aristolochic acid i has been researched along with Bladder Cancer in 27 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper urothelial carcinoma (UUC) was recently confirmed." | 3.75 | Molecular markers in upper urothelial carcinoma associated to Balkan endemic nephropathy. Aristolochic acid as the major risk factor of the worldwide disease. ( Hattori, T; Jankovic Velickovic, L; Stefanovic, V, 2009) |
| "Additionally, we allude to some of the cancer types where there is molecular epidemiological evidence that these agents are aetiological risk factors." | 2.58 | Carcinogens and DNA damage. ( Barnes, JL; John, K; Martin, FL; Poirier, MC; Zubair, M, 2018) |
| "UTUC and bladder cancer share some common risk factors, even if they are two different entities regarding practical, biological and clinical characteristics." | 2.55 | Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC). ( Babjuk, M; Chade, DC; Fernández, MI; Fritsche, HM; Grollman, AP; Kassouf, W; Kikuchi, E; Lerner, SP; Lotan, Y; Rink, M; Shariat, SF; Soria, F; Spiess, PE; Thalmann, GN; Ye, D, 2017) |
| "The incidence of ESRD was ascertained through cross-referencing with a registry for catastrophic illnesses." | 1.43 | Patients with urothelial carcinoma have poor renal outcome regardless of whether they receive nephrouretectomy. ( Chang, CH; Chung, CJ; Chung, MC; Hung, KY; Hung, PH; Muo, CH; Tsai, HB, 2016) |
| "The rats of Radix Aristolochice showed serious toxic responses of renal tubule atrophy and necrosis, meanwhile, the levels of BUN, Cr and NAG were increased obviously." | 1.34 | [Nephrotoxicity of Radix Aristolochice and it's substitution material Radix Inulae in rats]. ( Li, LD; Liu, YY; Qiao, HX; Wu, LM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 13 (48.15) | 2.80 |
| Authors | Studies |
|---|---|
| Karanović, S | 1 |
| Ardin, M | 1 |
| Tang, Z | 1 |
| Tomić, K | 1 |
| Villar, S | 1 |
| Renard, C | 1 |
| Venturini, E | 1 |
| Lorch, AH | 1 |
| Lee, DS | 1 |
| Stipančić, Ž | 1 |
| Slade, N | 1 |
| Vuković Brinar, I | 1 |
| Dittrich, D | 1 |
| Karlović, K | 1 |
| Borovečki, F | 1 |
| Dickman, KG | 2 |
| Olivier, M | 1 |
| Grollman, AP | 4 |
| Jelaković, B | 1 |
| Zavadil, J | 1 |
| Thangavelu, M | 1 |
| Ismail, A | 1 |
| Zakaria, A | 1 |
| Elmansy, H | 1 |
| Shahrour, W | 1 |
| Prowse, O | 1 |
| Kotb, A | 1 |
| Chen, CH | 2 |
| Pu, YS | 2 |
| Li, S | 1 |
| Zhang, J | 2 |
| Tian, Y | 2 |
| Zhu, Y | 1 |
| Guo, Y | 1 |
| Wang, Z | 1 |
| Yang, Y | 1 |
| Ding, G | 1 |
| Lin, J | 1 |
| Komatsu, M | 1 |
| Funakoshi, T | 1 |
| Aki, T | 1 |
| Unuma, K | 1 |
| Uemura, K | 1 |
| Jhuang, JR | 1 |
| Chiu, PC | 1 |
| Hsieh, TC | 1 |
| Lee, WC | 1 |
| Liao, CI | 1 |
| Fang, HC | 1 |
| Lee, PT | 1 |
| Hsu, CY | 1 |
| Chen, CL | 1 |
| Huang, CW | 1 |
| Chen, XY | 1 |
| Ou, SH | 1 |
| Tsai, CT | 1 |
| Chou, KJ | 1 |
| Radic Savic, Z | 1 |
| Coric, V | 1 |
| Vidovic, S | 1 |
| Vidovic, V | 1 |
| Becarevic, J | 1 |
| Milovac, I | 1 |
| Reljic, Z | 1 |
| Mirjanic-Azaric, B | 1 |
| Skrbic, R | 1 |
| Gajanin, R | 1 |
| Matic, M | 1 |
| Simic, T | 1 |
| Boot, A | 1 |
| Jiang, N | 1 |
| Rozen, SG | 1 |
| Shan, H | 1 |
| Tian, W | 1 |
| Hong, Y | 1 |
| Xu, B | 1 |
| Wang, C | 1 |
| Yu, B | 1 |
| Wang, X | 1 |
| Rebhan, K | 1 |
| Ertl, IE | 1 |
| Shariat, SF | 2 |
| Rosenquist, T | 1 |
| Li, R | 1 |
| Du, Y | 1 |
| Chen, Z | 1 |
| Xu, D | 1 |
| Lin, T | 1 |
| Jin, S | 1 |
| Wang, G | 1 |
| Liu, Z | 1 |
| Lu, M | 1 |
| Chen, X | 1 |
| Xu, T | 1 |
| Bai, F | 1 |
| Bellamri, M | 1 |
| Brandt, K | 1 |
| Brown, CV | 1 |
| Wu, MT | 1 |
| Turesky, RJ | 1 |
| Barnes, JL | 1 |
| Zubair, M | 1 |
| John, K | 1 |
| Poirier, MC | 1 |
| Martin, FL | 1 |
| Yang, HY | 1 |
| Yang, CC | 1 |
| Wu, CY | 1 |
| Wang, LJ | 1 |
| Lu, KL | 1 |
| Zhang, A | 1 |
| Shang, D | 1 |
| Zhang, L | 1 |
| Shi, R | 1 |
| Fu, F | 1 |
| Roumeguère, T | 2 |
| Broeders, N | 1 |
| Jayaswal, A | 1 |
| Rorive, S | 2 |
| Quackels, T | 1 |
| Pozdzik, A | 1 |
| Arlt, VM | 2 |
| Schmeiser, HH | 3 |
| Nortier, JL | 2 |
| Kanaan, N | 1 |
| Hassoun, Z | 1 |
| Raggi, C | 1 |
| Jadoul, M | 1 |
| Mourad, M | 1 |
| De Meyer, M | 1 |
| Aydin, S | 1 |
| Cosyns, JP | 1 |
| Goffin, E | 1 |
| Hung, PH | 1 |
| Tsai, HB | 1 |
| Hung, KY | 1 |
| Muo, CH | 1 |
| Chung, MC | 1 |
| Chang, CH | 1 |
| Chung, CJ | 1 |
| Soria, F | 1 |
| Lerner, SP | 1 |
| Fritsche, HM | 1 |
| Rink, M | 1 |
| Kassouf, W | 1 |
| Spiess, PE | 1 |
| Lotan, Y | 1 |
| Ye, D | 1 |
| Fernández, MI | 1 |
| Kikuchi, E | 1 |
| Chade, DC | 1 |
| Babjuk, M | 1 |
| Thalmann, GN | 1 |
| Jankovic Velickovic, L | 1 |
| Hattori, T | 1 |
| Stefanovic, V | 1 |
| Laing, C | 1 |
| Hamour, S | 1 |
| Sheaff, M | 1 |
| Miller, R | 1 |
| Woolfson, R | 1 |
| Stiborová, M | 1 |
| vom Brocke, J | 1 |
| Simões, ML | 1 |
| Lord, GM | 1 |
| Hollstein, M | 1 |
| Phillips, DH | 1 |
| Lemy, A | 1 |
| Wissing, KM | 1 |
| Zlotta, A | 1 |
| Muniz Martinez, MC | 1 |
| Decaestecker, C | 1 |
| Salmon, I | 1 |
| Abramowicz, D | 1 |
| Vanherweghem, JL | 1 |
| Nortier, J | 2 |
| Qiao, HX | 2 |
| Liu, YY | 2 |
| Wu, LM | 2 |
| Li, LD | 2 |
5 reviews available for aristolochic acid i and Bladder Cancer
| Article | Year |
|---|---|
Aristolochic acid-containing Chinese herbal medicine and upper urinary tract urothelial carcinoma in Taiwan: a narrative review.
Topics: Aristolochic Acids; Carcinogens; Carcinoma, Transitional Cell; DNA Adducts; Drugs, Chinese Herbal; F | 2023 |
Carcinogens and DNA damage.
Topics: Amines; Animals; Aristolochic Acids; Benzo(a)pyrene; Carcinogens; Cross-Linking Reagents; Diet; DNA; | 2018 |
Aristolochic Acid and Immunotherapy for Urothelial Carcinoma: Directions for unmet Needs.
Topics: Animals; Aristolochic Acids; Carcinogens; Carcinoma; Humans; Immunotherapy; Urinary Bladder Neoplasm | 2019 |
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Topics: Aristolochic Acids; Carcinoma, Transitional Cell; Colorectal Neoplasms, Hereditary Nonpolyposis; Hum | 2017 |
Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.
Topics: Animals; Aristolochic Acids; Balkan Nephropathy; Cell Transformation, Neoplastic; DNA Adducts; Genes | 2007 |
22 other studies available for aristolochic acid i and Bladder Cancer
| Article | Year |
|---|---|
Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure.
Topics: Aristolochic Acids; Biomarkers, Tumor; Carcinoma, Transitional Cell; Exome; Follow-Up Studies; Gene | 2022 |
Aristolochic acid: What urologists should know.
Topics: Aristolochic Acids; Carcinoma, Transitional Cell; Humans; Urinary Bladder Neoplasms; Urologists | 2022 |
De novo upper tract urothelial carcinoma after renal transplantation: a single-center experience in China.
Topics: Carcinoma, Transitional Cell; Humans; Kidney Transplantation; Neoplasm Recurrence, Local; Prognosis; | 2023 |
Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells.
Topics: Animals; Apoptosis; Aristolochic Acids; Carcinoma, Transitional Cell; Cell Line; Cyclooxygenase 2; D | 2023 |
Latency period of aristolochic acid-induced upper urinary tract urothelial carcinoma.
Topics: Adult; Carcinoma, Transitional Cell; Cohort Studies; Female; Humans; Kidney Neoplasms; Male; Middle | 2023 |
Trends in the incidence of urothelial carcinoma in Taiwan after the ban on aristolochic acid-containing Chinese herbal preparations, 2001-2018: a national population-based cohort study.
Topics: Carcinoma, Transitional Cell; Cohort Studies; Humans; Incidence; Taiwan; Urinary Bladder Neoplasms; | 2023 |
Topics: Balkan Nephropathy; Carcinoma, Transitional Cell; Female; Glutathione Peroxidase; Humans; Kelch-Like | 2023 |
Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma.
Topics: Aristolochic Acids; Humans; Mutagens; Mutation; Neoplasm Proteins; Urinary Bladder Neoplasms; Urothe | 2020 |
Clinicopathologic characteristics and prognosis of upper tract urothelial carcinoma complicated with aristolochic acid nephropathy after radical nephroureterectomy.
Topics: Adult; Aged; Aged, 80 and over; Aristolochic Acids; Drugs, Chinese Herbal; Female; Humans; Kidney Di | 2020 |
Aristolochic acid and its effect on different cancers in uro-oncology.
Topics: Aristolochic Acids; Balkan Nephropathy; Carcinogens; DNA Adducts; Drugs, Chinese Herbal; Humans; Uri | 2020 |
Macroscopic somatic clonal expansion in morphologically normal human urothelium.
Topics: Aristolochic Acids; Chromatin Assembly and Disassembly; Class I Phosphatidylinositol 3-Kinases; DNA- | 2020 |
Cytotoxicity and genotoxicity of the carcinogen aristolochic acid I (AA-I) in human bladder RT4 cells.
Topics: Aminobiphenyl Compounds; Aristolochic Acids; Carcinogens; Cell Line, Tumor; Cytochrome P-450 CYP1A1; | 2021 |
A retrospective review of patients with urothelial cancer in 3,370 recipients after renal transplantation: a single-center experience.
Topics: Adult; Aged; Aristolochic Acids; Carcinoma, Transitional Cell; China; Cystectomy; Drugs, Chinese Her | 2015 |
Bacillus Calmette-Guerin therapy in non-muscle-invasive bladder carcinoma after renal transplantation for end-stage aristolochic acid nephropathy.
Topics: Administration, Intravesical; Adult; Aged; Aristolochic Acids; BCG Vaccine; Female; Follow-Up Studie | 2015 |
Long-term Outcome of Kidney Recipients Transplanted for Aristolochic Acid Nephropathy.
Topics: Adult; Aged; Aristolochic Acids; Belgium; Carcinoma; Drug Therapy, Combination; Female; Graft Reject | 2016 |
Patients with urothelial carcinoma have poor renal outcome regardless of whether they receive nephrouretectomy.
Topics: Adult; Aged; Aristolochic Acids; Cohort Studies; Female; Humans; Kidney; Kidney Failure, Chronic; Ma | 2016 |
Molecular markers in upper urothelial carcinoma associated to Balkan endemic nephropathy. Aristolochic acid as the major risk factor of the worldwide disease.
Topics: Adult; Aged; Aged, 80 and over; Aristolochia; Aristolochic Acids; Balkan Nephropathy; Biomarkers, Tu | 2009 |
Chinese herbal uropathy and nephropathy.
Topics: Adult; Aristolochic Acids; Carcinogens; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Humans; | 2006 |
Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up.
Topics: Administration, Intravesical; Adult; Antibiotics, Antineoplastic; Aristolochic Acids; Carcinogens; D | 2008 |
[Renal interstitial fibrosis and urotelial carcinomas after ingestion of a Chinese herb (Aristolochia fangchi)].
Topics: Anti-Obesity Agents; Aristolochia; Aristolochic Acids; Atrophy; Biomarkers; Carcinogens; Carcinoma, | 2002 |
[Hepatic and renal injury induced by Radix Aristolochiae or Guanxin Suhe Wan for a long-term in rats].
Topics: Animals; Aristolochia; Drugs, Chinese Herbal; Kidney; Liver; Male; Rats; Rats, Sprague-Dawley; Stoma | 2008 |
[Nephrotoxicity of Radix Aristolochice and it's substitution material Radix Inulae in rats].
Topics: Acetylglucosaminidase; Animals; Aristolochia; Blood Urea Nitrogen; Creatinine; Drugs, Chinese Herbal | 2007 |