arginine and Hyperhomocysteinemia

arginine has been researched along with Hyperhomocysteinemia in 67 studies

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's39 (58.21)29.6817
2010's23 (34.33)24.3611
2020's5 (7.46)2.80

Authors

AuthorsStudies
Fast, W; Hong, L1
Chen, YC; Hsiao, CC; Hsu, MH; Huang, LT; Sheen, JM; Wang, SC1
Abdel-Latif, Y; Badawy, E; El-Laithy, N; El-Naggar, M; El-Waseef, M; Hassan, H; Hussein, J1
Fishchuk, L; Gorovenko, N; Medvedieva, N; Rossokha, Z; Sheyko, L1
Aarsand, AK; Aguilera, P; Brunet, M; Deulofeu, R; García-Villoria, J; Gómez-Gómez, À; Pozo, OJ; Sandberg, S; To-Figueras, J; Wijngaard, R1
Beykirch, MK; Klein, M; Loehr, C; Molitor, B; Obermeier, Z; Petrides, PE; Schuhmann, E; Torkler, H1
Çelik, SF; Dündar, MA; Karakükçü, Ç; Tartıcı, EK; Torun, YA1
Blom, HJ; Castro, R; de Vriese, AS; Esse, R; Florindo, C; Imbard, A; Rocha, MS; Smulders, YM; Tavares de Almeida, I; Teerlink, T1
Kundu, S; Metreveli, N; Pushpakumar, SB; Sen, U1
Bekpinar, S; Genc, S; Gurdol, F; Kusku-Kiraz, Z; Olgac, V; Unlucerci, Y; Uysal, M1
Borderie, D; Bos, C; Huneau, JF; Magné, J; Mariotti, F; Mathé, V1
Doyle, V; Givvimani, S; Kundu, S; Metreveli, N; Narayanan, N; Pushpakumar, S; Tyagi, SC; Veeranki, S; Winchester, LJ1
Yamauchi, M1
Cakmak, S; Cumhur Cure, M; Cure, E; Kirbas, A; Kirbas, S; Tufekci, A; Yazici, T1
Haller, H; Menzel, D; Robenek, H; Wilhelm, M1
Goyvaerts, B; Reule, CA; Schoen, C1
Arning, E; Bottiglieri, T; Cooke, JP; Dayal, S; Faraci, FM; Kimoto, M; Lentz, SR; Murry, DJ; Rodionov, RN1
Fukada, S; Morita, T; Sugiyama, K1
Verit, FF; Vural, M1
Kida, Y; Marumo, K; Saito, M; Shinohara, A; Soshi, S; Ushiku, C1
Arning, E; Baumbach, GL; Bottiglieri, T; Cooke, JP; Dayoub, H; Faraci, FM; Kimoto, M; Lentz, SR; Lynch, CM; Murry, DJ; Rodionov, RN; Stevens, JW; Wilson, KM1
Dohi, Y; Ito, A; Itoh, T; Kajikuri, J; Koyama, K; Kumagai, H; Nakamura, H; Nishio, T; Ohte, N; Sano, A; Yamamoto, J1
Azqueta, M; Cases, A; Coll, E; Collado, S; Cruzado, JM; de la Torre, B; Deulofeu, R; Guerrero, L; Nicolau, C; Pons, M; Vera, M1
Marumo, K; Saito, M2
Máñez, S; Marín, M1
Antoniades, C; Bouras, G; Hatzis, G; Marinou, K; Miliou, A; Papageorgiou, N; Stefanadi, E; Stefanadis, C; Tousoulis, D; Tsioufis, C1
Barroso, M; Blom, HJ; Castro, R; de Almeida, IT; Esse, R; Gomes, AQ; Gonçalves, I; Jakobs, C; Loscalzo, J; Rivera, I; Rocha, MS; Teerlink, T1
Damaske, A; Fasola, F; Fineschi, M; Forconi, S; Gori, T; Jabs, A; Munzel, T; Muxel, S; Orphal, D; Parker, JD; Radmacher, MC; Schaefer, S; Wild, P1
Bleich, S; Frieling, H; Haschemi-Nassab, M; Hillemacher, T; Kornhuber, J; Leitmeier, V; Rhein, M1
Balligand, JL1
Feng, M; Guo, Z; He, ZM; Liu, LH; Wu, ZZ; Xiong, Y1
Samson, RH1
Arakawa, N; Bode-Böger, SM; Böger, RH; Frölich, JC; Hornig, B; Schwedhelm, E; Sydow, K; Tsikas, D1
Aukrust, P; Haugstad, TS; Holm, T; Holven, KB; Nenseter, MS; Ose, L1
Zoccali, C1
Hedner, T; Hultberg, B; Jonasson, TF; Ohlin, H1
Cooke, JP; Graf, EE; Kapoor, O; Malinow, MR; Oka, RK; Pachinger, O; Schmölzer, I; Stühlinger, MC; Szuba, A; Upson, BM; Wascher, TC1
Böger, RH; Cooke, JP; Vallance, P1
Dayal, S; Lentz, SR; Rodionov, RN1
Faraci, FM; Lentz, SR1
Nishio, I; Tsuda, K1
Cohen, JJ; Harrington, JT; Hörl, WH; Madias, NE; Zusman, CJ1
Arakawa, N; Bode-Böger, SM; Böger, RH; Hornig, B; Münzel, T; Sydow, K; Tsikas, D1
Minar, E; Mittermayer, F; Plank, C; Schernthaner, GH; Wolzt, M; Ziegler, S1
Kumar, J; Shah, SV1
Stanger, O; Stühlinger, MC1
Allen, R; Boger, R; Doshi, S; Goodfellow, J; Lewis, M; McDowell, I; Moat, S; Newcombe, R; Stabler, S1
Boger, RH1
Brodsky, SV; Chen, J; Goligorsky, MS; Li, H; O'Riordan, E; Smirnova, I1
Enia, G; Mallamaci, F; Panuccio, V; Tripepi, G; Zoccali, C1
Lentz, SR1
Cibulka, R; Eiselt, J; Filipovský, J; Racek, J; Rajdl, D; Rusnáková, H; Siroká, R; Trefil, L1
Bryan, RM; Durante, W; Jiang, X; Liao, D; Randhawa, JK; Rumbaut, RE; Schafer, AI; Tan, H; Wang, H; Yang, F; Yang, X1
Dayal, S; Lentz, SR1
Maas, R1
Brouwer, CB; Rauwerda, JA; Smulders, YM; Spoelstra-de Man, AM; Stehouwer, CD; Teerlink, T1
Cottin, Y; Duvillard, L; Gambert, P; Guilland, JC; Korandji, C; Moreau, D; Rochette, L; Sicard, P; Vergely, C; Zeller, M1
Antoniades, C; Bouras, G; Marinou, K; Pitsavos, C; Stefanadis, C; Tentolouris, C; Tousoulis, D; Vasiliadou, C1
Boeger, RH; Deussen, A; Henle, T; Pexa, A; Schwedhelm, E1
Lentz, SR; Rodionov, RN1
Bode-Böger, SM; Böger, RH; Heistad, DD; Lentz, SR; Sydow, K1
Akita, T; Duan, J; Ikeda, H; Imaizumi, T; Murohara, T; Sasaki, K; Shimada, T; Shintani, S1
Bode-Böger, SM; Böger, RH; Haynes, WG; Knapp, HR; Lentz, SR1
Vallance, P1
Balint, RF; Cooke, JP; Her, JH; Kimoto, M; Stühlinger, MC; Tsao, PS1
Du, J; Li, J; Tang, C; Yao, X; Zhang, B; Zhang, Y1

Reviews

15 review(s) available for arginine and Hyperhomocysteinemia

ArticleYear
[The assessment of bone quality in lifestyle-related diseases].
    Clinical calcium, 2016, Volume: 26, Issue:1

    Topics: Arginine; Biomarkers; Bone and Bones; Bone Remodeling; Collagen; Diabetes Mellitus, Type 2; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Lysine; Osteoporosis; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Risk; Tomography, X-Ray Computed

2016
[CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). Bone quality in chronic kidney disease : enzymatic and non-enzymatic glycation or oxidation induced cross-links in bone].
    Clinical calcium, 2010, Volume: 20, Issue:7

    Topics: Animals; Arginine; Bone and Bones; Bone Diseases, Metabolic; Chronic Disease; Collagen; Fractures, Bone; Glycation End Products, Advanced; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Lysine; Osteoporosis; Oxidative Stress; Risk

2010
Pharmacological interventions on asymmetric dimethylarginine, a clinical marker of vascular disease.
    Current medicinal chemistry, 2011, Volume: 18, Issue:5

    Topics: Adrenergic Antagonists; Angiotensins; Arginine; Diabetes Complications; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperhomocysteinemia; Hypertension; Kidney Diseases; Microcirculation; Nitric Oxide Synthase Type III; Peroxisome Proliferator-Activated Receptors; Receptors, Cytoplasmic and Nuclear; Vascular Diseases

2011
[Bone quality in lifestyle-related diseases].
    Clinical calcium, 2011, Volume: 21, Issue:5

    Topics: Arginine; Bone and Bones; Collagen; Fractures, Bone; Glycation End Products, Advanced; Humans; Hyperglycemia; Hyperhomocysteinemia; Life Style; Lysine; Oxidative Stress; Risk; Vitamin B 6 Deficiency

2011
Peripheral hemorheological and vascular correlates of coronary blood flow.
    Clinical hemorheology and microcirculation, 2011, Volume: 49, Issue:1-4

    Topics: Arginine; Blood Flow Velocity; Chest Pain; Coronary Circulation; Diagnosis, Differential; Endothelium, Vascular; Female; Hemorheology; Humans; Hyperhomocysteinemia; Inflammation; Male; Microvessels; Myocardial Ischemia; Nitric Oxide; Platelet Activation; Syndrome; Vascular Resistance; Vasodilator Agents

2011
Miscellaneous medications for the management of atherosclerosis: mayhem or miracle?
    Seminars in vascular surgery, 2002, Volume: 15, Issue:4

    Topics: Alcohol Drinking; Antioxidants; Arginine; Arteriosclerosis; Ascorbic Acid; Cholesterol, LDL; Complementary Therapies; Diet; Estrogen Replacement Therapy; Ginkgo biloba; Humans; Hyperhomocysteinemia; Particle Size; Vitamin E

2002
[Cardiovascular events in chronic advanced renal insufficiency. Current concepts].
    Recenti progressi in medicina, 2003, Volume: 94, Issue:3

    Topics: Anemia; Arginine; C-Reactive Protein; Cardiovascular Diseases; Humans; Hyperhomocysteinemia; Hyperlipidemias; Hypertension; Inflammation; Kidney Failure, Chronic; Nitric Oxide Synthase; Risk Factors; Sleep Apnea Syndromes; Smoking

2003
Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hyperhomocysteinemia; Risk Factors

2003
Kidney disease as an independent risk factor for cardiovascular events.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2005, Volume: 15, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Humans; Hyperhomocysteinemia; Inflammation; Kidney Diseases; Kidney Failure, Chronic; Kidney Transplantation; Lipoproteins; Lipoproteins, LDL; Nitric Oxide Synthase; Oxidative Stress; Proteinuria; Renal Dialysis; Risk Factors

2005
Asymmetric dimethyl-L-arginine (ADMA): a possible link between homocyst(e)ine and endothelial dysfunction.
    Current drug metabolism, 2005, Volume: 6, Issue:1

    Topics: Animals; Arginine; Arteriosclerosis; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Nitric Oxide; Vascular Diseases

2005
Endothelial cell dysfunction: the syndrome in making.
    Kidney international, 2005, Volume: 67, Issue:5

    Topics: Animals; Apoptosis; Arginine; Cardiovascular Diseases; Cellular Senescence; Endothelium, Vascular; Glycation End Products, Advanced; Humans; Hyperhomocysteinemia; Kidney Diseases; Models, Biological; Oxidative Stress; Syndrome

2005
Clinical epidemiology of major nontraditional risk factors in peritoneal dialysis patients.
    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2005, Volume: 25 Suppl 3

    Topics: Arginine; Autonomic Nervous System Diseases; C-Reactive Protein; Cardiovascular Diseases; Humans; Hyperhomocysteinemia; Inflammation; Italy; Kidney Failure, Chronic; Nitric Oxide Synthase; Norepinephrine; Peritoneal Dialysis; Risk Factors

2005
Mechanisms of homocysteine-induced atherothrombosis.
    Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:8

    Topics: Animals; Apolipoproteins E; Apoptosis; Arginine; Atherosclerosis; Coronary Thrombosis; Cysteine; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Mice; Models, Biological; Nitric Oxide; Oxidative Stress; Oxygen; Phenotype; Signal Transduction

2005
ADMA and hyperhomocysteinemia.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Humans; Hyperhomocysteinemia; Nitric Oxide; Nitric Oxide Synthase Type III; Risk Factors; Superoxides; Vasodilation

2005
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Nitric Oxide; Nitric Oxide Synthase; Protein-Arginine N-Methyltransferases; Renal Insufficiency

2005

Trials

11 trial(s) available for arginine and Hyperhomocysteinemia

ArticleYear
L-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation.
    European journal of nutrition, 2018, Volume: 57, Issue:2

    Topics: Arginine; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Cohort Studies; Dietary Supplements; Disease Progression; Double-Blind Method; Endothelium, Vascular; Essential Hypertension; Female; Follow-Up Studies; Humans; Hyperhomocysteinemia; Hypertension; Male; Middle Aged; Overweight; Prehypertension; Severity of Illness Index; Vascular Resistance; Vitamin B Complex

2018
Effects of an L-arginine-based multi ingredient product on endothelial function in subjects with mild to moderate hypertension and hyperhomocysteinemia - a randomized, double-blind, placebo-controlled, cross-over trial.
    BMC complementary and alternative medicine, 2017, Feb-02, Volume: 17, Issue:1

    Topics: Aged; Arginine; Blood Pressure; Cross-Over Studies; Drug Combinations; Endothelium, Vascular; Female; Humans; Hyperhomocysteinemia; Hypertension; Male; Middle Aged

2017
Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 55, Issue:6

    Topics: Administration, Oral; Aged; Arginine; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Injections, Intravenous; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Risk Factors; Vitamin B 12; Vitamin B Complex

2010
ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.
    Cardiovascular research, 2003, Volume: 57, Issue:1

    Topics: Aged; Analysis of Variance; Arginine; Arterial Occlusive Diseases; Double-Blind Method; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase; Oxidative Stress; Peripheral Vascular Diseases; Vitamin B 12; Vitamin B 6; Vitamins

2003
Folic acid treatment reduces elevated plasma levels of asymmetric dimethylarginine in hyperhomocysteinaemic subjects.
    The British journal of nutrition, 2003, Volume: 89, Issue:3

    Topics: Adult; Aged; Arginine; Biomarkers; Dietary Supplements; Enzyme Inhibitors; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase

2003
Hyperhomocysteinaemia is not associated with increased levels of asymmetric dimethylarginine in patients with ischaemic heart disease.
    European journal of clinical investigation, 2003, Volume: 33, Issue:7

    Topics: Adult; Arginine; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Myocardial Ischemia; Nitric Oxide Synthase; Pyridoxine; Vitamin B 12

2003
Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine.
    Circulation, 2003, Aug-26, Volume: 108, Issue:8

    Topics: Adult; Age Factors; Aged; Arginine; Arteriosclerosis; Brachial Artery; Endothelium, Vascular; Female; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Peripheral Vascular Diseases; Regional Blood Flow; Regression Analysis; Vasodilation

2003
Homocyst(e)ine-lowering therapy does not affect plasma asymmetrical dimethylarginine concentrations in patients with peripheral artery disease.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:4

    Topics: Aged; Arginine; Double-Blind Method; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Peripheral Vascular Diseases; Vitamin B Complex

2005
Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia.
    Metabolism: clinical and experimental, 2005, Volume: 54, Issue:3

    Topics: Acetylcysteine; Adult; Arginine; Blood Flow Velocity; Brachial Artery; Cross-Over Studies; Cystathionine; Cysteine; Dipeptides; Double-Blind Method; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kinetics; Male; Methionine; Placebos; S-Adenosylhomocysteine; S-Adenosylmethionine; Vasodilation

2005
No effect of B vitamins on ADMA levels in patients at increased cardiovascular risk.
    Clinical endocrinology, 2006, Volume: 64, Issue:5

    Topics: Adolescent; Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Humans; Hyperhomocysteinemia; Linear Models; Male; Middle Aged; Pyridoxine; Risk Factors; Time Factors; Treatment Failure; Vitamin B Complex

2006
Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines.
    The American journal of clinical nutrition, 2006, Volume: 84, Issue:4

    Topics: Adult; alpha-Tocopherol; Arginine; Ascorbic Acid; Cholesterol, LDL; Chronic Disease; Cytokines; Double-Blind Method; Endothelium, Vascular; Female; Forearm; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Interleukin-6; Male; Methionine; Oxidative Stress; Time Factors; Vascular Resistance; von Willebrand Factor

2006

Other Studies

41 other study(ies) available for arginine and Hyperhomocysteinemia

ArticleYear
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
    The Journal of biological chemistry, 2007, Nov-30, Volume: 282, Issue:48

    Topics: Amidohydrolases; Amino Acid Sequence; Animals; Binding Sites; Cloning, Molecular; Cysteine; Dose-Response Relationship, Drug; Drug Design; Homocysteine; Humans; Hydrogen Peroxide; Hyperhomocysteinemia; Kinetics; Molecular Sequence Data; Oxidation-Reduction; Sequence Homology, Amino Acid; Substrate Specificity

2007
Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats.
    Life sciences, 2020, Feb-01, Volume: 242

    Topics: Animals; Animals, Newborn; Antimetabolites, Antineoplastic; Arginine; Disease Models, Animal; Hippocampus; Hyperhomocysteinemia; Male; Maze Learning; Melatonin; Methotrexate; Rats; Rats, Sprague-Dawley; Spatial Behavior

2020
Homocysteine and Asymmetrical Dimethylarginine in Diabetic Rats Treated with Docosahexaenoic Acid-Loaded Zinc Oxide Nanoparticles.
    Applied biochemistry and biotechnology, 2020, Volume: 191, Issue:3

    Topics: Animals; Arginine; Cellulose; Diabetes Mellitus, Experimental; Docosahexaenoic Acids; Homocysteine; Hyperhomocysteinemia; Insulin; Insulin Resistance; Male; Metal Nanoparticles; Microscopy, Electron, Transmission; Nitric Oxide; Rats; Risk Factors; Zinc Oxide

2020
POSITIVE EFFECT OF BETAINE-ARGININE SUPPLEMENT ON IMPROVED HYPERHOMOCYSTEINEMIA TREATMENT IN MARRIED COUPLES WITH REPRODUCTIVE DISORDERS.
    Georgian medical news, 2020, Issue:309

    Topics: Arginine; Betaine; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Vitamin B 12

2020
Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran.
    Journal of inherited metabolic disease, 2021, Volume: 44, Issue:4

    Topics: Acetylgalactosamine; Adult; Arginine; Cystathionine beta-Synthase; Female; Folic Acid; Heme; Homeostasis; Homocysteine; Homocystinuria; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Porphyria, Acute Intermittent; Pyridoxal Phosphate; Pyrrolidines; Young Adult

2021
Severe homocysteinemia in two givosiran-treated porphyria patients: is free heme deficiency the culprit?
    Annals of hematology, 2021, Volume: 100, Issue:7

    Topics: 5-Aminolevulinate Synthetase; Acetylgalactosamine; Adult; Arginine; Colitis; Colon, Sigmoid; Controlled Clinical Trials as Topic; Drug Hypersensitivity; Female; Fibrosis; Heme; Hepatocytes; High-Throughput Nucleotide Sequencing; Homocysteine; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Models, Biological; Pancreatitis; Porphyria, Acute Intermittent; Pyrrolidines

2021
Increased asymmetric dimethylarginine in vitamin B12 deficient adolescents.
    Cardiology in the young, 2019, Volume: 29, Issue:2

    Topics: Adolescent; Arginine; Atherosclerosis; Biomarkers; Carotid Arteries; Carotid Intima-Media Thickness; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Echocardiography; Female; Humans; Hyperhomocysteinemia; Male; Vascular Stiffness; Vitamin B 12 Deficiency

2019
Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia.
    Biochimica et biophysica acta, 2013, Volume: 1832, Issue:10

    Topics: Animals; Arginine; Diet; Disease Models, Animal; Female; Histones; Hyperhomocysteinemia; Methylation; Proteins; Rats; Rats, Wistar

2013
Folic acid mitigates angiotensin-II-induced blood pressure and renal remodeling.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Angiotensin II; Animals; Arginine; Blood Pressure; Collagen; Drinking; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Hypertension; Kidney; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; RNA, Messenger; Tissue Inhibitor of Metalloproteinases

2013
Circulating levels of apelin, glucagon-like peptide and visfatin in hypercholesterolemic-hyperhomocysteinemic guinea-pigs: their relation with NO metabolism.
    Molecular and cellular biochemistry, 2015, Volume: 400, Issue:1-2

    Topics: Animals; Arginine; Cholesterol; Glucagon-Like Peptides; Guinea Pigs; Humans; Hyperhomocysteinemia; Intercellular Signaling Peptides and Proteins; Male; Nicotinamide Phosphoribosyltransferase; Nitric Oxide; Tyrosine

2015
Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Amidohydrolases; Animals; Arginine; Cathepsin D; Disease Models, Animal; Endothelium, Vascular; Gene Expression Regulation; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; Ubiquitin

2015
Hyperhomocysteinemia: a missing link to dysfunctional HDL via paraoxanase-1.
    Canadian journal of physiology and pharmacology, 2015, Volume: 93, Issue:9

    Topics: Amidohydrolases; Animals; Arginine; Aryldialkylphosphatase; Atherosclerosis; Blood Pressure; Connexins; Diet, Atherogenic; Endothelium, Vascular; Fibrosis; Gap Junction alpha-4 Protein; Gap Junction alpha-5 Protein; Hyperhomocysteinemia; Lipoproteins, HDL; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Ventricular Dysfunction, Left

2015
Serum levels of homocysteine, asymmetric dimethylarginine and nitric oxide in patients with Parkinson's disease.
    Acta clinica Belgica, 2016, Volume: 71, Issue:2

    Topics: Aged; Arginine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Immunoassay; Male; Middle Aged; Nitric Oxide; Parkinson Disease

2016
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents

2008
Effects of various amino acids on methionine-induced hyperhomocysteinemia in rats.
    Bioscience, biotechnology, and biochemistry, 2008, Volume: 72, Issue:7

    Topics: Amino Acids; Animals; Arginine; Dietary Supplements; Glutamic Acid; Histidine; Homocysteine; Hyperhomocysteinemia; Methionine; Rats

2008
Asymmetric dimethylorginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome.
    Fertility and sterility, 2009, Volume: 92, Issue:1

    Topics: Arginine; Carotid Arteries; Female; Humans; Hyperhomocysteinemia; Obesity; Polycystic Ovary Syndrome; Reference Values; Tunica Intima; Tunica Media

2009
Raloxifene ameliorates detrimental enzymatic and nonenzymatic collagen cross-links and bone strength in rabbits with hyperhomocysteinemia.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010, Volume: 21, Issue:4

    Topics: Animals; Arginine; Bone and Bones; Bone Density; Bone Density Conservation Agents; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glycation End Products, Advanced; Hyperhomocysteinemia; Lysine; Methionine; Osteoporosis; Rabbits; Raloxifene Hydrochloride; Stress, Mechanical

2010
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.
    Circulation research, 2010, Feb-19, Volume: 106, Issue:3

    Topics: Acetylcholine; Amidohydrolases; Animals; Arginine; Arterioles; Carotid Artery Thrombosis; Cerebral Arterial Diseases; Diet; Folic Acid Deficiency; Humans; Hyperhomocysteinemia; Hypertrophy; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papaverine; Vasodilation; Vasodilator Agents

2010
[Prevalence of cardiovascular disease in uraemia and relevance of cardiovascular risk factors].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2010, Volume: 30, Issue:3

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Blood Proteins; Cardiovascular Diseases; Comorbidity; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Hyperhomocysteinemia; Hyperlipidemias; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Prevalence; Risk Factors; Smoking; Stroke Volume; Ultrasonography; Uremia

2010
Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins.
    American journal of hypertension, 2011, Volume: 24, Issue:8

    Topics: Adult; Antioxidants; Arginine; Ascorbic Acid; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methionine; Middle Aged; Vasodilation; Vitamin E

2011
Cellular hypomethylation is associated with impaired nitric oxide production by cultured human endothelial cells.
    Amino acids, 2012, Volume: 42, Issue:5

    Topics: Arginine; Cells, Cultured; Endothelial Cells; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Methylation; Nitric Oxide; Nitric Oxide Synthase Type III; S-Adenosylhomocysteine; Vascular Diseases

2012
Reduced plasma levels of asymmetric di-methylarginine (ADMA) in patients with alcohol dependence normalize during withdrawal.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:11

    Topics: Adult; Alcoholism; Arginine; Diagnostic and Statistical Manual of Mental Disorders; Germany; Homocysteine; Humans; Hyperhomocysteinemia; International Classification of Diseases; Male; Middle Aged; Nitric Oxide Synthase; Pilot Projects; Prospective Studies; Risk Factors; Severity of Illness Index; Substance Withdrawal Syndrome; Time Factors; Vascular Diseases

2012
Vitamin B or L-arginine supplementation in hyperhomocysteinaemia: think twice!
    Cardiovascular research, 2012, Nov-01, Volume: 96, Issue:2

    Topics: Arginine; Arterial Occlusive Diseases; Female; Humans; Hyperhomocysteinemia; Male; Vitamins

2012
Protection of DDAH2 overexpression against homocysteine-induced impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 30, Issue:6

    Topics: Amidohydrolases; Arginine; Cells, Cultured; Endothelium; Gene Expression; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; L-Lactate Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase Type III; Signal Transduction

2012
Asymmetric dimethylarginine (ADMA): a key regulator of nitric oxide synthase.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Homeostasis; Humans; Hyperhomocysteinemia; Hyperlipidemias; Nitric Oxide Synthase; Vasodilation

2003
Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction.
    Stroke, 2004, Volume: 35, Issue:2

    Topics: Arginine; Cerebrovascular Circulation; DNA Methylation; Homocysteine; Humans; Hyperhomocysteinemia; Oxidative Stress; Reactive Oxygen Species; Risk Factors; Stroke

2004
Serum homocysteine and endothelial dysfunction in circulatory disorders in women.
    Circulation, 2004, Jul-27, Volume: 110, Issue:4

    Topics: Arginine; Coronary Disease; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Middle Aged; Myocardial Infarction; Nitric Oxide; Risk; Risk Factors

2004
Atherosclerosis and uremic retention solutes.
    Kidney international, 2004, Volume: 66, Issue:4

    Topics: Arginine; Arteriosclerosis; Female; Glomerulosclerosis, Focal Segmental; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Middle Aged; Nitric Oxide; Oxidative Stress; Phosphates; Uremia

2004
Endothelial dysfunction in patients with peripheral arterial disease and chronic hyperhomocysteinemia: potential role of ADMA.
    Vascular medicine (London, England), 2004, Volume: 9, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Arterial Occlusive Diseases; Chronic Disease; Endothelium, Vascular; Enzyme Inhibitors; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase; Peripheral Vascular Diseases; Radial Artery; Ultrasonography; Vasodilation

2004
Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults.
    Atherosclerosis, 2005, Volume: 179, Issue:2

    Topics: Acute Disease; Animals; Arginine; Biological Availability; Enzyme Inhibitors; Haplorhini; Humans; Hyperhomocysteinemia; Methionine; Nitric Oxide; Oxidative Stress; Reproducibility of Results

2005
Asymmetric dimethylarginine, homocysteine and renal function--is there a relation?
    Clinical chemistry and laboratory medicine, 2005, Volume: 43, Issue:10

    Topics: Adult; Age Factors; Arginine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kidney; Kidney Function Tests; Male; Middle Aged; Renal Dialysis

2005
Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation.
    Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:12

    Topics: Animals; Antioxidants; Aorta, Thoracic; Arginine; Biopterins; Cells, Cultured; Cystathionine beta-Synthase; Endothelium, Vascular; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Kinase C; Pterins; Superoxide Dismutase; Vasodilation

2005
Asymmetric dimethylarginine (ADMA) and hyperhomocysteinemia in patients with acute myocardial infarction.
    Clinical biochemistry, 2007, Volume: 40, Issue:1-2

    Topics: Aged; Arginine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Myocardial Infarction; Regression Analysis; Risk Factors; Statistics, Nonparametric; Stereoisomerism

2007
Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats.
    The British journal of nutrition, 2008, Volume: 99, Issue:5

    Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Diet; Homocysteine; Hyperhomocysteinemia; Male; Mesenteric Arteries; Methionine; Rats; Rats, Wistar; Vasodilation

2008
The homocysteine paradox.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:6

    Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Risk Factors; Vitamin B 12; Vitamin B 6

2008
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:6

    Topics: Animals; Arginine; Cell Line, Transformed; Cholesterol; Diet; Dietary Fats; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Humans; Hypercholesterolemia; Hyperhomocysteinemia; Macaca fascicularis; Methionine; Nitric Oxide Synthase; Regression Analysis; Vasodilation

2000
Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:12

    Topics: Angiography; Animals; Arginine; Blood Pressure; Body Weight; Collateral Circulation; Cyclic GMP; Disease Models, Animal; Heart Rate; Hindlimb; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Ischemia; Laser-Doppler Flowmetry; Muscle, Skeletal; Neovascularization, Physiologic; Nitrates; Nitrites; Rats; Regional Blood Flow; Time Factors

2000
Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans.
    Clinical science (London, England : 1979), 2001, Volume: 100, Issue:2

    Topics: Acute Disease; Adult; Arginine; Brachial Artery; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitroglycerin; Vasodilation; Vasodilator Agents

2001
Comment: the asymmetrical dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in the regulation of nitric oxide generation.
    Clinical science (London, England : 1979), 2001, Volume: 100, Issue:2

    Topics: Amidohydrolases; Arginine; Endothelium, Vascular; Humans; Hydrolases; Hyperhomocysteinemia; Nitric Oxide

2001
Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine.
    Circulation, 2001, Nov-20, Volume: 104, Issue:21

    Topics: Amidohydrolases; Animals; Aorta; Arginine; Arteriosclerosis; Cattle; Cell Line; Culture Techniques; Endothelium, Vascular; Homocysteine; Hydrolases; Hyperhomocysteinemia; Kinetics; Methionine; Nitric Oxide; Nitric Oxide Synthase; Recombinant Fusion Proteins; Signal Transduction

2001
Effect of homocysteine on the L-arginine/nitric oxide synthase/nitric oxide pathway in human platelets.
    Heart and vessels, 2002, Volume: 16, Issue:2

    Topics: Adult; Arginine; Biomarkers; Blood Platelets; Cardiovascular Diseases; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Nitric Oxide; Nitric Oxide Synthase; Risk Factors

2002