arginyl-glycyl-aspartic acid has been researched along with B16 Melanoma in 70 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (4.29) | 18.7374 |
1990's | 14 (20.00) | 18.2507 |
2000's | 29 (41.43) | 29.6817 |
2010's | 23 (32.86) | 24.3611 |
2020's | 1 (1.43) | 2.80 |
Authors | Studies |
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Fu, C; Hu, Y; Jiang, X; Jin, T; Li, LA; Liu, M; Ma, J; Pan, C; Yu, E; Yu, X; Zhang, X; Zhao, R | 1 |
Cheng, R; Meng, F; Meng, H; Zhang, J; Zhong, P; Zhong, Z; Zou, Y | 1 |
Bi, S; Hu, B; Lv, X; Ren, L; Shan, W; Wu, Y; Ye, S; Zhang, D; Zhang, X; Zhou, X | 1 |
Chaudhary, G; Chen, J; Ewoldt, RH; Luo, J; Mohagheghian, E; Sun, J; Wang, N | 1 |
Cao, Y; Deng, L; Guo, D; Huang, J; Liu, M; Luo, Y; Tan, M; Wang, Z; Zhang, P | 1 |
Lv, L; Wang, JH; Xiao, R; Yan, HJ; Zhang, LX; Zheng, YY | 1 |
Klajnert-Maculewicz, B; Liu, J; Peng, C; Shen, M; Shi, X; Xiong, Z; Zhang, J | 1 |
Aitken, JB; Austin, CJ; Harris, HH; Jolliffe, KA; Rendina, LM; Sheridan, EJ; Vogt, S | 1 |
Banerjee, S; Bhadwal, M; Chakraborty, S; Mittal, S; Pillai, MR; Sarma, HD | 1 |
Kim, IS; Kim, S; Nam, JO; Son, HN | 1 |
Chen, J; Lao, X; Liu, M; Zheng, H | 1 |
Dai, W; Guo, Z; He, B; Jin, H; Wang, J; Wang, X; Zhang, H; Zhang, L; Zhang, Q; Zhang, X | 1 |
Miao, Y; Xu, J; Yang, J | 1 |
Chen, W; Li, Y; Liu, Z; Xu, Q | 1 |
Adem, A; Basu, I; Claros, CS; Gorecka, J; Guha, C; Healy, N; Kabarriti, R; Liu, L; Maggi, E; Quinn, TJ; Sara, A; Scandiuzzi, L; Yuan, Z | 1 |
Manickam, DS; Oupický, D; Wu, C; Zhou, QH | 1 |
Da Violante, G; Gourlaouen, M; Hart, IR; Hodivala-Dilke, KM; Jones, DT; Jones, MC; Kostourou, V; Norman, JC; Perron-Sierra, F; Reynolds, AR; Robinson, SD; Salih, M; Saunders, G; Silva, RG; Tucker, GC; Watson, AR; Welti, JC | 1 |
Berwick, M; Gallazzi, F; Guo, H; Miao, Y; Padilla, RS; Yang, J | 1 |
Bian, DY; Wang, JC; Zhang, Q; Zhang, X; Zhang, YF | 1 |
Ge, Q; Guo, Z; Jin, G; Wang, E; Wang, Y; Zhang, X | 1 |
Berwick, M; Guo, H; Miao, Y; Padilla, RS; Yang, J | 1 |
Guo, FQ; Kang, L; Li, L; Wang, RF; Yan, P; Yang, M; Zhang, CL; Zhang, L | 1 |
Asai, T; Dewa, T; Kenjo, E; Nango, M; Oku, N; Shimizu, K; Tsuruta, A; Yonenaga, N | 1 |
Griffioen, AW; Hectors, SJ; Jacobs, I; Kluza, E; Mayo, KH; Nicolay, K; Strijkers, GJ | 1 |
Faintuch, BL; Moro, AM; Nanda, PK; Núñez, EG; Oliveira, ÉA; Smith, CJ | 1 |
Lu, J; Miao, Y; Yang, J | 1 |
Hu, JL; Huang, XF; Li, YB; Pu, CY; Xu, HM; Yang, YJ; Zhang, C; Zheng, H | 1 |
Bos, EJ; de Leij, LF; Kok, RJ; Meijer, DK; Molema, G; Moorlag, HE; Proost, JH; Schraa, AJ | 1 |
Fujita, T; Hayakawa, T; Iiyama, S; Masunaga, Y; Mayumi, T; Mizuguchi, H; Mori, N; Nakagawa, S; Okada, N; Okada, Y; Sasaki, A; Yamamoto, A | 1 |
Bazan-Socha, S; Calvete, JJ; Kisiel, DG; Marcinkiewicz, C; Sheppard, D; Theakston, RD; Young, B | 1 |
Hayakawa, T; Mayumi, T; Mizuguchi, H; Mizuno, N; Okada, N; Okada, Y; Takahashi, K | 1 |
Chen, RQ; Jin, Y; Lu, QM; Wang, WY; Wu, JB; Xiong, YL; Zhou, XD | 1 |
Corti, A; Monaco, L; Zarovni, N | 1 |
Eto, Y; Gao, JQ; Hayakawa, T; Inoue, S; Katayama, K; Kurachi, S; Mayumi, T; Mizuguchi, H; Nakagawa, S; Tsukada, Y; Tsutsumi, Y | 1 |
Eto, Y; Gao, JQ; Hayakawa, T; Katayama, K; Kawasaki, K; Kurachi, S; Maeda, M; Mayumi, T; Mizuguchi, H; Nakagawa, S; Sekiguchi, F; Tsutsumi, Y | 1 |
Hayakawa, T; Mayumi, T; Mizuguchi, H; Nakagawa, S; Okada, N; Okada, Y | 1 |
Huang, Y; Lu, WL; Nagai, T; Xiong, XB; Zhang, H; Zhang, Q; Zhang, X | 2 |
Fujita, T; Hatanaka, Y; Mizuguchi, H; Nakagawa, S; Niwa, M; Okada, N; Okada, Y; Sasaki, A; Tani, Y; Yamamoto, A | 1 |
Huang, Y; Lü, WL; Xiong, XB; Zhang, H; Zhang, Q; Zhang, X | 1 |
Bueno, NR; Chammas, R; Franco, CR; Jasiulionis, MG; Nader, HB; Nakahata, AM; Nakaie, CR; Oliva, ML; Rocha, HA; Sampaio, MU; Santana, LA | 1 |
Bachi, A; Cattaneo, A; Corti, A; Crippa, L; Curnis, F; Dondossola, E; Longhi, R | 1 |
Cichoń, T; Graja, K; Hucz, J; Smolarczyk, R; Sochanik, A; Szala, S | 1 |
Barcellos, GG; Barja-Fidalgo, C; Benedeta Zingali, R; Coelho, RM; Marcinkiewicz, C; Oliva, IB; Saldanha-Gama, R; Wermelinger, LS | 1 |
Alon, R; Cahalon, L; Greenspoon, N; Hardan, I; Hershkoviz, R; Lider, O; Reich, S; Slavin, S; Weiss, L | 1 |
Boyer, J; Kieber-Emmons, T; Prammer, KV; Shattil, SJ; Ugen, K | 1 |
Phillips, NC; Stewart-Phillips, J; Wang, P | 1 |
Aumailley, M; Knolle, J; Pfaff, M; Specks, U; Timpl, R; Zerwes, HG | 1 |
Kato, M; Kuroda, K; Mitsuishi, Y; Miyata, K; Nishimura, K; Sakae, N; Shikama, H | 1 |
Koike, C; Mori, H; Nishikawa, N; Okada, S; Oku, N; Saiki, I; Tokudome, Y | 1 |
Kuwashima, N | 1 |
Koivunen, E; Pasqualini, R; Ruoslahti, E | 1 |
Orr, FW; Scherbarth, S | 1 |
Izuno, Y; Kaneda, Y; Kawasaki, K; Maeda, M; Mayumi, T; Mu, Y; Nakagawa, S; Tsutsumi, Y | 1 |
Ayukawa, K; Azuma, I; Fujii, H; Itoh, I; Kojima, M; Komazawa, H; Nishikawa, N; Obata, A; Saiki, I; Suzuki, M | 1 |
Azuma, I; Fujii, H; Hayakawa, Y; Inobe, M; Kimura, F; Murakami, M; Onishi, Y; Saiki, I; Uede, T | 1 |
Krutzsch, HC; Lawler, J; Roberts, DD; Sipes, JM | 1 |
Burgess, BT; Dickinson, RB; Myles, JL | 1 |
Chung, KH; Jang, Y; Kang, IC; Kim, DS | 1 |
Kurohane, K; Namba, Y; Oku, N | 1 |
Burkhart, F; Goodman, SL; Haubner, R; Kessler, H; Schwaiger, M; Senekowitsch-Schmidtke, R; Weber, W; Wester, HJ | 1 |
Sasaki, T; Timpl, R | 1 |
Hayakawa, T; Kanehira, M; Mayumi, T; Mizuguchi, H; Mizuno, N; Nakagawa, S; Nishino, N; Okada, N; Okada, Y; Takahashi, K | 1 |
Hayakawa, T; Mizuguchi, H | 1 |
Contino-Pépin, C; Jasseron, S; Maurizis, JC; Pucci, B; Rapp, M | 1 |
Fujita, T; Hayakawa, T; Mayumi, T; Mizuguchi, H; Mizuno, N; Nakagawa, S; Okada, N; Okada, Y; Takahashi, K; Yamamoto, A | 1 |
Beviglia, L; Knudsen, KA; Niewiarowski, S; Poggi, A; Rossi, C; Soszka, T | 1 |
Azuma, I; Iida, J; Kawahara, H; Murata, J; Nishi, N; Saiki, I; Tokura, S | 1 |
Chelberg, MK; Hauser, AR; McCarthy, JB; Tsilibary, EC | 1 |
Azuma, I; Iida, J; Matsuno, K; Murata, J; Nishi, N; Saiki, I; Sakurai, T | 1 |
70 other study(ies) available for arginyl-glycyl-aspartic acid and B16 Melanoma
Article | Year |
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Antineoplastic Effects and Mechanisms of a New RGD Chimeric Peptide from Bullfrog Skin on the Proliferation and Apoptosis of B16F10 Cells.
Topics: Amphibian Proteins; Animals; Antineoplastic Agents; Apoptosis; Melanoma, Experimental; Mice; Oligopeptides; Rana catesbeiana; Skin | 2021 |
A Smart Nano-Prodrug Platform with Reactive Drug Loading, Superb Stability, and Fast Responsive Drug Release for Targeted Cancer Therapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Survival; Dioxanes; Disulfides; Drug Liberation; Gene Expression; Glutathione; Integrin alpha5; Maytansine; Melanoma, Experimental; Mice; Nanocapsules; Oligopeptides; Particle Size; Polyethylene Glycols; Polymerization; Prodrugs; Skin Neoplasms; Sulfhydryl Compounds; Survival Analysis; Tumor Burden | 2017 |
Modularized peptides modified HBc virus-like particles for encapsulation and tumor-targeted delivery of doxorubicin.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Drug Delivery Systems; Genetic Engineering; Hepatitis B Core Antigens; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nanoparticles; Oligopeptides; Vaccines, Virus-Like Particle; Virion | 2018 |
Quantifying compressive forces between living cell layers and within tissues using elastic round microgels.
Topics: Actomyosin; Alginates; Animals; Biomechanical Phenomena; Cell Line, Tumor; Elasticity; Embryo, Nonmammalian; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Glucuronic Acid; Glycoconjugates; Hexuronic Acids; Lab-On-A-Chip Devices; Melanoma, Experimental; Mice; Microspheres; Oligopeptides; Pressure; Stress, Mechanical; Zebrafish | 2018 |
IR780-based light-responsive nanocomplexes combining phase transition for enhancing multimodal imaging-guided photothermal therapy.
Topics: Animals; Cell Line, Tumor; Cell Survival; Hemolysis; Indoles; Infrared Rays; Melanoma, Experimental; Mice; Nanoparticles; Oligopeptides; Phase Transition; Phototherapy; Polyglactin 910; Ultrasonography | 2019 |
A Novel Mutant of rLj-RGD3 (rLj-112) Suppressed the Proliferation and Metastasis of B16 Cells through the EGFR Signaling Pathway.
Topics: Amino Acid Sequence; Animals; Apoptosis; Caspase 3; Caspase 7; Cell Movement; Cell Proliferation; ErbB Receptors; Female; Fish Venoms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Phosphatidylinositol 3-Kinases; Poly (ADP-Ribose) Polymerase-1; Proto-Oncogene Proteins c-akt; Random Allocation; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Zwitterionic Gadolinium(III)-Complexed Dendrimer-Entrapped Gold Nanoparticles for Enhanced Computed Tomography/Magnetic Resonance Imaging of Lung Cancer Metastasis.
Topics: Animals; Cell Line, Tumor; Cell Survival; Contrast Media; Coordination Complexes; Dendrimers; Gadolinium; Gold; Heterocyclic Compounds, 1-Ring; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Melanoma, Experimental; Metal Nanoparticles; Mice; Oligopeptides; RAW 264.7 Cells; Signal-To-Noise Ratio; Tomography, X-Ray Computed; Transplantation, Homologous | 2019 |
Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells.
Topics: Animals; Bromine; Humans; Lung Neoplasms; Melanoma, Experimental; Mice; Neovascularization, Pathologic; Oligopeptides; Peptides, Cyclic; Spectrometry, X-Ray Emission; Tumor Cells, Cultured | 2013 |
A novel concept of radiosynthesis of a (99m)Tc-labeled dimeric RGD peptide as a potential radiotracer for tumor imaging.
Topics: Animals; Dimerization; Half-Life; Integrin alphaVbeta3; Isotope Labeling; Magnetic Resonance Imaging; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Organotechnetium Compounds; Protein Binding; Radiography; Radiopharmaceuticals; Thiocarbamates; Tissue Distribution | 2013 |
Multiple FAS1 domains and the RGD motif of TGFBI act cooperatively to bind αvβ3 integrin, leading to anti-angiogenic and anti-tumor effects.
Topics: Animals; Antibodies, Monoclonal; Antibody Formation; Blotting, Western; Carcinoma, Lewis Lung; Cell Proliferation; Endothelium, Vascular; Extracellular Matrix Proteins; fas Receptor; Humans; Immunoenzyme Techniques; Integrin alphaVbeta3; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Oligopeptides; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured | 2013 |
A tumor-penetrating peptide modification enhances the antitumor activity of thymosin alpha 1.
Topics: Amino Acid Motifs; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Escherichia coli; Humans; Integrin alphaVbeta3; Lymphocytes; Melanoma, Experimental; Mice; Models, Molecular; Molecular Sequence Data; Oligopeptides; Permeability; Protein Binding; Recombinant Fusion Proteins; Spleen; Thymalfasin; Thymosin | 2013 |
Targeting efficiency of RGD-modified nanocarriers with different ligand intervals in response to integrin αvβ3 clustering.
Topics: Humans; Integrin alphaVbeta3; MCF-7 Cells; Melanoma, Experimental; Molecular Targeted Therapy; Nanocapsules; Nanocomposites; Oligopeptides; Protein Binding | 2014 |
Dual receptor-targeting ⁹⁹mTc-labeled Arg-Gly-Asp-conjugated Alpha-Melanocyte stimulating hormone hybrid peptides for human melanoma imaging.
Topics: alpha-MSH; Animals; Caprylates; Cell Line, Tumor; Cell Transformation, Neoplastic; Diagnostic Imaging; Humans; Isotope Labeling; Melanoma, Experimental; Mice; Mice, Nude; Oligopeptides; Polyethylene Glycols; Technetium; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2015 |
Integrin α
Topics: Breast Neoplasms; Carbon; Cell Line, Tumor; Cell Survival; Female; Humans; Integrin alphaVbeta3; Mammary Neoplasms, Experimental; Melanoma; Melanoma, Experimental; Microscopy, Confocal; Nanocomposites; Oligopeptides; Particle Size; Photoacoustic Techniques; Quantum Dots; Surface Properties | 2016 |
Preclinical evaluation of radiation and systemic, RGD-targeted, adeno-associated virus phage-TNF gene therapy in a mouse model of spontaneously metastatic melanoma.
Topics: Animals; Cell Line, Tumor; Combined Modality Therapy; Dependovirus; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Genetic Therapy; Genetic Vectors; Melanoma; Melanoma, Experimental; Mice; Neoplasm Metastasis; Neovascularization, Pathologic; Oligopeptides; Radiotherapy; Radiotherapy, Image-Guided; Survival Analysis; Treatment Outcome; Tumor Burden; Tumor Microenvironment; Tumor Necrosis Factor-alpha | 2017 |
Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR.
Topics: Acrylamides; Animals; Disulfides; DNA; Gene Transfer Techniques; Genetic Therapy; Male; Melanoma, Experimental; Methacrylates; Mice; Mice, Inbred C57BL; Nanoparticles; Oligopeptides; Oxidation-Reduction; Polyamines; Polyelectrolytes; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity | 2009 |
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Humans; Integrin alphaVbeta3; Lung Neoplasms; Melanoma, Experimental; Mice; Neoplasms; Neovascularization, Pathologic; Oligopeptides; Receptors, Vitronectin; Vascular Endothelial Growth Factor A | 2009 |
Evaluation of a novel Arg-Gly-Asp-conjugated α-melanocyte stimulating hormone hybrid peptide for potential melanoma therapy.
Topics: alpha-MSH; Animals; Antineoplastic Agents; Cell Survival; Female; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Structure-Activity Relationship; Technetium; Tissue Distribution; Xenograft Model Antitumor Assays | 2009 |
Targeted delivery of RGD-modified liposomes encapsulating both combretastatin A-4 and doxorubicin for tumor therapy: in vitro and in vivo studies.
Topics: Animals; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Carriers; Drug Combinations; Drug Compounding; Drug Delivery Systems; Endothelial Cells; Flow Cytometry; Humans; Liposomes; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Stilbenes; Xenograft Model Antitumor Assays | 2010 |
Preparation and characterization of RGD tumour-homing-peptide-modified plasminogen K5.
Topics: Animals; Antibodies; Cancer Vaccines; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Cloning, Molecular; Female; Histocytochemistry; Humans; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Oligopeptides; Peptide Fragments; Pichia; Plasminogen; Recombinant Fusion Proteins; Xenograft Model Antitumor Assays | 2010 |
Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide.
Topics: alpha-MSH; Amino Acid Sequence; Animals; Antineoplastic Agents; Arginine; Isotope Labeling; Kidney; Lysine; Melanocyte-Stimulating Hormones; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Organoplatinum Compounds; Technetium; Whole Body Imaging | 2010 |
[(131)I labeling and bioactivity evaluation of a novel RGD dimer targeted to integrin αvβ3 receptor].
Topics: Animals; Dimerization; Integrin alphaVbeta3; Iodine Radioisotopes; Isotope Labeling; Melanoma, Experimental; Mice; Neovascularization, Pathologic; Oligopeptides; Radionuclide Imaging | 2011 |
RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment.
Topics: Animals; Cations; Cell Line, Tumor; Drug Carriers; Ethylenediamines; Genetic Therapy; Liposomes; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Organophosphates; Polyethylene Glycols; RNA Interference; RNA, Small Interfering; Xenograft Model Antitumor Assays | 2012 |
Dual-targeting of αvβ3 and galectin-1 improves the specificity of paramagnetic/fluorescent liposomes to tumor endothelium in vivo.
Topics: Animals; Cell Line, Tumor; Contrast Media; Endothelium, Vascular; Galectin 1; Integrin alphaVbeta3; Liposomes; Magnetics; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Oligopeptides; Peptides | 2012 |
Radiotracers for different angiogenesis receptors in a melanoma model.
Topics: Animals; Disease Models, Animal; Humans; Melanoma; Melanoma, Experimental; Mice; Neovascularization, Pathologic; Oligopeptides; Polyethylene Glycols; Polyvinyls; Radioactive Tracers; Radionuclide Imaging; Radiopharmaceuticals; Technetium; Technetium Compounds | 2012 |
Structural modification on the Lys linker enhanced tumor to kidney uptake ratios of 99mTc-labeled RGD-conjugated α-MSH hybrid peptides.
Topics: alpha-MSH; Animals; Female; Kidney; Melanoma, Experimental; Mice; Oligopeptides; Organotechnetium Compounds; Peptides; Radiopharmaceuticals | 2012 |
RGD-modified endostatin fragments showed an antitumor effect through antiangiogenesis.
Topics: Animals; Antineoplastic Agents; Aorta, Thoracic; Cell Adhesion; Cell Movement; Drug Delivery Systems; Endostatins; Female; Human Umbilical Vein Endothelial Cells; Humans; Integrin alphaVbeta3; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Oligopeptides; Rats, Sprague-Dawley | 2012 |
Targeting of RGD-modified proteins to tumor vasculature: a pharmacokinetic and cellular distribution study.
Topics: Animals; Antibodies, Monoclonal; Endothelium, Vascular; Liver; Macromolecular Substances; Macrophages; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Spleen; Tissue Distribution | 2002 |
Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice.
Topics: Adenoviridae; Animals; Dendritic Cells; Female; Genetic Therapy; Genetic Vectors; gp100 Melanoma Antigen; Humans; Immunotherapy, Adoptive; Killer Cells, Natural; Lung Neoplasms; Melanoma, Experimental; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Mutation; Neoplasm Proteins; Oligopeptides; Skin Neoplasms; T-Lymphocytes, Cytotoxic; Transduction, Genetic | 2003 |
Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Cell Line, Tumor; Dimerization; Disintegrins; Humans; Integrin alpha4beta1; Integrins; Jurkat Cells; K562 Cells; Melanoma, Experimental; Mice; Molecular Sequence Data; Oligopeptides; Peptides; Protein Structure, Tertiary; Snake Venoms; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Optimization of antitumor efficacy and safety of in vivo cytokine gene therapy using RGD fiber-mutant adenovirus vector for preexisting murine melanoma.
Topics: Adenoviridae; Animals; Antineoplastic Agents; Body Weight; Cytokines; Female; Genetic Therapy; Genetic Vectors; Injections, Intralesional; Interferon-gamma; Interleukin-12; Killer Cells, Natural; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Spleen; Time Factors; Transduction, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2004 |
Purification, cloning and biological characterization of a novel disintegrin from Trimeresurus jerdonii venom.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Base Sequence; Chromatography, High Pressure Liquid; Cloning, Molecular; Crotalid Venoms; Disintegrins; DNA, Complementary; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oligopeptides; Sequence Homology; Survival Rate; Trimeresurus | 2004 |
Inhibition of tumor growth by intramuscular injection of cDNA encoding tumor necrosis factor alpha coupled to NGR and RGD tumor-homing peptides.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; DNA, Complementary; Doxorubicin; Endothelium, Vascular; Feedback, Physiological; Female; Genetic Therapy; Injections, Intramuscular; Lymphoma, T-Cell; Melanoma, Experimental; Melphalan; Mice; Mice, Inbred C57BL; Oligopeptides; Peptide Fragments; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2004 |
High gene expression of the mutant adenovirus vector, both in vitro and in vivo, with the insertion of integrin-targeting peptide into the fiber.
Topics: Adenoviridae; Animals; DNA Transposable Elements; Gene Expression Regulation, Viral; Genetic Vectors; Humans; Integrins; Luciferases; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mutation; Oligopeptides; Peptides | 2004 |
PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability.
Topics: Adenoviridae; Animals; Antibodies, Viral; Cell Line, Tumor; Female; Genetic Vectors; Humans; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Oligopeptides; Polyethylene Glycols; Propionates; Skin Neoplasms; Transduction, Genetic | 2005 |
Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma.
Topics: Adenoviridae; Animals; Body Weight; DNA-Binding Proteins; Gene Transfer Techniques; Genes, Transgenic, Suicide; Genetic Therapy; Genetic Vectors; Humans; Injections, Intralesional; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Oligopeptides; Promoter Regions, Genetic; Simplexvirus; Skin Neoplasms; Telomerase; Thymidine Kinase; Transduction, Genetic; Transgenes; Tumor Cells, Cultured | 2005 |
Intracellular delivery of doxorubicin with RGD-modified sterically stabilized liposomes for an improved antitumor efficacy: in vitro and in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Area Under Curve; Cell Line, Tumor; Chemistry, Pharmaceutical; Doxorubicin; Drug Carriers; Humans; Liposomes; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Oligopeptides; Therapeutic Equivalency; Tissue Distribution | 2005 |
Enhanced intracellular delivery and improved antitumor efficacy of doxorubicin by sterically stabilized liposomes modified with a synthetic RGD mimetic.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Drug Delivery Systems; Flow Cytometry; Liposomes; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neoplasm Transplantation; Oligopeptides; Pharmaceutic Aids; Polyethylene Glycols; Spectrometry, Fluorescence; Tissue Distribution | 2005 |
Tumor suppressive efficacy through augmentation of tumor-infiltrating immune cells by intratumoral injection of chemokine-expressing adenoviral vector.
Topics: Adenoviridae; Animals; Capsid Proteins; Cell Line, Tumor; Chemokines; Dendritic Cells; Female; Genetic Therapy; Genetic Vectors; gp100 Melanoma Antigen; Lymphocyte Subsets; Lymphocytes, Tumor-Infiltrating; Melanoma, Experimental; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mutation; Oligopeptides; T-Lymphocytes, Cytotoxic; Transduction, Genetic | 2006 |
[Preparation of doxorubicin-loaded stealth liposomes modified with RGD mimetic and cellular association in vitro].
Topics: Animals; Antibiotics, Antineoplastic; Cell Adhesion; Cell Line, Tumor; Cell Nucleus; Doxorubicin; Drug Carriers; Drug Delivery Systems; Humans; Liposomes; Melanoma, Experimental; Oligopeptides; Phosphatidylethanolamines; Polyethylene Glycols | 2005 |
Structural and inhibitory properties of a plant proteinase inhibitor containing the RGD motif.
Topics: Amino Acid Sequence; Animals; Bauhinia; Cell Adhesion; Cell Line, Tumor; Endothelial Cells; Humans; In Vitro Techniques; Kallikreins; Melanoma, Experimental; Mice; Molecular Sequence Data; Oligopeptides; Peptides; Plant Proteins; Rabbits; Sequence Homology, Amino Acid | 2006 |
Spontaneous formation of L-isoaspartate and gain of function in fibronectin.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Adhesion; Extracellular Matrix; Fibronectins; Humans; Integrins; Isoaspartic Acid; Melanoma, Experimental; Mice; Models, Molecular; Molecular Sequence Data; Oligopeptides; Recombinant Proteins | 2006 |
Antitumor effect of RGD-4C-GG-D(KLAKLAK)2 peptide in mouse B16(F10) melanoma model.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Melanoma, Experimental; Mice; Oligopeptides; Survival Rate; Treatment Outcome; Tumor Burden | 2006 |
Effect of RGD-disintegrins on melanoma cell growth and metastasis: involvement of the actin cytoskeleton, FAK and c-Fos.
Topics: Actins; Active Transport, Cell Nucleus; Animals; Cell Line, Tumor; Cell Proliferation; Cytoskeleton; Disintegrins; Focal Adhesion Protein-Tyrosine Kinases; Melanoma, Experimental; Mice; Mitogen-Activated Protein Kinase 1; NF-kappa B; Oligopeptides; Phosphorylation; Proto-Oncogene Proteins c-fos | 2007 |
Inhibition of metastatic cell colonization in murine lungs and tumor-induced morbidity by non-peptidic Arg-Gly-Asp mimetics.
Topics: Animals; Cell Adhesion; Dipeptides; Female; Fibronectins; Glycoproteins; Guanidines; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Valerates; Vitronectin | 1993 |
Bioactive Arg-Gly-Asp conformations in anti-integrin GPIIb-IIIa antibodies.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Binding, Competitive; Cell Adhesion; Immunoglobulin Fragments; Integrins; Melanoma, Experimental; Models, Molecular; Molecular Mimicry; Molecular Probes; Molecular Sequence Data; Oligopeptides; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Structure, Secondary; Receptors, Cytoadhesin; Structure-Activity Relationship | 1994 |
Tumor cell binding and induction of endothelial cell tumoricidal activity in vitro by muramyl dipeptide is enhanced by liposomal encapsulation.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Cell Adhesion; Cells, Cultured; Cytotoxicity, Immunologic; Endothelium, Vascular; Liposomes; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nitric Oxide; Oligopeptides; Phagocytosis; Phospholipids; Rats | 1994 |
Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Breast; Cell Adhesion; Collagen; Epithelial Cells; Epithelium; Female; Fibrosarcoma; Glioma; Humans; Integrins; Melanoma; Melanoma, Experimental; Mice; Molecular Sequence Data; Oligopeptides; Protein Binding; Rats; Receptors, Cell Surface; Receptors, Collagen; Rhabdomyosarcoma; Skin Neoplasms; Tumor Cells, Cultured | 1993 |
Overcoming the metastasis-enhancing potential of human tumor necrosis factor alpha by introducing the cell-adhesive Arg-Gly-Asp sequence.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Adhesion; Cell Death; Fibrosarcoma; Humans; Lung Neoplasms; Lymphatic Metastasis; Melanoma, Experimental; Mice; Molecular Sequence Data; Mutagenesis, Insertional; Neoplasm Metastasis; Oligopeptides; Recombinant Fusion Proteins; Skin Neoplasms; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Liposomal Arg-Gly-Asp analogs effectively inhibit metastatic B16 melanoma colonization in murine lungs.
Topics: Amino Acid Sequence; Animals; Drug Carriers; Liposomes; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oligopeptides; Particle Size; Tumor Cells, Cultured | 1996 |
Organ-specific adhesion of neuroblastoma cells in vitro: correlation with their hepatic metastasis potential.
Topics: Animals; beta-Galactosidase; Cell Adhesion; Extracellular Matrix Proteins; Female; Fibronectins; Kidney; Liver; Liver Neoplasms; Lung; Melanoma, Experimental; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neuraminidase; Neuroblastoma; Oligopeptides; Organ Specificity; Spleen; Transplantation, Isogeneic; Tumor Cells, Cultured; Tunicamycin; Vitronectin | 1997 |
Alpha v integrins as receptors for tumor targeting by circulating ligands.
Topics: Amino Acid Sequence; Animals; Antigens, Viral; Bacteriophages; Breast Neoplasms; Drug Carriers; Female; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Neovascularization, Pathologic; Oligopeptides; Receptors, Vitronectin; Transplantation, Heterologous | 1997 |
Intravital videomicroscopic evidence for regulation of metastasis by the hepatic microvasculature: effects of interleukin-1alpha on metastasis and the location of B16F1 melanoma cell arrest.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Cycle; Interleukin-1; Liver; Liver Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Microcirculation; Neoplasm Metastasis; Oligopeptides; Video Recording | 1997 |
Amino acids and peptides. XXX. Preparation of Arg-Gly-Asp (RGD) hybrids with poly(ethylene glycol) analogs and their antimetastatic effect.
Topics: Animals; Antineoplastic Agents; Chromatography, Gel; Chromatography, High Pressure Liquid; Drug Delivery Systems; Humans; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplastic Stem Cells; Oligopeptides; Polyethylene Glycols; Tumor Cells, Cultured | 1997 |
A new pseudo-peptide of Arg-Gly-Asp (RGD) with inhibitory effect on tumor metastasis and enzymatic degradation of extracellular matrix.
Topics: Animals; Cell Adhesion; Cell Movement; Dose-Response Relationship, Drug; Extracellular Matrix; Female; Humans; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Oligopeptides; Specific Pathogen-Free Organisms; Tumor Cells, Cultured | 1998 |
Vaccination with B7-1+ tumor and anti-adhesion therapy with RGD pseudo-peptide (FC-336) efficiently induce anti-metastatic effect.
Topics: Animals; Antineoplastic Agents; B7-1 Antigen; Cancer Vaccines; Combined Modality Therapy; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Receptors, Immunologic; Specific Pathogen-Free Organisms; Tumor Cells, Cultured | 1998 |
Cooperation between thrombospondin-1 type 1 repeat peptides and alpha(v)beta(3) integrin ligands to promote melanoma cell spreading and focal adhesion kinase phosphorylation.
Topics: Amino Acid Sequence; Cell Adhesion; Cell Adhesion Molecules; Cell Size; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Heparan Sulfate Proteoglycans; Humans; Ligands; Melanoma, Experimental; Models, Biological; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Vitronectin; Repetitive Sequences, Amino Acid; Signal Transduction; Thrombospondin 1; Tumor Cells, Cultured; Vitronectin | 1999 |
Quantitative analysis of adhesion-mediated cell migration in three-dimensional gels of RGD-grafted collagen.
Topics: Animals; Biomedical Engineering; Cell Adhesion; Cell Movement; Collagen; Culture Media; Gels; Integrins; Melanoma, Experimental; Mice; Microscopy, Video; Oligopeptides; Tumor Cells, Cultured | 2000 |
Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis.
Topics: Animals; Antineoplastic Agents; Cell Adhesion; Cell Division; Collagen; Crotalid Venoms; Disintegrins; Dose-Response Relationship, Drug; Drug Combinations; Extracellular Matrix Proteins; Histocytochemistry; Laminin; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Transplantation; Oligopeptides; Peptide Fragments; Proteoglycans; Receptors, Vitronectin; Recombinant Proteins; Tumor Cells, Cultured | 2000 |
Liposomes modified with a synthetic Arg-Gly-Asp mimetic inhibit lung metastasis of B16BL6 melanoma cells.
Topics: Animals; Antineoplastic Agents; Cell Adhesion; Drug Carriers; Fibronectins; Liposomes; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oligopeptides; Phosphatidylethanolamines; Tumor Cells, Cultured | 2000 |
Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics.
Topics: Animals; Extracellular Matrix Proteins; Glycosylation; Humans; Integrins; Iodine Radioisotopes; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Oligopeptides; Osteosarcoma; Radionuclide Imaging; Receptors, Vitronectin | 2001 |
Domain IVa of laminin alpha5 chain is cell-adhesive and binds beta1 and alphaVbeta3 integrins through Arg-Gly-Asp.
Topics: Animals; Binding Sites; Cell Adhesion; Cell Adhesion Molecules; Humans; Integrin beta1; Kidney; Laminin; Melanoma, Experimental; Mice; Muscle, Skeletal; Oligopeptides; Peptide Fragments; Protein Structure, Tertiary; Receptors, Vitronectin; Recombinant Proteins | 2001 |
Fiber-mutant technique can augment gene transduction efficacy and anti-tumor effects against established murine melanoma by cytokine-gene therapy using adenovirus vectors.
Topics: Adenoviridae; Animals; Antigens, Viral; Antineoplastic Agents; Capsid; Capsid Proteins; Drug Delivery Systems; Female; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Luciferases; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mutation; Oligopeptides; Receptors, Virus; Skin Neoplasms; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase.
Topics: Adenoviridae; Animals; Antiviral Agents; Capsid; Capsid Proteins; Cell Survival; Female; Ganciclovir; Genetic Therapy; Genetic Vectors; Humans; Integrins; Liver; Luciferases; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Transplantation; Oligopeptides; Receptors, Vitronectin; Simplexvirus; Thymidine Kinase | 2002 |
Synthesis and preliminary biological assessments of RGD bearing biocompatible telomers.
Topics: Acetylation; Animals; Biocompatible Materials; Drug Carriers; Iodine Radioisotopes; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oligopeptides; Radionuclide Imaging; Telomere; Tissue Distribution | 2002 |
Tumor necrosis factor alpha-gene therapy for an established murine melanoma using RGD (Arg-Gly-Asp) fiber-mutant adenovirus vectors.
Topics: Adenoviridae; Animals; Antibodies, Monoclonal; Cell Line, Tumor; Cricetinae; Enterovirus; Flow Cytometry; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; HeLa Cells; Humans; Integrin alphaV; Lac Operon; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mutation; Necrosis; Oligopeptides; Polymerase Chain Reaction; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Necrosis Factor-alpha | 2002 |
Inhibition of murine melanoma cell-matrix adhesion and experimental metastasis by albolabrin, an RGD-containing peptide isolated from the venom of Trimeresurus albolabris.
Topics: Animals; Cell Adhesion; Crotalid Venoms; Fibronectins; Integrins; Laminin; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oligopeptides; Peptides; Platelet Aggregation Inhibitors; Snake Venoms; Tumor Cells, Cultured | 1991 |
Inhibition of tumour cell adhesion by anti-metastatic polypeptide containing a repetitive Arg-Gly-Asp sequence.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Female; Fibronectins; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Neoplasm Metastasis; Oligopeptides; Peptides; Repetitive Sequences, Nucleic Acid; Substrate Specificity; Tumor Cells, Cultured | 1989 |
Type IV collagen-mediated melanoma cell adhesion and migration: involvement of multiple, distinct domains of the collagen molecule.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cell Membrane; Cell Movement; Collagen; Melanoma, Experimental; Mice; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Tumor Cells, Cultured | 1989 |
Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences.
Topics: Amino Acid Sequence; Animals; Blood Platelets; Cell Adhesion; Cell Adhesion Molecules; Female; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligopeptides | 1989 |