aristolochic acid i has been researched along with Breast Cancer in 3 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "AAI and AAII were reacted with human mammary carcinoma (MCF-7) DNA in vitro and the major DNA adducts formed were identified by the (32)P-postlabeling method." | 1.31 | Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR. ( Arlt, VM; Pfeifer, GP; Schmeiser, HH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lord, GM | 1 |
| Hollstein, M | 1 |
| Arlt, VM | 2 |
| Roufosse, C | 1 |
| Pusey, CD | 1 |
| Cook, T | 1 |
| Schmeiser, HH | 2 |
| Pfeifer, GP | 1 |
| Chaouki, W | 1 |
| Leger, DY | 1 |
| Eljastimi, J | 1 |
| Beneytout, JL | 1 |
| Hmamouchi, M | 1 |
3 other studies available for aristolochic acid i and Breast Cancer
| Article | Year |
|---|---|
DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.
Topics: Aristolochia; Aristolochic Acids; Breast Neoplasms; DNA Adducts; Female; Genes, p53; Humans; Kidney | 2004 |
Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR.
Topics: Aristolochic Acids; Breast Neoplasms; Carcinogens; Chromosome Mapping; DNA; DNA Adducts; DNA Nucleot | 2001 |
Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7.
Topics: Antineoplastic Agents, Phytogenic; Aristolochia; Aristolochic Acids; Betulinic Acid; Breast Neoplasm | 2010 |