arginine-aspartate and Alcoholism

Oral arginine aspartate treatment effects (acute administration: 1 g 30 minutes after load, chronic administration: 0.33 g a day during 9 months) are researched on rabbit acute alcoholizing load (1 ml alcohol 40 degrees/100 g) and alcohol chronic intoxication (0,5 ml alcohol 40 degrees/100 g a day during 9 months). 1) Arginine aspartate acute administration decreases 6 h alcoholemic rates, when compared to normals T + t receiving an equal nutritional placebo at 30 minutes (p < 0.01), without 1 h peak modification, and increases ethyloxydation coefficient (p < 0,01). Aspartate, arginine or pyruvate isolated administration at 30 minutes, increases ethyloxydation coefficient in following order: arginine (no significant difference with T + t), pyruvate + arginine and pyruvate (limit p 0,10 or p < 0,05), aspartate (p < 0,05). It is maximum with arginine aspartate (p < 0.01). 2) Arginine aspartate chronic administration partially reduces hyperalcoholemy (p < 0,01) and hypertriglyceridemy (p < 0.10), strongly increased in non treated alcoholized (p < 0.01). Transaminases rates, which remained about normal in non treated alcoholized, decrease under same time alcoholized (p < 0,10) and 0 values (p < 0.05). Hepatic histology shows, after 9 months, in alcoholized group, inflammatory oedema with some cellular damage, without steatosis. Arginine aspartate seems to provoke some hepatic protection with cellular regeneration.

Topics: Alcoholic Intoxication; Alcoholism; Animals; Arginine; Aspartic Acid; Drug Interactions; Ethanol; Female; Humans; Male; Rabbits; Time Factors; Triglycerides