aristolochic acid i has been researched along with Albuminuria in 3 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Differences in bioavailability or hepatic metabolism of AAI, expression of CYP1A2, or efficiency of a competing nitroreduction pathway in vivo may explain the apparent differences between human and rodent sensitivity to AAI." | 1.36 | Cytochrome P450 1A2 detoxicates aristolochic acid in the mouse. ( Dickman, KG; Einolf, HJ; Grollman, AP; Rosenquist, TA; Smith, A; Wang, L, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Taguchi, S | 1 |
| Azushima, K | 1 |
| Yamaji, T | 1 |
| Urate, S | 1 |
| Suzuki, T | 1 |
| Abe, E | 1 |
| Tanaka, S | 1 |
| Tsukamoto, S | 1 |
| Kamimura, D | 1 |
| Kinguchi, S | 1 |
| Yamashita, A | 1 |
| Wakui, H | 1 |
| Tamura, K | 1 |
| Zhou, Y | 1 |
| Bian, X | 1 |
| Fang, L | 1 |
| He, W | 1 |
| Dai, C | 1 |
| Yang, J | 1 |
| Rosenquist, TA | 1 |
| Einolf, HJ | 1 |
| Dickman, KG | 1 |
| Wang, L | 1 |
| Smith, A | 1 |
| Grollman, AP | 1 |
3 other studies available for aristolochic acid i and Albuminuria
| Article | Year |
|---|---|
Effects of tumor necrosis factor-α inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy.
Topics: Albuminuria; Animals; Aristolochic Acids; Collagen; Disease Models, Animal; Etanercept; Fibrosis; In | 2021 |
Aristolochic acid causes albuminuria by promoting mitochondrial DNA damage and dysfunction in podocyte.
Topics: Albuminuria; Animals; Aristolochic Acids; Carcinogens; Cell Line, Transformed; DNA Damage; DNA, Mito | 2013 |
Cytochrome P450 1A2 detoxicates aristolochic acid in the mouse.
Topics: Albuminuria; Animals; Aristolochic Acids; Biocatalysis; Creatinine; Cytochrome P-450 CYP1A1; Cytochr | 2010 |