arginine and MELAS

arginine has been researched along with MELAS in 49 studies

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (22.45)	29.6817
2010's	31 (63.27)	24.3611
2020's	7 (14.29)	2.80

Authors

Authors	Studies
Boyle, K; Browne, E; Ni Cathain, D; Skehan, K	1
Ahmed, M; Chiaramello, A; Gropman, A; Hao, L; Li, H; Navarro, R; Uittenbogaard, M	1
Auriel, E; Barnea, R; Landau, YE; Mermelstein, M; Naftali, J; Peretz, S; Shelly, S	1
Sunada, Y	1
Fukuda, M; Nagao, Y	1
Ikawa, M; Koga, Y; Povalko, N	1
Song, T; Wang, S	1
Fisher, JA; Mikulis, DJ; Poublanc, J; Rodan, LH; Sobczyk, O; Tein, I	1
El-Hattab, AW; Jahoor, F	2
Tsikas, D	1
Chong, RA; DeGiorgio, CM; Galati, A; Hovsepian, DA; Mazumder, R; Mishra, S; Yim, C	1
Cui, L; Pen, B; Wei, Y	1
Fujii, K; Inoue, E; Ishii, A; Kanda, F; Koga, Y; Kubota, M; Nakamura, H; Okada, H; Povalko, N; Suzuki, Y; Yoneda, M	1
Fu, H; Jiang, G; Ju, X; Sun, X	1
Chanprasert, S; Craigen, WJ; El-Hattab, AW; Emrick, LT; Scaglia, F	1
Kawamura, N; Sano, H; Sudo, A	1
Hasegawa, Y; Hoshiyama, M; Tsujikawa, K; Yanagi, T; Yasui, K; Yokoi, S	1
Banks, L; Rodan, LH; Schneiderman, JE; Tein, I; Thompson, S; Wells, GD	1
Siddiq, I; Tein, I; Widjaja, E	1
Almannai, M; Chanprasert, S; Craigen, WJ; El-Hattab, AW; Emrick, LT; Hsu, JW; Jahoor, F; Scaglia, F	1
Abe, T; Kitamura, M; Koga, Y; Povalko, N; Saiki, R; Ushijima, K; Yamashita, Y; Yatsuga, S	1
Das, AM; Hanff, E; Herrmann, C; Kayacelebi, AA; Obermann, M; Tsikas, D	2
Finsterer, J; Wakil, SM	1
El-Hattab, AW	1
Das, AM; Hanff, E; Herrmann, C; Kayacelebi, AA; Mariotti, F; Obermann, M; Tsikas, D	1
Boneh, A; Coman, D; Yaplito-Lee, J	1
El Otmani, H; Fadel, H; Moutaouakil, F; Sefrioui, F; Slassi, I	1
Koga, Y	1
Kakimoto, N; Katayama, K; Koga, Y; Matsuishi, T; Nishioka, J; Povalko, N	1
Fukuda, M; Ishii, E; Morimoto, T; Shigemi, R; Suzuki, Y	1
Arakawa, K; Ikawa, M; Kawai, Y; Kudo, T; Kuriyama, M; Lee, JD; Miyamori, I; Morikawa, N; Okazawa, H; Sahashi, K; Yoneda, M	1
Ikawa, M; Tanaka, M; Yoneda, M	1
Kakimoto, N; Kakuma, T; Katayama, K; Koga, Y; Matsuishi, T; Nishioka, J; Povalko, N; Yatsuga, S	1
Cho, TH; Derex, L; Kouamé-Assouan, AE; Lekoubou, A; Luauté, J; Nighoghossian, N	1
Arakawa, K; Fujibayashi, Y; Ikawa, M; Kimura, H; Kudo, T; Okazawa, H; Yoneda, M	1
Katayama, K; Koga, Y; Matsuishi, T; Nishioka, J; Povalko, N; Yatsuga, S	1
Amati-Bonneau, P; Barth, M; Bonneau, D; Chevrollier, A; Desquiret-Dumas, V; Gueguen, N; Hancock, S; Henrion, D; Procaccio, V; Reynier, P; Wallace, DC	1
Craigen, WJ; El-Hattab, AW; Emrick, LT; Hsu, JW; Jahoor, F; Scaglia, F; Wong, LJ	1
Craigen, WJ; El-Hattab, AW; Emrick, LT; Scaglia, F	1
Kubota, M; Momoi-Yoshida, M; Mori, M; Sakakihara, Y; Yamagata, T	1
Akita, Y; Fujimoto, S; Koga, Y; Matsuishi, T; Nishioka, J; Povalko, N; Tanabe, Y; Yatsuga, S	1
De Vivo, DC; Engelstad, K; Kaufmann, P; Naini, A; Schon, EA; Shanske, S	1
Chakrapani, A; Geberhiwot, T; Hendriksz, C	1
Akita, Y; Fukiyama, R; Ishii, M; Junko, N; Koga, Y; Matsuishi, T; Povalko, N; Yatsuga, S	1
Ogawa, K; Suzuki, Y; Tominaga, K; Toribe, Y	1
Akita, Y; Hirata, K; Koga, Y; Matsuishi, T; Nishioka, J; Povalko, N; Yatsuga, S	1
Akita, Y; Fukiyama, R; Ishibashi, M; Koga, Y; Matsuishi, T; Ueki, I; Yatsuga, S	1

Reviews

11 review(s) available for arginine and MELAS

Article	Year
Arginine therapy in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. Current opinion in clinical nutrition and metabolic care, 2020, Volume: 23, Issue:1 Topics: Administration, Intravenous; Arginine; Clinical Trials as Topic; Follow-Up Studies; Humans; MELAS Syndrome; Treatment Outcome	2020
Mitochondrial DNA 10158T>C mutation in a patient with mitochondrial encephalomyopathy with lactic acidosis, and stroke-like episodes syndrome: A case-report and literature review (CARE-complaint). Medicine, 2020, Jun-12, Volume: 99, Issue:24 Topics: Acidosis, Lactic; Administration, Oral; Arginine; Awareness; Brain; DNA, Mitochondrial; Female; Humans; Magnetic Resonance Imaging; MELAS Syndrome; Micronutrients; Mitochondrial Encephalomyopathies; Muscle, Skeletal; Mutation; Stroke; Succinate Dehydrogenase; Ubiquinone; Young Adult	2020
Assessment of Nitric Oxide Production in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome with the Use of a Stable Isotope Tracer Infusion Technique. The Journal of nutrition, 2017, Volume: 147, Issue:7 Topics: Arginine; Citrulline; Diagnostic Techniques, Radioisotope; Humans; MELAS Syndrome; Mitochondria; Nitric Oxide	2017
Mitochondria: role of citrulline and arginine supplementation in MELAS syndrome. The international journal of biochemistry & cell biology, 2014, Volume: 48 Topics: Arginine; Citrulline; Humans; MELAS Syndrome; Mitochondria; Nitric Oxide	2014
Stroke-like episodes, peri-episodic seizures, and MELAS mutations. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2016, Volume: 20, Issue:6 Topics: Aged; Anticonvulsants; Arginine; Diet, Ketogenic; DNA, Mitochondrial; Female; Humans; Male; MELAS Syndrome; Middle Aged; Mutation; Seizures; Stroke	2016
New indications and controversies in arginine therapy. Clinical nutrition (Edinburgh, Scotland), 2008, Volume: 27, Issue:4 Topics: Acidosis, Lactic; Amino Acid Metabolism, Inborn Errors; Arginine; Central Nervous System; Creatine; Dietary Supplements; Humans; MELAS Syndrome; Mitochondrial Myopathies; Nitric Oxide; Vascular Diseases	2008
[L-arginine therapy on MELAS]. Rinsho shinkeigaku = Clinical neurology, 2008, Volume: 48, Issue:11 Topics: Administration, Oral; Adolescent; Adult; Age of Onset; Arginine; Child; Cohort Studies; Female; Humans; Infusions, Intravenous; Male; MELAS Syndrome; Nitric Oxide; RNA, Transfer, Leu; Severity of Illness Index; Young Adult	2008
MELAS and L-arginine therapy: pathophysiology of stroke-like episodes. Annals of the New York Academy of Sciences, 2010, Volume: 1201 Topics: Arginine; Brain; Endothelium; Glucose; Homeostasis; Humans; Magnetic Resonance Imaging; MELAS Syndrome; Mitochondria; Mitochondrial Diseases; Models, Biological; Muscles; Oxygen; Stroke; Tomography, Emission-Computed, Single-Photon	2010
In vivo functional brain imaging and a therapeutic trial of L-arginine in MELAS patients. Biochimica et biophysica acta, 2012, Volume: 1820, Issue:5 Topics: Adolescent; Arginine; Humans; Male; MELAS Syndrome; Neuroimaging; Prognosis	2012
Molecular pathology of MELAS and L-arginine effects. Biochimica et biophysica acta, 2012, Volume: 1820, Issue:5 Topics: Arginine; Humans; MELAS Syndrome	2012
Citrulline and arginine utility in treating nitric oxide deficiency in mitochondrial disorders. Molecular genetics and metabolism, 2012, Volume: 107, Issue:3 Topics: Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Citrulline; Clinical Trials as Topic; Electron Transport; Electron Transport Complex IV; Humans; MELAS Syndrome; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Nitrogen Species	2012

Trials

7 trial(s) available for arginine and MELAS

Article	Year
L-arginine effects on cerebrovascular reactivity, perfusion and neurovascular coupling in MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) syndrome. PloS one, 2020, Volume: 15, Issue:9 Topics: Administration, Oral; Adolescent; Arginine; Brain; Brain Mapping; Carbon Dioxide; Cerebrovascular Circulation; Female; Humans; Magnetic Resonance Imaging; Male; MELAS Syndrome; Neurovascular Coupling; Ornithine; Oxygen; Pilot Projects; Prospective Studies; Treatment Outcome; Visual Cortex; Young Adult	2020
Therapeutic regimen of L-arginine for MELAS: 9-year, prospective, multicenter, clinical research. Journal of neurology, 2018, Volume: 265, Issue:12 Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Arginine; Central Nervous System Agents; Female; Follow-Up Studies; Humans; Male; MELAS Syndrome; Prospective Studies; Treatment Outcome; Young Adult	2018
L-Arginine Affects Aerobic Capacity and Muscle Metabolism in MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes) Syndrome. PloS one, 2015, Volume: 10, Issue:5 Topics: Adolescent; Arginine; Case-Control Studies; Dose-Response Relationship, Drug; Ergometry; Exercise; Female; Humans; Magnetic Resonance Spectroscopy; Male; MELAS Syndrome; Muscles; Neuroimaging; Phosphocreatine; Rest; Young Adult	2015
Abnormal myocardial energy-production state in mitochondrial cardiomyopathy and acute response to L-arginine infusion. C-11 acetate kinetics revealed by positron emission tomography. Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:12 Topics: Acetates; Adult; Arginine; Carbon Isotopes; Cardiomyopathies; Citric Acid Cycle; Coronary Circulation; Energy Metabolism; Female; Humans; Male; MELAS Syndrome; Middle Aged; Positron-Emission Tomography; Radiography	2010
L-arginine improves the symptoms of strokelike episodes in MELAS. Neurology, 2005, Feb-22, Volume: 64, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Amino Acids; Arginine; Cerebral Arteries; Child; Child, Preschool; Cholesterol; Cyclic GMP; Female; Headache; Humans; Male; MELAS Syndrome; Nitric Oxide; Paresis; Seizures; Stroke; Treatment Outcome; Vasodilation; Vision Disorders; Vomiting	2005
Hypocitrullinemia in patients with MELAS: an insight into the "MELAS paradox". Journal of the neurological sciences, 2005, Mar-15, Volume: 229-230 Topics: Adult; Amino Acids; Arginine; Chromatography, High Pressure Liquid; Citrulline; Female; Humans; Male; MELAS Syndrome; Nitric Oxide; Prostaglandin-Endoperoxide Synthases	2005
Endothelial dysfunction in MELAS improved by l-arginine supplementation. Neurology, 2006, Jun-13, Volume: 66, Issue:11 Topics: Administration, Oral; Adolescent; Adult; Arginine; Blood Flow Velocity; Cerebrovascular Circulation; Child; Dietary Supplements; Endothelium, Vascular; Female; Humans; Male; MELAS Syndrome; Middle Aged; Stroke; Vasodilator Agents	2006

Other Studies

31 other study(ies) available for arginine and MELAS

Article	Year
MELAS syndrome: an acute stroke-like episode complicated by renal tubular acidosis. BMJ case reports, 2021, Nov-02, Volume: 14, Issue:11 Topics: Acidosis, Renal Tubular; Arginine; Humans; MELAS Syndrome; Stroke	2021
Integrated proteomic and metabolomic analyses of the mitochondrial neurodegenerative disease MELAS. Molecular omics, 2022, 03-28, Volume: 18, Issue:3 Topics: Arginine; Chromatography, Liquid; Humans; MELAS Syndrome; Metabolomics; Neurodegenerative Diseases; Proteomics; Stroke; Tandem Mass Spectrometry	2022
Clinical score for early diagnosis and treatment of stroke-like episodes in MELAS syndrome. Acta neurologica Belgica, 2023, Volume: 123, Issue:3 Topics: Arginine; Early Diagnosis; Humans; Ischemic Stroke; MELAS Syndrome; Retrospective Studies; Seizures; Stroke	2023
[Therapeutics for Mitochondrial Encephalomyopathy]. Brain and nerve = Shinkei kenkyu no shinpo, 2023, Volume: 75, Issue:5 Topics: Arginine; Humans; MELAS Syndrome; Mitochondria; Stroke; Taurine	2023
Dynamic derangement in amino acid profile during and after a stroke-like episode in adult-onset mitochondrial disease: a case report. Journal of medical case reports, 2019, Oct-21, Volume: 13, Issue:1 Topics: Arginine; Aspartic Acid; Biomarkers; Deafness; Diabetes Mellitus, Type 2; DNA, Mitochondrial; Growth Differentiation Factor 15; Humans; Male; MELAS Syndrome; Middle Aged; Mitochondrial Diseases; Mutation	2019
The utility of arginine-citrulline stable isotope tracer infusion technique in the assessment of nitric oxide production in MELAS syndrome. International journal of cardiology, 2018, 03-01, Volume: 254 Topics: Arginine; Citrulline; Humans; Isotopes; MELAS Syndrome; Nitric Oxide	2018
Measuring NO production rate from l-arginine in MELAS by mass spectrometry-based approaches: GC-MS or LC-MS/MS? International journal of cardiology, 2018, 04-01, Volume: 256 Topics: Arginine; Biomarkers; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Humans; MELAS Syndrome; Nitric Oxide	2018
MELAS: Monitoring treatment with magnetic resonance spectroscopy. Acta neurologica Scandinavica, 2019, Volume: 139, Issue:1 Topics: Arginine; Aspartic Acid; Brain; Choline; Female; Humans; Magnetic Resonance Spectroscopy; MELAS Syndrome; Middle Aged; Stroke; Treatment Outcome	2019
L-Arginine prevents stroke-like episodes but not brain atrophy: a 20-year follow-up of a MELAS patient. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019, Volume: 40, Issue:1 Topics: Adolescent; Adult; Arginine; Atrophy; Brain; Female; Follow-Up Studies; Humans; MELAS Syndrome; Stroke; Young Adult	2019
MELAS and macroangiopathy: A case report and literature review. Medicine, 2018, Volume: 97, Issue:52 Topics: Acidosis, Lactic; Adult; Arginine; Ascorbic Acid; Carotid Stenosis; Humans; Male; MELAS Syndrome; Mitochondrial Encephalomyopathies; Point Mutation; Ubiquinone; Valproic Acid	2018
[Determination of the critical time point for efficacy of L-arginine infusion therapy in a case of MELAS with frequent stroke-like episodes]. No to hattatsu = Brain and development, 2014, Volume: 46, Issue:1 Topics: Arginine; Child; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; MELAS Syndrome; Stroke; Time Factors; Treatment Outcome	2014
[Effectiveness of midazolam for L-arginine-resistant headaches during stroke-like episodes in MELAS: a case report]. Rinsho shinkeigaku = Clinical neurology, 2014, Volume: 54, Issue:11 Topics: Adolescent; Anesthetics, Intravenous; Arginine; DNA, Mitochondrial; Drug Resistance; Electroencephalography; Female; Headache; Humans; Infusions, Parenteral; Magnetic Resonance Imaging; MELAS Syndrome; Midazolam; Mutation	2014
Clinical and radiologic reversal of stroke-like episodes in MELAS with high-dose L-arginine. Neurology, 2015, Jul-14, Volume: 85, Issue:2 Topics: Arginine; Child; Humans; Male; MELAS Syndrome; Stroke	2015
Impaired nitric oxide production in children with MELAS syndrome and the effect of arginine and citrulline supplementation. Molecular genetics and metabolism, 2016, Volume: 117, Issue:4 Topics: Adolescent; Arginine; Case-Control Studies; Child; Child, Preschool; Citrulline; Dietary Supplements; Female; Humans; Male; MELAS Syndrome; Nitric Oxide; Treatment Outcome	2016
L-Arginine intervention at hyper-acute phase protects the prolonged MRI abnormality in MELAS. Journal of neurology, 2016, Volume: 263, Issue:8 Topics: Arginine; Child; Female; Humans; Magnetic Resonance Imaging; MELAS Syndrome; Stroke	2016
Unaltered l-arginine/NO pathway in a MELAS patient: Is mitochondrial NO synthase involved in the MELAS syndrome? International journal of cardiology, 2016, Nov-15, Volume: 223 Topics: Arginine; DNA, Mitochondrial; Humans; Male; MELAS Syndrome; Middle Aged; Mitochondria; Nitric Oxide Synthase	2016
The l-arginine/NO pathway in the MELAS syndrome: An insufficiently explored and controversial research area. International journal of cardiology, 2017, Feb-15, Volume: 229 Topics: Arginine; DNA; Humans; MELAS Syndrome; Point Mutation	2017
Letter to the Editor: "Unaltered L-arginine/NO pathway in a MELAS patient: Is mitochondrial NO synthase involved in the MELAS syndrome?" International journal of cardiology, 2017, Feb-15, Volume: 229 Topics: Arginine; DNA, Mitochondrial; Humans; MELAS Syndrome; Mutation; Nitric Oxide	2017
Analytical challenges in the assessment of NO synthesis from L-arginine in the MELAS syndrome. International journal of cardiology, 2017, 05-01, Volume: 234 Topics: Arginine; Humans; MELAS Syndrome; Nitric Oxide	2017
[l-arginine efficiency in MELAS syndrome. A case report]. Revue neurologique, 2009, Volume: 165, Issue:5 Topics: Arginine; Biopsy; Brain; Calcinosis; Child; Disease Progression; Humans; Lactates; Male; MELAS Syndrome; Muscle, Skeletal; Pyruvates; Tomography, X-Ray Computed	2009
L-arginine is effective in stroke-like episodes of MELAS associated with the G13513A mutation. Brain & development, 2011, Volume: 33, Issue:6 Topics: Adolescent; Arginine; Brain; Humans; Male; MELAS Syndrome; Point Mutation; Stroke	2011
Energy States in mitochondrial cardiomyopathy. In vivo functional imaging and L-arginine therapy. Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:12 Topics: Acetates; Adult; Arginine; Carbon Isotopes; Cardiomyopathies; Citric Acid Cycle; Coronary Circulation; Energy Metabolism; Female; Humans; Male; MELAS Syndrome; Middle Aged; Positron-Emission Tomography; Radiography	2010
MELAS: a nationwide prospective cohort study of 96 patients in Japan. Biochimica et biophysica acta, 2012, Volume: 1820, Issue:5 Topics: Adolescent; Adult; Arginine; Diagnostic Imaging; Disease Progression; Female; Humans; Japan; Male; MELAS Syndrome; Prevalence; Prognosis; Prospective Studies; Surveys and Questionnaires; Young Adult	2012
Effect of long-term oral treatment with L-arginine and idebenone on the prevention of stroke-like episodes in an adult MELAS patient. Revue neurologique, 2011, Volume: 167, Issue:11 Topics: Administration, Oral; Adult; Antioxidants; Arginine; Drug Combinations; Female; Humans; MELAS Syndrome; Stroke; Time Factors; Treatment Outcome; Ubiquinone	2011
Metabolically induced heteroplasmy shifting and l-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS. Biochimica et biophysica acta, 2012, Volume: 1822, Issue:6 Topics: Arginine; Cell Line, Tumor; DNA, Mitochondrial; Glucose; Glycolysis; Humans; Hybrid Cells; MELAS Syndrome; Mitochondria; Mutation; Neuroblastoma; Neurons; RNA, Transfer, Leu	2012
Restoration of impaired nitric oxide production in MELAS syndrome with citrulline and arginine supplementation. Molecular genetics and metabolism, 2012, Volume: 105, Issue:4 Topics: Adolescent; Adult; Arginine; Case-Control Studies; Citrulline; Dietary Supplements; Female; Humans; Male; MELAS Syndrome; Middle Aged; Nitric Oxide; Prognosis; Young Adult	2012
Beneficial effect of L-arginine for stroke-like episode in MELAS. Brain & development, 2004, Volume: 26, Issue:7 Topics: Adolescent; Arginine; Brain; Brain Ischemia; Drug Therapy, Combination; Energy Metabolism; Female; Glycerol; Humans; Lactic Acid; MELAS Syndrome; Mitochondria; Nitric Oxide; Prednisolone; Seizures; Stroke; Treatment Outcome; Vasodilator Agents; Vision Disorders	2004
Case 36-2005: a woman with seizure, disturbed gait, and altered mental status. The New England journal of medicine, 2006, Mar-09, Volume: 354, Issue:10 Topics: Arginine; Female; Humans; MELAS Syndrome	2006
[Usefulness of L-arginine infusion for status epilepticus in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes]. No to hattatsu = Brain and development, 2007, Volume: 39, Issue:1 Topics: Arginine; Child; Electroencephalography; Female; Humans; Infusions, Intravenous; MELAS Syndrome; Status Epilepticus	2007
Effect of L-arginine on synaptosomal mitochondrial function. Brain & development, 2008, Volume: 30, Issue:4 Topics: Animals; Arginine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; MELAS Syndrome; Mice; Mice, Inbred ICR; Mitochondria; Oxygen Consumption; Potassium; Succinic Acid; Synaptosomes	2008
Effects of L-arginine on the acute phase of strokes in three patients with MELAS. Neurology, 2002, Mar-12, Volume: 58, Issue:5 Topics: Acute Disease; Adolescent; Arginine; Female; Humans; Male; MELAS Syndrome; Stroke	2002