aristolochic acid i has been researched along with Acute Liver Injury, Drug-Induced in 9 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aristolochic acid I (AAI) was regarded as the major toxic component of aristolochic acid (AA)." | 1.51 | The Disturbance of Hepatic and Serous Lipids in Aristolochic Acid Ι Induced Rats for Hepatotoxicity Using Lipidomics Approach. ( Bian, B; Si, N; Wang, H; Wei, X; Yang, J; Yang, Y; Zhao, H; Zhou, J; Zhou, Y, 2019) |
| " Pattern recognition analysis indicated that the renal proximal tubule lesion was the main damage induced by AA, and the renal toxicity induced by AA was a progressive course with the accumulation of dosage by monitoring the toxicological processes from onset, development and part-recovery." | 1.33 | NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats. ( Li, X; Liao, P; Ni, J; Pei, F; Wu, H; Zhang, X, 2006) |
| "(1) To study the acute and chronic toxicity of stem of Aristolochia manshuriensis (AMA Guanmuton) which is a Chinese medicinal herb in order to provide basis for safe clinical use." | 1.32 | Studies on the toxicity of Aristolochia manshuriensis (Guanmuton). ( Chan, K; Hu, SL; Mei, QX; Zhang, HQ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 2 |
| Guan, H | 1 |
| Feng, M | 1 |
| Du, C | 1 |
| Zhang, Q | 1 |
| Shou, Y | 1 |
| Qi, G | 1 |
| Yu, D | 1 |
| Jin, Y | 1 |
| Zhou, J | 1 |
| Yang, Y | 1 |
| Wang, H | 1 |
| Bian, B | 1 |
| Yang, J | 1 |
| Wei, X | 1 |
| Zhou, Y | 1 |
| Si, N | 1 |
| Zhao, H | 1 |
| Liu, X | 1 |
| Cheng, M | 1 |
| Xiao, H | 1 |
| Tripatara, P | 1 |
| Onlamul, W | 1 |
| Booranasubkajorn, S | 1 |
| Wattanarangsan, J | 1 |
| Huabprasert, S | 1 |
| Lumlerdkij, N | 1 |
| Akarasereenont, P | 1 |
| Laohapand, T | 1 |
| Wojcikowski, K | 1 |
| Johnson, DW | 1 |
| Gobé, G | 1 |
| Zhang, X | 1 |
| Wu, H | 1 |
| Liao, P | 1 |
| Li, X | 1 |
| Ni, J | 1 |
| Pei, F | 1 |
| Zhang, L | 1 |
| Mu, X | 1 |
| Fu, J | 1 |
| Zhou, Z | 1 |
| Tanaka, A | 1 |
| Nishida, R | 1 |
| Maeda, K | 1 |
| Sugawara, A | 1 |
| Kuwahara, T | 1 |
| Hu, SL | 1 |
| Zhang, HQ | 1 |
| Chan, K | 1 |
| Mei, QX | 1 |
1 review available for aristolochic acid i and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Medicinal herbal extracts -- renal friend or foe? Part one: the toxicities of medicinal herbs.
Topics: Aristolochic Acids; Chemical and Drug Induced Liver Injury; Humans; Metals, Heavy; Phytotherapy; Pla | 2004 |
8 other studies available for aristolochic acid i and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced hepatotoxicity by directly targeting the key bioactivating enzyme NQO1.
Topics: Animals; Aristolochic Acids; Chemical and Drug Induced Liver Injury; Humans; MicroRNAs; NAD(P)H Dehy | 2023 |
The Disturbance of Hepatic and Serous Lipids in Aristolochic Acid Ι Induced Rats for Hepatotoxicity Using Lipidomics Approach.
Topics: Animals; Aristolochic Acids; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Administration | 2019 |
[Application of ultra high performance liquid chromatography-mass spectrometry to metabolomics study of drug-induced hepatotoxicity].
Topics: Acetaminophen; Aristolochic Acids; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced | 2015 |
The safety of Homnawakod herbal formula containing Aristolochia tagala Cham. in Wistar rats.
Topics: Animals; Aristolochia; Aristolochic Acids; Blood Pressure; Chemical and Drug Induced Liver Injury; C | 2012 |
NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats.
Topics: Animals; Aristolochic Acids; Blood Chemical Analysis; Body Weight; Chemical and Drug Induced Liver I | 2006 |
In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney.
Topics: Acetaminophen; Aristolochic Acids; Cadmium Chloride; Cell Line; Cell Survival; Chemical and Drug Ind | 2007 |
Chinese herb nephropathy in Japan presents adult-onset Fanconi syndrome: could different components of aristolochic acids cause a different type of Chinese herb nephropathy?
Topics: Adult; Aristolochic Acids; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Fanconi Sy | 2000 |
Studies on the toxicity of Aristolochia manshuriensis (Guanmuton).
Topics: Animals; Aristolochia; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Dru | 2004 |