arginyl-glycyl-aspartic acid has been researched along with Metastase in 62 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (3.23) | 18.7374 |
1990's | 21 (33.87) | 18.2507 |
2000's | 23 (37.10) | 29.6817 |
2010's | 15 (24.19) | 24.3611 |
2020's | 1 (1.61) | 2.80 |
Authors | Studies |
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Han, T; Huang, S; Ji, X; Kang, N; Liu, Y | 1 |
Wang, H; Xu, J; Yang, J; Yin, H; Zhang, Q; Zheng, J | 1 |
Bartolomé, RA; Casal, JI | 1 |
Fu, L; Hou, Y; Liu, M; Qin, Y; Sun, K; Teng, Y; Wen, S; Xi, L; Yang, D; Zhao, M | 1 |
Cai, X; Li, L; Tong, L; Wang, C; Wang, M; Xiao, J; Yang, J | 1 |
Bartolomé, RA; Casal, JI; Escudero-Paniagua, B; Fernandez-Aceñero, MJ; Gomez, I; Imbaud, JI; Peláez-García, A; Torres, S | 1 |
Braun, GB; de Mendoza, TH; French, RP; Kotamraju, VR; Lowy, AM; Ruoslahti, E; Sugahara, KN; Teesalu, T | 1 |
Blehm, BH; Jiang, N; Kotobuki, Y; Tanner, K | 1 |
Chen, Y; Gao, J; Gong, Z; Li, B; Li, W; Liu, J; Lu, Y; Mao, X; Sun, Z; Yu, Y; Zhang, H; Zhong, Y; Zou, H | 1 |
Cai, J; Jiang, J; Li, Q; Wu, H; Xu, H | 1 |
Adem, A; Basu, I; Claros, CS; Gorecka, J; Guha, C; Healy, N; Kabarriti, R; Liu, L; Maggi, E; Quinn, TJ; Sara, A; Scandiuzzi, L; Yuan, Z | 1 |
Bartolomé, RA; Calviño, E; Casal, JI; Escudero-Paniagua, B; Isern de Val, S; Teixidó, J; Torres, S | 1 |
Chen, SZ; He, H; Li, Y; Qiao, X; Shang, Y; Wang, X; Zhang, S | 1 |
Barnes, LA; Cheresh, DA; Lutu-Fuga, K; Majeti, BK; Makale, M; Murphy, EA; Weis, SM; Wrasidlo, W | 1 |
Lavasanifar, A; Mahmud, A; Uludağ, H; Xiong, XB | 1 |
Basson, MD; Craig, DH; Gayer, CP; Laouar, Y; Li, J; Schaubert, KL; Wei, Y | 1 |
Arap, W; Do, KA; Hu, DD; Knowles, SK; Lin, EC; Mandelin, J; Pasqualini, R; Sage, EH; Smith, JW; Wang, X | 1 |
Kessler, H; Laufer, B; Schottelius, M; Wester, HJ | 1 |
Boerman, OC; Dijkgraaf, I | 1 |
Banh, A; Bouley, DM; Brustugun, OT; Cao, H; Courter, D; Denko, NC; Giaccia, A; Kong, C; Koong, AC; Kuo, P; Kwok, S; Le, QT; Vice, C | 1 |
Abo-Ramadan, U; Bauerschmitz, G; Diaconu, I; Escutenaire, S; Halavaara, J; Hemminki, A; Kanerva, A; Lavilla-Alonso, S; Pesonen, S; Tatlisumak, T | 1 |
Buckle, T; Bunschoten, A; Josephson, L; Kuil, J; Vahrmeijer, AL; van Leeuwen, FW; Visser, NL; Yuan, H | 1 |
Adams, HP; Broxterman, HJ; de Groot, FM; Elderkamp, YW; Kok, RJ; Molema, G; Pinedo, HM; Scheeren, HW; Schraa, AJ; Tesser, GI; van Vliet, A | 1 |
Hill-Bator, A; Opolski, A | 1 |
Fujita, T | 1 |
Berman, AE; Chubukina, AN; Eltsov, IA; Kozlova, NI; Morozevich, GE | 1 |
Bamberger, AM; Brümmer, J; Ebrahimnejad, A; Horst, AK; Nollau, P; Streichert, T; Wagener, C | 1 |
Arrues, S; Felding-Habermann, B; Gao, C; Janda, KD; Lerner, RA; Lillo, A; Mao, S; Saven, A; Weber, MR; Zhuang, S | 1 |
Asai, T; Oku, N | 1 |
Bading, JR; Bart, R; Bremner, R; Chen, X; Conti, PS; Hou, Y; Park, R; Sievers, E; Tohme, M | 1 |
Boturyn, D; Coll, JL; Dumy, P; Favrot, MC; Garanger, E; Jin, Z | 1 |
Beer, AJ; Goebel, M; Grosu, AL; Haubner, R; Luderschmidt, S; Martinez, MJ; Niemeyer, M; Schwaiger, M; Weber, WA; Wester, HJ; Wolf, I | 1 |
Annabi, B; Béliveau, R; Bouzeghrane, M; Currie, JC; Daigneault, L; Dulude, H; Garde, S; Panchal, C; Rabbani, SA; Wu, JJ | 1 |
Hayakawa, T; Kanehira, M; Kikuchi, T; Mizuguchi, H; Nukiwa, T; Saijo, Y; Xin, H | 1 |
Murata, J; Saiki, I | 1 |
Chiang, HS; Huang, TF; Yang, RS | 1 |
Donati, MB; Poggi, A; Stella, M | 1 |
Dixit, VM; Mansfield, PJ; Suchard, SJ; Yabkowitz, R | 1 |
Chambers, AF; Hota, C; Prince, CW | 1 |
Nicolson, GL | 1 |
Kato, M; Kuroda, K; Mitsuishi, Y; Miyata, K; Nishimura, K; Sakae, N; Shikama, H | 1 |
Ruoslahti, E | 1 |
Azuma, I; Saiki, I | 1 |
Carpenter, R; Gui, GP; Puddefoot, JR; Vinson, GP; Wells, CA | 1 |
Orr, FW; Scherbarth, S | 1 |
Iizuka, J; Katagiri, Y; Murakami, M; Uede, T | 1 |
Izuno, Y; Kaneda, Y; Kawasaki, K; Maeda, M; Mayumi, T; Mu, Y; Nakagawa, S; Tsutsumi, Y | 1 |
Cornelissen, IM; Danen, EH; Marcinkiewicz, C; Niewiarowski, S; Pachter, JA; Ruiter, DJ; van Kraats, AA; van Muijen, GN | 1 |
Ayukawa, K; Azuma, I; Fujii, H; Itoh, I; Kojima, M; Komazawa, H; Nishikawa, N; Obata, A; Saiki, I; Suzuki, M | 1 |
Bal de Kier Joffé, E; Baralle, FE; Kornblihtt, AR; Muro, AF; Porro, F; Puricelli, L; Urtreger, A; Werbajh, S | 1 |
Kurohane, K; Namba, Y; Oku, N | 1 |
Montgomery, AM; Ramjeesingh, RA; Siu, CH; Voura, EB | 1 |
Saiki, I; Sawada, S; Tsuchiya, Y; Tsukada, K | 1 |
Buerkle, MA; Dellian, M; Jonczyk, A; Messmer, K; Pahernik, SA; Sutter, A | 1 |
Baril, P; Boukerche, H; Nejjari, M; Scoazek, JY | 1 |
Giga-Hama, Y; Goto, H; Isoai, A; Kumagai, H; Ueno, Y | 1 |
Azuma, I; Murata, J; Nishi, N; Ogawa, R; Saiki, I; Tokura, S | 1 |
Beviglia, L; Knudsen, KA; Niewiarowski, S; Poggi, A; Rossi, C; Soszka, T | 1 |
Bereta, J; Bereta, M; Cohen, MC; Cohen, S; Zaifert, K | 1 |
Dedhar, S | 1 |
Azuma, I; Iida, J; Kawahara, H; Murata, J; Nishi, N; Saiki, I; Tokura, S | 1 |
Liotta, LA; Stracke, ML | 1 |
13 review(s) available for arginyl-glycyl-aspartic acid and Metastase
Article | Year |
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iRGD as a tumor‑penetrating peptide for cancer therapy (Review).
Topics: Antineoplastic Agents; Doxorubicin; Drug Carriers; Humans; Integrins; Neoplasm Metastasis; Neoplasms; Oligopeptides | 2017 |
RGD cadherins and α2β1 integrin in cancer metastasis: A dangerous liaison.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents, Immunological; Binding Sites; Cadherins; Cell Adhesion; Cell Movement; Cell Proliferation; Humans; Integrin alpha2beta1; Neoplasm Metastasis; Neoplasms; Oligopeptides; Protein Binding; Receptors, Immunologic; Receptors, Peptide; Signal Transduction | 2018 |
Radionuclide imaging of tumor angiogenesis.
Topics: Alternative Splicing; Angiogenesis Inhibitors; Animals; Endothelium, Vascular; Fluorodeoxyglucose F18; Humans; Indium Radioisotopes; Integrin alphaVbeta3; Magnetic Resonance Imaging; Matrix Metalloproteinases; Mice; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Neovascularization, Pathologic; Oligopeptides; Positron-Emission Tomography; Receptors, Immunologic; Receptors, Peptide; Receptors, Vascular Endothelial Growth Factor | 2009 |
[Biological activity of synthetic analogs of laminin active sequences: YIGSR, RGD, SIKVAV].
Topics: Animals; Antineoplastic Agents; Humans; Laminin; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neoplastic Processes; Neovascularization, Pathologic; Oligopeptides; Platelet Aggregation; Thrombosis | 2002 |
[Bone sialoprotein].
Topics: Amino Acid Motifs; Animals; Bone Matrix; Bone Neoplasms; Cell Adhesion; Humans; Integrin-Binding Sialoprotein; Neoplasm Metastasis; Oligopeptides; Osteoblasts; Osteoclasts; Sialoglycoproteins | 2004 |
[Inhibition of tumor metastasis by synthetic peptide analogues of cell-adhesive RGD sequence of fibronectin].
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Molecular Sequence Data; Neoplasm Metastasis; Oligopeptides; Peptides; Recombinant Proteins | 1995 |
The importance of blood cell-vessel wall interactions in tumour metastasis.
Topics: Amino Acid Sequence; Animals; Blood Cells; Blood Platelets; Blood Proteins; Cell Adhesion; Cytokines; Cytoplasmic Granules; Disintegrins; Endothelium, Vascular; Extracellular Matrix; Fatty Acids; Growth Substances; Humans; Immunotherapy; Leukocytes; Macrophages; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Neoplastic Cells, Circulating; Neoplastic Stem Cells; Oligopeptides; Peptides; Platelet Activation; Platelet Aggregation Inhibitors | 1993 |
Tumor cell interactions with the vascular endothelium and their role in cancer metastasis.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cell Differentiation; Cell Movement; Endothelium, Vascular; Growth Inhibitors; Growth Substances; Humans; Microcirculation; Models, Biological; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Oligopeptides | 1995 |
Cell adhesion and tumor metastasis.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Extracellular Matrix Proteins; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Neoplasm Metastasis; Neoplasm Proteins; Oligopeptides; Peptide Fragments; Peptide Library; Peptides, Cyclic; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Fibronectin; Signal Transduction | 1994 |
Prevention of cancer metastasis in mice with fibronectin-related substances.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Chitin; Drug Design; Fibronectins; Humans; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms, Experimental; Oligopeptides; Peptide Fragments; Peptides; Recombinant Fusion Proteins | 1994 |
Osteopontin, a coordinator of host defense system: a cytokine or an extracellular adhesive protein?
Topics: Amino Acid Sequence; Animals; Cardiovascular Physiological Phenomena; Humans; Hyaluronan Receptors; Mice; Molecular Sequence Data; Neoplasm Metastasis; Neoplasms; Oligopeptides; Osteopontin; Protein Binding; Protein Conformation; Rats; Sialoglycoproteins; Signal Transduction; Urinary Tract Physiological Phenomena | 1997 |
Integrins and tumor invasion.
Topics: Amino Acid Sequence; Basement Membrane; Cell Adhesion; Cell Differentiation; Cell Transformation, Neoplastic; Extracellular Matrix; Gene Expression Regulation; Integrins; Ligands; Models, Biological; Molecular Sequence Data; Molecular Structure; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Oligopeptides | 1990 |
Tumor invasion and metastases: biochemical mechanisms.
Topics: Amino Acid Sequence; Cell Movement; Extracellular Matrix; Humans; In Vitro Techniques; Laminin; Melanoma; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Oligopeptides; Peptide Hydrolases; Receptors, Immunologic; Receptors, Laminin; Signal Transduction | 1988 |
49 other study(ies) available for arginyl-glycyl-aspartic acid and Metastase
Article | Year |
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Preparation of RGD4C fused anti-TNFα nanobody and inhibitory activity on triple-negative breast cancer in vivo.
Topics: Animals; Antineoplastic Agents, Immunological; Cell Line; Cell Line, Tumor; Cell Proliferation; Female; Fibroblasts; Gene Expression; Humans; Integrin alphaVbeta3; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Oligopeptides; Pichia; Recombinant Fusion Proteins; Single-Domain Antibodies; Triple Negative Breast Neoplasms; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2020 |
Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3-p38 MAPK signalling.
Topics: Animals; Antigens, CD; Breast Neoplasms; Cadherins; Cancer-Associated Fibroblasts; Cell Movement; Coculture Techniques; Epithelial-Mesenchymal Transition; Female; Fibronectins; Humans; Integrin beta3; Interleukins; MCF-7 Cells; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Paracrine Communication; Protein Binding; Protein Interaction Domains and Motifs; Signal Transduction; Vimentin; Xenograft Model Antitumor Assays | 2019 |
A Targeted and pH-Responsive Bortezomib Nanomedicine in the Treatment of Metastatic Bone Tumors.
Topics: Animals; Bone Neoplasms; Bortezomib; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Nanomedicine; Neoplasm Metastasis; Oligopeptides; Xenograft Model Antitumor Assays | 2018 |
An RGD motif present in cadherin 17 induces integrin activation and tumor growth.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Humans; Integrin alpha2beta1; Integrins; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutation; Neoplasm Metastasis; Oligopeptides; Pancreatic Neoplasms; Protein Structure, Tertiary; Signal Transduction | 2014 |
Tumor-penetrating iRGD peptide inhibits metastasis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell-Penetrating Peptides; Drug Delivery Systems; Humans; Male; Metal Nanoparticles; Mice; Mice, Nude; Neoplasm Metastasis; Neuropilin-1; Oligopeptides; Organ Specificity; Prostatic Neoplasms; Silver; Xenograft Model Antitumor Assays | 2015 |
Deconstructing the role of the ECM microenvironment on drug efficacy targeting MAPK signaling in a pre-clinical platform for cutaneous melanoma.
Topics: Animals; Binding Sites; Biomimetics; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Screening Assays, Antitumor; Extracellular Matrix; Fibronectins; Humans; Hyaluronic Acid; Hydrogels; Laminin; MAP Kinase Signaling System; Melanoma; Mice; Neoplasm Metastasis; Oligopeptides; Polyethylene Glycols; Skin Neoplasms | 2015 |
iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells.
Topics: AC133 Antigen; Animals; Antigens, CD; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Gene Expression Regulation, Neoplastic; Glycoproteins; Hep G2 Cells; Humans; Liposomes; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Nanomedicine; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Stem Cells; Neuropilin-1; Oligopeptides; Peptides; Phosphatidylethanolamines; Polyethylene Glycols; Pyrans; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2015 |
RGD mimetics γ-AApeptides and methods of use (US 20,140,004,039 A1): a patent evaluation.
Topics: Animals; Antineoplastic Agents; Drug Design; Humans; Integrin alphaVbeta3; Mice; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Oligopeptides; Patents as Topic; Positron-Emission Tomography | 2016 |
Preclinical evaluation of radiation and systemic, RGD-targeted, adeno-associated virus phage-TNF gene therapy in a mouse model of spontaneously metastatic melanoma.
Topics: Animals; Cell Line, Tumor; Combined Modality Therapy; Dependovirus; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Genetic Therapy; Genetic Vectors; Melanoma; Melanoma, Experimental; Mice; Neoplasm Metastasis; Neovascularization, Pathologic; Oligopeptides; Radiotherapy; Radiotherapy, Image-Guided; Survival Analysis; Treatment Outcome; Tumor Burden; Tumor Microenvironment; Tumor Necrosis Factor-alpha | 2017 |
VE-cadherin RGD motifs promote metastasis and constitute a potential therapeutic target in melanoma and breast cancers.
Topics: Animals; Antigens, CD; Antineoplastic Agents; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Gene Expression; Heterografts; Humans; Integrins; Melanoma; Mice; Models, Biological; Molecular Targeted Therapy; Neoplasm Metastasis; Oligopeptides; Prognosis; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Maps; Signal Transduction | 2017 |
RGD and NGR modified TRAIL protein exhibited potent anti-metastasis effects on TRAIL-insensitive cancer cells in vitro and in vivo.
Topics: A549 Cells; Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cloning, Molecular; Female; Gene Expression; Genetic Vectors; HEK293 Cells; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; NIH 3T3 Cells; Oligopeptides; Pichia; Recombinant Fusion Proteins; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays | 2017 |
Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis.
Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Drug Delivery Systems; Endothelium; Integrin alphaVbeta3; Kidney Neoplasms; Mice; Nanoparticles; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Oligopeptides; Pancreatic Neoplasms; Xenograft Model Antitumor Assays | 2008 |
Multifunctional polymeric micelles for enhanced intracellular delivery of doxorubicin to metastatic cancer cells.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Doxorubicin; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Micelles; Neoplasm Metastasis; Neoplasms; Oligopeptides; Polymers; Solubility | 2008 |
Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789.
Topics: Actinin; Animals; Binding Sites; Cell Adhesion; Cell Line, Tumor; Chlorocebus aethiops; Colonic Neoplasms; COS Cells; Fibronectins; Focal Adhesion Kinase 1; Humans; Integrin beta1; Mechanotransduction, Cellular; Mice; Mice, Knockout; Neoplasm Metastasis; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Pressure; Protein Conformation; Recombinant Fusion Proteins; src-Family Kinases; Threonine; Time Factors; Transfection; Tumor Cells, Cultured | 2009 |
Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin.
Topics: Actins; Animals; Cell Adhesion; Cell Line, Tumor; Endothelium, Vascular; Genes, src; Humans; Melanoma; Mice; Mutation; Neoplasm Metastasis; Oligopeptides; Osteopontin; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sarcoma; Signal Transduction | 2009 |
Ligands for mapping alphavbeta3-integrin expression in vivo.
Topics: Animals; Antineoplastic Agents; Female; Humans; Integrin alphaVbeta3; Isotope Labeling; Ligands; Mice; Nanoparticles; Neoplasm Metastasis; Oligopeptides; Organotechnetium Compounds; Peptides, Cyclic; Positron-Emission Tomography; Radiopharmaceuticals | 2009 |
The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.
Topics: Animals; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Mice; Mutation; Neoplasm Metastasis; Neoplasm Transplantation; Oligopeptides; Osteopontin; Phosphorylation; Protein Isoforms; Protein Structure, Tertiary | 2010 |
Adenoviruses with an αvβ integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases.
Topics: Adenoviridae; Animals; Capsid; Cell Line, Tumor; Colorectal Neoplasms; Cytotoxicity, Immunologic; Gene Transfer Techniques; Genetic Vectors; Humans; Liver Neoplasms; Magnetic Resonance Imaging; Mice; Neoplasm Metastasis; Oligopeptides; Organ Specificity; Receptors, Vitronectin; Splenic Neoplasms; Tissue Distribution; Virus Replication; Xenograft Model Antitumor Assays | 2010 |
Multimodal interventional molecular imaging of tumor margins and distant metastases by targeting αvβ3 integrin.
Topics: Animals; Female; Immunohistochemistry; Indium Radioisotopes; Integrin alphaVbeta3; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Imaging; Multimodal Imaging; Neoplasm Metastasis; Oligopeptides; Organometallic Compounds; Positron-Emission Tomography; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2012 |
Design, synthesis, and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrug.
Topics: Amino Acid Sequence; Antineoplastic Agents; Benzyl Alcohols; Binding Sites; Cell Adhesion; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Doxorubicin; Drug Design; Endothelium; Endothelium, Vascular; Fibrinolysin; Humans; Inhibitory Concentration 50; Integrin alphaVbeta3; Integrins; Ligands; Models, Chemical; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Oligopeptides; Peptides; Prodrugs; Protein Binding; Protein Structure, Tertiary; Receptors, Vitronectin | 2002 |
Expression and role of integrins in invasive activity of oncotransformed fibroblasts differing in spontaneous metastasizing.
Topics: Animals; Avian Sarcoma Viruses; Cell Adhesion; Cell Line, Transformed; Cell Transformation, Viral; Cricetinae; Extracellular Matrix Proteins; Fibroblasts; Gene Expression; Integrins; Matrix Metalloproteinase 2; Neoplasm Metastasis; Oligopeptides; Signal Transduction | 2004 |
CEACAM1 enhances invasion and migration of melanocytic and melanoma cells.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cytoplasm; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Integrin alphaVbeta3; Integrin beta3; Melanocytes; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Oligopeptides; Protein Structure, Tertiary; Time Factors; Transfection; Tyrosine; Up-Regulation | 2004 |
Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis.
Topics: Amino Acid Sequence; Animals; Antibodies, Neoplasm; Apoptosis; Breast Neoplasms; Female; Humans; Immunoglobulin Fragments; Integrin alphaVbeta3; Ligands; Lung Neoplasms; Mice; Molecular Mimicry; Neoplasm Metastasis; Neoplasm Transplantation; Oligopeptides; Peptide Library | 2004 |
Liposomalized oligopeptides in cancer therapy.
Topics: Animals; Antineoplastic Agents; Cell Line; Drug Carriers; Humans; Liposomes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Oligopeptides | 2005 |
Integrin alpha v beta 3-targeted imaging of lung cancer.
Topics: Animals; Cell Adhesion; Chromatography, High Pressure Liquid; Copper; Dimerization; Dose-Response Relationship, Drug; Fluorodeoxyglucose F18; Humans; Integrin alphaVbeta3; Kinetics; Lung; Lung Neoplasms; Male; Mice; Mice, SCID; Microscopy, Fluorescence; Models, Chemical; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Oligopeptides; Peptides; Polyethylene Glycols; Positron-Emission Tomography; Protein Binding; Protein Structure, Tertiary; Radiopharmaceuticals; Time Factors | 2005 |
New multifunctional molecular conjugate vector for targeting, imaging, and therapy of tumors.
Topics: Animals; Binding, Competitive; Cell Adhesion; Cell Line; Cell Line, Tumor; Cell Separation; Dose-Response Relationship, Drug; Endosomes; Female; Flow Cytometry; Genetic Therapy; Genetic Vectors; Humans; Immunohistochemistry; Infusions, Intravenous; Integrin alphaVbeta3; Ligands; Mice; Mice, Nude; Models, Chemical; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Oligopeptides; Ovarian Neoplasms; Peptides; Peptides, Cyclic; Polymers; Stereoisomerism; Vitronectin | 2005 |
PET-based human dosimetry of 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression.
Topics: Adult; Aged; Aged, 80 and over; Female; Fluorodeoxyglucose F18; Humans; Integrin alphaVbeta3; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Oligopeptides; Positron-Emission Tomography; Radiometry; Radiopharmaceuticals | 2006 |
Contribution of the 37-kDa laminin receptor precursor in the anti-metastatic PSP94-derived peptide PCK3145 cell surface binding.
Topics: Catechin; Cell Communication; Cell Line, Tumor; Collagen Type I; Drug Synergism; Humans; Kinetics; Matrix Metalloproteinase 9; Neoplasm Metastasis; Oligopeptides; Peptide Fragments; Prostatic Secretory Proteins; Protein Precursors; Receptors, Cell Surface; Receptors, Laminin | 2006 |
Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells.
Topics: 3T3 Cells; Adenoviridae; Animals; beta-Galactosidase; CD8-Positive T-Lymphocytes; Cell Differentiation; Chemokine CX3CL1; Chemokines, CX3C; Female; Genetic Therapy; Genetic Vectors; Killer Cells, Natural; Lung Neoplasms; Membrane Proteins; Mesenchymal Stem Cells; Mice; Neoplasm Metastasis; Oligopeptides; Organ Specificity; Transduction, Genetic; Tropism | 2007 |
The Arg-Gly-Asp-containing peptide, rhodostomin, inhibits in vitro cell adhesion to extracellular matrices and platelet aggregation caused by saos-2 human osteosarcoma cells.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Apyrase; Blood Coagulation Disorders; Blood Coagulation Factors; Bone Neoplasms; Cell Adhesion; Enzyme Activation; Extracellular Matrix; Hirudins; Humans; Integrins; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Oligopeptides; Osteosarcoma; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Binding; Thrombin; Tumor Cells, Cultured | 1995 |
Motility of human carcinoma cells in response to thrombospondin: relationship to metastatic potential and thrombospondin structural domains.
Topics: Carcinoma, Squamous Cell; Cell Movement; Chemotaxis; Heparin; Humans; In Vitro Techniques; Integrins; Neoplasm Metastasis; Oligopeptides; Peptide Fragments; Platelet Membrane Glycoproteins; Structure-Activity Relationship; Thrombospondins; Tumor Cells, Cultured | 1993 |
Adhesion of metastatic, ras-transformed NIH 3T3 cells to osteopontin, fibronectin, and laminin.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding Sites; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Fibronectins; Genes, ras; Laminin; Mice; Molecular Sequence Data; Neoplasm Metastasis; Oligopeptides; Osteopontin; Phosphorus Radioisotopes; Protein Binding; Sensitivity and Specificity; Sialoglycoproteins | 1993 |
Overcoming the metastasis-enhancing potential of human tumor necrosis factor alpha by introducing the cell-adhesive Arg-Gly-Asp sequence.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Adhesion; Cell Death; Fibrosarcoma; Humans; Lung Neoplasms; Lymphatic Metastasis; Melanoma, Experimental; Mice; Molecular Sequence Data; Mutagenesis, Insertional; Neoplasm Metastasis; Oligopeptides; Recombinant Fusion Proteins; Skin Neoplasms; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Altered cell-matrix contact: a prerequisite for breast cancer metastasis?
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Basement Membrane; Breast Neoplasms; Cell Adhesion; Cell Communication; Collagen; Disease Progression; Extracellular Matrix; Female; Fibronectins; Humans; Integrins; Laminin; Middle Aged; Neoplasm Metastasis; Oligopeptides; Vitronectin | 1997 |
Intravital videomicroscopic evidence for regulation of metastasis by the hepatic microvasculature: effects of interleukin-1alpha on metastasis and the location of B16F1 melanoma cell arrest.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Cycle; Interleukin-1; Liver; Liver Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Microcirculation; Neoplasm Metastasis; Oligopeptides; Video Recording | 1997 |
Amino acids and peptides. XXX. Preparation of Arg-Gly-Asp (RGD) hybrids with poly(ethylene glycol) analogs and their antimetastatic effect.
Topics: Animals; Antineoplastic Agents; Chromatography, Gel; Chromatography, High Pressure Liquid; Drug Delivery Systems; Humans; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplastic Stem Cells; Oligopeptides; Polyethylene Glycols; Tumor Cells, Cultured | 1997 |
The disintegrin eristostatin interferes with integrin alpha 4 beta 1 function and with experimental metastasis of human melanoma cells.
Topics: Animals; Binding Sites; Humans; Infant, Newborn; Integrin alpha4beta1; Integrins; Intercellular Signaling Peptides and Proteins; Male; Melanocytes; Melanoma; Mice; Mice, Nude; Neoplasm Metastasis; Oligopeptides; Peptides; Platelet Aggregation Inhibitors; Receptors, Lymphocyte Homing; Skin; Skin Neoplasms; Snake Venoms; Viper Venoms | 1998 |
A new pseudo-peptide of Arg-Gly-Asp (RGD) with inhibitory effect on tumor metastasis and enzymatic degradation of extracellular matrix.
Topics: Animals; Cell Adhesion; Cell Movement; Dose-Response Relationship, Drug; Extracellular Matrix; Female; Humans; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Oligopeptides; Specific Pathogen-Free Organisms; Tumor Cells, Cultured | 1998 |
Expression of RGD minus fibronectin that does not form extracellular matrix fibrils is sufficient to decrease tumor metastasis.
Topics: Adenocarcinoma; Animals; Cell Adhesion; Cell Division; Cell Movement; Extracellular Matrix; Extracellular Matrix Proteins; Female; Fibronectins; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Oligopeptides; Transfection | 1998 |
Liposomes modified with a synthetic Arg-Gly-Asp mimetic inhibit lung metastasis of B16BL6 melanoma cells.
Topics: Animals; Antineoplastic Agents; Cell Adhesion; Drug Carriers; Fibronectins; Liposomes; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oligopeptides; Phosphatidylethanolamines; Tumor Cells, Cultured | 2000 |
Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells.
Topics: Cell Adhesion; Cell Movement; Cells, Cultured; Coculture Techniques; Endothelium, Vascular; Gene Deletion; Humans; Leukocyte L1 Antigen Complex; Lung; Melanoma; Membrane Glycoproteins; Microscopy, Confocal; Neoplasm Metastasis; Neural Cell Adhesion Molecules; Oligopeptides; Pseudopodia; Receptors, Vitronectin; Time Factors; Tumor Cells, Cultured | 2001 |
A new pseudo-peptide of Arg-Gly-Asp (RGD) inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Death; Cell Division; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Oligopeptides; Tumor Cells, Cultured | 2002 |
Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo.
Topics: Animals; Antigens, CD; Antineoplastic Agents; Cricetinae; Endothelium; Infusions, Parenteral; Integrin alpha1; Leukocytes; Male; Melanoma; Microcirculation; Neoplasm Metastasis; Neoplasms, Experimental; Neovascularization, Pathologic; Oligopeptides; Skin Neoplasms | 2002 |
Blocking a novel 55 kDa melanoma-associated cell surface antigen inhibits the development of spontaneous metastases and interactions with frozen lung section.
Topics: Animals; Animals, Newborn; Antigens, Neoplasm; Basement Membrane; Cell Adhesion; Cell Adhesion Molecules; Cell Membrane; Cold Temperature; Collagen; Drug Combinations; Humans; Immunohistochemistry; Laminin; Lung; Melanoma; Neoplasm Metastasis; Oligopeptides; Protein Binding; Proteoglycans; Rats; Temperature; Tumor Cells, Cultured | 2002 |
A novel Arg-Gly-Asp containing peptide specific for platelet aggregation and its effect on tumor metastasis: a possible mechanism of RGD peptide-mediated inhibition of tumor metastasis.
Topics: Animals; Anticarcinogenic Agents; Arginine; Aspartic Acid; Carcinoma, Squamous Cell; Cell Adhesion; Collagen; Female; Fibronectins; Glycine; Glycoproteins; Lung Neoplasms; Mice; Mice, Inbred C3H; Neoplasm Metastasis; Oligopeptides; Peptides, Cyclic; Platelet Aggregation; Protein Binding; Vitronectin | 1992 |
Molecular properties of poly(RGD) and its binding capacities to metastatic melanoma cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Transformed; Cell Membrane; Fibronectins; Melanoma; Mice; Neoplasm Metastasis; Oligopeptides; Peptides; Protein Conformation | 1991 |
Inhibition of murine melanoma cell-matrix adhesion and experimental metastasis by albolabrin, an RGD-containing peptide isolated from the venom of Trimeresurus albolabris.
Topics: Animals; Cell Adhesion; Crotalid Venoms; Fibronectins; Integrins; Laminin; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oligopeptides; Peptides; Platelet Aggregation Inhibitors; Snake Venoms; Tumor Cells, Cultured | 1991 |
Effect of inflammatory cytokines on the adherence of tumor cells to endothelium in a murine model.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Culture Media; Cycloheximide; Cytokines; Dactinomycin; Dose-Response Relationship, Drug; Endothelium, Vascular; Interleukin-1; Lipopolysaccharides; Mast-Cell Sarcoma; Membrane Proteins; Mice; Mice, Inbred DBA; Molecular Sequence Data; Neoplasm Metastasis; Oligopeptides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1991 |
Inhibition of tumour cell adhesion by anti-metastatic polypeptide containing a repetitive Arg-Gly-Asp sequence.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Female; Fibronectins; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Neoplasm Metastasis; Oligopeptides; Peptides; Repetitive Sequences, Nucleic Acid; Substrate Specificity; Tumor Cells, Cultured | 1989 |