outcome of acute renal injury induced by Aristolochia manshuriensis Kom in rats. ( Chen, HP; Li, LS; Liu, ZH; Qiu, Q; Yin, HL, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 14 (42.42) | 29.6817 |
| 2010's | 13 (39.39) | 24.3611 |
| 2020's | 4 (12.12) | 2.80 |
| Authors | Studies |
|---|---|
| Dickman, KG | 4 |
| Chen, CH | 4 |
| Grollman, AP | 4 |
| Pu, YS | 4 |
| Jhuang, JR | 2 |
| Chiu, PC | 1 |
| Hsieh, TC | 1 |
| Lee, WC | 2 |
| Chiang, CJ | 1 |
| Su, SY | 1 |
| Yang, YW | 1 |
| Wang, XM | 1 |
| Lu, Y | 1 |
| Song, YM | 1 |
| Dong, J | 1 |
| Li, RY | 1 |
| Wang, GL | 1 |
| Wang, X | 1 |
| Zhang, SD | 1 |
| Dong, ZH | 1 |
| Lu, M | 1 |
| Wang, SY | 1 |
| Ge, LY | 1 |
| Luo, GD | 1 |
| Ma, RZ | 1 |
| George Rozen, S | 1 |
| Bai, F | 1 |
| Wu, D | 1 |
| Ma, LL | 1 |
| Anger, EE | 1 |
| Yu, F | 1 |
| Li, J | 1 |
| Shao, IH | 1 |
| Chang, YH | 1 |
| Pang, ST | 1 |
| Liu, Y | 1 |
| Chan, CK | 1 |
| Jin, L | 1 |
| Wong, SK | 1 |
| Chan, W | 1 |
| Jelaković, B | 3 |
| Dika, Ž | 1 |
| Arlt, VM | 1 |
| Stiborova, M | 1 |
| Pavlović, NM | 1 |
| Nikolić, J | 1 |
| Colet, JM | 1 |
| Vanherweghem, JL | 2 |
| Nortier, JL | 2 |
| Karanović, S | 2 |
| Lela, IV | 1 |
| Peić, AK | 1 |
| Dittrich, D | 1 |
| Knežević, M | 1 |
| Matijević, V | 1 |
| Fernandes, AS | 1 |
| Miller, F | 1 |
| Fang, D | 1 |
| Zhang, L | 1 |
| Li, X | 1 |
| Xiong, G | 1 |
| Chen, X | 1 |
| Han, W | 1 |
| He, Z | 1 |
| Zhou, L | 1 |
| Castells, X | 1 |
| Tomić, K | 1 |
| Ardin, M | 1 |
| Zavadil, J | 2 |
| Li, Z | 1 |
| Qin, T | 1 |
| Wang, K | 1 |
| Hackenberg, M | 1 |
| Yan, J | 1 |
| Gao, Y | 1 |
| Yu, LR | 1 |
| Shi, L | 1 |
| Su, Z | 1 |
| Chen, T | 1 |
| Turesky, RJ | 3 |
| Yun, BH | 2 |
| Brennan, P | 1 |
| Mates, D | 1 |
| Jinga, V | 1 |
| Harnden, P | 1 |
| Banks, RE | 1 |
| Blanche, H | 1 |
| Bihoreau, MT | 1 |
| Chopard, P | 1 |
| Letourneau, L | 1 |
| Lathrop, GM | 1 |
| Scelo, G | 1 |
| Hoang, ML | 1 |
| Chen, PC | 2 |
| Roberts, NJ | 1 |
| Vogelstein, B | 1 |
| Papadopoulos, N | 1 |
| Kinzler, KW | 1 |
| Rosenquist, TA | 1 |
| Soria, F | 1 |
| Shariat, SF | 1 |
| Lerner, SP | 1 |
| Fritsche, HM | 1 |
| Rink, M | 1 |
| Kassouf, W | 1 |
| Spiess, PE | 1 |
| Lotan, Y | 1 |
| Ye, D | 1 |
| Fernández, MI | 1 |
| Kikuchi, E | 1 |
| Chade, DC | 1 |
| Babjuk, M | 1 |
| Thalmann, GN | 1 |
| Yang, HY | 1 |
| Wang, JD | 1 |
| Lo, TC | 1 |
| Stemmer, K | 3 |
| Ellinger-Ziegelbauer, H | 3 |
| Ahr, HJ | 3 |
| Dietrich, DR | 3 |
| Witkowicz, J | 1 |
| Moriya, M | 1 |
| Sidorenko, VS | 1 |
| Edwards, KL | 1 |
| Gnatenko, DV | 1 |
| Wu, L | 1 |
| Wu, XR | 1 |
| Schetter, AJ | 1 |
| Harris, CC | 1 |
| Kanaan, N | 1 |
| Cosyns, JP | 2 |
| Jadoul, M | 2 |
| Goffin, E | 1 |
| Cui, M | 1 |
| Liu, ZH | 3 |
| Qiu, Q | 3 |
| Li, H | 1 |
| Li, LS | 2 |
| Lotz, K | 1 |
| Pfohl-Leszkowicz, A | 1 |
| Tozlovanu, M | 1 |
| Manderville, R | 1 |
| Peraica, M | 1 |
| Castegnaro, M | 1 |
| Stefanovic, V | 1 |
| Debelle, FD | 1 |
| Squifflet, JP | 1 |
| Wese, FX | 1 |
| van Ypersele de Strihou, C | 1 |
| De Broe, ME | 1 |
| Lampert, N | 1 |
| Xu, Y | 1 |
| Nortier, J | 1 |
| Yin, HL | 2 |
| Li, YM | 1 |
| Chen, HP | 1 |
7 reviews available for aristolochic acid i and Cancer of Kidney
| Article | Year |
|---|---|
Aristolochic acid-containing Chinese herbal medicine and upper urinary tract urothelial carcinoma in Taiwan: a narrative review.
Topics: Aristolochic Acids; Carcinogens; Carcinoma, Transitional Cell; DNA Adducts; Drugs, Chinese Herbal; F | 2023 |
Aristolochic Acid-Induced Nephrotoxicity: Molecular Mechanisms and Potential Protective Approaches.
Topics: Animals; Aristolochic Acids; Carcinogens; DNA Adducts; Humans; Kidney Neoplasms; Mutagens; Tumor Sup | 2020 |
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Topics: Animals; Antineoplastic Agents; Aristolochic Acids; Arsenic; Carcinogens; Carcinoma, Transitional Ce | 2019 |
Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid.
Topics: Animals; Aristolochia; Aristolochic Acids; Balkan Nephropathy; Carcinogens; Carcinoma, Transitional | 2019 |
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Topics: Aristolochic Acids; Carcinoma, Transitional Cell; Colorectal Neoplasms, Hereditary Nonpolyposis; Hum | 2017 |
[Aristolochic acid nephropathy].
Topics: Animals; Anti-Obesity Agents; Aristolochiaceae; Aristolochic Acids; Carcinogens; Drugs, Chinese Herb | 2009 |
Aristolochic acid nephropathy: a worldwide problem.
Topics: Animals; Aristolochia; Aristolochic Acids; Balkan Nephropathy; Belgium; Cell Transformation, Neoplas | 2008 |
26 other studies available for aristolochic acid i and Cancer of Kidney
| Article | Year |
|---|---|
Latency period of aristolochic acid-induced upper urinary tract urothelial carcinoma.
Topics: Adult; Carcinoma, Transitional Cell; Cohort Studies; Female; Humans; Kidney Neoplasms; Male; Middle | 2023 |
Reduction in the Incidence of Urological Cancers after the Ban on Chinese Herbal Products Containing Aristolochic Acid: An Interrupted Time-Series Analysis.
Topics: Aristolochic Acids; Carcinogens; Drugs, Chinese Herbal; Humans; Incidence; Kidney Neoplasms; Kidney | 2019 |
Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus.
Topics: Adult; Aged; Aged, 80 and over; Aristolochic Acids; Asian People; Carcinoma, Renal Cell; China; Coho | 2020 |
Quantitation of DNA Adducts in Target and Nontarget Organs of Aristolochic Acid I-Exposed Rats: Correlating DNA Adduct Levels with Organotropic Activities.
Topics: Animals; Aristolochia; Aristolochic Acids; Carcinogens; Chromatography, Liquid; DNA Adducts; Kidney; | 2019 |
Variation in presentation and presence of DNA adducts and p53 mutations in patients with endemic nephropathy--an environmental form of the aristolochic acid nephropathy.
Topics: Aristolochic Acids; Balkan Nephropathy; DNA Adducts; Environmental Exposure; Genes, p53; Humans; Kid | 2013 |
Risk factors and treatment outcomes of new contralateral upper urinary urothelial carcinoma after nephroureterectomy: the experiences of a large Chinese center.
Topics: Aged; Aristolochic Acids; Carcinogens; Carcinoma, Transitional Cell; China; Female; Humans; Kaplan-M | 2014 |
Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid.
Topics: Adult; Aged; Aristolochic Acids; Balkan Nephropathy; Carcinogens; Carcinoma, Renal Cell; Exome; Fema | 2015 |
Integrated microRNA, mRNA, and protein expression profiling reveals microRNA regulatory networks in rat kidney treated with a carcinogenic dose of aristolochic acid.
Topics: Animals; Aristolochic Acids; Carcinogens; Gene Expression Regulation, Neoplastic; Gene Regulatory Ne | 2015 |
Aristolochic acid exposure in Romania and implications for renal cell carcinoma.
Topics: Aristolochic Acids; Carcinoma, Renal Cell; Deoxyadenosines; Humans; Kidney Neoplasms; Mutation; Roma | 2016 |
Aristolochic Acid in the Etiology of Renal Cell Carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Aristolochic Acids; Carcinogens; Carcinoma, Renal Cell; Case-Control | 2016 |
Increased mortality risk for cancers of the kidney and other urinary organs among Chinese herbalists.
Topics: Adolescent; Adult; Aristolochic Acids; Asian People; Carcinogens; Cohort Studies; Female; Health Sur | 2009 |
Molecular characterization of preneoplastic lesions provides insight on the development of renal tumors.
Topics: Animals; Apoptosis; Aristolochic Acids; Bromodeoxyuridine; Cell Proliferation; Gene Expression Profi | 2009 |
Aristolochic acid-associated urothelial cancer in Taiwan.
Topics: Adult; Aged; Aged, 80 and over; Aristolochic Acids; Carcinoma, Renal Cell; Carcinoma, Transitional C | 2012 |
Tumor suppressor p53 (TP53) at the crossroads of the exposome and the cancer genome.
Topics: Aristolochic Acids; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Fema | 2012 |
The importance of a histology-based diagnosis of interstitial nephropathy in two patients with renal insufficiency.
Topics: Aged; Aristolochic Acids; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Female; Humans; Kidne | 2003 |
Tumour induction in rats following exposure to short-term high dose aristolochic acid I.
Topics: Adenoma, Oxyphilic; Animals; Aristolochic Acids; Carcinogens; Female; Kidney; Kidney Neoplasms; Rats | 2005 |
Establishment of a protocol for the gene expression analysis of laser microdissected rat kidney samples with affymetrix genechips.
Topics: Animals; Aristolochic Acids; Cryopreservation; Gene Expression Profiling; Kidney Neoplasms; Lasers; | 2006 |
Carcinogen-specific gene expression profiles in short-term treated Eker and wild-type rats indicative of pathways involved in renal tumorigenesis.
Topics: Animals; Aristolochic Acids; Carcinogens; Cell Cycle; Cell Growth Processes; Cell Transformation, Ne | 2007 |
New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor.
Topics: Aged; Aged, 80 and over; Anti-Obesity Agents; Aristolochic Acids; Balkan Nephropathy; Belgium; Bulga | 2007 |
Urothelial lesions in Chinese-herb nephropathy.
Topics: Adult; Aristolochic Acids; Carcinogens; Carcinoma in Situ; Carcinoma, Transitional Cell; Drugs, Chin | 1999 |
On a nephrotoxic and carcinogenic slimming regimen.
Topics: Analgesics; Animals; Aristolochic Acids; Balkan Nephropathy; Carcinogens; Carcinoma, Transitional Ce | 1999 |
Chinese herbal nephropathy.
Topics: Aristolochic Acids; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Humans; Kidney Failure, Chr | 2002 |
[Renal interstitial fibrosis and urotelial carcinomas after ingestion of a Chinese herb (Aristolochia fangchi)].
Topics: Anti-Obesity Agents; Aristolochia; Aristolochic Acids; Atrophy; Biomarkers; Carcinogens; Carcinoma, | 2002 |
[Experimental study on oncogenicity of Aristolochia manshuriensis in rats].
Topics: Animals; Aristolochia; Carcinogens; Drugs, Chinese Herbal; Female; Kidney Neoplasms; Plant Stems; Pr | 2001 |
[Query on the cause of "belgium nephropathy" (Chinese herb nephropathy) and the speculation on carcinogenesis of Chinese herbs].
Topics: Aristolochia; Aristolochic Acids; Belgium; Drugs, Chinese Herbal; Humans; Kidney Neoplasms; Nephriti | 2002 |
Long-term outcome of acute renal injury induced by Aristolochia manshuriensis Kom in rats.
Topics: Acute Kidney Injury; Animals; Aristolochia; Drugs, Chinese Herbal; Female; Kidney; Kidney Neoplasms; | 2000 |