arginyl-glycyl-aspartic acid has been researched along with Malignant Melanoma in 88 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (7.95) | 18.7374 |
| 1990's | 23 (26.14) | 18.2507 |
| 2000's | 28 (31.82) | 29.6817 |
| 2010's | 28 (31.82) | 24.3611 |
| 2020's | 2 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Atyabi, F; Dinarvand, R; Fatahi, Y; Khabazian, E; Norouzi, P; Vakhshiteh, F | 1 |
| Chai, J; Deng, Z; Wu, J; Xu, X; Zeng, Q; Zhang, B; Zheng, W | 1 |
| Feng, C; Flook, AM; Miao, Y; Yang, J | 1 |
| Aboagye, EO; Alam, IS; Gallo, J; Gu, YJ; Jin, J; Long, NJ; Wong, WT | 1 |
| Kapp, TG; Kessler, H; Notni, J; Simeček, J; Wester, HJ | 1 |
| Guo, L; He, G; Huang, W; Li, X; Lin, D; Ouyang, L; Song, X; Wu, F; Zhao, Y | 1 |
| Hu, CA; Miao, Y; Yang, J | 1 |
| Andreucci, E; Bianchini, F; Bottoncetti, A; Calorini, L; Fabbrizzi, P; Guarna, A; Menchi, G; Passeri, A; Pupi, A; Raspanti, S; Trabocchi, A | 1 |
| Blehm, BH; Jiang, N; Kotobuki, Y; Tanner, K | 1 |
| Jasti, B; Li, X; Saraf, P; Wrischnik, L | 1 |
| Fu, S; Li, BX; Li, P; Shi, YW; Shi, ZL; Xu, WC; Zhou, C | 1 |
| Decristoforo, C; Franssen, GM; Haas, H; Haubner, R; Laverman, P; Petrik, M; Rangger, C; Summer, D; Zhai, C | 1 |
| Choy, HE; Hong, Y; Jiang, SN; Kim, DY; Min, JH; Min, JJ; Nguyen, VH; Park, SH; Szardenings, M; Zheng, JH | 1 |
| Ashur-Fabian, O; Gellerman, G; Gerlitz, G; Luboshits, G; Pinhasov, A; Redko, B; Segal, T; Tobi, D; Tuchinsky, H | 1 |
| Chen, W; Li, Y; Liu, Z; Xu, Q | 1 |
| Adem, A; Basu, I; Claros, CS; Gorecka, J; Guha, C; Healy, N; Kabarriti, R; Liu, L; Maggi, E; Quinn, TJ; Sara, A; Scandiuzzi, L; Yuan, Z | 1 |
| Bartolomé, RA; Calviño, E; Casal, JI; Escudero-Paniagua, B; Isern de Val, S; Teixidó, J; Torres, S | 1 |
| Griffioen, AW; Mulder, WJ; Nicolay, K; Reutelingsperger, CP; Strijkers, GJ; van der Schaft, DW; van Tilborg, GA | 1 |
| Arap, W; Do, KA; Hu, DD; Knowles, SK; Lin, EC; Mandelin, J; Pasqualini, R; Sage, EH; Smith, JW; Wang, X | 1 |
| Ariizumi, K; Chung, JS; Cruz, PD; Hwang, SH; Tomihari, M | 1 |
| Achilefu, S; Anderson, CJ; Lewis, JS; Wadas, TJ; Wei, L; Welch, MJ; Ye, Y | 1 |
| Wang, J; Wang, X; Wang, Y; Yang, S; Zhang, Q; Zhang, X; Zhang, Y | 1 |
| Chen, R; Pawlicki, MA; Tolbert, TJ; Xiao, J | 1 |
| Cavelier, F; Garambois, V; Martinez, J; Pèlegrin, A; Rocheblave, L; Schmidt, J; Vivès, E | 1 |
| Bianchini, F; Bottoncetti, A; Calorini, L; Cini, N; Guarna, A; Menchi, G; Pupi, A; Raspanti, S; Trabocchi, A | 1 |
| Guo, H; Miao, Y; Yang, J | 1 |
| Cui, D; He, R; Huang, P; Li, Z; Lin, J; Liu, B; Ren, Q; Xi, P; Yang, S; Zhang, X | 1 |
| Chen, FF; Di, JH; Li, HZ; Liu, JJ; Pei, DS; Wu, YP; Xu, W; Yang, ZX; Zhang, BF; Zheng, JN | 1 |
| Faintuch, BL; Moro, AM; Nanda, PK; Núñez, EG; Oliveira, ÉA; Smith, CJ | 1 |
| Miao, Y; Yang, J | 1 |
| Cui, D; Fu, S; Li, P; Luo, T; Pang, B; Ren, Q; Xu, W; Zhou, C | 1 |
| Bianchini, F; Bottoncetti, A; Calorini, L; Cini, N; Guarna, A; Menchi, G; Pupi, A; Raspanti, S; Trabocchi, A; Vanzi, E | 1 |
| Jasti, B; Javali, NM; Li, X; Raj, A; Saraf, P | 1 |
| Notni, J; Pohle, K; Wester, HJ | 1 |
| Kadyrova, EL; Manuvera, VA; Rubtsov, MA; Shirokov, DA; Syrkina, MS; Veiko, VP | 1 |
| Alberto, R; De Simone, M; Kessler, H; Pohle, K; Schmutz, P; Schottelius, M; Shen, Y; Wester, HJ; Zelenka, K | 1 |
| Bigda, J; Dobrzańska-Paprocka, Z; Okrój, M; Rolka, K | 1 |
| Bach, M; Hoffmann, S; Hölig, P; Kontermann, RE; Müller, R; Nahde, T; Völkel, T | 1 |
| Deisseroth, A; Liu, Y; Maynard, J; Sun, D; Ye, T | 1 |
| Chu, JJ; Ng, ML | 1 |
| Barbas, CF; Das, S; Lerner, RA; Li, LS; Matsushita, M; Rader, C; Sinha, SC | 1 |
| Bamberger, AM; Brümmer, J; Ebrahimnejad, A; Horst, AK; Nollau, P; Streichert, T; Wagener, C | 1 |
| Campbell, ML; Li, C; McMurray, JS; Wang, W; Wu, Q | 1 |
| Charnsangavej, C; Chow, D; Dong, L; Gelovani, JG; Houston, J; Ke, S; Li, C; Sevick-Muraca, E; Wang, W; Wu, Q | 1 |
| Haubner, R | 1 |
| Hesse, A; Kontermann, RE; Kosmides, D; Nettelbeck, DM | 1 |
| Collins, JT; Devadas, B; Duffin, TD; Engleman, VW; Finn, MB; Freeman, SK; Green, NF; Griggs, DW; Keene, JL; Kleine, HP; Landis, BH; Lantz, MK; Lu, HF; Malecha, JW; Marrufo, LD; Meyer, DM; Miller, LM; Nagarajan, SR; Nickols, GA; Nickols, MA; Pegg, JA; Rico, JG; Rogers, TE; Ruminski, PG; Russell, MA; Shannon, KE; Steininger, C; Westlin, MM; Williams, ML; Zhu, J | 1 |
| Chan Kwon, I; Chi, DY; Choi, K; Kang, E; Kim, IS; Kim, JH; Kim, K; Kim, YS; Lee, S; Nam, HY; Park, JH; Park, K; Park, RW | 1 |
| Arbiser, JL; Bruijn, JA; Byers, HR; Dekker, SK; van Leeuwen, RL; Vermeer, BJ | 1 |
| Fujii, K; Imamura, S | 1 |
| Aota, S; Danen, EH; Ruiter, DJ; van Kraats, AA; van Muijen, GN; Yamada, KM | 1 |
| Dixon, WT; Jimbow, K; Searles, GE; Thomas, PD | 1 |
| Fujii, K; Lazarus, GS; Schechter, NM | 1 |
| Hara, T; Katagiri, Y; Mori, K; Murakami, M; Tanaka, K; Uede, T | 1 |
| Aumailley, M; Knolle, J; Pfaff, M; Specks, U; Timpl, R; Zerwes, HG | 1 |
| Arfsten, A; Campbell, AM; Charo, IF; Nannizzi, L; Naughton, MA; Phillips, DR; Rose, JW; Scarborough, RM; Teng, W | 1 |
| Mann, K; Poschl, E; Schulze, B; Timpl, R; Yamada, Y | 1 |
| Aznavoorian, S; Liotta, LA; McClanahan, J; Parsons, J; Stracke, ML | 1 |
| Becker, JC; Cheresh, DA; Lemmon, VP; Montgomery, AM; Pancook, JD; Reisfeld, RA; Siu, CH; Zhao, X | 1 |
| Chambers, AF; Hara, T; Iizuka, J; Jia, WY; Katagiri, YU; Mori, K; Murakami, M; Tanaka, K; Uede, T | 1 |
| Koivunen, E; Pasqualini, R; Ruoslahti, E | 1 |
| Cai, Y; Honn, KV; Lundy, SK; Porter, AT; Szekeres, K; Timar, J; Trikha, M | 1 |
| Kong, L; Korthuis, RJ | 1 |
| Cornelissen, IM; Danen, EH; Marcinkiewicz, C; Niewiarowski, S; Pachter, JA; Ruiter, DJ; van Kraats, AA; van Muijen, GN | 1 |
| Bielby, S; Mac Neil, S; Rennie, IG; Wagner, M | 1 |
| Giachelli, CM; Smith, LL | 1 |
| Bruno-Bossio, G; Clezardin, P; Delmas, P; Lawler, J; Lecerf, J; Magnetto, S; Silverstein, R; Voland, C | 1 |
| Courtenay-Luck, NS; Epenetos, AA; Konstantinides, K; Milonakis, A; Pectasides, D; Sirmalis, G; Sivolapenko, GB; Skarlos, D; Stathopoulou, E; Stuttle, A | 1 |
| Byzova, TV; Kim, W; Midura, RJ; Plow, EF | 1 |
| Drobny, GP; Giachelli, CM; Gilbert, M; Long, JR; Nelson, K; Shaw, WJ; Stayton, PS | 1 |
| Colorado, PC; Kalluri, R; Maeshima, Y | 1 |
| Casaroli-Marano, RP; Castel, S; García, R; Mitjans, F; Pagan, R; Piulats, J; Reina, M; Vilaró, S | 1 |
| Boger, DL; Cheresh, DA; Goldberg, J; Kessler, T; Silletti, S | 1 |
| Armstrong, L; Kumar, CC; Liu, M; Malkowski, M; Nechuta, T; Neustadt, B; Presta, M; Smith, EM; Tanghetti, E; Varner, J; Yaremko, B; Yin, Z | 1 |
| Montgomery, AM; Ramjeesingh, RA; Siu, CH; Voura, EB | 1 |
| Buerkle, MA; Dellian, M; Jonczyk, A; Messmer, K; Pahernik, SA; Sutter, A | 1 |
| Fujita, T; Hayakawa, T; Mayumi, T; Mizuguchi, H; Mizuno, N; Nakagawa, S; Okada, N; Okada, Y; Takahashi, K; Yamamoto, A | 1 |
| Baril, P; Boukerche, H; Nejjari, M; Scoazek, JY | 1 |
| Azuma, I; Murata, J; Nishi, N; Ogawa, R; Saiki, I; Tokura, S | 1 |
| Greatorex, D; Kleinman, HK; Martin, GR; Sasaki, M; Sephel, GC; Shirashi, N; Tashiro, K; Yamada, Y | 1 |
| Furcht, LT; Klein, DJ; McCarthy, JB; Mickelson, DJ; Qi, Z; Skubitz, AP; Yi, XY | 1 |
| Cheresh, DA; Harper, JR | 1 |
| Cheresh, DA; Klier, FG; Pierschbacher, MD; Pytela, R; Reisfeld, RA; Ruoslahti, E | 1 |
| Cheresh, DA; Spiro, RC | 1 |
| Argraves, WS; Gehlsen, KR; Pierschbacher, MD; Ruoslahti, E | 1 |
| Burns, GF; Krissansen, GW; Lucas, CM; Scanlon, DB; Simpson, RJ; Vadas, MA; Werkmeister, JA | 1 |
| Liotta, LA; Stracke, ML | 1 |
| Huang, TF; Knudsen, KA; Niewiarowski, S; Tuszynski, GP | 1 |
2 review(s) available for arginyl-glycyl-aspartic acid and Malignant Melanoma
| Article | Year |
|---|---|
Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis?
Topics: Animals; Humans; Image Processing, Computer-Assisted; Integrin alphaVbeta3; Melanoma; Mice; Neoplasms, Experimental; Neovascularization, Pathologic; Oligopeptides; Positron-Emission Tomography; Radioisotopes | 2006 |
Tumor invasion and metastases: biochemical mechanisms.
Topics: Amino Acid Sequence; Cell Movement; Extracellular Matrix; Humans; In Vitro Techniques; Laminin; Melanoma; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Oligopeptides; Peptide Hydrolases; Receptors, Immunologic; Receptors, Laminin; Signal Transduction | 1988 |
1 trial(s) available for arginyl-glycyl-aspartic acid and Malignant Melanoma
| Article | Year |
|---|---|
Imaging of metastatic melanoma utilising a technetium-99m labelled RGD-containing synthetic peptide.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Female; Gamma Cameras; Humans; Integrins; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Oligopeptides; Radionuclide Imaging; Radiopharmaceuticals; Technetium; Tissue Distribution | 1998 |
85 other study(ies) available for arginyl-glycyl-aspartic acid and Malignant Melanoma
| Article | Year |
|---|---|
Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells.
Topics: Animals; Cations; Cell Line, Tumor; Humans; Liposomes; Melanoma; Mice; Oligopeptides; Peptides; Peptides, Cyclic; RNA, Small Interfering | 2022 |
Disintegrin Tablysin-15 Suppresses Cancer Hallmarks in Melanoma Cells by Blocking FAK/Akt/ERK and NF-κB Signaling.
Topics: Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Disintegrins; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 1; Humans; Insect Proteins; Integrin alphaVbeta3; MAP Kinase Signaling System; Melanoma; NF-kappa B; Oligopeptides; Phosphorylation; Proto-Oncogene Proteins c-akt; Salivary Proteins and Peptides; Skin Neoplasms | 2020 |
Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide.
Topics: alpha-MSH; Animals; Kidney; Melanoma; Mice; Mice, Inbred C57BL; Molecular Structure; Oligopeptides; Technetium; Tissue Distribution | 2014 |
PET imaging with multimodal upconversion nanoparticles.
Topics: Animals; Cell Line, Tumor; Contrast Media; Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Humans; Integrin alphaVbeta3; Melanoma; Mice; Microscopy, Electron, Transmission; Nanoparticles; Oligopeptides; Peptides, Cyclic; Positron-Emission Tomography; Radiopharmaceuticals | 2014 |
Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK).
Topics: Animals; Cell Line, Tumor; Chelating Agents; Gallium Radioisotopes; Humans; Integrin alphaVbeta3; Melanoma; Mice; Oligopeptides; Peptides; Positron-Emission Tomography; Radiopharmaceuticals; Xenograft Model Antitumor Assays | 2014 |
Discovery and in vivo evaluation of novel RGD-modified lipid-polymer hybrid nanoparticles for targeted drug delivery.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cholesterol; Curcumin; Drug Carriers; Drug Evaluation, Preclinical; Female; Human Umbilical Vein Endothelial Cells; Humans; Lactic Acid; Lipids; Melanoma; Mice; Mice, Inbred BALB C; Nanoparticles; Oligopeptides; Polyesters; Polyethylene Glycols; Polymers; Transplantation, Homologous | 2014 |
Tc-99m-labeled RGD-conjugated alpha-melanocyte stimulating hormone hybrid peptides with reduced renal uptake.
Topics: alpha-MSH; Animals; Cell Line, Tumor; Female; Humans; Kidney; Melanoma; Mice; Mice, Inbred C57BL; Oligopeptides; Radiopharmaceuticals; Receptor, Melanocortin, Type 1; Technetium; Tissue Distribution | 2015 |
Radiosynthesis and micro-SPECT analysis of triazole-based RGD integrin ligands as non-peptide molecular imaging probes for angiogenesis.
Topics: Animals; Heterografts; Humans; Integrins; Ligands; Melanoma; Mice; Models, Molecular; Molecular Probes; Neovascularization, Pathologic; Oligopeptides; Tomography, Emission-Computed, Single-Photon; Triazoles | 2015 |
Deconstructing the role of the ECM microenvironment on drug efficacy targeting MAPK signaling in a pre-clinical platform for cutaneous melanoma.
Topics: Animals; Binding Sites; Biomimetics; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Screening Assays, Antitumor; Extracellular Matrix; Fibronectins; Humans; Hyaluronic Acid; Hydrogels; Laminin; MAP Kinase Signaling System; Melanoma; Mice; Neoplasm Metastasis; Oligopeptides; Polyethylene Glycols; Skin Neoplasms | 2015 |
In Vitro and In Vivo Efficacy of Self-Assembling RGD Peptide Amphiphiles for Targeted Delivery of Paclitaxel.
Topics: Animals; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Fluorescein-5-isothiocyanate; Humans; Integrin alphaVbeta3; Melanoma; Mice; Micelles; Microscopy, Confocal; Oligopeptides; Paclitaxel | 2015 |
Photo-thermal effect enhances the efficiency of radiotherapy using Arg-Gly-Asp peptides-conjugated gold nanorods that target αvβ3 in melanoma cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Gold; Humans; Hyperthermia, Induced; Infrared Rays; Integrin alphaVbeta3; Melanoma; Nanotubes; Oligopeptides; Phototherapy | 2015 |
Comparison of Ga-68-Labeled Fusarinine C-Based Multivalent RGD Conjugates and [(68)Ga]NODAGA-RGD-In Vivo Imaging Studies in Human Xenograft Tumors.
Topics: Acetates; Animals; Cell Line, Tumor; Endocytosis; Female; Ferric Compounds; Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Humans; Hydroxamic Acids; Imaging, Three-Dimensional; Melanoma; Mice, Inbred BALB C; Mice, Nude; Oligopeptides; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Tissue Distribution; Xenograft Model Antitumor Assays | 2016 |
RGD Peptide Cell-Surface Display Enhances the Targeting and Therapeutic Efficacy of Attenuated Salmonella-mediated Cancer Therapy.
Topics: Animals; Antineoplastic Agents; Bacterial Adhesion; Bacterial Outer Membrane Proteins; Breast Neoplasms; Cell Surface Display Techniques; Disease Models, Animal; Drug Carriers; Heterografts; Humans; Integrin alphaVbeta3; Melanoma; Mice; Oligopeptides; Recombinant Fusion Proteins; Salmonella typhimurium; Survival Analysis; Treatment Outcome | 2016 |
Toward the development of a novel non-RGD cyclic peptide drug conjugate for treatment of human metastatic melanoma.
Topics: Animals; Antineoplastic Agents; Caspase 3; Cell Line, Tumor; Cell Survival; Disease Models, Animal; DNA Damage; Drug Discovery; Drug Evaluation, Preclinical; Drug Stability; Humans; Integrin alphaVbeta3; Melanoma; Mice; Models, Molecular; Molecular Conformation; Molecular Structure; Oligopeptides; Peptides, Cyclic; Protein Binding; Xenograft Model Antitumor Assays | 2017 |
Integrin α
Topics: Breast Neoplasms; Carbon; Cell Line, Tumor; Cell Survival; Female; Humans; Integrin alphaVbeta3; Mammary Neoplasms, Experimental; Melanoma; Melanoma, Experimental; Microscopy, Confocal; Nanocomposites; Oligopeptides; Particle Size; Photoacoustic Techniques; Quantum Dots; Surface Properties | 2016 |
Preclinical evaluation of radiation and systemic, RGD-targeted, adeno-associated virus phage-TNF gene therapy in a mouse model of spontaneously metastatic melanoma.
Topics: Animals; Cell Line, Tumor; Combined Modality Therapy; Dependovirus; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Genetic Therapy; Genetic Vectors; Melanoma; Melanoma, Experimental; Mice; Neoplasm Metastasis; Neovascularization, Pathologic; Oligopeptides; Radiotherapy; Radiotherapy, Image-Guided; Survival Analysis; Treatment Outcome; Tumor Burden; Tumor Microenvironment; Tumor Necrosis Factor-alpha | 2017 |
VE-cadherin RGD motifs promote metastasis and constitute a potential therapeutic target in melanoma and breast cancers.
Topics: Animals; Antigens, CD; Antineoplastic Agents; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Gene Expression; Heterografts; Humans; Integrins; Melanoma; Mice; Models, Biological; Molecular Targeted Therapy; Neoplasm Metastasis; Oligopeptides; Prognosis; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Maps; Signal Transduction | 2017 |
Improved magnetic resonance molecular imaging of tumor angiogenesis by avidin-induced clearance of nonbound bimodal liposomes.
Topics: Animals; Avidin; Cell Line, Tumor; Endothelium, Vascular; Humans; Integrin alphaVbeta3; Liposomes; Magnetic Resonance Imaging; Melanoma; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Nanoparticles; Neovascularization, Pathologic; Oligopeptides | 2008 |
Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin.
Topics: Actins; Animals; Cell Adhesion; Cell Line, Tumor; Endothelium, Vascular; Genes, src; Humans; Melanoma; Mice; Mutation; Neoplasm Metastasis; Oligopeptides; Osteopontin; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sarcoma; Signal Transduction | 2009 |
Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion.
Topics: Amino Acid Motifs; Animals; Cell Adhesion; Cell Line; Cell Line, Tumor; Cells, Cultured; Eye Proteins; Humans; Integrins; Keratinocytes; Melanocytes; Melanoma; Melanosomes; Membrane Glycoproteins; Mice; Oligopeptides; Skin Neoplasms; Ultraviolet Rays | 2009 |
(64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity.
Topics: Animals; Binding, Competitive; Chelating Agents; Dipeptides; Heterocyclic Compounds; Humans; Integrin alphaVbeta3; Male; Melanoma; Mice; Neovascularization, Pathologic; Oligopeptides; Organometallic Compounds; Positron-Emission Tomography; Sarcosine; Staining and Labeling; Tissue Distribution | 2009 |
RGD-modified polymeric micelles as potential carriers for targeted delivery to integrin-overexpressing tumor vasculature and tumor cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cells, Cultured; Drug Carriers; Drug Delivery Systems; Endothelium, Vascular; Humans; Integrin alphaVbeta3; Melanoma; Mice; Micelles; Neovascularization, Pathologic; Oligopeptides; Polyethylene Glycols; Receptors, Vitronectin; Umbilical Veins | 2009 |
Targeting a homogeneously glycosylated antibody Fc to bind cancer cells using a synthetic receptor ligand.
Topics: Cell Adhesion; Cell Line, Tumor; Fluorescein-5-isothiocyanate; Glycosylation; Humans; Immunoglobulin Fc Fragments; Immunoglobulin G; Ligands; Mannosidases; Melanoma; Oligopeptides; Saccharomyces cerevisiae | 2009 |
Cyclization of peptides through a urea bond: application to the Arg-Gly-Asp tripeptide.
Topics: Angiogenesis Inhibitors; Animals; Cell Line; Cell Line, Tumor; Cyclization; Humans; Integrin alphaVbeta3; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Oligopeptides; Urea | 2010 |
Click-chemistry-derived triazole ligands of arginine-glycine-aspartate (RGD) integrins with a broad capacity to inhibit adhesion of melanoma cells and both in vitro and in vivo angiogenesis.
Topics: Alkynes; Angiogenesis Inhibitors; Animals; Azides; Cell Adhesion; Cell Line, Tumor; Drug Screening Assays, Antitumor; Endothelial Cells; Extracellular Matrix Proteins; Humans; Integrin alphaVbeta3; Ligands; Melanoma; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Mimicry; Neovascularization, Pathologic; Oligopeptides; Phenylpropionates; Protein Binding; Radioligand Assay; Receptors, Vitronectin; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2010 |
Technetium-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptides for human melanoma imaging.
Topics: alpha-MSH; Amino Acid Sequence; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Design; Feasibility Studies; Humans; Imaging, Three-Dimensional; Integrin alphaVbeta3; Melanoma; Mice; Molecular Imaging; Oligopeptides; Organotechnetium Compounds; Receptor, Melanocortin, Type 1; Sugar Acids; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2010 |
Arginine-glycine-aspartic acid-conjugated dendrimer-modified quantum dots for targeting and imaging melanoma.
Topics: Animals; Cell Line, Tumor; Cell Survival; Dendrimers; Drug Delivery Systems; Female; Flow Cytometry; Humans; Immunohistochemistry; Melanoma; Mice; Mice, Nude; Microscopy, Fluorescence; Molecular Imaging; Nanoconjugates; Oligopeptides; Quantum Dots; Spectrometry, Fluorescence; Tissue Distribution; Whole Body Imaging; Xenograft Model Antitumor Assays | 2010 |
Potent antitumor effect elicited by RGD-mda-7, an mda-7/IL-24 mutant, via targeting the integrin receptor of tumor cells.
Topics: Apoptosis; Cell Growth Processes; Cell Line, Tumor; Cell Survival; HeLa Cells; Humans; Integrins; Interferon-gamma; Interleukin-6; Interleukins; Melanoma; Molecular Targeted Therapy; Oligopeptides; Recombinant Fusion Proteins; Tumor Necrosis Factor-alpha | 2011 |
Radiotracers for different angiogenesis receptors in a melanoma model.
Topics: Animals; Disease Models, Animal; Humans; Melanoma; Melanoma, Experimental; Mice; Neovascularization, Pathologic; Oligopeptides; Polyethylene Glycols; Polyvinyls; Radioactive Tracers; Radionuclide Imaging; Radiopharmaceuticals; Technetium; Technetium Compounds | 2012 |
Substitution of Gly with Ala enhanced the melanoma uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide.
Topics: alpha-MSH; Animals; Binding, Competitive; Cell Line, Tumor; Glycine; Inhibitory Concentration 50; Melanoma; Mice; Molecular Structure; Oligopeptides; Peptide Fragments; Radionuclide Imaging; Radiopharmaceuticals; Technetium | 2012 |
RGD-conjugated gold nanorods induce radiosensitization in melanoma cancer cells by downregulating α(v)β₃ expression.
Topics: Analysis of Variance; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Down-Regulation; Gold; Humans; Integrin alphaVbeta3; Melanoma; Nanotubes; Oligopeptides; Radiation-Sensitizing Agents | 2012 |
¹²⁵I-radiolabeled morpholine-containing arginine-glycine-aspartate (RGD) ligand of αvβ₃ integrin as a molecular imaging probe for angiogenesis.
Topics: Cell Adhesion; Cell Movement; Human Umbilical Vein Endothelial Cells; Humans; Integrin alphaVbeta3; Iodine Radioisotopes; Ligands; Melanoma; Models, Molecular; Molecular Probes; Morpholines; Multimodal Imaging; Neoplasm Transplantation; Neovascularization, Pathologic; Oligopeptides; Peptides, Cyclic; Positron-Emission Tomography; Radiopharmaceuticals; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution; Tomography, X-Ray Computed; Transplantation, Heterologous | 2012 |
Fatty acid-RGD peptide amphiphile micelles as potential paclitaxel delivery carriers to α(v)β₃ integrin overexpressing tumors.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Fatty Acids; Humans; Integrin alphaVbeta3; Melanoma; Micelles; Oligopeptides; Paclitaxel; Surface-Active Agents | 2012 |
Be spoilt for choice with radiolabelled RGD peptides: preclinical evaluation of ⁶⁸Ga-TRAP(RGD)₃.
Topics: Animals; Coordination Complexes; Drug Stability; Female; Gallium Radioisotopes; Humans; Integrins; Isotope Labeling; Melanoma; Mice; Oligopeptides; Organophosphorus Compounds; Peptides, Cyclic; Positron-Emission Tomography | 2013 |
Preparation and functional evaluation of RGD-modified streptavidin targeting to integrin-expressing melanoma cells.
Topics: Animals; Cattle; Cell Line, Tumor; Chromatography, Gel; Enteropeptidase; Escherichia coli; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Integrin alphaVbeta3; Male; Melanoma; Mice; Oligopeptides; Protein Binding; Protein Engineering; Proteolysis; Recombinant Fusion Proteins; Staining and Labeling; Streptavidin | 2013 |
Orthogonally protected artificial amino acid as tripod ligand for automated peptide synthesis and labeling with [(99m)Tc(OH(2))(3)(CO)(3)](+).
Topics: Animals; Bombesin; Cell Line, Tumor; Chelating Agents; Humans; Integrin alphaVbeta3; Lysine; Melanoma; Mice; Mice, Nude; Oligopeptides; Organotechnetium Compounds; Peptide Fragments; Propionates; Solid-Phase Synthesis Techniques | 2013 |
In vitro and in vivo analyses of the biological activity of RGD peptides towards Ab Bomirski melanoma.
Topics: Animals; Apoptosis; Cell Adhesion; Cell Division; Cricetinae; Fibronectins; Humans; Jurkat Cells; Melanoma; Oligopeptides; Skin Neoplasms; Tumor Cells, Cultured | 2003 |
Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma; Colonic Neoplasms; Doxorubicin; Endothelial Cells; Integrins; Lipoproteins; Liposomes; Melanoma; Mice; Oligopeptides; Peptide Library; Peptides; Spectrometry, Fluorescence | 2004 |
Conditionally replication-competent adenoviral vectors with enhanced infectivity for use in gene therapy of melanoma.
Topics: Adenoviridae; Adenovirus E1A Proteins; Animals; Capsid Proteins; Cell Line, Tumor; Enhancer Elements, Genetic; Genetic Therapy; Genetic Vectors; Humans; Melanoma; Mice; Mice, SCID; Monophenol Monooxygenase; Oligopeptides; Promoter Regions, Genetic; Receptors, Virus; Virus Replication; Xenograft Model Antitumor Assays | 2004 |
Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells.
Topics: Animals; Antibodies; Binding Sites; Cations, Divalent; Cell Line; Chick Embryo; Chlorocebus aethiops; Cricetinae; Gene Expression; Gene Silencing; HeLa Cells; Humans; Integrin alphaVbeta3; Integrin beta3; Kidney; Melanoma; Oligopeptides; Receptors, Virus; Recombinant Proteins; Signal Transduction; Solubility; Transfection; Tumor Cells, Cultured; Vero Cells; West Nile virus | 2004 |
Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Line, Tumor; Drug Design; Female; Fructose-Bisphosphate Aldolase; Humans; Immunotherapy; Integrin alphaVbeta3; Integrins; Ketones; Lysine; Melanoma; Models, Molecular; Molecular Mimicry; Oligopeptides; Protein Binding; Receptors, Vitronectin; Structure-Activity Relationship | 2004 |
CEACAM1 enhances invasion and migration of melanocytic and melanoma cells.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cytoplasm; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Integrin alphaVbeta3; Integrin beta3; Melanocytes; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Oligopeptides; Protein Structure, Tertiary; Time Factors; Transfection; Tyrosine; Up-Regulation | 2004 |
Convenient solid-phase synthesis of diethylenetriaminepenta-acetic acid (DTPA)- conjugated cyclic RGD peptide analogues.
Topics: Amino Acid Motifs; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Fluoresceins; Humans; Inhibitory Concentration 50; Integrins; Mass Spectrometry; Melanoma; Mice; Mice, Nude; Models, Chemical; Neoplasm Transplantation; Oligopeptides; Pentetic Acid; Peptides; Time Factors | 2005 |
Dual optical and nuclear imaging in human melanoma xenografts using a single targeted imaging probe.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Fluorescent Dyes; Humans; Indium Radioisotopes; Indoles; Integrin alphaVbeta3; Melanoma; Mice; Mice, Nude; Microscopy, Fluorescence; Molecular Probe Techniques; Oligopeptides; Pentetic Acid; Positron-Emission Tomography; Tomography, Emission-Computed, Single-Photon; Transplantation, Heterologous | 2006 |
Tropism modification of adenovirus vectors by peptide ligand insertion into various positions of the adenovirus serotype 41 short-fiber knob domain.
Topics: Adenoviruses, Human; Amino Acid Sequence; Capsid; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Endothelium, Vascular; Feasibility Studies; Fibroblasts; Gene Transfer Techniques; Genetic Vectors; Humans; Keratinocytes; Ligands; Melanoma; Models, Molecular; Molecular Sequence Data; Oligopeptides; Recombinant Fusion Proteins; Skin; Transduction, Genetic; Umbilical Veins | 2007 |
R-isomers of Arg-Gly-Asp (RGD) mimics as potent alphavbeta3 inhibitors.
Topics: Amino Acids; Animals; Antineoplastic Agents; Colonic Neoplasms; Hypercalcemia; Integrin alphaVbeta3; Isomerism; Melanoma; Mice; Mice, Inbred Strains; Molecular Mimicry; Oligopeptides; Skin Neoplasms; Xenograft Model Antitumor Assays | 2007 |
Self-assembled glycol chitosan nanoparticles for the sustained and prolonged delivery of antiangiogenic small peptide drugs in cancer therapy.
Topics: Angiogenesis Inhibitors; Animals; Chitosan; Delayed-Action Preparations; Drug Carriers; Glycols; Male; Materials Testing; Melanoma; Mice; Mice, Nude; Nanoparticles; Neovascularization, Pathologic; Oligopeptides; Treatment Outcome | 2008 |
Phorbol ester induced rapid attachment and spreading of melanoma cells and the role of extracellular matrix proteins.
Topics: Amino Acid Sequence; Cell Adhesion; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Humans; Integrins; Melanoma; Molecular Sequence Data; Naphthalenes; Oligopeptides; Polycyclic Compounds; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Cell surface proteolysis by serine proteinases enhances RGD-sensitive melanoma cell adhesion on fibrinogen and vitronectin.
Topics: Amino Acid Sequence; Cell Adhesion; Chymotrypsin; Extracellular Matrix Proteins; Fibrinogen; Fibrinolysin; Glycoproteins; Humans; Integrins; Laminin; Melanoma; Molecular Sequence Data; Oligopeptides; Receptors, Cytoadhesin; Receptors, Vitronectin; Serine Endopeptidases; Trypsin; Tumor Cells, Cultured; Up-Regulation; Vitronectin | 1995 |
Requirement for the synergy site for cell adhesion to fibronectin depends on the activation state of integrin alpha 5 beta 1.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Cell Adhesion; Cell Line; Cloning, Molecular; Escherichia coli; Fibronectins; Flow Cytometry; Humans; Integrins; Kinetics; Leukemia, Erythroblastic, Acute; Melanoma; Molecular Sequence Data; Oligopeptides; Receptors, Fibronectin; Recombinant Proteins; Transfection; Tumor Cells, Cultured | 1995 |
Divalent cations control cell-substrate adhesion and laminin expression in normal and malignant human melanocytes in early and late stages of cellular differentiation.
Topics: Amino Acid Sequence; Cations, Divalent; Cell Adhesion; Cell Differentiation; Cells, Cultured; Centrifugation; Humans; Integrins; Laminin; Manganese; Melanocytes; Melanoma; Oligopeptides; Reference Values; Substrate Specificity | 1995 |
Modification of integrin-mediated cell attachment to substrata by serine proteinases in the presence and absence of divalent cations.
Topics: Amino Acid Sequence; Calcium; Cations, Divalent; Cell Adhesion; Chymotrypsin; Extracellular Matrix; Fibrinogen; Fibronectins; Glycoproteins; Humans; In Vitro Techniques; Integrins; Laminin; Melanoma; Molecular Sequence Data; Molecular Weight; Oligopeptides; Tumor Cells, Cultured; Vitronectin | 1993 |
Functional analysis of the osteopontin molecule.
Topics: Amino Acid Sequence; Animals; Autoimmune Diseases; Cell Adhesion; Extracellular Matrix Proteins; Humans; Melanoma; Mice; Molecular Sequence Data; Oligopeptides; Osteopontin; Sialoglycoproteins | 1995 |
Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Breast; Cell Adhesion; Collagen; Epithelial Cells; Epithelium; Female; Fibrosarcoma; Glioma; Humans; Integrins; Melanoma; Melanoma, Experimental; Mice; Molecular Sequence Data; Oligopeptides; Protein Binding; Rats; Receptors, Cell Surface; Receptors, Collagen; Rhabdomyosarcoma; Skin Neoplasms; Tumor Cells, Cultured | 1993 |
Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa.
Topics: Amino Acid Sequence; Cell Adhesion; Disintegrins; Humans; Kinetics; Melanoma; Molecular Sequence Data; Oligopeptides; Peptides; Peptides, Cyclic; Platelet Aggregation; Platelet Membrane Glycoproteins; Structure-Activity Relationship; Tumor Cells, Cultured; Venoms | 1993 |
Structural and functional analysis of the globular domain IVa of the laminin alpha 1 chain and its impact on an adjacent RGD site.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Adhesion; Clone Cells; Cloning, Molecular; DNA Primers; Female; Humans; Integrins; Laminin; Ligands; Macromolecular Substances; Mammals; Melanoma; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Placenta; Pregnancy; Protein Structure, Secondary; Recombinant Proteins; Tumor Cells, Cultured | 1996 |
Integrin alphavbeta3 mediates chemotactic and haptotactic motility in human melanoma cells through different signaling pathways.
Topics: Amino Acid Sequence; Antibodies; Cell Adhesion; Cell Line; Cell Movement; Chemotaxis; Cytoskeletal Proteins; Extracellular Matrix Proteins; GTP-Binding Proteins; Humans; Kinetics; Melanoma; Oligopeptides; Paxillin; Pertussis Toxin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Vitronectin; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella; Vitronectin | 1996 |
Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3.
Topics: Amino Acid Sequence; Animals; Antibodies; Antigens, Surface; Base Sequence; Binding Sites; Cell Adhesion; Cell Line; Cell Movement; DNA Primers; Humans; Kinetics; Leukocyte L1 Antigen Complex; Ligands; Melanoma; Molecular Sequence Data; Mutagenesis, Site-Directed; Neural Cell Adhesion Molecules; Oligopeptides; Polymerase Chain Reaction; Rats; Receptors, Vitronectin; Recombinant Fusion Proteins; Tumor Cells, Cultured | 1996 |
Non-RGD domains of osteopontin promote cell adhesion without involving alpha v integrins.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Cell Line; Cell Movement; Humans; Integrin alphaV; Melanoma; Mice; Molecular Sequence Data; Oligopeptides; Osteopontin; Receptors, Cell Surface; Sialoglycoproteins; Tumor Cells, Cultured | 1996 |
Alpha v integrins as receptors for tumor targeting by circulating ligands.
Topics: Amino Acid Sequence; Animals; Antigens, Viral; Bacteriophages; Breast Neoplasms; Drug Carriers; Female; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Neovascularization, Pathologic; Oligopeptides; Receptors, Vitronectin; Transplantation, Heterologous | 1997 |
The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Antibodies, Monoclonal; Blotting, Northern; Blotting, Southern; Cell Adhesion; Epitopes; Female; Fibronectins; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Melanoma; Microscopy, Confocal; Neoplasm Invasiveness; Oligopeptides; Platelet Glycoprotein GPIIb-IIIa Complex; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Melanoma cell adhesion to injured arterioles: mechanisms of stabilized tethering.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arterioles; Cadaverine; Cell Adhesion; Cricetinae; Endothelium, Vascular; Enzyme Inhibitors; Fibronectins; Hemorheology; Immune Sera; Male; Melanoma; Oligopeptides; Perfusion; Rats; Rats, Sprague-Dawley; Transglutaminases; Tumor Cells, Cultured | 1997 |
The disintegrin eristostatin interferes with integrin alpha 4 beta 1 function and with experimental metastasis of human melanoma cells.
Topics: Animals; Binding Sites; Humans; Infant, Newborn; Integrin alpha4beta1; Integrins; Intercellular Signaling Peptides and Proteins; Male; Melanocytes; Melanoma; Mice; Mice, Nude; Neoplasm Metastasis; Oligopeptides; Peptides; Platelet Aggregation Inhibitors; Receptors, Lymphocyte Homing; Skin; Skin Neoplasms; Snake Venoms; Viper Venoms | 1998 |
Attachment of human uveal melanocytes and melanoma cells to extracellular matrix proteins involves intracellular calcium and calmodulin.
Topics: Calcium; Calmodulin; Cell Adhesion; Cells, Cultured; Extracellular Matrix Proteins; Fibronectins; Humans; Laminin; Melanocytes; Melanoma; Oligopeptides; Tumor Cells, Cultured; Uvea; Uveal Neoplasms | 1997 |
Structural requirements for alpha 9 beta 1-mediated adhesion and migration to thrombin-cleaved osteopontin.
Topics: Binding Sites; Cell Adhesion; Cell Movement; Humans; Integrins; Melanoma; Mutagenesis, Site-Directed; Oligopeptides; Osteopontin; Recombinant Fusion Proteins; Sialoglycoproteins; Tenascin; Thrombin; Tumor Cells, Cultured | 1998 |
CD36 mediates binding of soluble thrombospondin-1 but not cell adhesion and haptotaxis on immobilized thrombospondin-1.
Topics: 3T3 Cells; Animals; CD36 Antigens; Cell Adhesion; Chemotaxis; Melanoma; Mice; Oligopeptides; Protein Binding; Recombinant Proteins; Solubility; Thrombospondin 1; Transfection; Tumor Cells, Cultured | 1998 |
Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein.
Topics: Cell Adhesion; Cell Line; Cells, Cultured; Chemotaxis; Endothelium, Vascular; Humans; Integrin-Binding Sialoprotein; Lymphocytes; Manganese; Melanoma; Oligopeptides; Osteoblasts; Receptors, Vitronectin; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Umbilical Veins | 2000 |
Chimeric peptides of statherin and osteopontin that bind hydroxyapatite and mediate cell adhesion.
Topics: Adsorption; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cell Adhesion; Circular Dichroism; Durapatite; Humans; Magnetic Resonance Spectroscopy; Melanoma; Models, Molecular; Molecular Sequence Data; Oligopeptides; Osteopontin; Peptide Fragments; Protein Binding; Protein Structure, Secondary; Receptors, Vitronectin; Recombinant Fusion Proteins; Salivary Proteins and Peptides; Sialoglycoproteins; Tumor Cells, Cultured | 2000 |
Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Autoantigens; Binding Sites; Cattle; Cell Adhesion; Cell Division; Collagen; Collagen Type IV; Endothelium, Vascular; Humans; Integrin alpha6beta1; Integrins; Melanoma; Mutation; Neovascularization, Pathologic; Oligopeptides; Peptide Fragments; Protein Binding; Receptors, Vitronectin; Sequence Deletion | 2000 |
Alpha v integrin antagonists induce the disassembly of focal contacts in melanoma cells.
Topics: Actins; Antibodies, Monoclonal; Antigens, CD; Cell Adhesion; Cytoskeleton; Focal Adhesions; Immunohistochemistry; Integrin alphaV; Melanoma; Microfilament Proteins; Microscopy, Confocal; Microscopy, Electron; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Oligopeptides; Protein Binding; Signal Transduction; Spectrophotometry; Tensins; Time Factors; Tumor Cells, Cultured; Vinculin | 2000 |
Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Division; Chick Embryo; Chorion; Collagen; Cricetinae; Endothelium, Vascular; Enzyme Activation; Histocytochemistry; Immunoblotting; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Melanoma; Neoplasm Transplantation; Neovascularization, Pathologic; Oligopeptides; Protein Binding; Receptors, Vitronectin; Tumor Cells, Cultured; Vitronectin | 2001 |
Inhibition of angiogenesis and tumor growth by SCH221153, a dual alpha(v)beta3 and alpha(v)beta5 integrin receptor antagonist.
Topics: Allantois; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Adhesion; Cell Division; Chick Embryo; Chorion; Endothelial Growth Factors; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Growth Inhibitors; Humans; Integrins; Intercellular Signaling Peptides and Proteins; Lymphokines; Melanoma; Mice; Mice, SCID; Molecular Mimicry; Neovascularization, Pathologic; Neovascularization, Physiologic; Oligopeptides; Peptides; Receptors, Vitronectin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vitronectin; Xenograft Model Antitumor Assays | 2001 |
Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells.
Topics: Cell Adhesion; Cell Movement; Cells, Cultured; Coculture Techniques; Endothelium, Vascular; Gene Deletion; Humans; Leukocyte L1 Antigen Complex; Lung; Melanoma; Membrane Glycoproteins; Microscopy, Confocal; Neoplasm Metastasis; Neural Cell Adhesion Molecules; Oligopeptides; Pseudopodia; Receptors, Vitronectin; Time Factors; Tumor Cells, Cultured | 2001 |
Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo.
Topics: Animals; Antigens, CD; Antineoplastic Agents; Cricetinae; Endothelium; Infusions, Parenteral; Integrin alpha1; Leukocytes; Male; Melanoma; Microcirculation; Neoplasm Metastasis; Neoplasms, Experimental; Neovascularization, Pathologic; Oligopeptides; Skin Neoplasms | 2002 |
Tumor necrosis factor alpha-gene therapy for an established murine melanoma using RGD (Arg-Gly-Asp) fiber-mutant adenovirus vectors.
Topics: Adenoviridae; Animals; Antibodies, Monoclonal; Cell Line, Tumor; Cricetinae; Enterovirus; Flow Cytometry; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; HeLa Cells; Humans; Integrin alphaV; Lac Operon; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mutation; Necrosis; Oligopeptides; Polymerase Chain Reaction; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Necrosis Factor-alpha | 2002 |
Blocking a novel 55 kDa melanoma-associated cell surface antigen inhibits the development of spontaneous metastases and interactions with frozen lung section.
Topics: Animals; Animals, Newborn; Antigens, Neoplasm; Basement Membrane; Cell Adhesion; Cell Adhesion Molecules; Cell Membrane; Cold Temperature; Collagen; Drug Combinations; Humans; Immunohistochemistry; Laminin; Lung; Melanoma; Neoplasm Metastasis; Oligopeptides; Protein Binding; Proteoglycans; Rats; Temperature; Tumor Cells, Cultured | 2002 |
Molecular properties of poly(RGD) and its binding capacities to metastatic melanoma cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Transformed; Cell Membrane; Fibronectins; Melanoma; Mice; Neoplasm Metastasis; Oligopeptides; Peptides; Protein Conformation | 1991 |
The RGD containing site of the mouse laminin A chain is active for cell attachment, spreading, migration and neurite outgrowth.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antibodies, Monoclonal; Axons; Cattle; Cell Adhesion; Cell Movement; Cells, Cultured; Endothelium; Fibrosarcoma; Humans; Hybridomas; Integrins; Laminin; Melanoma; Mice; Molecular Sequence Data; Oligopeptides; Precipitin Tests; Rhabdomyosarcoma | 1991 |
RGD-independent cell adhesion to the carboxy-terminal heparin-binding fragment of fibronectin involves heparin-dependent and -independent activities.
Topics: Amino Acid Sequence; Cell Adhesion; Cell Line; Fibronectins; Heparin; Humans; Kinetics; Melanoma; Molecular Sequence Data; Molecular Weight; Oligopeptides; Peptide Fragments; Tumor Cells, Cultured | 1990 |
Arg-Gly-Asp recognition by a cell adhesion receptor requires its 130-kDa alpha subunit.
Topics: Antibodies, Monoclonal; Biological Transport, Active; Cell Line; Cross Reactions; Electrophoresis, Polyacrylamide Gel; Epitopes; Humans; Macromolecular Substances; Melanoma; Molecular Weight; Oligopeptides; Platelet Membrane Glycoproteins; Protein Processing, Post-Translational; Receptors, Immunologic; Receptors, Peptide; Receptors, Vitronectin | 1987 |
An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Cell Adhesion; Cell Line; Cell Membrane; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Gangliosides; Humans; Melanoma; Oligopeptides; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Vitronectin | 1987 |
Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.
Topics: Cell Adhesion; Cell Line; Chromatography, Affinity; Fibrinogen; Flow Cytometry; Fluorescent Antibody Technique; Glycoproteins; Humans; Melanoma; Oligopeptides; Receptors, Immunologic; Receptors, Peptide; Tumor Cells, Cultured; Vitronectin; von Willebrand Factor | 1987 |
Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides.
Topics: Amino Acid Sequence; Antigens, Surface; Cell Adhesion Molecules; Collagen; Fibronectins; Glioma; Glycoproteins; Humans; Laminin; Melanoma; Membrane Glycoproteins; Neoplasm Invasiveness; Oligopeptides; Peptides; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Receptors, Immunologic; Tumor Cells, Cultured; Vitronectin | 1988 |
Synergism between membrane gangliosides and Arg-Gly-Asp-directed glycoprotein receptors in attachment to matrix proteins by melanoma cells.
Topics: Antibodies, Monoclonal; Cell Adhesion; Cell Membrane; Extracellular Matrix; Fibronectins; Gangliosides; Glycoproteins; Humans; Immunoglobulin M; Melanoma; Oligopeptides; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Receptors, Immunologic; Receptors, Vitronectin; Tumor Cells, Cultured | 1988 |
Trigramin, an RGD-containing peptide from snake venom, inhibits cell-substratum adhesion of human melanoma cells.
Topics: Cell Adhesion; Cells, Cultured; Fibrinogen; Fibronectins; Humans; Integrins; Intercellular Signaling Peptides and Proteins; Melanoma; Membrane Glycoproteins; Microscopy, Phase-Contrast; Oligopeptides; Peptides; Snake Venoms | 1988 |