arginine and Malignant Melanoma

arginine has been researched along with Malignant Melanoma in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (13.64)	18.7374
1990's	7 (10.61)	18.2507
2000's	18 (27.27)	29.6817
2010's	23 (34.85)	24.3611
2020's	9 (13.64)	2.80

Authors

Authors	Studies
Du, YZ; Guo, X; Jiang, M; Li, Q; Li, X; Liu, H; Liu, X; Lu, Y; Luo, L; Luo, Z; Qin, B; Wang, S; You, J; Zhang, J	1
Joo, J; Kim, S; Lee, H; Park, G; Park, HH; Park, TH; Son, B	1
Grabacka, M; Plonka, PM; Reiss, K	1
Aguiar, RB; Alves, WA; Hamley, IW; Mello, LR; Moraes, JZ; Reza, M; Ruokolainen, J; Silva, ER; Yamada, RY	1
Abdollahi, S; Ghasemi, Y; Irajie, C; Morowvat, MH; Najafipour, S; Savardashtaki, A; Zarei, M	1
Arcisio-Miranda, M; da Silva, AMB; de Almeida, MTG; de Souza, BM; Dos Santos Cabrera, MP; Martins, DB; Pacca, CC; Palma, MS	1
Bedogni, B; Boland, GM; Chang, M; Flaherty, K; Frederick, DT; Freitas, JT; Gao, M; Herlyn, M; Li, Y; Lu, Y; Marusak, C; Miao, B; Mills, GB; Moll, T; Sullivan, RJ; Tan, J; Thakur, V; Thakur, VS; Xiao, M; Zhang, G; Zmina, PM	1
Bessudo, A; Cheng, PNM; Liu, AM; Mussai, F	1
Feun, LG; Kuo, MT; Li, YY; Nguyen, D; Savaraj, N; Wangpaichitr, M; Wu, C; You, M	1
Barska, M; Bobak, Y; Chen, O; Igumentseva, N; Karatsai, O; Lyniv, L; Mayevska, O; Pavlyk, I; Redowicz, MJ; Rzhepetskyy, Y; Stasyk, O	1
Chen, SM; Feun, LG; Han, X; Kuo, MT; Li, YY; Prince, J; Savaraj, N; Shah, SS; Suarez, M; Wangpaichitr, M; Wu, C	1
Beggs, A; Bessudo, A; Cheng, P; De Santo, C; Egan, S; Mussai, F	1
Bøe, SL; Hovig, E; Jørgensen, JA; Longva, AS	1
Allegra, M; Bahadoran, P; Ballotti, R; Giacchero, D; Hofman, P; Lacour, JP; Le Duff, F; Long-Mira, E; Passeron, T	1
Feun, LG; Kuo, MT; Long, Y; Savaraj, N; Tsai, WB; Tsukamoto, T; Wangpaichitr, M	1
Bernhagen, J; Cheng, F; Lue, H; Schwaneberg, U; Zhu, L	1
Bernhagen, J; Cheng, F; Kardashliev, T; Lue, H; Pitzler, C; Schwaneberg, U; Shehzad, A; Zhu, L	1
Bomalaski, J; Feun, LG; He, W; Kuo, MT; Li, YY; Savaraj, N; Wangpaichitr, M; Wu, C; You, M	1
Kardos, GR; Robertson, GP	1
Chen, SM; Feun, LG; Kuo, MT; Li, YY; Prince, J; Savaraj, N; Shah, SS; Suarez, M; Wangpaichitr, M; Wu, C	1
Duncan, B; Hou, S; Jeong, Y; Jiang, Y; Kim, C; Kim, CS; Kim, ST; Park, MH; Rotello, VM; Saha, K; Tang, R; Yan, B; Yeh, YC	1
Bayles, I; Bedogni, B; Chang, M; Gao, M; Gooyit, M; Ma, J; Marusak, C	1
Chu, CC; Ji, Y; Zhao, J	1
Bannink, M; Eggermont, AM; Fekkes, D; Hengeveld, MW; Kruit, WH; Sleijfer, S; Stoter, G; van der Holt, B; Van Gool, AR	1
Jarmalavicius, S; Trefzer, U; Walden, P	1
Aiba, I; Feun, L; Kuo, MT; Lee, SY; Savaraj, N; Tsai, WB	1
Harashima, H; Hatakeyama, H; Hida, K; Ohga, N; Takara, K	1
Feun, LG; Kuo, MT; Savaraj, N; Wangpaichitr, M; Wu, C; You, M	1
Beloor, J; Choi, CS; Jackson, A; Kim, SH; Kim, SW; Kumar, P; Lee, KY; Lee, SK; Nam, HY; Park, M	1
Bomalaski, J; Elgart, G; Feun, LG; Jungbluth, AA; Kuo, MT; Marini, A; Moffat, F; Rodgers, SE; Savaraj, N; Sisson, W; Walker, G; Wangpaichitr, M; Wu, CJ; You, M	1
Feun, L; Kuo, MT; Nguyen, DM; Savaraj, N; Varona-Santos, J; Wangpaichitr, M; Wu, C; You, M	1
Ji, H; Meyskens, FL; Misner, B; Poulos, TL; Silverman, RB; Yang, S; Yang, Z	1
Clements, A; Kefford, RF; Klein, O; Long, GV; Menzies, AM; O'Toole, S	1
Bosserhoff, AK; Hellerbrand, C; Limm, K; Mueller, DW; Oefner, P; Ott, C; Wallner, S	1
Bomalaski, JS; Clark, MA; Ensor, CM; Holtsberg, FW	1
García-Borrón, JC; Ghanem, G; Haycock, J; Jiménez-Cervantes, C; Lozano Teruel, JA; Olivares Sánchez, C; Sánchez Más, J	1
Boyle, GM; Brown, DL; Chen, W; Cook, AL; Leonard, JH; Marks, LH; Parsons, PG; Smit, DJ; Stow, JL; Sturm, RA	1
Engelhard, VH; Ostankovitch, M; Robila, V	1
Bauer, UM; Behrmann, I; Haan, S; Heinrich, PC; Komyod, W	1
Ascierto, PA; Beneduce, G; Bomalaski, JS; Castello, G; Clark, MA; Daponte, A; De Rosa, V; Ensor, CM; Feun, LG; Holtsberg, FW; Izzo, F; Logan, TF; Melucci, MT; Ottaiano, A; Prestayko, AW; Savaraj, N; Scala, S; Simeone, E	1
Bannink, M; Eggermont, AM; Fekkes, D; Kruit, WH; Mulder, PG; Sleijfer, S; Stoter, G; Van Gool, AR	1
Feun, L; Savaraj, N	1
Bianchini, F; Calorini, L; Franchi, A; Ketabchi, S; Marconi, C; Massi, D; Miracco, C; Paglierani, M; Santucci, M	1
Miao, Y; Quinn, TP; Shelton, T	1
Bowen, G; Cannon-Albright, LA; Chen, W; Eliason, MJ; Florell, SR; Hansen, CB; Harris, RM; Hart, M; Leachman, SA; Porter-Gill, P; Sturm, RA; Swinyer, L	1
Feun, L; Kuo, MT; Savaraj, N; Spector, S; Wangpaichitr, M; Wu, CJ; You, M	1
Ambrogio, C; Gasic, G; Karpatkin, S; Pearlstein, E	1
Doré, JF; Quash, GA; Thomasset, N	1
Joshi, M	1
Arden, KC; Cavenee, WK; Gutzmer, R; Herbst, RA; Kapp, A; Matiaske, F; Mommert, S; Weiss, J	1
Ceha, HM; Medema, RH; Nasser, I; Slebos, RJ	1
de la Cuesta, RS; Donahoe, PK; Kurian, MS; MacLaughlin, DT; Manganaro, TF; Waneck, GL	1
Cerottini, JC; Men, Y; Miconnet, I; Rimoldi, D; Romero, P; Valmori, D	1
Chidambaram, A; Fraser, MC; Goldstein, AM; Struewing, JP; Tucker, MA	1
Pham, HT; Ruediger, R; Walter, G	1
Bendahl, PO; Borg , A; Hansson, J; Hashemi, J; Ingvar, C; Linder, S; Olsson, H; Platz, A; Sandberg, T; Stierner, U	1
Xu, Q; Zhang, XM	1
Baranowski, RL; Hibbs, JB; Kablitz, C; Kushner, JP; McMurry, MP; Menlove, RL; Taintor, R; Vavrin, Z; Ward, JH; Westenfelder, C	1
Hirai, Y; Kamogashira, T; Masui, Y; Mizuno, K; Nagamura, K; Nakai, S; Ohmoto, Y; Sakaguchi, M; Shimizu, R	1
Bertelli, R; Cornaglia-Ferraris, P; Knight, RA; Melino, G; Melodia, A; Perezzani, L	1
Vester, F	1
Campbell, ED; Carter, WH; Stablein, DM; Wampler, GL	1
Beijnen, JH; Boogerd, W; Nooijen, WJ; van Tellingen, O	1
Adamson, RH; Mead, JA; Sieber, SM	1
Bellet, RE; Berd, D; Catalno, RB; Koons, LS; Mastrangelo, MJ	1
Lönn, S; Lönn, U; Nylen, U; Winblad, G	1

Reviews

7 review(s) available for arginine and Malignant Melanoma

Article	Year
Enhancing the Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Signaling and Arginine Deprivation in Melanoma. International journal of molecular sciences, 2021, Jul-16, Volume: 22, Issue:14 Topics: Apoptosis; Arginine; Autophagy; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Hydrolases; Melanoma; Polyethylene Glycols; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand	2021
Therapeutic interventions to disrupt the protein synthetic machinery in melanoma. Pigment cell & melanoma research, 2015, Volume: 28, Issue:5 Topics: Amino Acids; Animals; Antineoplastic Agents; Arginine; Cell Proliferation; DNA, Ribosomal; Drug Resistance, Neoplasm; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Melanoma; Mice; Oligonucleotides; Phosphatidylinositol 3-Kinases; Proline; Protein Biosynthesis; Ribosomal Proteins; RNA, Messenger; Signal Transduction; Skin Neoplasms	2015
Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma. Current molecular medicine, 2010, Volume: 10, Issue:4 Topics: Apoptosis; Arginine; Argininosuccinate Synthase; Autophagy; Humans; Hydrolases; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Melanoma; Models, Biological; Polyethylene Glycols; Protein Serine-Threonine Kinases; Signal Transduction; TOR Serine-Threonine Kinases	2010
Pegylated arginine deiminase: a novel anticancer enzyme agent. Expert opinion on investigational drugs, 2006, Volume: 15, Issue:7 Topics: Amino Acid Sequence; Amino Acids; Animals; Antineoplastic Agents; Arginine; Argininosuccinate Synthase; Carcinoma, Hepatocellular; Citrulline; Clinical Trials as Topic; Dexamethasone; Dogs; Drug Screening Assays, Antitumor; Drug Synergism; Drugs, Investigational; Humans; Hydrolases; Liver Neoplasms; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Molecular Sequence Data; Mycoplasma hominis; Neoplasm Proteins; Neoplasms; Nutritional Requirements; Polyethylene Glycols; Rabbits; Randomized Controlled Trials as Topic; Recombinant Proteins; Skin Neoplasms; Species Specificity; Treatment Outcome	2006
Arginine deprivation as a targeted therapy for cancer. Current pharmaceutical design, 2008, Volume: 14, Issue:11 Topics: Animals; Antineoplastic Agents; Arginine; Argininosuccinate Synthase; Carcinoma, Hepatocellular; Clinical Trials as Topic; Drug Delivery Systems; Gene Expression Regulation, Neoplastic; Humans; Hydrolases; Liver Neoplasms; Melanoma; Polyethylene Glycols; Skin Neoplasms	2008
The importance of L-arginine metabolism in melanoma: an hypothesis for the role of nitric oxide and polyamines in tumor angiogenesis. Free radical biology & medicine, 1997, Volume: 22, Issue:3 Topics: Arginine; Humans; Melanoma; Models, Biological; Neovascularization, Pathologic; Nitric Oxide; Polyamines; Skin	1997
Pharmacology of antitumor agents from higher plants. Cancer treatment reports, 1976, Volume: 60, Issue:8 Topics: Animals; Antineoplastic Agents, Phytogenic; Aporphines; Camptothecin; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; Etoposide; Humans; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Maytansine; Melanoma; Naphthoquinones; Nasopharyngeal Neoplasms; Neoplasms; Neoplasms, Experimental; Phenanthrenes; Structure-Activity Relationship; Teniposide; Vinblastine; Vincristine	1976

Trials

5 trial(s) available for arginine and Malignant Melanoma

Article	Year
Safety, PK/PD and preliminary anti-tumor activities of pegylated recombinant human arginase 1 (BCT-100) in patients with advanced arginine auxotrophic tumors. Investigational new drugs, 2021, Volume: 39, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Arginase; Arginine; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Melanoma; Middle Aged; Prostatic Neoplasms, Castration-Resistant; Recombinant Proteins; Skin Neoplasms	2021
Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma. Journal of hematology & oncology, 2018, 05-18, Volume: 11, Issue:1 Topics: Aged; Antibodies; Arginase; Arginine; Citrullinemia; Drug Resistance; Humans; Immunotherapy; Male; Melanoma; Neoplasm Metastasis; Ornithine Carbamoyltransferase Deficiency Disease; Polyethylene Glycols; Remission Induction; Salvage Therapy; Treatment Failure	2018
Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Oct-20, Volume: 23, Issue:30 Topics: Adult; Aged; Aged, 80 and over; Arginine; Female; Humans; Hydrolases; Italy; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Nitric Oxide; Polyethylene Glycols; Skin Neoplasms; Survival Rate; Treatment Outcome; United States	2005
Influence of pegylated interferon-alpha therapy on plasma levels of citrulline and arginine in melanoma patients. Amino acids, 2007, Volume: 32, Issue:1 Topics: Antiviral Agents; Arginine; Citrulline; Female; Humans; Interferon alpha-2; Interferon-alpha; Male; Melanoma; Nitric Oxide; Polyethylene Glycols; Recombinant Proteins; Risk Factors; Time Factors	2007
Phase II trial of VM-26 in patients with metastatic malignant melanoma. Cancer treatment reports, 1978, Volume: 62, Issue:3 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Podophyllotoxin; Teniposide	1978

Other Studies

54 other study(ies) available for arginine and Malignant Melanoma

Article	Year
Arginine Supplementation Targeting Tumor-Killing Immune Cells Reconstructs the Tumor Microenvironment and Enhances the Antitumor Immune Response. ACS nano, 2022, 08-23, Volume: 16, Issue:8 Topics: Arginine; Cell Line, Tumor; Dietary Supplements; Humans; Immunity; Immunologic Factors; Immunotherapy; Melanoma; Tumor Microenvironment	2022
Enhancement of anti-tumor activity in melanoma using arginine deiminase fused with 30Kc19α protein. Applied microbiology and biotechnology, 2022, Volume: 106, Issue:22 Topics: Arginine; Argininosuccinate Synthase; Cell Line, Tumor; Escherichia coli; Humans; Hydrolases; Matrix Metalloproteinase 2; Melanoma; Polyethylene Glycols	2022
Melanoma-Time to fast or time to feast? An interplay between PPARs, metabolism and immunity. Experimental dermatology, 2020, Volume: 29, Issue:4 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Arginine; Cell Nucleus; Humans; Immune System; Immunotherapy; Inflammation; Melanocytes; Melanoma; Models, Theoretical; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; PPAR gamma; Signal Transduction; Skin Neoplasms; TOR Serine-Threonine Kinases; Tumor Microenvironment	2020
Amphipathic design dictates self-assembly, cytotoxicity and cell uptake of arginine-rich surfactant-like peptides. Journal of materials chemistry. B, 2020, 03-25, Volume: 8, Issue:12 Topics: Antineoplastic Agents; Arginine; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Hydrophobic and Hydrophilic Interactions; Melanoma; Particle Size; Peptides; Structure-Activity Relationship; Surface Properties; Tumor Cells, Cultured	2020
Amino Acids Sequence-based Analysis of Arginine Deiminase from Different Prokaryotic Organisms: An In Silico Approach. Recent patents on biotechnology, 2020, Volume: 14, Issue:3 Topics: Amino Acid Sequence; Antineoplastic Agents; Arginine; Bacteria; Bacterial Proteins; Carcinoma, Hepatocellular; Computational Biology; Computer Simulation; Conserved Sequence; Gene Expression; Humans; Hydrolases; Liver Neoplasms; Melanoma; Models, Molecular; Patents as Topic; Phylogeny; Polyethylene Glycols; Protein Interaction Domains and Motifs; Sequence Alignment; Sequence Homology, Amino Acid; Skin Neoplasms	2020
Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation. Amino acids, 2020, Volume: 52, Issue:5 Topics: Animals; Anti-Infective Agents; Antimicrobial Cationic Peptides; Antineoplastic Agents; Arginine; Candida; Cell Membrane; Hemolysis; Humans; Melanoma; Mice; Oligopeptides; Staphylococcus aureus; Streptococcus pneumoniae; Tryptophan	2020
Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 11-15, Volume: 26, Issue:22 Topics: Animals; Arginine; Cell Line, Tumor; Drug Resistance, Neoplasm; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Integrin beta1; Matrix Metalloproteinase 14; Melanoma; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Signal Transduction; Sulfones; Transforming Growth Factor beta; Vemurafenib	2020
Nitric oxide donor augments antineoplastic effects of arginine deprivation in human melanoma cells. Experimental cell research, 2017, 06-15, Volume: 355, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Arginine; Cell Proliferation; Cell Survival; Drug Therapy, Combination; Humans; Melanoma; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Structure-Activity Relationship; Tumor Cells, Cultured	2017
Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation. Molecular oncology, 2017, Volume: 11, Issue:12 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Arginine; Autophagy; Cell Line, Tumor; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Humans; Melanoma; Mice, Nude; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Proteolysis; Proto-Oncogene Proteins B-raf; Ubiquitin-Protein Ligases; Ubiquitins	2017
Evaluation of biodegradable peptide carriers for light-directed targeting. Nucleic acid therapeutics, 2013, Volume: 23, Issue:2 Topics: Arginine; Cell Line, Tumor; Cell Survival; Endosomes; Genetic Therapy; Humans; Light; Lysine; Melanoma; Molecular Targeted Therapy; Nucleic Acids; Peptides; Photosensitizing Agents; RNA, Small Interfering; Transfection	2013
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Jul-01, Volume: 31, Issue:19 Topics: Aged; Antineoplastic Agents; Arginine; Back; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Indoles; Leucine; Lung Neoplasms; MAP Kinase Signaling System; Melanoma; Niacinamide; Oximes; Phenylurea Compounds; Point Mutation; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sorafenib; Sulfonamides; Vemurafenib	2013
Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction. Molecular cancer therapeutics, 2013, Volume: 12, Issue:11 Topics: Arginine; Argininosuccinate Synthase; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glucose; Glutamine; Humans; Hydrolases; Lipids; Melanoma; Phosphatidylinositol 3-Kinases; Polyethylene Glycols; Proto-Oncogene Proteins c-myc; Signal Transduction; Transfection	2013
Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas. Applied microbiology and biotechnology, 2015, Volume: 99, Issue:3 Topics: Ammonia; Antineoplastic Agents; Arginine; Cell Line, Tumor; Directed Molecular Evolution; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Humans; Hydrolases; Inhibitory Concentration 50; Kinetics; Melanoma; Mutagenesis; Pseudomonas	2015
A Competitive Flow Cytometry Screening System for Directed Evolution of Therapeutic Enzyme. ACS synthetic biology, 2015, Jul-17, Volume: 4, Issue:7 Topics: Arginine; Cell Line, Tumor; Directed Molecular Evolution; Flow Cytometry; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Hydrolases; Melanoma; Mutation; Protein Engineering; Pseudomonas; Skin Neoplasms	2015
Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin. Oncotarget, 2015, Mar-20, Volume: 6, Issue:8 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arginine; Argininosuccinate Synthase; Cell Line, Tumor; Cisplatin; Citrullinemia; Female; Humans; Hydrolases; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Polyethylene Glycols; Xenograft Model Antitumor Assays	2015
BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma. Oncotarget, 2016, Apr-05, Volume: 7, Issue:14 Topics: Animals; Apoptosis; Arginine; Autophagy; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Melanoma; Mice; Mice, Nude; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Xenograft Model Antitumor Assays	2016
Nanoparticle-dendrimer hybrid nanocapsules for therapeutic delivery. Nanomedicine (London, England), 2016, Volume: 11, Issue:12 Topics: Animals; Antineoplastic Agents, Phytogenic; Arginine; Cell Line, Tumor; Cell Survival; Delayed-Action Preparations; Dendrimers; Female; Gold; Melanoma; Mice; Mice, Inbred C57BL; Nanocapsules; Nanoparticles; Paclitaxel; Thiocarbamates	2016
The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination. Pharmacological research, 2016, Volume: 113, Issue:Pt A Topics: Animals; Arginine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Male; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Melanoma; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Metastasis; Sulfides; Sulfones	2016
Biodegradable nanocomplex from hyaluronic acid and arginine based poly(ester amide)s as the delivery vehicles for improved photodynamic therapy of multidrug resistant tumor cells: An in vitro study of the performance of chlorin e6 photosensitizer. Journal of biomedical materials research. Part A, 2017, Volume: 105, Issue:5 Topics: Arginine; Biodegradable Plastics; Cell Line, Tumor; Chlorophyllides; Drug Carriers; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Hyaluronic Acid; Melanoma; Photosensitizing Agents; Polyesters; Porphyrins	2017
Nitric oxide production and monoamine oxidase activity in cancer patients during interferon-alpha therapy. Amino acids, 2009, Volume: 37, Issue:4 Topics: Adult; Aged; Arginine; Blood Platelets; Carcinoma, Renal Cell; Citrulline; Female; Humans; Interferon-alpha; Kidney Neoplasms; Male; Melanoma; Middle Aged; Monoamine Oxidase; Nitrates; Nitric Oxide; Nitrites; Prospective Studies; Skin Neoplasms	2009
Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:3 Topics: Arginine; Cell Line, Tumor; Cells, Cultured; Chromatography, High Pressure Liquid; HLA-A Antigens; HLA-A11 Antigen; Humans; Intracellular Signaling Peptides and Proteins; Leukocytes, Mononuclear; Mass Spectrometry; Melanoma; Methylation; Protein Binding; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; T-Lymphocytes	2010
Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4. Molecular cancer therapeutics, 2009, Volume: 8, Issue:12 Topics: Arginine; Argininosuccinate Synthase; Base Sequence; Binding Sites; Cell Line, Tumor; Chromatin Immunoprecipitation; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydrolases; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Melanoma; Polyethylene Glycols; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-myc; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sp4 Transcription Factor	2009
Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake. International journal of pharmaceutics, 2010, Aug-30, Volume: 396, Issue:1-2 Topics: Animals; Arginine; Biological Transport; CD13 Antigens; Cell Membrane Permeability; Cells, Cultured; Chemistry, Pharmaceutical; Drug Carriers; Drug Compounding; Endothelial Cells; Ligands; Liposomes; Melanoma; Mice; Mice, Nude; Nanotechnology; Oligopeptides; Particle Size; Polyethylene Glycols; Stearates; Technology, Pharmaceutical	2010
Arginine-engrafted biodegradable polymer for the systemic delivery of therapeutic siRNA. Biomaterials, 2012, Volume: 33, Issue:5 Topics: Animals; Arginine; Biocompatible Materials; Cell Line, Tumor; Cell Proliferation; Chemical Phenomena; Disease Models, Animal; Gene Knockdown Techniques; Gene Silencing; Gene Transfer Techniques; Melanoma; Mice; Polymers; RNA, Small Interfering	2012
Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase. British journal of cancer, 2012, Apr-24, Volume: 106, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Arginine; Argininosuccinate Synthase; Female; Humans; Hydrolases; Liver Neoplasms; Lung Neoplasms; Male; Melanoma; Middle Aged; Polyethylene Glycols; Skin Neoplasms; Survival Rate; Treatment Outcome	2012
TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation. Molecular and cellular biochemistry, 2013, Volume: 374, Issue:1-2 Topics: Apoptosis; Apoptosis Regulatory Proteins; Arginine; Autophagy; Autophagy-Related Protein 5; Beclin-1; Calpain; Caspase 10; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Enzyme Activation; Humans; Hydrolases; Melanoma; Membrane Proteins; Microtubule-Associated Proteins; Polyethylene Glycols; TNF-Related Apoptosis-Inducing Ligand	2013
Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma. Antioxidants & redox signaling, 2013, Aug-10, Volume: 19, Issue:5 Topics: Animals; Arginine; Blotting, Western; Cell Line; Cells, Cultured; Enzyme Inhibitors; Humans; Male; Melanocytes; Melanoma; Mice; Mice, Nude; Nitric Oxide; Nitric Oxide Synthase Type I; RNA, Small Interfering; Tumor Cells, Cultured; Ultraviolet Rays	2013
BRAF inhibitor activity in V600R metastatic melanoma. European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Antineoplastic Agents; Arginine; Compassionate Use Trials; Female; Humans; Imidazoles; Male; Melanoma; Middle Aged; Mutation, Missense; Neoplasm Metastasis; Oximes; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Valine; Young Adult	2013
Deregulation of protein methylation in melanoma. European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:6 Topics: Arginine; Cell Line, Tumor; Deoxyadenosines; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunohistochemistry; Melanoma; Methylation; Nuclear Proteins; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Polymerase Chain Reaction; Thionucleosides	2013
Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo. Cancer research, 2002, Oct-01, Volume: 62, Issue:19 Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Carcinoma, Hepatocellular; Female; Humans; Hydrolases; Liver Neoplasms; Melanoma; Mice; Mice, Nude; Mice, SCID; Polyethylene Glycols; RNA, Messenger; Substrate Specificity; Succinimides; Transfection; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2002
Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function. European journal of biochemistry, 2002, Volume: 269, Issue:24 Topics: Alleles; Amino Acid Sequence; Animals; Arginine; Blotting, Western; Cell Line; Cell Membrane; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; DNA, Complementary; Dose-Response Relationship, Drug; Heterozygote; Homozygote; Humans; Leucine; Melanoma; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Protein Structure, Tertiary; Receptors, Corticotropin; Receptors, Melanocortin; Sequence Homology, Amino Acid; Structure-Activity Relationship; Tumor Cells, Cultured; Ultraviolet Rays	2002
Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: pigmentation marker, ultrastructural and UV-survival studies. Pigment cell research, 2003, Volume: 16, Issue:3 Topics: Alleles; alpha-MSH; Antigens; Arginine; Cell Survival; Cells, Cultured; Cystine; Dihydroxyphenylalanine; DNA; Genetic Markers; Genotype; Heterozygote; Homozygote; Humans; Male; Melanins; Melanocytes; Melanoma; Melanosomes; Microscopy, Electron; Microscopy, Fluorescence; Monophenol Monooxygenase; Phenotype; Pigmentation; Tryptophan; Ultraviolet Rays	2003
Regulated folding of tyrosinase in the endoplasmic reticulum demonstrates that misfolded full-length proteins are efficient substrates for class I processing and presentation. Journal of immunology (Baltimore, Md. : 1950), 2005, Mar-01, Volume: 174, Issue:5 Topics: Alanine; Amino Acid Substitution; Animals; Antigen Presentation; Arginine; Cell Line; Cell Line, Tumor; Endoplasmic Reticulum; Epitopes; Glutamine; Histocompatibility Antigens Class I; Intracellular Fluid; Melanoma; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Folding; Protein Processing, Post-Translational; Protein Transport; Substrate Specificity; Threonine; Transfection; Tyrosine	2005
Are STATS arginine-methylated? The Journal of biological chemistry, 2005, Jun-10, Volume: 280, Issue:23 Topics: Animals; Arginine; Blotting, Western; Cell Line, Tumor; DNA-Binding Proteins; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glutathione Transferase; Humans; Immunoprecipitation; Interferon-alpha; Interferons; Interleukin-6; Lysine; Melanoma; Methylation; Methyltransferases; Mice; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Oncostatin M; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphatidylinositol 3-Kinases; Plasmids; Protein Structure, Tertiary; Receptors, Interleukin-6; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrosine	2005
Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors. Human pathology, 2007, Volume: 38, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arginase; Arginine; Cell Line, Tumor; Female; Humans; Macrophages; Male; Melanoma; Mice; Middle Aged; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Retrospective Studies; RNA, Messenger; Skin Neoplasms	2007
Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. Cancer biotherapy & radiopharmaceuticals, 2007, Volume: 22, Issue:3 Topics: alpha-MSH; Animals; Arginine; Chelating Agents; Disease Models, Animal; Heterocyclic Compounds, 1-Ring; Kidney; Lutetium; Melanoma; Mice; Radiography; Radioisotopes; Survival Analysis	2007
Multiple primary melanomas in a CDKN2A mutation carrier exposed to ionizing radiation. Archives of dermatology, 2007, Volume: 143, Issue:11 Topics: 5' Untranslated Regions; Adult; Arginine; Cysteine; Environmental Exposure; Female; Genes, p16; Genetic Predisposition to Disease; Hair Color; Heterozygote; Humans; Melanoma; Mutation; Neoplasms, Multiple Primary; Neoplasms, Radiation-Induced; Nuclear Weapons; Receptor, Melanocortin, Type 1; Skin Neoplasms	2007
Inhibition of the platelet-aggregating activity of two human adenocarcinomas of the colon and an anaplastic murine tumor with a specific thrombin inhibitor: dansylarginine N-(3-ethyl-1, 5-pentanediyl)amide. Progress in clinical and biological research, 1982, Volume: 89 Topics: Adenocarcinoma; Animals; Arginine; Cell Line; Cell Transformation, Viral; Colonic Neoplasms; Complement Inactivator Proteins; Dansyl Compounds; Humans; Melanoma; Mice; Neoplasm Metastasis; Neoplasms, Experimental; Platelet Aggregation; Rabbits; Simian virus 40	1982
The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines. FEBS letters, 1982, Nov-01, Volume: 148, Issue:1 Topics: Amidinotransferases; Arginase; Arginine; Cell Line; Glycine; Humans; Hydrogen-Ion Concentration; Melanoma; Ornithine; Urea	1982
Further evidence for ultraviolet light induction of CDKN2 (p16INK4) mutations in sporadic melanoma in vivo. The Journal of investigative dermatology, 1997, Volume: 108, Issue:6 Topics: Alanine; Alleles; Arginine; Carrier Proteins; Cyclin-Dependent Kinase Inhibitor p16; DNA, Neoplasm; Enzyme Inhibitors; Exons; Heterozygote; Humans; Leucine; Melanoma; Mutation; Polymerase Chain Reaction; Skin; Skin Neoplasms; Ultraviolet Rays; Valine	1997
Several noncontiguous domains of CDK4 are involved in binding to the P16 tumor suppressor protein. Biochemical and biophysical research communications, 1998, Aug-19, Volume: 249, Issue:2 Topics: Arginine; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Cysteine; Glutathione Transferase; Humans; Melanoma; Mutagenesis, Site-Directed; Mutation; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Structure-Activity Relationship; Tyrosine	1998
Cleavage of Müllerian inhibiting substance activates antiproliferative effects in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:3 Topics: Animals; Anti-Mullerian Hormone; Arginine; Cell Division; Eye Neoplasms; Female; Fibrinolysin; Glycoproteins; Growth Inhibitors; Humans; Lung Neoplasms; Male; Melanoma; Mice; Mice, SCID; Mullerian Ducts; Mutagenesis, Site-Directed; Recombinant Proteins; Serine; Testicular Hormones; Transfection; Tumor Cells, Cultured	1995
Assessment of immunogenicity of human Melan-A peptide analogues in HLA-A0201/Kb transgenic mice. Journal of immunology (Baltimore, Md. : 1950), 1999, Mar-15, Volume: 162, Issue:6* Topics: Alleles; Animals; Antigens, Neoplasm; Arginine; Cell Line; Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte; H-2 Antigens; HLA-A Antigens; Humans; Injections, Subcutaneous; Leucine; Lymphocyte Activation; MART-1 Antigen; Melanoma; Mice; Mice, Transgenic; Neoplasm Proteins; Oligopeptides; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer; Tumor Cells, Cultured	1999
Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations. Journal of the National Cancer Institute, 2000, Jun-21, Volume: 92, Issue:12 Topics: Adolescent; Adult; Age Factors; Aged; Arginine; Aspartic Acid; Cyclin-Dependent Kinases; Cysteine; Genes, p16; Genotype; Germ-Line Mutation; Glycine; Haplotypes; Humans; Melanoma; Middle Aged; Nevus; Pancreatic Neoplasms; Phenotype; Skin Neoplasms; Statistics, Nonparametric; Tryptophan; United States; Valine	2000
Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene. Oncogene, 2001, Jan-04, Volume: 20, Issue:1 Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Breast Neoplasms; Female; Glutamic Acid; Glycine; Humans; Lung Neoplasms; Melanoma; Molecular Sequence Data; Neoplasms; Peptide Fragments; Phosphoprotein Phosphatases; Point Mutation; Protein Binding; Protein Phosphatase 2; Protein Structure, Secondary; Tryptophan	2001
Haplotype analysis and age estimation of the 113insR CDKN2A founder mutation in Swedish melanoma families. Genes, chromosomes & cancer, 2001, Volume: 31, Issue:2 Topics: Alleles; Arginine; Female; Founder Effect; Gene Frequency; Genes, p16; Genetic Carrier Screening; Haplotypes; Humans; Likelihood Functions; Male; Melanoma; Mutagenesis, Insertional; Mutation; Sweden	2001
Metastatic melanoma cells escape from immunosurveillance through the novel mechanism of releasing nitric oxide to induce dysfunction of immunocytes. Melanoma research, 2001, Volume: 11, Issue:6 Topics: Animals; Arginine; Blotting, Western; Coculture Techniques; Concanavalin A; Cytotoxicity Tests, Immunologic; Female; Lipopolysaccharides; Lung Neoplasms; Lymphocyte Activation; Male; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; T-Lymphocytes; Tumor Cells, Cultured; Tumor Escape	2001
Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy. The Journal of clinical investigation, 1992, Volume: 89, Issue:3 Topics: Adult; Arginine; Carcinoma, Renal Cell; Female; Humans; Interferon-gamma; Interleukin-2; Kidney Neoplasms; Kidney Tubules; Male; Melanoma; Middle Aged; Nitric Oxide; Vascular Resistance	1992
Site-specific mutagenesis of the human interleukin-1 beta gene: the role of arginine residue at the N-terminal region. Journal of biochemistry, 1988, Volume: 104, Issue:5 Topics: Arginine; Binding Sites; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Interleukin-1; Melanoma; Mutation; Tumor Cells, Cultured	1988
In vitro response to mitogens and antigens in elderly and post-cytotoxic patients can be modified by a new hypoxanthine derivative (PCF-39). Bollettino dell'Istituto sieroterapico milanese, 1987, Volume: 66, Issue:6 Topics: Aged; Aging; Antineoplastic Agents; Arginine; Diabetes Mellitus, Type 2; Humans; Hypoxanthines; Immunity, Cellular; Lymphocyte Activation; Melanoma; Phytohemagglutinins	1987
Amino acid pattern and malignant growth. Biochimica et biophysica acta, 1965, Jun-15, Volume: 104, Issue:1 Topics: Amino Acids; Animals; Antineoplastic Agents; Arginine; Fishes; Histones; In Vitro Techniques; Melanoma; Mistletoe; Neoplasms, Experimental; Nucleic Acids; Plant Proteins; Plants, Medicinal; Taurine	1965
Drug activity and therapeutic synergism in cancer treatment. Cancer research, 1982, Volume: 42, Issue:8 Topics: Animals; Antineoplastic Agents; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Humans; Hydroxamic Acids; Lung Neoplasms; Male; Melanoma; Mice; Mitomycin; Mitomycins; Neoplasms; Neoplasms, Experimental; Rats; Razoxane; Teniposide	1982
The vascular compartment hampers accurate determination of teniposide penetration into brain tumor tissue. Cancer chemotherapy and pharmacology, 1997, Volume: 40, Issue:4 Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Brain; Brain Neoplasms; Breast Neoplasms; Capillary Permeability; Cerebrovascular Circulation; Female; Glioblastoma; Humans; Male; Melanoma; Middle Aged; Oligodendroglioma; Skin Neoplasms; Teniposide	1997
Altered formation of DNA in human cells treated with inhibitors of DNA topoisomerase II (etoposide and teniposide). Cancer research, 1989, Nov-15, Volume: 49, Issue:22 Topics: DNA Replication; DNA, Neoplasm; Etoposide; Humans; Kinetics; Melanoma; Podophyllotoxin; Teniposide; Thymidine; Topoisomerase II Inhibitors; Tumor Cells, Cultured	1989