aristolochic acid i has been researched along with Body Weight in 17 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Early renal injury via renal interstitial fibrosis was induced in rats by administration of aristolochic acid I (AAI) solution intragastrically for 8 weeks." | 3.77 | Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats. ( Cheng, XH; Lin, RC; Mao, JR; Sun, WJ; Zhang, L; Zhang, Y; Zhao, YY, 2011) |
| "Aristolochic acid I (AAI) is a potent carcinogen and was found to be toxic in animal and clinical studies." | 1.40 | Aristolochic Acid I induces ovarian toxicity by inhibition of akt phosphorylation. ( Kwak, DH; Lee, HS; Lee, S; Moon, JS; Park, JH, 2014) |
| "This study was designed to compare the possible toxic effects of Longdan Xieganwan and three different Aristolochia species, i." | 1.35 | Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice. ( Gong, L; Guan, S; Li, Y; Liu, Y; Lu, H; Qi, X; Ren, J; Wu, X; Xiao, Y; Xue, X; Zhang, Y, 2008) |
| " Pattern recognition analysis indicated that the renal proximal tubule lesion was the main damage induced by AA, and the renal toxicity induced by AA was a progressive course with the accumulation of dosage by monitoring the toxicological processes from onset, development and part-recovery." | 1.33 | NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats. ( Li, X; Liao, P; Ni, J; Pei, F; Wu, H; Zhang, X, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Li, WL | 1 |
| Padanilam, BJ | 1 |
| Kim, J | 1 |
| Kwak, DH | 1 |
| Park, JH | 1 |
| Lee, HS | 1 |
| Moon, JS | 1 |
| Lee, S | 1 |
| Tsutsumi, T | 1 |
| Okamoto, Y | 1 |
| Yamakawa, S | 1 |
| Bingjun, C | 1 |
| Ishihara, A | 1 |
| Tanaka, T | 1 |
| Tokumura, A | 1 |
| Koyama, N | 1 |
| Yonezawa, Y | 1 |
| Nakamura, M | 1 |
| Sanada, H | 1 |
| Matsui, K | 1 |
| Kamijo-Ikemorif, A | 1 |
| Sugaya, T | 1 |
| Yasuda, T | 1 |
| Kimura, K | 1 |
| Zhao, YY | 1 |
| Zhang, L | 1 |
| Mao, JR | 1 |
| Cheng, XH | 1 |
| Lin, RC | 1 |
| Zhang, Y | 3 |
| Sun, WJ | 1 |
| Debelle, F | 1 |
| Nortier, J | 1 |
| Arlt, VM | 1 |
| De Prez, E | 1 |
| Vienne, A | 1 |
| Salmon, I | 1 |
| Phillips, DH | 1 |
| Deschodt-Lanckman, M | 1 |
| Vanherweghem, JL | 2 |
| Zhang, X | 2 |
| Wu, H | 1 |
| Liao, P | 1 |
| Li, X | 1 |
| Ni, J | 1 |
| Pei, F | 1 |
| Chen, M | 1 |
| Su, M | 1 |
| Zhao, L | 1 |
| Jiang, J | 1 |
| Liu, P | 1 |
| Cheng, J | 1 |
| Lai, Y | 1 |
| Liu, Y | 2 |
| Jia, W | 1 |
| Mengs, U | 1 |
| Stotzem, CD | 1 |
| Zheng, F | 1 |
| Huang, Q | 1 |
| Debelle, FD | 1 |
| Nortier, JL | 1 |
| De Prez, EG | 1 |
| Garbar, CH | 1 |
| Vienne, AR | 1 |
| Salmon, IJ | 1 |
| Deschodt-Lanckman, MM | 1 |
| Wang, L | 1 |
| Ding, X | 1 |
| Li, C | 1 |
| Zhao, Y | 3 |
| Yu, C | 1 |
| Yi, Y | 1 |
| Gao, Y | 1 |
| Pan, C | 1 |
| Liu, S | 1 |
| Han, J | 1 |
| Tian, J | 1 |
| Liu, J | 1 |
| Deng, N | 1 |
| Li, G | 1 |
| Liang, A | 1 |
| Xue, X | 1 |
| Xiao, Y | 1 |
| Gong, L | 1 |
| Guan, S | 1 |
| Lu, H | 1 |
| Qi, X | 1 |
| Li, Y | 1 |
| Wu, X | 1 |
| Ren, J | 1 |
| Sato, N | 1 |
| Takahashi, D | 1 |
| Chen, SM | 1 |
| Tsuchiya, R | 1 |
| Mukoyama, T | 1 |
| Yamagata, S | 1 |
| Ogawa, M | 1 |
| Yoshida, M | 1 |
| Kondo, S | 1 |
| Satoh, N | 1 |
| Ueda, S | 1 |
| Du, GY | 2 |
| Zhou, SJ | 2 |
| Cu, HF | 2 |
| Wang, XR | 2 |
| Li, L | 2 |
| Xiao, YQ | 2 |
| Cao, CY | 2 |
| Zhang, CY | 1 |
| Wu, ZL | 2 |
| Gao, SR | 2 |
| He, R | 2 |
| Hui, LQ | 2 |
| Liu, BY | 2 |
17 other studies available for aristolochic acid i and Body Weight
| Article | Year |
|---|---|
The Presence of Testis Determines Aristolochic Acid-Induced Nephrotoxicity in Mice.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Body Weight; Female; Kidney; Male; Mice; Testis; W | 2023 |
Aristolochic Acid I induces ovarian toxicity by inhibition of akt phosphorylation.
Topics: Animals; Aristolochic Acids; Body Weight; CHO Cells; Cricetinae; Cricetulus; Female; Humans; Organ S | 2014 |
Reduced rat plasma lysophosphatidylglycerol or lysophosphatidic acid level as a biomarker of aristolochic acid-induced renal and adipose dysfunctions.
Topics: Adipose Tissue; Animals; Aristolochic Acids; Biomarkers; Body Weight; Feeding Behavior; Kidney; Lyso | 2016 |
Evaluation for a mutagenicity of aristolochic acid by Pig-a and PIGRET assays in rats.
Topics: Animals; Aristolochic Acids; Body Weight; Erythrocytes; Male; Membrane Proteins; Mutagenicity Tests; | 2016 |
Renal liver-type fatty acid binding protein (L-FABP) attenuates acute kidney injury in aristolochic acid nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Aquaporin 1; Aristolochic Acids; Body Weight; Chemokine CCL2; Fatty Ac | 2011 |
Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Body Weight; Cholestenones; Fibrosis; Kidney; Kidn | 2011 |
Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy.
Topics: Animals; Aristolochic Acids; Autoradiography; Body Weight; Creatinine; Dexfenfluramine; Disease Mode | 2003 |
NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats.
Topics: Animals; Aristolochic Acids; Blood Chemical Analysis; Body Weight; Chemical and Drug Induced Liver I | 2006 |
Metabonomic study of aristolochic acid-induced nephrotoxicity in rats.
Topics: Animals; Aristolochic Acids; Body Weight; Chromatography, Liquid; Creatinine; Kidney; Male; Mass Spe | 2006 |
Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology.
Topics: Animals; Aristolochic Acids; Body Weight; Carcinogens; Creatinine; Dose-Response Relationship, Drug; | 1993 |
[Establishment of model of aristolochic acid-induced chronic renal interstitial fibrosis in rats].
Topics: Animals; Aristolochic Acids; Blood Urea Nitrogen; Body Weight; Carcinogens; Chronic Disease; Creatin | 2001 |
Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats.
Topics: Animals; Aristolochic Acids; Body Weight; Carcinoma, Transitional Cell; Dose-Response Relationship, | 2002 |
Oral administration of Aristolochia manshuriensis Kom in rats induces tumors in multiple organs.
Topics: Administration, Oral; Anemia; Animals; Aristolochia; Body Weight; Carcinogens; Female; Kidney; Liver | 2018 |
Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice.
Topics: Administration, Oral; Animals; Aristolochia; Body Weight; Dose-Response Relationship, Drug; Drugs, C | 2008 |
Acute nephrotoxicity of aristolochic acids in mice.
Topics: Acute Disease; Administration, Oral; Animals; Aristolochia; Aristolochic Acids; Blood Urea Nitrogen; | 2004 |
[Experimental study of chronic renal tubular-interstitial injury induced by radix aristolochiae fangchi extract in rats].
Topics: Acetylglucosaminidase; Animals; Aristolochia; Aristolochic Acids; Blood Urea Nitrogen; Body Weight; | 2005 |
[Experimental study of chronic renal tubular-interstitial injury induced by Radix Aristolochiae Fangchi Extract in rats].
Topics: Animals; Aristolochia; Aristolochic Acids; Blood Urea Nitrogen; Body Weight; Dose-Response Relations | 2005 |