aristolochic acid i has been researched along with Acute Kidney Injury in 38 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " C57BL/6 mice were treated with AAI via intraperitoneal injection for an accumulated AAI dosage of 45 mg/kg body weight (BW) (15 mg/kg BW per day for 3 days)." | 5.51 | Renal chymase-dependent pathway for angiotensin II formation mediated acute kidney injury in a mouse model of aristolochic acid I-induced acute nephropathy. ( Chang, CC; Chang, HF; Chang, TH; Chuang, WH; Hsieh, WY; Lin, CS; Lu, LC; Yang, CW, 2019) |
| "Bardoxolone methyl (BARD) is an antioxidant modulator that acts through induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway." | 5.40 | Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway. ( Chen, W; Fan, J; Feng, X; Liu, X; Wang, J; Wu, J; Yang, X; Yu, X; Zeng, Y, 2014) |
| "With the aim to explore the possibility to generate a zebrafish model of renal fibrosis, in this study the fibrogenic renal effect of aristolochic acid I (AAI) after immersion was assessed." | 3.96 | Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid. ( de Witte, PA; Giusti, A; Ny, A; Wang, X, 2020) |
| " We used the Fucci mouse in conjunction with FlowSight to identify a discrete polyploid population in proximal tubules after aristolochic acid injury." | 3.91 | Novel kidney dissociation protocol and image-based flow cytometry facilitate improved analysis of injured proximal tubules. ( Alford, CE; Flaherty, DK; Gewin, LS; Ivanova, A; Lau, KS; Manolopoulou, M; Matlock, BK; Nlandu-Khodo, S; Phillips-Mignemi, M; Simmons, AJ, 2019) |
| "Exposure to aristolochic acid I (AAI) can lead to aristolochic acid nephropathy (AAN), Balkan endemic nephropathy (BEN) and urothelial cancer." | 3.81 | Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor. ( Feng, C; Gong, L; Li, C; Luan, Y; Qi, X; Ren, J; Wang, K; Xie, X; Xing, G; Yao, J; Zhu, X, 2015) |
| "Early renal injury via renal interstitial fibrosis was induced in rats by administration of aristolochic acid I (AAI) solution intragastrically for 8 weeks." | 3.77 | Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats. ( Cheng, XH; Lin, RC; Mao, JR; Sun, WJ; Zhang, L; Zhang, Y; Zhao, YY, 2011) |
| " Two major genetic factors that are discussed include genetic polymorphisms in plasma membrane transporters that catalyze uptake and accumulation or efflux and elimination of environmental chemicals, and genetic polymorphisms in bioactivation enzymes that generate toxic and reactive metabolites." | 2.61 | Environmental and Genetic Factors Influencing Kidney Toxicity. ( Lash, LH, 2019) |
| "Acute kidney injury is a common complication in hospitalized patients and is associated with substantially increased morbidity and mortality." | 2.48 | Drugs and AKI. ( Liangos, O, 2012) |
| " C57BL/6 mice were treated with AAI via intraperitoneal injection for an accumulated AAI dosage of 45 mg/kg body weight (BW) (15 mg/kg BW per day for 3 days)." | 1.51 | Renal chymase-dependent pathway for angiotensin II formation mediated acute kidney injury in a mouse model of aristolochic acid I-induced acute nephropathy. ( Chang, CC; Chang, HF; Chang, TH; Chuang, WH; Hsieh, WY; Lin, CS; Lu, LC; Yang, CW, 2019) |
| " Male Wistar rats were orally dosed with 0." | 1.40 | An exploratory evaluation of the utility of transcriptional and urinary kidney injury biomarkers for the prediction of aristolochic acid-induced renal injury in male rats. ( Beiman, M; Fuchs, TC; Hewitt, P; Mally, A; Wool, A, 2014) |
| "Bardoxolone methyl (BARD) is an antioxidant modulator that acts through induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway." | 1.40 | Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway. ( Chen, W; Fan, J; Feng, X; Liu, X; Wang, J; Wu, J; Yang, X; Yu, X; Zeng, Y, 2014) |
| "This report describes an investigation of the pathological mechanism of acute renal failure caused by toxic tubular necrosis after treatment with aristolochic acid I (AAI) in Sprague-Dawley (SD) rats." | 1.39 | Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity. ( Bao, Q; Huang, X; Jiang, Z; Li, H; Sun, L; Wang, T; Zhang, L; Zhang, S, 2013) |
| "According to the Rat's acute renal injury test, the influence of animal's renal function was investigated for representative samples." | 1.36 | [The determination of aristolochic acid A in different processed Aristolochia manshuriensis and the test of influence about renal function in rats]. ( Pan, JH; Song, J; Yan, GJ, 2010) |
| "1) Administration of large dosage of Aristolochia manshuriensis Kom induces acute renal failure in rats." | 1.31 | Long-term outcome of acute renal injury induced by Aristolochia manshuriensis Kom in rats. ( Chen, HP; Li, LS; Liu, ZH; Qiu, Q; Yin, HL, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 4 (10.53) | 29.6817 |
| 2010's | 23 (60.53) | 24.3611 |
| 2020's | 9 (23.68) | 2.80 |
| Authors | Studies |
|---|---|
| Mei, Y | 1 |
| Yang, G | 1 |
| Guo, Y | 2 |
| Zhao, K | 1 |
| Wu, S | 1 |
| Xu, Z | 1 |
| Zhou, S | 2 |
| Yan, C | 1 |
| Seeliger, E | 1 |
| Niendorf, T | 1 |
| Xu, Y | 1 |
| Feng, Y | 1 |
| Li, WL | 1 |
| Padanilam, BJ | 1 |
| Kim, J | 1 |
| Deng, YX | 1 |
| Liu, K | 2 |
| Qiu, QX | 1 |
| Tang, ZY | 1 |
| Que, RM | 1 |
| Li, DK | 1 |
| Gu, XR | 1 |
| Zhou, GL | 1 |
| Wu, YF | 1 |
| Zhou, LY | 1 |
| Yin, WJ | 1 |
| Zuo, XC | 1 |
| Ren, J | 2 |
| Wu, B | 1 |
| Lu, X | 1 |
| Sun, L | 2 |
| Privratsky, JR | 1 |
| Xing, C | 1 |
| Robson, MJ | 1 |
| Mao, H | 1 |
| Blakely, RD | 1 |
| Abe, K | 1 |
| Souma, T | 1 |
| Crowley, SD | 1 |
| Wang, X | 1 |
| Giusti, A | 1 |
| Ny, A | 1 |
| de Witte, PA | 1 |
| Huang, X | 2 |
| Wu, J | 2 |
| Liu, X | 2 |
| Wu, H | 1 |
| Fan, J | 2 |
| Yang, X | 2 |
| Chiou, YY | 1 |
| Jiang, ST | 1 |
| Ding, YS | 1 |
| Cheng, YH | 1 |
| Hu, M | 1 |
| Ma, J | 1 |
| Chinnathambi, A | 1 |
| Alharbi, SA | 1 |
| Shair, OHM | 1 |
| Ge, P | 1 |
| Li, L | 1 |
| Tao, S | 1 |
| Guo, F | 1 |
| Liu, J | 1 |
| Huang, R | 1 |
| Tan, Z | 1 |
| Zeng, X | 1 |
| Ma, L | 1 |
| Fu, P | 1 |
| Leung, JY | 1 |
| Wilson, HL | 1 |
| Voltzke, KJ | 1 |
| Williams, LA | 1 |
| Lee, HJ | 1 |
| Wobker, SE | 1 |
| Kim, WY | 1 |
| Succar, L | 1 |
| Pianta, TJ | 1 |
| Davidson, T | 1 |
| Pickering, JW | 1 |
| Endre, ZH | 1 |
| Honarpisheh, M | 1 |
| Foresto-Neto, O | 1 |
| Steiger, S | 1 |
| Kraft, F | 1 |
| Koehler, P | 1 |
| von Rauchhaupt, E | 1 |
| Potempa, J | 1 |
| Adamowicz, K | 1 |
| Koziel, J | 1 |
| Lech, M | 1 |
| Hsieh, WY | 1 |
| Chang, TH | 1 |
| Chang, HF | 1 |
| Chuang, WH | 1 |
| Lu, LC | 1 |
| Yang, CW | 1 |
| Lin, CS | 1 |
| Chang, CC | 1 |
| Wang, L | 1 |
| Liu, N | 1 |
| Xue, X | 1 |
| Manolopoulou, M | 1 |
| Matlock, BK | 1 |
| Nlandu-Khodo, S | 1 |
| Simmons, AJ | 1 |
| Lau, KS | 1 |
| Phillips-Mignemi, M | 1 |
| Ivanova, A | 1 |
| Alford, CE | 1 |
| Flaherty, DK | 1 |
| Gewin, LS | 1 |
| Lash, LH | 1 |
| Fuchs, TC | 1 |
| Mally, A | 1 |
| Wool, A | 1 |
| Beiman, M | 1 |
| Hewitt, P | 1 |
| Tang, Z | 2 |
| Chen, D | 2 |
| Zhang, Y | 2 |
| Chen, Z | 1 |
| Chen, H | 2 |
| Zeng, C | 1 |
| Liu, Z | 2 |
| Novitskaya, T | 1 |
| McDermott, L | 1 |
| Zhang, KX | 1 |
| Chiba, T | 1 |
| Paueksakon, P | 1 |
| Hukriede, NA | 1 |
| de Caestecker, MP | 1 |
| Chen, W | 1 |
| Wang, J | 1 |
| Zeng, Y | 1 |
| Feng, X | 1 |
| Yu, X | 1 |
| Wang, K | 1 |
| Feng, C | 1 |
| Li, C | 1 |
| Yao, J | 1 |
| Xie, X | 1 |
| Gong, L | 1 |
| Luan, Y | 1 |
| Xing, G | 1 |
| Zhu, X | 1 |
| Qi, X | 1 |
| Pu, XY | 1 |
| Shen, JY | 1 |
| Deng, ZP | 1 |
| Zhang, ZA | 1 |
| Shaohua, Z | 1 |
| Ananda, S | 1 |
| Ruxia, Y | 1 |
| Liang, R | 1 |
| Xiaorui, C | 1 |
| Liang, L | 1 |
| Matsui, K | 1 |
| Kamijo-Ikemorif, A | 1 |
| Sugaya, T | 1 |
| Yasuda, T | 1 |
| Kimura, K | 1 |
| Zhou, T | 1 |
| Xiao, XH | 1 |
| Wang, JY | 1 |
| Chen, JL | 1 |
| Xu, XF | 1 |
| He, ZF | 1 |
| Li, GK | 1 |
| Zhao, YY | 1 |
| Zhang, L | 2 |
| Mao, JR | 1 |
| Cheng, XH | 1 |
| Lin, RC | 1 |
| Sun, WJ | 1 |
| Liangos, O | 1 |
| Hutton, H | 1 |
| Dowling, J | 1 |
| Kerr, P | 1 |
| Luo, C | 1 |
| Jiang, Z | 1 |
| Bao, Q | 1 |
| Wang, T | 1 |
| Zhang, S | 1 |
| Li, H | 1 |
| Ueda, S | 1 |
| Sato, N | 1 |
| Misu, T | 1 |
| But, PP | 1 |
| Ma, SC | 1 |
| Okada, M | 1 |
| Yang, SS | 1 |
| Chu, P | 1 |
| Lin, YF | 1 |
| Chen, A | 1 |
| Lin, SH | 1 |
| Pan, JH | 1 |
| Yan, GJ | 1 |
| Song, J | 1 |
| Tazi, I | 1 |
| Nafil, H | 1 |
| Mahmal, L | 1 |
| Pan, CM | 1 |
| Qiu, Q | 1 |
| Liu, ZH | 1 |
| Chen, HP | 1 |
| Yin, HL | 1 |
| Li, LS | 1 |
3 reviews available for aristolochic acid i and Acute Kidney Injury
| Article | Year |
|---|---|
Environmental and Genetic Factors Influencing Kidney Toxicity.
Topics: Activation, Metabolic; Acute Kidney Injury; Aristolochic Acids; Arsenic; Cadmium; Drug Contamination | 2019 |
Drugs and AKI.
Topics: Acute Kidney Injury; Aminoglycosides; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal | 2012 |
[Aristolochic acid nephropathy and acute encephalopathy related to Pleurocybella porrigens (Sugihiratake)].
Topics: Acute Disease; Acute Kidney Injury; Agaricales; Animals; Aristolochic Acids; Drugs, Chinese Herbal; | 2006 |
35 other studies available for aristolochic acid i and Acute Kidney Injury
| Article | Year |
|---|---|
Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury.
Topics: Acute Kidney Injury; Animals; Kidney; Magnetic Resonance Imaging; Male; Rats; Rats, Wistar | 2022 |
The Presence of Testis Determines Aristolochic Acid-Induced Nephrotoxicity in Mice.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Body Weight; Female; Kidney; Male; Mice; Testis; W | 2023 |
Identification and validation of hub genes in drug induced acute kidney injury basing on integrated transcriptomic analysis.
Topics: Acute Kidney Injury; Animals; Mice; Toll-Like Receptor 4; Transcriptome; Vancomycin | 2023 |
Divergent Actions of Renal Tubular and Endothelial Type 1 IL-1 Receptor Signaling in Toxin-Induced AKI.
Topics: Acute Kidney Injury; Animals; Apolipoproteins M; Endothelial Cells; Endothelium; Humans; Interleukin | 2023 |
Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid.
Topics: Acute Kidney Injury; Animals; Animals, Genetically Modified; Aristolochic Acids; Collagen; Fibrosis; | 2020 |
The protective role of Nrf2 against aristolochic acid-induced renal tubular epithelial cell injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Aristolochic Acids; Cell Line; Epithelial Cells; Heme Oxyge | 2020 |
Kidney-based in vivo model for drug-induced nephrotoxicity testing.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Aristolochic Acids; Carcinogens; Cisplatin; Kid | 2020 |
Protective effect of panaxydol against repeated administration of aristolochic acid on renal function and lipid peroxidation products via activating Keap1-Nrf2/ARE pathway in rat kidney.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Diynes; Fatty Alcohols; Kelch-Like ECH-Associated | 2021 |
Genetic and pharmacological inhibition of fatty acid-binding protein 4 alleviated inflammation and early fibrosis after toxin induced kidney injury.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Biphenyl Compounds; Carcinogens; Disease Models, A | 2021 |
Topics: Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Animals; Aristolochic Acids; Cell Cycle P | 2017 |
Subclinical chronic kidney disease modifies the diagnosis of experimental acute kidney injury.
Topics: Acute Kidney Injury; Adenine; Animals; Aristolochic Acids; Biomarkers; Cell Adhesion Molecules; Chem | 2017 |
Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Cisplatin; Disease Models, Animal; Female; Fibrosi | 2018 |
Renal chymase-dependent pathway for angiotensin II formation mediated acute kidney injury in a mouse model of aristolochic acid I-induced acute nephropathy.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Aristolochic Acids; Chymases; Female; Kidney; Male; Mi | 2019 |
The Effect of Overexpression of the Enhancer of Zeste Homolog 1 (EZH1) Gene on Aristolochic Acid-Induced Injury in HK-2 Human Kidney Proximal Tubule Cells In Vitro.
Topics: Acute Kidney Injury; Apoptosis; Aristolochic Acids; Cell Survival; Cells, Cultured; Cytokines; Epith | 2019 |
Novel kidney dissociation protocol and image-based flow cytometry facilitate improved analysis of injured proximal tubules.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Biomarkers; Cell Cycle; Cell Separation; Disease M | 2019 |
An exploratory evaluation of the utility of transcriptional and urinary kidney injury biomarkers for the prediction of aristolochic acid-induced renal injury in male rats.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; beta 2-Microglobulin; Biomarkers, Pharmacological; | 2014 |
Acute kidney injury induced by aristolochic acid in patients with primary glomerular nephritis.
Topics: Acute Kidney Injury; Adult; Aged; Aristolochic Acids; beta-N-Acetyl-Galactosaminidase; Creatinine; D | 2014 |
A PTBA small molecule enhances recovery and reduces postinjury fibrosis after aristolochic acid-induced kidney injury.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Butyrates; Disease Models, Animal; Fibrosis; Histo | 2014 |
Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Cryoprotective Agents; Disease Models, Animal; Hem | 2014 |
Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aristolochic Acids; Balkan Ne | 2015 |
Plasma-specific microRNA response induced by acute exposure to aristolochic acid I in rats.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Biomarkers; Blood Urea Nitrogen; Creatinine; Gene | 2017 |
Fatal renal failure due to the Chinese herb "GuanMu Tong" (Aristolochia manshuriensis): autopsy findings and review of literature.
Topics: Acute Kidney Injury; Adult; Aristolochia; Aristolochic Acids; Drugs, Chinese Herbal; Epithelial Cell | 2010 |
Renal liver-type fatty acid binding protein (L-FABP) attenuates acute kidney injury in aristolochic acid nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Aquaporin 1; Aristolochic Acids; Body Weight; Chemokine CCL2; Fatty Ac | 2011 |
Evaluation of microwave-assisted extraction for aristolochic acid from Aristolochiae Fructus by chromatographic analysis coupled with nephrotoxicity studies.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Aristolochiaceae; Aristolochic Acids; Chemical F | 2012 |
Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Body Weight; Cholestenones; Fibrosis; Kidney; Kidn | 2011 |
Acute renal failure due to an aristolochic acid containing herbal remedy.
Topics: Acute Kidney Injury; Aged; Aristolochic Acids; Biopsy; Drugs, Chinese Herbal; Gastritis; Gastrointes | 2012 |
Clinical and pathological spectrums of aristolochic acid nephropathy.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aristolochic Acids; Biomarkers; Biopsy; Chi-Square Dis | 2012 |
Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Blood Urea Nitrogen; Creatinine; DNA, Mitochondria | 2013 |
Chinese-herb nephropathy.
Topics: Acute Kidney Injury; Aristolochic Acids; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fe | 1999 |
Chinese-herb nephropathy.
Topics: Acute Kidney Injury; Aristolochic Acids; Drug Contamination; Drugs, Chinese Herbal; Humans; Japan; P | 1999 |
Aristolochic acid-induced Fanconi's syndrome and nephropathy presenting as hypokalemic paralysis.
Topics: Acute Kidney Injury; Aristolochic Acids; Drugs, Chinese Herbal; Fanconi Syndrome; Humans; Hypokalemi | 2002 |
[The determination of aristolochic acid A in different processed Aristolochia manshuriensis and the test of influence about renal function in rats].
Topics: Acute Kidney Injury; Animals; Aristolochia; Aristolochic Acids; Chromatography, High Pressure Liquid | 2010 |
Fatal renal failure due to self administration of Aristolochia Longa after treatment with chemotherapy.
Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Aristolochia; Cyclophosphamide; | 2012 |
[A case report on acute renal failure caused by longdan xiegan pill].
Topics: Acute Kidney Injury; Aristolochia; Drug Therapy, Combination; Drugs, Chinese Herbal; Humans; Male; M | 2004 |
Long-term outcome of acute renal injury induced by Aristolochia manshuriensis Kom in rats.
Topics: Acute Kidney Injury; Animals; Aristolochia; Drugs, Chinese Herbal; Female; Kidney; Kidney Neoplasms; | 2000 |