arginine and HbS Disease

arginine has been researched along with HbS Disease in 79 studies

Research

Studies (79)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (3.80)	18.7374
1990's	8 (10.13)	18.2507
2000's	32 (40.51)	29.6817
2010's	26 (32.91)	24.3611
2020's	10 (12.66)	2.80

Authors

Authors	Studies
Alpoim, PN; Carvalho, MDG; da Silva, AJ; de Oliveira, MM; Dusse, LMS; Ferreira, LGR; Martins, SR; Mendes, FS; Pinheiro, MB; Rios, DRA; Toledo, SLO	1
Bakshi, N; Dampier, C; Figueroa, J; Khemani, K; Kumari, P; Lane, PA; Leake, D; Morris, CR; Reyes, LZ	1
El-Bradey, MH; Elhawary, EE; Elshanshory, MR; Khedr, SF; Nagy, HM	1
Archer, DR; Brown, LA; Hansen, L; Hurtado, J; Joseph, G; Jun, HW; Lewis, CV; Sellak, H; Taylor, WR	1
Gladwin, MT; Hopper, RK	1
Ahmad, F; Airewele, G; Bakshi, N; Brousseau, DC; Brown, K; Campbell, A; Casper, TC; Chang, T; Chumpitazi, CE; Cohen, DM; Coleman, KD; Dampier, C; Denton, C; Ellison, A; Hatabah, D; Leake, D; Leibovich, S; Morris, CR; Rees, CA; Robinson, M; Thompson, A; Vichinsky, E; Villella, A; Wilkinson, H	1
Brown, LAS; Dampier, CD; Figueroa, J; Harris, F; Kumari, P; Lane, PA; Manoranjithan, S; Mendis, RD; Morris, CR; Reynolds, M; Shiva, S; Watt, A	1
Gladwin, MT; Kim-Shapiro, DB	1
Adeomi, A; Akingbola, TS; Alagbe, AE; Aworanti, OW; Salako, AO	1
Eimunjeze, OP; Jaja, SI; Ogungbemi, SI; Temiye, EO	1
Morris, CR; Shilo, NR	1
Arlet, JB; Avellino, V; Bartolucci, P; Benzerara, Y; Chaignon, M; Djebbar, M; Galacteros, F; Girot, R; Girshovich, A; Grateau, G; Habibi, A; Hammoudi, N; Haymann, JP; Letavernier, E; Levy, P; Lionnet, F; Stankovic Stojanovic, K; Tabibzadeh, N	1
Bluck, L; Cox, SE; Kamuhabwa, A; Makani, J; Marealle, AI; Minzi, O; Prentice, AM; Sasi, P; Siervo, M; Soka, D; Wassel, S	1
Cox, SE; Ellins, EA; Halcox, JP; Johnson, W; Kirkham, FJ; Luca Di Tanna, G; Makani, J; Marealle, AI; Newton, CR; Prentice, AM; Sasi, P; Soka, D	1
Benites, BD; Olalla-Saad, ST	1
Abd El-Hameed, F; Badraia, I; Donia, A; El-Shanshory, M; Mabrouk, M	1
Ansari, M; Gildengorin, G; Kuypers, FA; Lavrisha, L; Morris, CR; Neumayr, L; Stewart, M; Sweeters, N; Vichinsky, EP	1
Anigbogu, CN; Jaja, SI; Kehinde, MO; Ogungbemi, SI	1
Morris, CR	5
Knight-Madden, JM; Martí-Carvajal, AJ; Martinez-Zapata, MJ	2
Biemond, BJ; Brandjes, DP; Duits, AJ; Kappers-Klunne, MC; Landburg, PP; Mac Gillavry, MR; Muskiet, FA; Schnog, JJ; Teerlink, T; van Beers, EJ; van Esser, JW	1
Castro, O; Gladwin, MT; Harris, A; Hauser, KP; Kato, G; Little, JA; Machado, R; Maric, I; Martyr, SE; Morris, CR; Suh, JH; Taylor, J	1
Blackwelder, WC; Hazen, SL; Kato, GJ; Machado, RF; Taylor, JG; Wang, Z	1
McCarty, MF	1
Biemond, BJ; Brandjes, DP; Duits, AJ; Landburg, PP; Muskiet, FA; Schnog, JB; Teerlink, T	1
Billecke, SS; D'Alecy, LG	1
Gardner, RV; Leiva, L; Monjure, H; Scavella, A; Zea, AH	1
Biemond, BJ; Brandjes, DP; Fijnvandraat, K; Nur, E; Otten, HM; Schalkwijk, CG; Schnog, JJ	1
Gladwin, MT; Jain, S	1
Brown, M; Duckworth, L; Froyen, M; Gauger, C; Kissoon, N; Murphy, S; Sandler, E; Sullivan, KJ	1
Baliga, BS; Haynes, J; Mishra, N; Obiako, B	1
Adams-Graves, P; Askin, M; Castaneda, SA; Eberhardt, RT; Faller, DV; McMahon, L; Perrine, SP; Sutton, M; Tamary, H; Wright, EC	1
Cox, SE; Kirkham, FJ; Komba, AN; Makani, J; Newton, CR; Prentice, AM; Soka, D	1
Hardy, KA; Morris, CR; Newaskar, M	1
Fabry, ME; Kaul, DK; Suzuka, SM; Zhang, X	1
Barbosa, MC; Dutra, LL; Elias, DB; Gonçalves, RP; Martins, AM; Rocha, LB; Silva, HF	1
Vichinsky, E	2
Ballas, SK; Davis-Moon, L; Kreshak, AA; Lopez, BL; Ma, XL; Morris, CR	1
Claster, S; Hagar, W; Kepka-Lenhart, D; Kuypers, FA; Machado, L; Morris, CR; Morris, SM; Van Warmerdam, J; Vichinsky, EP	1
Gladwin, MT; Jison, ML	1
Kepka-Lenhart, D; Kuypers, FA; Machado, L; Morris, CR; Morris, SM; van Warmerdam, J; Vichinsky, EP	1
Baliga, BS; Haynes, J; Obiako, B; Ofori-Acquah, S; Pace, B	1
Aslan, M; Freeman, BA	1
Duits, AJ; Jager, EH; Moshage, H; Muskiet, FA; Muskiet, FD; Schnog, JJ; van der Dijs, FP	1
Brunini, TM; Mendes Ribeiro, AC	1
Atweh, GF; Galperin, Y; Ji, X; Li, Q; Liebhaber, SA; Perrine, S; Stamatoyannopoulos, G; Sutton, M; Weinberg, RS	1
Duits, AJ; Muskiet, FA; Schnog, JB; Teerlink, T; van der Dijs, FP	1
Eva, R; Fabry, ME; Fasipe, FR; Ubawike, AE	1
Blackwelder, WC; Gladwin, MT; Hazen, SL; Kato, GJ; Morris, CR; Morris, SM; Poljakovic, M; Sachdev, V; Vichinsky, EP; Wang, X	1
Waugh, WH	1
Cooke, JP; Kielstein, JT	1
Morris, CR; Singer, ST; Walters, MC	1
Dasgupta, T; Hebbel, RP; Kaul, DK	1
Habib, MJ; Millis, RM; Nahavandi, M; Tavakkoli, F; Tavakoli, N; Wyche, MQ	1
Barb, J; Danner, RL; Gladwin, MT; Harris, A; Kato, G; Logun, C; Morris, SM; Munson, PJ; Raghavachari, N; Solomon, MA; Suffredini, AF; Villagra, J; Xu, X	1
Duits, AJ; Landburg, PP; Muskiet, FA; Schnog, JJ; Teerlink, T	1
Dasgupta, T; Fabry, ME; Kaul, DK; Zhang, X	1
Gladwin, MT; Hsu, LL; Krajewski, ML	1
Dover, GJ; Faller, DV; Ginder, GD; Olivieri, NF; Perrine, SP; Vichinsky, EP	1
Bunn, HF	1
Cai, SP; Dover, GH; Faller, DV; Ginder, GD; Ikuta, T; Olivieri, NF; Perrine, SP; Vichinsky, EP; Witkowska, HE	1
Dover, GJ; Ginder, GD; Little, J; Olivieri, NF; Sher, GD; Yang, S	1
Olivieri, NF; Sher, GD	1
Arruda, VR; Condino-Neto, A; Costa, FF; De Nucci, G; Dias-Da-Motta, P; Muscará, MN; Saad, ST	1
Bolton, LL; Cackovic, M; Chung, C; Kerstein, MD	1
Fabry, ME; Kaul, DK; Liu, XD; Nagel, RL	1
Bayne, E; Duckworth, LJ; Freeman, B; Kissoon, N; Lima, JJ; Sandler, E; Sullivan, KJ; Sylvester, JE	1
Rezaei Kalantari, H	1
Fabry, ME; Nagel, RL; Romero, JR; Suzuka, SM	1
Enwonwu, CO; Turner, E; Xu, XX	1
Fales, FW; Grush, OC; Sophianopoulos, AJ; Sophianopoulos, JA; Wilson, JS	1
Levy, HL	1
Cotton, E; Hathaway, W; Solomons, C	1

Reviews

16 review(s) available for arginine and HbS Disease

Article	Year
Pathways to pulmonary hypertension in sickle cell disease: the search for prevention and early intervention. Expert review of hematology, 2017, Volume: 10, Issue:10 Topics: Anemia, Sickle Cell; Arginine; Biomarkers; Blood Coagulation; Echocardiography; Genetic Predisposition to Disease; Hemolysis; Humans; Hypertension, Pulmonary; Hypoxia; Nitric Oxide; Oxidative Stress; Respiratory Function Tests; Risk Assessment	2017
An update on arginine in sickle cell disease. Expert review of hematology, 2019, Volume: 12, Issue:4 Topics: Anemia, Sickle Cell; Animals; Arginine; Hemolysis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III	2019
Alterations of the arginine metabolome in sickle cell disease: a growing rationale for arginine therapy. Hematology/oncology clinics of North America, 2014, Volume: 28, Issue:2 Topics: Anemia, Sickle Cell; Antisickling Agents; Arginine; Drug Therapy, Combination; Fetal Hemoglobin; Humans; Hydroxyurea; Metabolome; Treatment Outcome	2014
Interventions for treating leg ulcers in people with sickle cell disease. The Cochrane database of systematic reviews, 2014, Dec-08, Issue:12 Topics: Actihaemyl; Anemia, Sickle Cell; Anti-Bacterial Agents; Arginine; Bandages; Butyrates; Carnitine; Humans; Isoxsuprine; Leg Ulcer; Oligopeptides; Randomized Controlled Trials as Topic	2014
Mechanisms of vasculopathy in sickle cell disease and thalassemia. Hematology. American Society of Hematology. Education Program, 2008 Topics: Anemia, Sickle Cell; Apolipoproteins; Arginine; Biological Transport; Endothelium, Vascular; Hemolysis; Humans; Inflammation; Kidney Diseases; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Reperfusion Injury; Thalassemia	2008
Asthma management: reinventing the wheel in sickle cell disease. American journal of hematology, 2009, Volume: 84, Issue:4 Topics: Acute Disease; Adult; Anemia, Sickle Cell; Anti-Asthmatic Agents; Arginase; Arginine; Asthma; Black or African American; Chest Pain; Child; Child, Preschool; Combined Modality Therapy; Comorbidity; Erythrocytes, Abnormal; Genetic Predisposition to Disease; Humans; Hypertension, Pulmonary; Hypoxia; Long QT Syndrome; Nitric Oxide; Oxidative Stress; Oxygen Inhalation Therapy; Prevalence; United States	2009
Asthma in sickle cell disease. TheScientificWorldJournal, 2011, May-26, Volume: 11 Topics: Anemia, Sickle Cell; Arginine; Asthma; Humans; Incidence; Leukotrienes; Lung; Nitric Oxide; Pneumonia	2011
Interventions for treating leg ulcers in people with sickle cell disease. The Cochrane database of systematic reviews, 2012, Nov-14, Volume: 11 Topics: Actihaemyl; Anemia, Sickle Cell; Anti-Bacterial Agents; Arginine; Bandages; Butyrates; Carnitine; Humans; Isoxsuprine; Leg Ulcer; Oligopeptides; Randomized Controlled Trials as Topic	2012
Emerging 'A' therapies in hemoglobinopathies: agonists, antagonists, antioxidants, and arginine. Hematology. American Society of Hematology. Education Program, 2012, Volume: 2012 Topics: Anemia, Sickle Cell; Antioxidants; Arginine; Cell Adhesion; Clinical Trials as Topic; Endothelium, Vascular; Hemoglobinopathies; Humans; Inflammation; Iron; Mutation; Nitric Oxide; Oxygen; Research Design; Treatment Outcome	2012
New therapies in sickle cell disease. Lancet (London, England), 2002, Aug-24, Volume: 360, Issue:9333 Topics: Anemia, Sickle Cell; Animals; Antioxidants; Arginine; Blood Transfusion; Enzyme Inhibitors; Fetal Hemoglobin; Fibrinolytic Agents; Genetic Therapy; Hematopoietic Stem Cell Transplantation; Hemoglobin, Sickle; Humans; Mice; Mice, Transgenic; Models, Animal; Nitric Oxide; Platelet Aggregation Inhibitors	2002
Hemolytic anemia-associated pulmonary hypertension of sickle cell disease and the nitric oxide/arginine pathway. American journal of respiratory and critical care medicine, 2003, Jul-01, Volume: 168, Issue:1 Topics: Anemia, Hemolytic; Anemia, Sickle Cell; Arginine; Biological Availability; Humans; Hypertension, Pulmonary; Nitric Oxide; Prognosis; Pulmonary Wedge Pressure; Syndrome; Vasodilator Agents	2003
Oxidant-mediated impairment of nitric oxide signaling in sickle cell disease--mechanisms and consequences. Cellular and molecular biology (Noisy-le-Grand, France), 2004, Volume: 50, Issue:1 Topics: Anemia, Sickle Cell; Animals; Arginine; Cytoskeletal Proteins; Free Radicals; Humans; Nitric Oxide; Oxidants; Signal Transduction	2004
L-Arginine transport in disease. Current medicinal chemistry. Cardiovascular and hematological agents, 2004, Volume: 2, Issue:2 Topics: Amino Acid Transport Systems, Basic; Anemia, Sickle Cell; Arginine; Biological Transport; Diabetes Mellitus; Heart Failure; Humans; Hypertension; Kidney Failure, Chronic; Nitric Oxide; Shock, Septic	2004
Clinical hemoglobinopathies: iron, lungs and new blood. Current opinion in hematology, 2006, Volume: 13, Issue:6 Topics: Anemia, Sickle Cell; Arginine; beta-Thalassemia; Child; Hematopoietic Stem Cell Transplantation; Humans; Hypertension, Pulmonary; Iron Chelating Agents; Iron Overload; Prognosis	2006
[How I treat ... sickle cell anemia: current therapies]. Revue medicale de Liege, 2001, Volume: 56, Issue:10 Topics: Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antisickling Agents; Arginine; Aspirin; Blood Transfusion; Fluid Therapy; Hematopoietic Stem Cell Transplantation; Hemolysis; Humans; Hydroxyurea; Nitric Oxide; Thromboembolism; Transplantation, Homologous	2001
Genetic screening. Advances in human genetics, 1973, Volume: 4 Topics: Amino Acid Metabolism, Inborn Errors; Anemia, Sickle Cell; Arginine; Carbohydrate Metabolism, Inborn Errors; Cystinuria; Erythrocytes; Fanconi Syndrome; Galactosemias; Genetics, Population; Glucosephosphate Dehydrogenase; Glycine; Hartnup Disease; Heterozygote; Histidine; Homocystine; Humans; Lysine; Maple Syrup Urine Disease; Mass Screening; Methods; Ornithine; Phenylalanine; Phenylketonurias; Succinates; Tyrosine	1973

Trials

11 trial(s) available for arginine and HbS Disease

Article	Year
Safety of intravenous arginine therapy in children with sickle cell disease hospitalized for vaso-occlusive pain: A randomized placebo-controlled trial in progress. American journal of hematology, 2022, 01-01, Volume: 97, Issue:1 Topics: Administration, Intravenous; Adolescent; Adult; Anemia, Sickle Cell; Arginine; Child; Child, Preschool; Hospitalization; Humans; Pain; Placebo Effect; Prospective Studies; Young Adult	2022
Sickle Cell Disease Treatment with Arginine Therapy (STArT): study protocol for a phase 3 randomized controlled trial. Trials, 2023, Aug-17, Volume: 24, Issue:1 Topics: Academies and Institutes; Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Arginine; Child; Clinical Trials, Phase III as Topic; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Saline Solution; Young Adult	2023
Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain. Blood, 2020, 09-17, Volume: 136, Issue:12 Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Arginine; Child; Female; Humans; Male; Mitochondria; Oxidative Stress; Pain; Prospective Studies	2020
Renin-angiotensin system blockade promotes a cardio-renal protection in albuminuric homozygous sickle cell patients. British journal of haematology, 2017, Volume: 179, Issue:5 Topics: Adult; Albuminuria; Anemia, Sickle Cell; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Blood Pressure; Creatinine; Female; Glomerular Filtration Rate; Humans; Male; Pulse Wave Analysis; Renin-Angiotensin System; Tricuspid Valve Insufficiency	2017
A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes. Haematologica, 2013, Volume: 98, Issue:9 Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Arginine; Child; Double-Blind Method; Female; Hospitalization; Humans; Infusions, Intravenous; Male; Pain; Pain Measurement; Prospective Studies; Treatment Outcome	2013
Effect of oral arginine supplementation on exhaled nitric oxide concentration in sickle cell anemia and acute chest syndrome. Journal of pediatric hematology/oncology, 2010, Volume: 32, Issue:7 Topics: Acute Chest Syndrome; Acute Disease; Administration, Oral; Adolescent; Anemia, Sickle Cell; Arginine; Aspartic Acid; Breath Tests; Child; Citrulline; Female; Glutamic Acid; Humans; Male; Nitrates; Nitric Oxide; Nitrites; Ornithine; Young Adult	2010
A randomized phase II trial of Arginine Butyrate with standard local therapy in refractory sickle cell leg ulcers. British journal of haematology, 2010, Volume: 151, Issue:5 Topics: Adult; Anemia, Sickle Cell; Arginine; Butyrates; Chronic Disease; Female; Humans; Leg Ulcer; Male; Middle Aged; Prospective Studies; Treatment Outcome; Wound Healing; Young Adult	2010
Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? American journal of respiratory and critical care medicine, 2003, Jul-01, Volume: 168, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Amino Acids; Anemia, Sickle Cell; Arginase; Arginine; Biological Availability; Case-Control Studies; Echocardiography; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Nitric Oxide; Ornithine; Oximetry; Pulmonary Wedge Pressure; Treatment Outcome	2003
Hydroxyurea and arginine therapy: impact on nitric oxide production in sickle cell disease. Journal of pediatric hematology/oncology, 2003, Volume: 25, Issue:8 Topics: Adolescent; Adult; Anemia, Sickle Cell; Antineoplastic Agents; Arginine; Child; Drug Interactions; Drug Therapy, Combination; Female; Free Radical Scavengers; Humans; Hydroxyurea; Male; Nitric Oxide	2003
Butyrate increases the efficiency of translation of gamma-globin mRNA. Blood, 2005, Feb-15, Volume: 105, Issue:4 Topics: Adult; Anemia, Sickle Cell; Arginine; Butyrates; Fetal Hemoglobin; Globins; Humans; Peptide Chain Initiation, Translational; Protein Biosynthesis; Reticulocytes; RNA, Messenger	2005
A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders. The New England journal of medicine, 1993, Jan-14, Volume: 328, Issue:2 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; beta-Thalassemia; Butyrates; Child; Child, Preschool; Female; Fetal Hemoglobin; Globins; Humans; Infusions, Intravenous; Male; RNA, Messenger	1993

Other Studies

52 other study(ies) available for arginine and HbS Disease

Article	Year
Endothelial dysfunction biomarkers in sickle cell disease: is there a role for ADMA and PAI-1? Annals of hematology, 2022, Volume: 101, Issue:2 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Biomarkers; Child; Cross-Sectional Studies; Endothelium; Female; Humans; Male; Plasminogen Activator Inhibitor 1; Severity of Illness Index; Young Adult	2022
Correlation of Asymmetric Dimethyl Arginine Level to Sickle Retinopathy in Children With Sickle Cell Disease. Journal of pediatric hematology/oncology, 2023, 01-01, Volume: 45, Issue:1 Topics: Anemia, Sickle Cell; Arginine; Child; Cross-Sectional Studies; Humans; Retinal Diseases	2023
Increasing nitric oxide bioavailability fails to improve collateral vessel formation in humanized sickle cell mice. Laboratory investigation; a journal of technical methods and pathology, 2022, Volume: 102, Issue:8 Topics: Anemia, Sickle Cell; Animals; Arginine; Biological Availability; Drinking Water; Hindlimb; Ischemia; Mice; Muscle, Skeletal; Necrosis; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Regional Blood Flow	2022
Revisiting Arginine Therapy for Sickle Cell Acute Vasoocclusive Painful Crisis. American journal of respiratory and critical care medicine, 2022, 07-01, Volume: 206, Issue:1 Topics: Anemia, Sickle Cell; Arginine; Child; Child, Hospitalized; Hemodynamics; Humans; Pain; Prospective Studies	2022
Arginine for mitochondrial oxidative enzymopathy. Blood, 2020, 09-17, Volume: 136, Issue:12 Topics: Anemia, Sickle Cell; Arginine; Child; Humans; Mitochondria; Oxidative Stress; Pain	2020
Plasma L-Arginine in Sickle Cell Anaemia Patients in Crises and its Correlation with Markers of Severity of Disease. West African journal of medicine, 2021, Apr-23, Volume: 38, Issue:4 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Cross-Sectional Studies; Humans; Middle Aged; Nigeria; Plasma; Quality of Life; Severity of Illness Index; Young Adult	2021
Blood pressure, hematologic and biochemical changes following L-arginine supplementation in children with sickle cell anaemia already on hydroxyurea therapy. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2020, Dec-31, Volume: 35, Issue:2 Topics: Anemia, Sickle Cell; Arginine; Blood Pressure; Child; Dietary Supplements; Humans; Hydroxyurea	2020
A pilot study of a non-invasive oral nitrate stable isotopic method suggests that arginine and citrulline supplementation increases whole-body NO production in Tanzanian children with sickle cell disease. Nitric oxide : biology and chemistry, 2018, 04-01, Volume: 74 Topics: Administration, Oral; Anemia, Sickle Cell; Arginine; Child; Citrulline; Dietary Supplements; Female; Humans; Male; Nitrates; Nitric Oxide; Nitrogen Isotopes; Pilot Projects; Tanzania	2018
Ready-to-use food supplement, with or without arginine and citrulline, with daily chloroquine in Tanzanian children with sickle-cell disease: a double-blind, random order crossover trial. The Lancet. Haematology, 2018, Volume: 5, Issue:4 Topics: Anemia, Sickle Cell; Arginine; Child; Chloroquine; Citrulline; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Humans; Male; Tanzania	2018
Asymmetric dimethylarginine levels in children with sickle cell disease and its correlation to tricuspid regurgitant jet velocity. European journal of haematology, 2013, Volume: 91, Issue:1 Topics: Adolescent; Anemia, Sickle Cell; Arginine; Blood Transfusion; Case-Control Studies; Child; Cross-Sectional Studies; Echocardiography, Doppler; Female; Hemolysis; Humans; Hypertension, Pulmonary; Male; Risk Factors; Tricuspid Valve Insufficiency	2013
L-arginine increases nitric oxide and attenuates pressor and heart rate responses to change in posture in sickle cell anemia subjects. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2013, Jun-30, Volume: 28, Issue:1 Topics: Anemia, Sickle Cell; Arginine; Heart Rate; Humans; Nitric Oxide; Posture	2013
Arginine Therapy Shows Promise for Treatment of Sickle Cell Disease Clinical Subphenotypes of Hemolysis and Arginine Deficiency. Anesthesia and analgesia, 2017, Volume: 124, Issue:4 Topics: Anemia, Sickle Cell; Arginine; Cell Death; Hemolysis; Humans; Nitric Oxide	2017
Association of asymmetric dimethylarginine with sickle cell disease-related pulmonary hypertension. Haematologica, 2008, Volume: 93, Issue:9 Topics: Adult; Anemia, Sickle Cell; Arginine; Biomarkers; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged	2008
Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy. European journal of haematology, 2009, Volume: 82, Issue:4 Topics: Adult; Anemia, Sickle Cell; Arginase; Arginine; beta-Globins; Citrulline; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Fetal Hemoglobin; Humans; Hydroxyurea; Male; Middle Aged; Ornithine; Phosphodiesterase Inhibitors; Piperazines; Purines; Reticulocyte Count; Sildenafil Citrate; Sulfones	2009
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death. British journal of haematology, 2009, Volume: 145, Issue:4 Topics: Anemia, Sickle Cell; Arginine; Case-Control Studies; Citrulline; Follow-Up Studies; Hemolysis; Humans; Hypertension, Pulmonary; Kidney Diseases; Linear Models; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen; Proportional Hazards Models; Risk; Survival Rate	2009
Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease. Medical hypotheses, 2010, Volume: 74, Issue:6 Topics: Anemia, Sickle Cell; Animals; Antioxidants; Arginine; Citrulline; Hemoglobins; Humans; Models, Biological; Nitrates; Nitric Oxide; Oxidative Stress; Vegetables	2010
Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype. Blood cells, molecules & diseases, 2010, Apr-15, Volume: 44, Issue:4 Topics: Adult; Albuminuria; Anemia, Sickle Cell; Arginine; beta-Thalassemia; Cholelithiasis; Female; Hemolysis; Humans; Hypertension, Pulmonary; Leg Ulcer; Male; Middle Aged; Nitric Oxide; Osteonecrosis; Phenotype; Priapism; Retinal Diseases; Sickle Cell Trait; Young Adult	2010
Massive quantities of asymmetric dimethylarginine (ADMA) are incorporated in red blood cell proteins and may be released by proteolysis following hemolytic stress. Blood cells, molecules & diseases, 2010, Jun-15, Volume: 45, Issue:1 Topics: Anemia, Sickle Cell; Arginine; Blood Proteins; Erythrocytes; Hemolysis; Humans	2010
Effect of L-arginine supplementation on immune responsiveness in patients with sickle cell disease. Pediatric blood & cancer, 2010, Volume: 55, Issue:2 Topics: Adolescent; Anemia, Sickle Cell; Arginine; Case-Control Studies; CD3 Complex; Cells, Cultured; Child; Female; Humans; Immunity; Lymphocyte Activation; Male; Phytohemagglutinins; T-Lymphocyte Subsets; Up-Regulation; Young Adult	2010
Plasma levels of advanced glycation end products are associated with haemolysis-related organ complications in sickle cell patients. British journal of haematology, 2010, Volume: 151, Issue:1 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Biomarkers; Female; Glycation End Products, Advanced; Hemolysis; Humans; Lysine; Male; Middle Aged; Oxidative Stress; Young Adult	2010
Arginine metabolism and nitric oxide bioavailability in sickle cell disease. Journal of pediatric hematology/oncology, 2010, Volume: 32, Issue:7 Topics: Anemia, Sickle Cell; Arginine; Endothelial Cells; Hemoglobins; Humans; Nitric Oxide; Nitric Oxide Synthase Type III	2010
Combined effects of arginine and hydroxyurea on BFU-E derived colony growth and HbF synthesis in erythroid progenitors isolated from sickle cell blood. Cellular and molecular biology (Noisy-le-Grand, France), 2010, Jun-01, Volume: 56 Suppl Topics: Anemia, Sickle Cell; Arginine; Cell Proliferation; Erythroid Precursor Cells; Fetal Hemoglobin; Humans; Hydroxyurea; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase	2010
Global arginine bioavailability in Tanzanian sickle cell anaemia patients at steady-state: a nested case control study of deaths versus survivors. British journal of haematology, 2011, Volume: 155, Issue:4 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Biological Availability; Case-Control Studies; Cohort Studies; Female; Hemoglobin, Sickle; Humans; Male; Prospective Studies; Retrospective Studies; Survival Analysis; Tanzania; Young Adult	2011
Antisickling fetal hemoglobin reduces hypoxia-inducible factor-1α expression in normoxic sickle mice: microvascular implications. American journal of physiology. Heart and circulatory physiology, 2013, Jan-01, Volume: 304, Issue:1 Topics: alpha-Globins; Anemia, Sickle Cell; Animals; Arginine; Arterioles; beta-Globins; Blood Pressure; Disease Models, Animal; Down-Regulation; Endothelin-1; Fetal Hemoglobin; Heme Oxygenase-1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microcirculation; Nitric Oxide; Regional Blood Flow; Vascular Endothelial Growth Factor A; Vasodilation	2013
L-arginine as an adjuvant drug in the treatment of sickle cell anaemia. British journal of haematology, 2013, Volume: 160, Issue:3 Topics: Adjuvants, Pharmaceutic; Anemia, Sickle Cell; Arginine; Erythrocyte Indices; Humans; Nitrites; Oxidative Stress	2013
L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department. British journal of haematology, 2003, Volume: 120, Issue:3 Topics: Acute Disease; Adult; Anemia, Sickle Cell; Arginine; Biomarkers; Constriction, Pathologic; Humans; Nitric Oxide; Pain Measurement; Vascular Diseases	2003
Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway. Blood, 2004, May-15, Volume: 103, Issue:10 Topics: Anemia, Sickle Cell; Arginine; Case-Control Studies; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Erythroid Precursor Cells; Fetal Hemoglobin; Gene Expression Regulation; Humans; Hydroxyurea; K562 Cells; Nitric Oxide; Nitric Oxide Synthase; Signal Transduction	2004
Evidence for a metabolic shift of arginine metabolism in sickle cell disease. Annals of hematology, 2004, Volume: 83, Issue:6 Topics: Adult; Amino Acids; Anemia, Sickle Cell; Arginase; Arginine; Case-Control Studies; Hemoglobin A; Hemoglobin, Sickle; Hemoglobins; Humans; Middle Aged; Statistics as Topic	2004
Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease. Annals of hematology, 2005, Volume: 84, Issue:5 Topics: Adult; Anemia, Sickle Cell; Arginine; Female; Hemoglobin, Sickle; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Vascular Cell Adhesion Molecule-1	2005
Arginine supplementation improves rotorod performance in sickle transgenic mice. Hematology (Amsterdam, Netherlands), 2004, Volume: 9, Issue:4 Topics: Anemia, Sickle Cell; Animals; Arginine; Diet; Disease Models, Animal; Hemoglobin A; Hemoglobin, Sickle; Homozygote; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Nitric Oxide; Vasodilation	2004
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA, 2005, Jul-06, Volume: 294, Issue:1 Topics: Adult; Aged; Amino Acids; Anemia, Sickle Cell; Arginase; Arginine; Case-Control Studies; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Nitric Oxide; Ornithine; Proportional Hazards Models	2005
Arginine metabolism, pulmonary hypertension, and sickle cell disease. JAMA, 2005, Nov-16, Volume: 294, Issue:19 Topics: Anemia, Sickle Cell; Arginase; Arginine; Citrulline; Dietary Supplements; Humans; Hypertension, Pulmonary	2005
Arginine metabolism, pulmonary hypertension, and sickle cell disease. JAMA, 2005, Nov-16, Volume: 294, Issue:19 Topics: Anemia, Sickle Cell; Arginase; Arginine; Humans; Hypertension, Pulmonary; Nitric Oxide Synthase	2005
New strategies for the treatment of pulmonary hypertension in sickle cell disease : the rationale for arginine therapy. Treatments in respiratory medicine, 2006, Volume: 5, Issue:1 Topics: Anemia, Sickle Cell; Arginase; Arginine; Humans; Hypertension, Pulmonary; Nitric Oxide; Prospective Studies	2006
Protective effect of arginine on oxidative stress in transgenic sickle mouse models. Free radical biology & medicine, 2006, Dec-15, Volume: 41, Issue:12 Topics: Anemia, Sickle Cell; Animals; Antioxidants; Arginine; Catalase; Dietary Supplements; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Superoxide Dismutase	2006
Effects of hydroxyurea and L-arginine on the production of nitric oxide metabolites in cultures of normal and sickle erythrocytes. Hematology (Amsterdam, Netherlands), 2006, Volume: 11, Issue:4 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Cells, Cultured; Erythrocytes; Erythrocytes, Abnormal; Female; Hemoglobin A; Hemoglobin, Sickle; Humans; Hydrogen Peroxide; Hydroxyurea; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Oxidative Stress; Sampling Studies	2006
Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation, 2007, Mar-27, Volume: 115, Issue:12 Topics: Adult; Anemia, Sickle Cell; Arginase; Arginine; Black People; Blood Platelets; Female; Gene Expression Profiling; Humans; Male; Middle Aged; Models, Biological; Nitric Oxide; Nucleic Acid Amplification Techniques; Oligonucleotide Array Sequence Analysis; Polyamines; Transcription, Genetic	2007
Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis. American journal of hematology, 2008, Volume: 83, Issue:7 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Child; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Stereoisomerism	2008
Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:1 Topics: Acetylcholine; Anemia, Sickle Cell; Animals; Arginine; Citrulline; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Globins; Heme Oxygenase-1; Hemodynamics; Hemoglobins; Hemolysis; Humans; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Tyrosine; Vasodilator Agents	2008
The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiology. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:1 Topics: Anemia, Sickle Cell; Animals; Arginine; Disease Models, Animal; Hemodynamics; Hemoglobins; Hemolysis; Humans; Microcirculation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Tyrosine; Vasodilator Agents	2008
Butyrate derivatives. New agents for stimulating fetal globin production in the beta-globin disorders. The American journal of pediatric hematology/oncology, 1994, Volume: 16, Issue:1 Topics: Adolescent; Adult; Amides; Anemia, Sickle Cell; Animals; Arginine; beta-Thalassemia; Butyrates; Child; Child, Preschool; Fetal Hemoglobin; Globins; Humans; Promoter Regions, Genetic	1994
Reversing ontogeny. The New England journal of medicine, 1993, Jan-14, Volume: 328, Issue:2 Topics: Anemia, Sickle Cell; Arginine; beta-Thalassemia; Butyrates; Fetal Hemoglobin; Globins; Humans; Hydroxyurea	1993
Extended therapy with intravenous arginine butyrate in patients with beta-hemoglobinopathies. The New England journal of medicine, 1995, Jun-15, Volume: 332, Issue:24 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; beta-Thalassemia; Biomarkers; Butyrates; Child; Child, Preschool; Female; Hemoglobins; Humans; Infusions, Intravenous; Male	1995
Rapid healing of chronic leg ulcers during arginine butyrate therapy in patients with sickle cell disease and thalassemia. Blood, 1994, Oct-01, Volume: 84, Issue:7 Topics: Adult; Anemia, Sickle Cell; Arginine; Butyrates; Female; Hemoglobins, Abnormal; Humans; Leg Ulcer; Thalassemia	1994
The release of nitric oxide and superoxide anion by neutrophils and mononuclear cells from patients with sickle cell anaemia. British journal of haematology, 1996, Volume: 93, Issue:2 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Female; Humans; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Aggregation; Superoxide Dismutase; Superoxides	1996
Leg ulceration in the sickle cell patient. Journal of the American College of Surgeons, 1998, Volume: 187, Issue:3 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Bandages, Hydrocolloid; Butyrates; Colloids; Combined Modality Therapy; Cost-Benefit Analysis; Erythropoietin; Female; Hospital Costs; Humans; Leg Ulcer; Length of Stay; Male; Occlusive Dressings; Recombinant Proteins; Recurrence; Retrospective Studies; Wound Healing	1998
Impaired nitric oxide-mediated vasodilation in transgenic sickle mouse. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:6 Topics: Anemia, Sickle Cell; Animals; Arginine; Blood Pressure; Colforsin; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hemoglobin, Sickle; Humans; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Vasodilation; Vasodilator Agents	2000
Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome. American journal of respiratory and critical care medicine, 2001, Dec-15, Volume: 164, Issue:12 Topics: Acute Disease; Adolescent; Anemia, Sickle Cell; Arginine; Breath Tests; Child; Citrulline; Forced Expiratory Volume; Genotype; Humans; Lung Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Polymorphism, Genetic; Syndrome; Trinucleotide Repeats; Vital Capacity	2001
Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity. Blood, 2002, Feb-15, Volume: 99, Issue:4 Topics: Anemia, Sickle Cell; Animals; Arginine; Citrulline; Disease Models, Animal; Erythrocyte Count; Erythrocytes; Hemoglobins; Humans; Kinetics; Mice; Mice, Transgenic; Oxygen; Potassium; Potassium Channels, Calcium-Activated	2002
Nitrogen metabolism in sickle cell anemia: free amino acids in plasma and urine. The American journal of the medical sciences, 1990, Volume: 300, Issue:6 Topics: Adult; Amino Acids; Anemia, Sickle Cell; Arginine; Humans; Nitrogen	1990
Two new antisickling agents and the use of amino acid salts. Clinical biochemistry, 1974, Volume: 7, Issue:2 Topics: Anemia, Sickle Cell; Arginine; Aspartic Acid; Drug Synergism; Edetic Acid; Glucose; Glutamates; Hemoglobins, Abnormal; Homozygote; Humans; Hydrogen-Ion Concentration; Lysine; Osmolar Concentration	1974
L-arginine, the sickling phenomenon, and cystic fibrosis. Pediatrics, 1972, Volume: 49, Issue:6 Topics: Aerosols; Anemia, Sickle Cell; Arginine; Cystic Fibrosis; Fever; Humans	1972