Compounds > arginine

arginine and Carcinoma, Hepatocellular

arginine has been researched along with Carcinoma, Hepatocellular in 97 studies

Research

Studies (97)

TimeframeStudies, this research(%)All Research%
pre-199026 (26.80)18.7374
1990's9 (9.28)18.2507
2000's24 (24.74)29.6817
2010's18 (18.56)24.3611
2020's20 (20.62)2.80

Authors

AuthorsStudies
Abdollahi, S; Ghasemi, Y; Irajie, C; Morowvat, MH; Najafipour, S; Savardashtaki, A1
Bao, S; Huang, X; Li, Q; Mei, M; Wang, J; Zheng, D1
Anderson, NM; Burrows, M; Carens, M; Kim, LC; Li, F; Missiaen, R; Nance, B; Riscal, R; Simon, MC; Skuli, N; Steensels, A1
Abd Elbaset, M; Ahmed, RF; Ahmed-Farid, OAH; Hessin, AF; Nasr, M; Shabana, ME; Shaffie, NM1
Henneberg, AL; Opitz, CA1
Bibi, K; Fatima, T; Haider, G; Ilyas, A; Sohrab, S; Zarina, S1
Ai, J; Deng, W; Huang, Z; Jiang, H; Li, M; Wu, Z; Yan, L; Zhang, L; Zhang, W; Zhou, Z1
Blukacz, L; Bosch, F; Colombi, M; Coto-Llerena, M; Dazert, E; Ercan, C; Hall, MN; Heim, MH; Jimenez, V; Mossmann, D; Müller, C; Nuciforo, S; Park, S; Piscuoglio, S; Ritter, N; Ryback, B; Sauer, U; Terracciano, LM; Weißenberger, D1
Abdollahi, S; Ghasemi, Y; Irajie, C; Morowvat, MH; Najafipour, S; Savardashtaki, A; Zarei, M1
Aizaki, H; Aizawa, M; Fujimi, TJ; Kojima, S; Masaki, T; Matsumoto, Y; Matsuura, T; Mezaki, Y; Murai, N; Nakamura, M; Tajima, A; Yoshikawa, A1
Cao, Y; Ge, J; Hu, G; Shao, J; Xie, P; Yan, C1
Aillot, L; Glendová, K; Hirsch, I; Hodek, J; Hubálek, M; Janovec, V; Langerová, H; Lubyová, B; Strunin, D; Weber, J; Zábranský, A1
Hao, X; Li, W1
Al-Shahari, EA; Alm-Eldeen, AA; El Barky, AR; Mohamed, TM1
Cai, J; Chen, L; Gao, Y; Gonzalez, FJ; Guo, X; Jiang, J; Krausz, KW; Liu, W; Luo, Y; Qu, A; Sun, L; Takahashi, S; Tang, W; Wang, Y; Xie, C; Yang, S; Yang, Y1
Bhudhisawasdi, V; Li, YY; Navasumrit, P; Parnlob, V; Ruchirawat, M; Savaraj, N; Sricharunrat, T; Thongkum, A; Wangpaichitr, M; Wu, C1
Buijs, N; Geller, DA; Houdijk, AP; Jessup, M; Oosterink, JE; Schierbeek, H; Stolz, DB; van Leeuwen, PA1
Adams, A; Cox, J; Kumer, S; Li, Z; O'Neil, M; Roberts, B; Schmitt, T; Tikhanovich, I; Vittal, A; Weinman, SA; Zhao, J1
Cao, W; Cao, Y; Ding, W; Du, R; Fang, L; Gao, Q; Wang, Z; Yang, H; Zhang, J1
Chang, YS; Chen, WC; Cho, CY; Hsu, HP; Huang, HL; Hung, WC; Lai, MD; Shieh, SC; Su, IJ; Teng, CF1
Chan, SL; Yeo, W1
Davis, MP; Sharma, P; Shinde, SS1
Floriano, WB; Freywald, A; Kamstra, RL1
Hoshida, Y; Kishikawa, T; Koike, K; Kojima, K; Kondo, Y; Noyama, T; Ohishi, M; Ohno, M; Ota, S; Otsuka, M; Sato, M; Shibata, C; Soga, T; Sun, X; Takata, A; Takehana, K; Tan, PS; Yoshikawa, T1
Choi, JW; Kim, HA; Kim, S; Na, Y; Nam, K; Yun, CO1
Bécsi, B; Darula, Z; Erdődi, F; Horváth, D; Iván, J; Lontay, B; Medzihradszky, KF; Sipos, A; Tamás, I1
Barańczyk-Kuźma, A; Chrzanowska, A; Krawczyk, M1
Bahr, MJ; Bode-Böger, SM; Gebel, M; Haller, H; Hesse, G; Kielstein, JT; Manns, MP; Martens-Lobenhoffer, J; Panning, B; Terkamp, C; Tsikas, D1
Albino, V; Ascierto, PA; Beneduce, G; Castello, G; Curley, SA; De Rosa, V; Di Giacomo, R; Glazer, ES; Izzo, F; Mastro, AA; Palaia, R; Petrillo, A; Piccirillo, M1
Baek, KH; Choi, JJ; Han, SE; Huh, JH; Kim, JS; Kim, K; Kim, MS; Kwon, IC; Lee, HY; Noh, SM; Oh, YK; Park, MO; Shim, G1
Curley, SA; Glazer, ES; Kaluarachchi, WD; Massey, KL; Zhu, C1
Chao, Y; Chen, LT; Chen, PJ; Chen, SC; Liao, LY; Lin, CC; Lu, SN; Sheen, IS; Thomson, JA; Wang, JH; Wang, TE; Wang-Peng, J; Yang, TS1
Kim, J; Kim, M; Kim, PH; Kim, SW; Kim, TI; Nam, HY; Yockman, JW; Yun, CO1
Chan, P; Chan, W; Chen, L; Cheng, PN; Fan, ST; Pang, R; Poon, RT; Yau, T; Yuen, J1
Li, L; Lin, M; Mao, Z; Meng, S; Qi, R; Wu, L1
Bomalaski, JS; Clark, MA; Ensor, CM; Holtsberg, FW1
Cao, X; Ma, J; Novotny-Diermayr, V; Tan, AL; Zhang, T1
Duong, FH; Filipowicz, M; Heim, MH; La Monica, N; Tripodi, M1
Cuijpers, V; de Jong, S; Schipper, RG; Teerlink, T; van den Berg, J; van Rijn, J; Verhofstad, AA1
Arrisi-Mercado, P; Baralle, FE; Muro, AF; Romano, M1
Díaz-Troya, S; Najib, S; Sánchez-Margalet, V1
Cong, WM; Dong, H; Liu, SF; Wu, MC; Zhu, GS; Zhu, ZZ1
Cheng, PN; Lam, KC; Leung, YC; Lo, WH; Tsui, SM1
Feun, L; Savaraj, N1
Beneduce, G; Bomalaski, JS; Castello, G; Clark, MA; Cremona, F; Curley, SA; Ensor, CM; Holtzberg, FW; Izzo, F; Korba, BE; Montella, M; Nasti, G; Orlando, AP; Orlando, R; Scordino, F1
Cheng, AW; Cheng, PN; Lam, TL; Lam, WM; Leung, YC; Lo, WH; Tsui, SM1
Huang, XH; Kong, QY; Zhang, LJ; Zhou, J; Zhou, ZX1
Jiang, JM; Liu, JY; Yin, XY; Zhu, JR1
Haagsman, HP; Peters, SJ; van Norren, K1
Blanke, CD; Chan, JS; Harding, CO1
Feun, L; Kuo, MT; Savaraj, N; Spector, S; Wangpaichitr, M; Wu, CJ; You, M1
Imai, Y; Ishikawa, T; Nakatsuru, Y; Oda, H1
Ghebranious, N; Knoll, BJ; Lozano, G; Sell, S; Wu, H1
Fontanière, B; Frébourg, T; Fröschl, G; Michot, JP; Morel, AP; Oberhammer, F; Ozturk, M; Ponchel, F; Puisieux, A; Tabone, E1
Bode, BP; Souba, WW; Wasa, M1
Fidge, N; Pyle, L; Sviridov, D1
Katz, R; Rose, E; Winter, SS1
Ando, A; Del Monte, MA; Ito, S; Maeda, H; Masu, Y; Ueda, M; Uyama, M1
Chen, WN; Leong, AL; Oon, CJ; Teng, SW; Zhao, Y1
Bréchot, C; Camus-Randon, AM; Goedert, JJ; Hainaut, P; Kirk, GD; Mendy, M; Merle, P; Montesano, R; Trépo, C1
Albina, JE; Campbell, WA; Coleman, WB; Medina, MM; Sah, DE; Thompson, NL1
Bode, BP; Pawlik, TM; Souba, WW; Sweeney, TJ1
Julkunen, I; Kinnunen, L; Melen, K1
Doss, M; Doss, MO; Gross, U; Schurek, JO1
Ezirike, J; Kim, S; Morris, HP; Paik, WK1
Ballard, FJ; Knowles, SE1
Allen, TD; Iype, PT1
Akamatsu, K; Ito, Y; Ohkubo, K; Tada, K1
Kobayashi, T; Nihei, J; Ohneda, A; Sakai, T1
Gabrielli, F; Tsugita, A1
Nuzum, CT; Richardson, UI; Snodgrass, PJ; Tashjian, AH1
Hnilica, LS; Hnilica, VS; Kappler, HA1
Frankel, HH; Glass, RM; Weisburger, JH; Yamamoto, RS1
Simberkoff, MS; Thomas, L; Thorbecke, GJ1
Desai, L; Mauritzen, CM; Ogawa, Y; Starbuck, WC; Taylor, CW1
Busch, H; Moskowitz, G; Ogawa, Y; Starbuck, WC1
Sasada, M; Terayama, H1
De Lamirande, G; Dupras, M1
Akino, T; Amano, M1
Busch, H; Jordan, J; Starbuck, WC; Taylor, CW; Wilson, RK1
Byvoet, P; Morris, HP1
Gorbacheva, LB; Kukushkina, GV1
Byvoet, P2
Colwell, JA; Wilber, JF1
Paresys-Richli, M; Sentenac, A; Simonnet, GM1
de Lamirande, G; Pinard, J1
Shigesada, K; Tatibana, M1
Beck, JP; Befort, N; Ebel, JP; Mercier, J1
Hogan, BL; Murden, S1
Gong, Y; Huang, Y; Li, K; Qin, Y; Qiu, D; Tang, H; Yang, Y; Ye, L; Yuan, Z; Zhang, J1
Lv, J; Xu, CQ; Yang, KS1
Li, K; Qin, Y; Ye, L1
Gao, Y; Hu, Y; Huang, Q; Jiang, Y; Jin, S; Luo, K; Lv, C; Lv, D; Qian, Z; Shang, D; Shao, J; Zhu, K1
Pandey, S; Sikorska, M; Smith, B; Walker, PR1
Bezwoda, WR; Derman, DP; Kew, M; Weaving, A1

Reviews

4 review(s) available for arginine and Carcinoma, Hepatocellular

ArticleYear
Development of systemic therapy for hepatocellular carcinoma at 2013: updates and insights.
    World journal of gastroenterology, 2014, Mar-28, Volume: 20, Issue:12

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Arginine; Carcinoma, Hepatocellular; Clinical Trials as Topic; Histone Deacetylase Inhibitors; Humans; Immunotherapy; Liver Neoplasms; Medical Oncology; Proto-Oncogene Proteins c-met; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor Receptor-2

2014
Pegylated arginine deiminase: a novel anticancer enzyme agent.
    Expert opinion on investigational drugs, 2006, Volume: 15, Issue:7

    Topics: Amino Acid Sequence; Amino Acids; Animals; Antineoplastic Agents; Arginine; Argininosuccinate Synthase; Carcinoma, Hepatocellular; Citrulline; Clinical Trials as Topic; Dexamethasone; Dogs; Drug Screening Assays, Antitumor; Drug Synergism; Drugs, Investigational; Humans; Hydrolases; Liver Neoplasms; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Molecular Sequence Data; Mycoplasma hominis; Neoplasm Proteins; Neoplasms; Nutritional Requirements; Polyethylene Glycols; Rabbits; Randomized Controlled Trials as Topic; Recombinant Proteins; Skin Neoplasms; Species Specificity; Treatment Outcome

2006
Arginine deprivation as a targeted therapy for cancer.
    Current pharmaceutical design, 2008, Volume: 14, Issue:11

    Topics: Animals; Antineoplastic Agents; Arginine; Argininosuccinate Synthase; Carcinoma, Hepatocellular; Clinical Trials as Topic; Drug Delivery Systems; Gene Expression Regulation, Neoplastic; Humans; Hydrolases; Liver Neoplasms; Melanoma; Polyethylene Glycols; Skin Neoplasms

2008
Two carbamyl phosphate synthetases of mammals: specific roles in control of pyrimidine and urea biosynthesis.
    Advances in enzyme regulation, 1972, Volume: 10

    Topics: Adenosine Triphosphate; Animals; Arginine; Aspartic Acid; Carbamates; Carbon Isotopes; Carcinoma, Hepatocellular; Dietary Proteins; Glutamates; Humans; Liver; Liver Neoplasms; Magnesium; Mice; Models, Chemical; Neurospora; Phosphotransferases; Pyrimidines; Rats; Spleen; Transferases; Uracil Nucleotides; Urea

1972

Trials

6 trial(s) available for arginine and Carcinoma, Hepatocellular

ArticleYear
Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, May-01, Volume: 28, Issue:13

    Topics: Aged; Aged, 80 and over; alpha-Fetoproteins; Antibodies; Antineoplastic Agents; Arginine; Biomarkers; Carcinoma, Hepatocellular; Chi-Square Distribution; Female; Humans; Hydrolases; Injections, Intramuscular; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Polyethylene Glycols; Time Factors; Treatment Outcome

2010
A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients.
    British journal of cancer, 2010, Sep-28, Volume: 103, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Arginine; Asian People; Carcinoma, Hepatocellular; Disease-Free Survival; Female; Humans; Hydrolases; Liver Neoplasms; Male; Middle Aged; Polyethylene Glycols; Retreatment

2010
A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma.
    Investigational new drugs, 2013, Volume: 31, Issue:1

    Topics: Adult; Aged; Arginase; Arginine; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; Middle Aged; Polyethylene Glycols; Recombinant Proteins

2013
Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocellular c
    Cancer letters, 2005, Jun-16, Volume: 224, Issue:1

    Topics: Adult; Aged; Arginase; Arginine; Carcinoma, Hepatocellular; Embolization, Therapeutic; Female; Humans; Hypoglycemic Agents; Insulin; Liver; Liver Neoplasms; Male; Middle Aged; Treatment Outcome

2005
[Arginine supplementation in total parenteral nutrition improves postoperative cellular immune function of patients with hepatocellular carcinoma after operation].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2007, Volume: 27, Issue:7

    Topics: Adult; Aged; Arginine; Carcinoma, Hepatocellular; Cytokines; Dietary Supplements; Female; Humans; Immunity, Cellular; Liver Neoplasms; Male; Middle Aged; Parenteral Nutrition; Postoperative Period; T-Lymphocyte Subsets

2007
Combination chemotherapy of hepatocellular cancer. Comparison of adriamycin + VM 26 + 5-fluorouracil with mAMSA + VM 26 + 5-fluorouracil.
    Oncology, 1987, Volume: 44, Issue:4

    Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; Doxorubicin; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Podophyllotoxin; Random Allocation; Teniposide; Time Factors

1987

Other Studies

87 other study(ies) available for arginine and Carcinoma, Hepatocellular

ArticleYear
Evaluating Five Escherichia coli Derivative Strains as a Platform for Arginine Deiminase Overproduction.
    Recent patents on biotechnology, 2022, Volume: 16, Issue:2

    Topics: Arginine; Carcinoma, Hepatocellular; Escherichia coli; Humans; Hydrolases; Liver Neoplasms; Patents as Topic; Recombinant Proteins

2022
PRMT5 determines the pattern of polyploidization and prevents liver from cirrhosis and carcinogenesis.
    Journal of genetics and genomics = Yi chuan xue bao, 2023, Volume: 50, Issue:2

    Topics: Aged; Animals; Arginine; Carcinogenesis; Carcinoma, Hepatocellular; Histones; Humans; Liver Cirrhosis; Liver Neoplasms; Mice; Protein-Arginine N-Methyltransferases

2023
GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment.
    Cell metabolism, 2022, 08-02, Volume: 34, Issue:8

    Topics: Arginine; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Protein Serine-Threonine Kinases; Senotherapeutics

2022
Arginine Depletion plus GCN2 Inhibition Sensitizes HCC Cells to Senolytic Therapies.
    Cancer discovery, 2022, 09-02, Volume: 12, Issue:9

    Topics: Arginine; Carcinoma, Hepatocellular; Eukaryotic Initiation Factor-2; Humans; Liver Neoplasms; Protein Serine-Threonine Kinases; Senotherapeutics

2022
Combating hematopoietic and hepatocellular abnormalities resulting from administration of cisplatin: role of liver targeted glycyrrhetinic acid nanoliposomes loaded with amino acids.
    Pharmaceutical development and technology, 2022, Volume: 27, Issue:9

    Topics: Amino Acids; Arginine; Carcinoma, Hepatocellular; Cisplatin; Glutamine; Glycyrrhetinic Acid; Humans; Liver Neoplasms

2022
Making liver cancer cells go ARGh!
    The EMBO journal, 2022, 11-02, Volume: 41, Issue:21

    Topics: Arginine; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Humans; Liver; Liver Neoplasms

2022
Polymorphic Variants of
    Protein and peptide letters, 2023, Volume: 30, Issue:7

    Topics: Arginine; Argininosuccinate Synthase; Carcinoma, Hepatocellular; Humans; Liver Neoplasms

2023
Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression.
    Journal of translational medicine, 2023, 09-15, Volume: 21, Issue:1

    Topics: Arginine; Carcinoma, Hepatocellular; Ferroptosis; Hepatitis B virus; HSC70 Heat-Shock Proteins; Humans; Liver Neoplasms; Methylation

2023
Arginine reprograms metabolism in liver cancer via RBM39.
    Cell, 2023, 11-09, Volume: 186, Issue:23

    Topics: Animals; Arginine; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Lipid Metabolism; Liver Neoplasms; Mice

2023
Amino Acids Sequence-based Analysis of Arginine Deiminase from Different Prokaryotic Organisms: An In Silico Approach.
    Recent patents on biotechnology, 2020, Volume: 14, Issue:3

    Topics: Amino Acid Sequence; Antineoplastic Agents; Arginine; Bacteria; Bacterial Proteins; Carcinoma, Hepatocellular; Computational Biology; Computer Simulation; Conserved Sequence; Gene Expression; Humans; Hydrolases; Liver Neoplasms; Melanoma; Models, Molecular; Patents as Topic; Phylogeny; Polyethylene Glycols; Protein Interaction Domains and Motifs; Sequence Alignment; Sequence Homology, Amino Acid; Skin Neoplasms

2020
Investigation of the effects of urea cycle amino acids on the expression of ALB and CEBPB in the human hepatocellular carcinoma cell line FLC-4.
    Human cell, 2020, Volume: 33, Issue:3

    Topics: Amino Acids; Arginine; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Protein-beta; Cell Line, Tumor; Culture Media; Gene Expression; Hepatocytes; Humans; Liver Neoplasms; Ornithine; RNA, Messenger; Serum Albumin, Human

2020
PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation.
    Experimental cell research, 2020, 09-15, Volume: 394, Issue:2

    Topics: Animals; Apoptosis; Arginine; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Male; Methylation; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Promoter Regions, Genetic; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-bcl-2; Up-Regulation

2020
Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination.
    Cells, 2020, 11-26, Volume: 9, Issue:12

    Topics: Arginine; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; HEK293 Cells; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Humans; Lysine; Protein Processing, Post-Translational; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination; Viral Proteins

2020
Molybdenum Dioxide (MoS₂)/Gadolinium (Gd) Containing Arginine-Glycine-Aspartic Acid (RGD) Sequences as New Nano-Contrast Agent for Cancer Magnetic Resonance Imaging (MRI).
    Journal of nanoscience and nanotechnology, 2021, 03-01, Volume: 21, Issue:3

    Topics: Animals; Arginine; Aspartic Acid; Carcinoma, Hepatocellular; Contrast Media; Gadolinium; Glycine; Liver Neoplasms; Magnetic Resonance Imaging; Mice; Mice, Nude; Molybdenum; Nanoparticles; Oligopeptides; Oxides

2021
Doxorubicin, L-arginine, or their combination as a prophylactic agent against hepatic carcinoma in mice.
    Environmental science and pollution research international, 2021, Volume: 28, Issue:28

    Topics: Alanine Transaminase; Animals; Arginine; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Doxorubicin; Liver; Liver Neoplasms; Mice

2021
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma.
    Hepatology (Baltimore, Md.), 2021, Volume: 74, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Animals; Arginine; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Diethylnitrosamine; Enzyme Inhibitors; Female; Histocompatibility Antigens Class II; Humans; Immune Checkpoint Inhibitors; Liver Neoplasms; Liver Neoplasms, Experimental; Lymphocytes, Tumor-Infiltrating; Male; Mice; Mice, Transgenic; Middle Aged; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-myc; Pyrimidines; Quinolines; Up-Regulation; Young Adult

2021
The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma.
    International journal of molecular sciences, 2017, Jun-01, Volume: 18, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arginine; Argininosuccinate Synthase; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Female; Fluorouracil; Gene Expression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydrolases; Liver Neoplasms; Male; Middle Aged; Models, Biological; Polyethylene Glycols; Treatment Outcome

2017
A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1.
    Angiogenesis, 2017, Volume: 20, Issue:4

    Topics: Aged; Amidohydrolases; Arginine; Carcinoma, Hepatocellular; Cell Hypoxia; Female; Hep G2 Cells; Humans; Liver Neoplasms; Male; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase Type II; Vascular Endothelial Growth Factor A

2017
Protein arginine methyl transferase 1- and Jumonji C domain-containing protein 6-dependent arginine methylation regulate hepatocyte nuclear factor 4 alpha expression and hepatocyte proliferation in mice.
    Hepatology (Baltimore, Md.), 2018, Volume: 67, Issue:3

    Topics: Animals; Arginine; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Proliferation; Chromatin Immunoprecipitation; Ethanol; Gene Expression Regulation, Neoplastic; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein-Arginine N-Methyltransferases; Real-Time Polymerase Chain Reaction; Receptors, Cell Surface

2018
Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.
    Journal of proteome research, 2019, 05-03, Volume: 18, Issue:5

    Topics: Adult; Aged; Arginine; Blood Vessels; Carcinoma, Hepatocellular; Cholesterol; Fatty Acids; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Gluconeogenesis; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Annotation; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Staging; Proteomics; Urea

2019
Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:11

    Topics: Animals; Arginine; Argininosuccinate Lyase; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cyclin A2; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Nitric Oxide; RNA, Small Interfering

2013
Acute hyperammonemic encephalopathy in a non-cirrhotic patient with hepatocellular carcinoma reversed by arginine therapy.
    Journal of pain and symptom management, 2014, Volume: 47, Issue:4

    Topics: Antineoplastic Agents; Arginine; Brain Diseases, Metabolic; Carcinoma, Hepatocellular; Humans; Hyperammonemia; Indoles; Liver Neoplasms; Male; Pyrroles; Sunitinib; Young Adult

2014
N-(2,4)-dinitrophenyl-L-arginine Interacts with EphB4 and Functions as an EphB4 Kinase Modulator.
    Chemical biology & drug design, 2015, Volume: 86, Issue:4

    Topics: Antineoplastic Agents; Arginine; Carcinoma, Hepatocellular; Dinitrobenzenes; Humans; Liver Neoplasms; Neoplasm Proteins; Receptor, EphB4

2015
Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.
    Oncotarget, 2015, Apr-10, Volume: 6, Issue:10

    Topics: Animals; Apoptosis; Arginine; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs; Niacinamide; Phenylurea Compounds; Sorafenib

2015
Hepatoma targeting peptide conjugated bio-reducible polymer complexed with oncolytic adenovirus for cancer gene therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Dec-28, Volume: 220, Issue:Pt B

    Topics: Adaptive Immunity; Adenoviridae; Arginine; Carcinoma, Hepatocellular; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hep G2 Cells; Humans; Immunity, Innate; Liver Neoplasms; Oncolytic Virotherapy; Oncolytic Viruses; Peptides; Polyamines; Polyethylene Glycols; Proto-Oncogene Proteins c-met; RNA Interference; RNA, Small Interfering; RNAi Therapeutics; Transduction, Genetic; Transfection; Vascular Endothelial Growth Factor A

2015
Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells.
    Scientific reports, 2017, 01-11, Volume: 7

    Topics: Arginine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Down-Regulation; Gene Expression Regulation, Neoplastic; Gene Silencing; Hep G2 Cells; Humans; Liver Neoplasms; Methylation; Models, Biological; Myosin-Light-Chain Phosphatase; Oligonucleotide Array Sequence Analysis; Phosphorylation; Phosphothreonine; Protein Binding; Protein Interaction Mapping; Protein-Arginine N-Methyltransferases; rho-Associated Kinases; Substrate Specificity

2017
Changes in arginase isoenzymes pattern in human hepatocellular carcinoma.
    Biochemical and biophysical research communications, 2008, Dec-12, Volume: 377, Issue:2

    Topics: Adult; Aged; Arginase; Arginine; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Enzyme Activation; Female; Humans; Isoenzymes; Liver Neoplasms; Male; Middle Aged

2008
Procedure-related pulmonary hypertension in patients with hepatocellular carcinoma undergoing percutaneous ethanol injection--role of ethanol, hemolysis, asymmetric dimethylarginine, and the nitric oxide system.
    Critical care medicine, 2009, Volume: 37, Issue:4

    Topics: Aged; Arginine; Carcinoma, Hepatocellular; Cross-Sectional Studies; Ethanol; Female; Hemolysis; Humans; Hypertension, Pulmonary; Injections; Liver Neoplasms; Male; Nitric Oxide

2009
Pegylated poly-l-arginine derivatives of chitosan for effective delivery of siRNA.
    Journal of controlled release : official journal of the Controlled Release Society, 2010, Jul-14, Volume: 145, Issue:2

    Topics: Animals; Arginine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Hemolysis; Humans; Liver Neoplasms; Lung Neoplasms; Mice; Molecular Weight; Polyethylene Glycols; Polymers; RNA, Small Interfering

2010
Bioengineered arginase I increases caspase-3 expression of hepatocellular and pancreatic carcinoma cells despite induction of argininosuccinate synthetase-1.
    Surgery, 2010, Volume: 148, Issue:2

    Topics: Apoptosis; Arginase; Arginine; Argininosuccinate Synthase; Carcinoma, Hepatocellular; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Induction; Humans; Ki-67 Antigen; Liver Neoplasms; Models, Biological; Pancreatic Neoplasms; Protein Engineering; Recombinant Proteins

2010
Bioreducible polymer-conjugated oncolytic adenovirus for hepatoma-specific therapy via systemic administration.
    Biomaterials, 2011, Volume: 32, Issue:35

    Topics: Adaptive Immunity; Adenoviridae; Animals; Arginine; Biocompatible Materials; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Dithiothreitol; Green Fluorescent Proteins; Humans; Immune Evasion; Immunity, Innate; Liver; Liver Neoplasms; Mice; Mice, Inbred BALB C; Oncolytic Viruses; Particle Size; Polymers; Static Electricity; Transduction, Genetic; Treatment Outcome

2011
Expression of argininosuccinate synthetase in patients with hepatocellular carcinoma.
    Journal of gastroenterology and hepatology, 2013, Volume: 28, Issue:2

    Topics: Adult; Arginine; Argininosuccinate Synthase; Biomarkers, Tumor; Blotting, Western; Carcinoma, Hepatocellular; Case-Control Studies; DNA Methylation; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Liver Neoplasms; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction

2013
Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo.
    Cancer research, 2002, Oct-01, Volume: 62, Issue:19

    Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Carcinoma, Hepatocellular; Female; Humans; Hydrolases; Liver Neoplasms; Melanoma; Mice; Mice, Nude; Mice, SCID; Polyethylene Glycols; RNA, Messenger; Substrate Specificity; Succinimides; Transfection; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2002
A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation.
    The Journal of biological chemistry, 2003, Aug-01, Volume: 278, Issue:31

    Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biological Transport; Carcinoma, Hepatocellular; Cell Fractionation; Cell Nucleus; Conserved Sequence; COS Cells; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Fluorescent Antibody Technique; Gene Deletion; Gene Expression; Humans; Immunosorbent Techniques; Leucine; Liver Neoplasms; Mice; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Phosphorylation; Polymerase Chain Reaction; Protein Structure, Secondary; Signal Transduction; STAT3 Transcription Factor; Structure-Activity Relationship; Trans-Activators; Transfection; Tumor Cells, Cultured; Tyrosine

2003
Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A.
    Gastroenterology, 2004, Volume: 126, Issue:1

    Topics: Adult; Aged; Animals; Antiviral Agents; Arginine; Carcinoma, Hepatocellular; Cells, Cultured; DNA-Binding Proteins; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoenzymes; Liver; Liver Neoplasms; Male; Methylation; Mice; Mice, Transgenic; Middle Aged; Phosphoprotein Phosphatases; Protein Inhibitors of Activated STAT; Protein Phosphatase 2; Protein-Tyrosine Kinases; Proteins; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Up-Regulation

2004
Induction of hyperammonia in irradiated hepatoma cells: a recapitulation and possible explanation of the phenomenon.
    British journal of cancer, 2004, Jul-05, Volume: 91, Issue:1

    Topics: Ammonia; Arginine; Carcinoma, Hepatocellular; Culture Media; Humans; Hydrogen-Ion Concentration; Hydrolases; Liver Neoplasms; Mycoplasma; Tumor Cells, Cultured; X-Rays

2004
An exonic splicing enhancer offsets the atypical GU-rich 3' splice site of human apolipoprotein A-II exon 3.
    The Journal of biological chemistry, 2004, Sep-17, Volume: 279, Issue:38

    Topics: Apolipoprotein A-II; Arginine; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromosome Mapping; Electrophoretic Mobility Shift Assay; Enhancer Elements, Genetic; Exons; Fibronectins; Genetic Complementation Test; Guanine; Humans; Introns; Liver Neoplasms; Molecular Sequence Data; Mutagenesis; Nuclear Proteins; Point Mutation; Protein Structure, Tertiary; RNA Splice Sites; RNA Splicing; RNA-Binding Proteins; Serine; Serine-Arginine Splicing Factors

2004
eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin, a chromogranin A-derived peptide, on growth and proliferation of hepatoma cells.
    Regulatory peptides, 2005, Feb-15, Volume: 125, Issue:1-3

    Topics: Aminoquinolines; Animals; Arginine; Calcium; Carbazoles; Carcinoma, Hepatocellular; Cell Enlargement; Cell Proliferation; Chromogranin A; Chromogranins; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Isoenzymes; Leucine; Liver; MAP Kinase Signaling System; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Ornithine; Pancreatic Hormones; Peptides; Phospholipase C beta; Protein Isoforms; Rats; Receptors, Atrial Natriuretic Factor; Spermidine; Thymidine; Time Factors; Type C Phospholipases

2005
Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population.
    World journal of gastroenterology, 2005, Jan-14, Volume: 11, Issue:2

    Topics: Amino Acid Substitution; Arginine; Base Sequence; Carcinoma, Hepatocellular; China; DNA Primers; Gene Frequency; Humans; Liver Neoplasms; Mutation, Missense; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Risk Factors; Tumor Suppressor Protein p53

2005
Pegylated arginine deiminase lowers hepatitis C viral titers and inhibits nitric oxide synthesis.
    Journal of gastroenterology and hepatology, 2007, Volume: 22, Issue:1

    Topics: Adult; Arginine; Carcinoma, Hepatocellular; Hepacivirus; Humans; Hydrolases; Liver Neoplasms; Nitric Oxide; Polyethylene Glycols; RNA, Viral; Statistics, Nonparametric; Tomography, Spiral Computed

2007
Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion.
    Cancer research, 2007, Jan-01, Volume: 67, Issue:1

    Topics: Animals; Arginase; Arginine; Carcinoma, Hepatocellular; Cell Growth Processes; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Ornithine Carbamoyltransferase; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Xenograft Model Antitumor Assays

2007
Effects of endogenous nitric oxide induced by 5-fluorouracil and L-Arg on liver carcinoma in nude mice.
    World journal of gastroenterology, 2007, Dec-14, Volume: 13, Issue:46

    Topics: Animals; Antimetabolites; Apoptosis; Arginine; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Fluorouracil; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Xenograft Model Antitumor Assays

2007
Arginase release by primary hepatocytes and liver slices results in rapid conversion of arginine to urea in cell culture media.
    Toxicology in vitro : an international journal published in association with BIBRA, 2008, Volume: 22, Issue:4

    Topics: Animals; Arginase; Arginine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cells, Cultured; Hepatocytes; Humans; Liver; Liver Function Tests; Liver Neoplasms; Male; Rats; Rats, Sprague-Dawley; Urea

2008
Postchemotherapy hyperammonemic encephalopathy emulating ornithine transcarbamoylase (OTC) deficiency.
    Southern medical journal, 2008, Volume: 101, Issue:5

    Topics: Adult; Arginine; Carcinoma, Hepatocellular; Citrulline; Female; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Neoplasms; Ornithine; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Polymorphism, Single-Stranded Conformational; Syndrome

2008
A polymorphism at codon 160 of human O6-methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assay.
    Carcinogenesis, 1995, Volume: 16, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Base Sequence; Carcinoma, Hepatocellular; Child; Cholangiocarcinoma; Codon; Cysteine; DNA Primers; Exons; Female; Glycine; Humans; Kidney; Liver Neoplasms; Male; Methyltransferases; Middle Aged; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Reference Values; Spleen; Stomach Neoplasms

1995
Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure.
    Molecular carcinogenesis, 1995, Volume: 13, Issue:2

    Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Arginine; Base Sequence; Carcinoma, Hepatocellular; Codon; Creatine Kinase; Genes, p53; Hepatitis B; Humans; Liver Neoplasms; Mice; Molecular Sequence Data; Mutation; Neoplastic Stem Cells; Osteosarcoma; Promoter Regions, Genetic; Protein Conformation; Sequence Homology, Amino Acid; Serine; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1995
Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis.
    Cancer research, 1994, Apr-15, Volume: 54, Issue:8

    Topics: Amino Acid Sequence; Animals; Apoptosis; Arginine; Base Sequence; Carcinoma, Hepatocellular; Cell Division; Cell Line; DNA Primers; Genes, p53; Humans; Liver Neoplasms; Mice; Mice, Nude; Mitosis; Mitotic Index; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Serine; Transfection; Transforming Growth Factor beta; Transplantation, Heterologous; Tumor Cells, Cultured

1994
Adaptive regulation of amino acid transport in nutrient-deprived human hepatomas.
    American journal of surgery, 1996, Volume: 171, Issue:1

    Topics: Adaptation, Physiological; Alanine; Amino Acids; Arginine; Biological Transport; Carcinoma, Hepatocellular; Cell Division; Cell Line; Glutamine; Humans; Leucine; Liver Neoplasms; Tumor Cells, Cultured

1996
Identification of a sequence of apolipoprotein A-I associated with the efflux of intracellular cholesterol to human serum and apolipoprotein A-I containing particles.
    Biochemistry, 1996, Jan-09, Volume: 35, Issue:1

    Topics: Amino Acid Sequence; Antibodies, Monoclonal; Apolipoprotein A-I; Arginine; Aspartic Acid; Binding Sites; Blotting, Western; Carcinoma, Hepatocellular; Cell Line; Cell Membrane; Cholesterol; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Epitopes; Humans; Immunoglobulin Fab Fragments; Kinetics; Lipoproteins, HDL; Liposomes; Liver Neoplasms; Membrane Lipids; Phosphatidylcholines; Tumor Cells, Cultured

1996
Hyperammonemia after chemotherapy in an adolescent with hepatocellular carcinoma.
    Journal of pediatric gastroenterology and nutrition, 1997, Volume: 25, Issue:5

    Topics: Adolescent; Ammonia; Antineoplastic Combined Chemotherapy Protocols; Arginine; Brain Diseases; Carcinoma, Hepatocellular; Female; Humans; Lactulose; Neomycin; Parenteral Nutrition, Total; Renal Dialysis

1997
Prevention of ornithine cytotoxicity by proline in human retinal pigment epithelial cells.
    Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:5

    Topics: Arginine; Carcinoma, Hepatocellular; Cell Death; Cell Division; Cell Line; Cell Survival; DNA; DNA Replication; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Fluorescent Antibody Technique, Indirect; Humans; Keratins; Liver Neoplasms; Ornithine; Ornithine-Oxo-Acid Transaminase; Pigment Epithelium of Eye; Proline

1998
Detection of hepatitis B surface antigen mutants and their integration in human hepatocellular carcinoma.
    Cancer letters, 1999, Feb-08, Volume: 136, Issue:1

    Topics: Arginine; Blotting, Southern; Carcinoma, Hepatocellular; DNA, Neoplasm; Glycine; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Methionine; Mutation; Threonine

1999
Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia.
    Journal of the National Cancer Institute, 2000, Jan-19, Volume: 92, Issue:2

    Topics: Adult; Aflatoxins; Aged; Aged, 80 and over; Arginine; Black People; Carcinoma, Hepatocellular; Case-Control Studies; DNA, Neoplasm; Endonucleases; Female; France; Gambia; Hepatitis B; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Molecular Epidemiology; Mutation; Odds Ratio; Polymerase Chain Reaction; Prevalence; Prospective Studies; Sequence Analysis, DNA; Serine; Tumor Suppressor Protein p53; White People

2000
TA1/LAT-1/CD98 light chain and system L activity, but not 4F2/CD98 heavy chain, respond to arginine availability in rat hepatic cells. Loss Of response in tumor cells.
    The Journal of biological chemistry, 2000, Feb-25, Volume: 275, Issue:8

    Topics: Amino Acid Transport Systems; Animals; Antigens, CD; Arginine; Biological Transport; Blotting, Northern; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line; Fusion Regulatory Protein-1; Gene Expression Regulation; Leucine; Liver; Male; Rats; Rats, Inbred F344; RNA; Time Factors; Tumor Cells, Cultured

2000
Amino acid uptake and regulation in multicellular hepatoma spheroids.
    The Journal of surgical research, 2000, Jun-01, Volume: 91, Issue:1

    Topics: Amino Acid Transport System ASC; Amino Acids; Arginine; beta-Alanine; Biological Transport; Blotting, Northern; Carcinogens; Carcinoma, Hepatocellular; Carrier Proteins; Cell Culture Techniques; Cell Division; Gene Expression; Glutamine; Humans; Leucine; Liver Neoplasms; Microscopy, Electron, Scanning; Minor Histocompatibility Antigens; Protein Kinase C; Receptors, Virus; RNA, Messenger; Sodium; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2000
Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.
    The Journal of biological chemistry, 2001, May-11, Volume: 276, Issue:19

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Carcinoma, Hepatocellular; Cell Line; Cell Nucleus; Dimerization; DNA-Binding Proteins; Humans; Interferon-alpha; Interferon-gamma; Kinetics; Liver Neoplasms; Lysine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Transport; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Spodoptera; STAT1 Transcription Factor; STAT2 Transcription Factor; Trans-Activators; Transfection; Tumor Cells, Cultured

2001
Haem arginate interferes with estimation of carcinoembryonic antigen.
    Annals of clinical biochemistry, 2001, Volume: 38, Issue:Pt 3

    Topics: Adult; alpha-Fetoproteins; Arginine; Carcinoembryonic Antigen; Carcinoma, Hepatocellular; Chemistry, Clinical; Erythrocytes; False Positive Reactions; Female; Heme; Hemoglobins; Humans; Porphyrias, Hepatic; Prostate-Specific Antigen

2001
S-adenosylmethionine:protein methyltransferases in hepatomas.
    Cancer research, 1975, Volume: 35, Issue:5

    Topics: Adenine; Animals; Arginine; Carcinoma, Hepatocellular; Cell Nucleus; Cytosol; Histones; Liver; Liver Neoplasms; Lysine; Methionine; Methyltransferases; Neoplasms, Experimental; Oxidoreductases, N-Demethylating; Rats; Sulfuric Acids

1975
Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells.
    The Biochemical journal, 1976, Jun-15, Volume: 156, Issue:3

    Topics: Amino Acids; Arginine; Canavanine; Carcinoma, Hepatocellular; Cells, Cultured; Cycloheximide; Fetal Blood; Insulin; Leucine; Leupeptins; Liver Neoplasms; Neoplasm Proteins; Neoplasms, Experimental; Pepstatins; Phenylmethylsulfonyl Fluoride; Phosphoenolpyruvate Carboxykinase (GTP); Puromycin

1976
The surface morphology of normal and malignant rat liver epithelial cells in culture.
    In vitro, 1976, Volume: 12, Issue:12

    Topics: Animals; Arginine; Carcinoma, Hepatocellular; Cell Line; Cell Transformation, Neoplastic; Culture Media; Epithelial Cells; Epithelium; Liver; Liver Neoplasms; Male; Rats

1976
[Growth rate of hepatocellular carcinoma and nutritional state].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:5

    Topics: Amino Acids; Arginine; Carcinoma, Hepatocellular; Energy Intake; Humans; Liver Neoplasms; Middle Aged; Nutritional Status; Retrospective Studies

1992
Secretion of glucagon in liver cell carcinoma.
    The Tohoku journal of experimental medicine, 1985, Volume: 146, Issue:1

    Topics: Aged; Animals; Arginine; Blood Glucose; Carcinoma, Hepatocellular; Dogs; Glucagon; Humans; Insulin; Liver Cirrhosis; Liver Neoplasms; Middle Aged; Secretory Rate; Tissue Extracts

1985
H1(0) histones of normal and cancer human cells. Amino acid composition of H1 purified by polyacrylamide gel electrophoresis.
    Molecular and cellular biochemistry, 1986, Volume: 71, Issue:2

    Topics: Amino Acids; Arginine; Carcinoma, Hepatocellular; Cell Line; Histones; Humans; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Lysine; Neoplasms

1986
Establishment of a clonal strain of hepatoma cells which maintain in culture the five enzymes of the urea cycle.
    Journal of cellular physiology, 1974, Volume: 83, Issue:1

    Topics: Ammonia; Animals; Arginase; Arginine; Bucladesine; Carbamates; Carcinoma, Hepatocellular; Chromosomes; Clone Cells; Epithelium; Glucagon; Hydrocortisone; Ligases; Liver Neoplasms; Lyases; Microscopy, Phase-Contrast; Neoplasms, Experimental; Organophosphorus Compounds; Ornithine Carbamoyltransferase; Phosphotransferases; Rats; Succinates; Time Factors; Tyrosine Transaminase; Urea

1974
Biosynthess of histones and acidic nuclear proteins under different conditions of growth.
    Science (New York, N.Y.), 1965, Dec-10, Volume: 150, Issue:3702

    Topics: Animals; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Chemistry Techniques, Analytical; Histones; In Vitro Techniques; Liver; Liver Neoplasms; Liver Regeneration; Lysine; Male; Nucleoproteins; Radiometry; Rats

1965
Prevention by arginine glutamate of the carcinogenicity of acetamide in rats.
    Toxicology and applied pharmacology, 1969, Volume: 14, Issue:1

    Topics: Acetates; Animals; Arginine; Carcinogens; Carcinoma, Hepatocellular; Citrates; Glutamates; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Quaternary Ammonium Compounds; Rats

1969
Studies of PPLO infection. V. Inhibition of lymphocyte mitosis and antibody formation by mycoplasmal extracts.
    The Journal of experimental medicine, 1969, Jun-01, Volume: 129, Issue:6

    Topics: Animals; Antibody Formation; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Culture Techniques; Humans; Hydrolases; Immunoelectrophoresis; Lectins; Liver Neoplasms; Lymph Nodes; Lymphocytes; Mice; Mitosis; Mycoplasma; Mycoplasma Infections; Protein Biosynthesis; Rabbits; Rats

1969
Carboxyl-terminal sequence of the glycine-arginine-rich histone from bovine lymphosarcoma, Novikoff hepatoma and fetal calf thymus.
    Biochimica et biophysica acta, 1969, Volume: 181, Issue:1

    Topics: Amino Acids; Animals; Arginine; Bromine; Carcinoma, Hepatocellular; Cattle; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Cyanides; Electrophoresis; Glycine; Histones; Liver Neoplasms; Lymphoma, Non-Hodgkin; Peptides; Species Specificity; Thymus Gland; Trypsin

1969
Comparative effects on RNA polymerase of the whole GAR histone and its peptides containing clusters of basic amino acids.
    Biochemical and biophysical research communications, 1969, Jun-06, Volume: 35, Issue:5

    Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Cattle; Cell Nucleolus; Chemical Precipitation; Depression, Chemical; DNA; Glycine; Histones; Hydrogen-Ion Concentration; Liver Neoplasms; Micrococcus; Peptides; RNA Nucleotidyltransferases; Stimulation, Chemical; Thymus Gland; Uracil Nucleotides

1969
The nature of inhibitors of DNA synthesis in rat-liver hepatoma cells.
    Biochimica et biophysica acta, 1969, Sep-17, Volume: 190, Issue:1

    Topics: Animals; Animals, Newborn; Antineoplastic Agents; Arginase; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Chromatography, Ion Exchange; DNA, Neoplasm; Hepatectomy; Liver Neoplasms; Lysine; Male; Neoplasms, Experimental; Ornithine; p-Dimethylaminoazobenzene; Rats; Regeneration; Thymidine; Tissue Extracts

1969
Arginine incorporation into proteins by supernatant fractions of rat liver and Novikoff hepatoma.
    Cancer research, 1970, Volume: 30, Issue:5

    Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; Escherichia coli; In Vitro Techniques; Liver; Liver Neoplasms; Male; Neoplasm Proteins; Neoplasms, Experimental; Protein Biosynthesis; Rats; RNA, Transfer

1970
Stimulation of amino acid incorporation into protein in vitro by various nuclear RNA fractions of the AH-130 hepatoma cells.
    Journal of biochemistry, 1970, Volume: 67, Issue:4

    Topics: Amino Acids; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Nucleus; Centrifugation, Density Gradient; In Vitro Techniques; Leucine; Liver Neoplasms; Neoplasm Proteins; Phenylalanine; RNA, Neoplasm

1970
Structure of the glycine-rich, arginine-rich histone of the Novikoff hepatoma.
    Cancer research, 1970, Volume: 30, Issue:12

    Topics: Amino Acid Sequence; Arginine; Carcinoma, Hepatocellular; Chymotrypsin; Glycine; Histones; Liver Neoplasms; Neoplasm Proteins; Pepsin A

1970
N-acetylation of arginine-rich hepatoma histones.
    Cancer research, 1971, Volume: 31, Issue:4

    Topics: Acetates; Alanine; Animals; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Half-Life; Histones; Liver; Liver Neoplasms; Neoplasms, Experimental; Rats; Tritium

1971
Some aspects of the mechanism of action of 1-propyl-1-nitrosourea.
    Biochemical pharmacology, 1970, Volume: 19, Issue:5

    Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Line; Centrifugation, Density Gradient; Chlorophyta; DNA, Neoplasm; Formates; Histones; Leukemia L1210; Liver; Liver Neoplasms; Lysine; Mice; Molecular Weight; Neoplasm Proteins; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds; Protein Hydrolysates; RNA, Neoplasm; RNA, Ribosomal; RNA, Transfer; Spleen; Time Factors; Urea

1970
Uptake of label into methylated amino acids from rat tissue histones after in vivo administration of (Me- 14 C)methionine.
    Biochimica et biophysica acta, 1971, May-13, Volume: 238, Issue:2

    Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; Histidine; Histones; Liver; Liver Neoplasms; Lysine; Male; Methionine; Methylation; Neoplasms, Experimental; Rats; Thymus Gland; Time Factors

1971
Studies of insulin and growth hormone secretion in a subject with hepatoma and gypoglycemia.
    Diabetes, 1971, Volume: 20, Issue:9

    Topics: Adipose Tissue; Adult; Animals; Arginine; Blood Glucose; Carcinoma, Hepatocellular; Dexamethasone; Fatty Acids, Nonesterified; Glucagon; Gluconeogenesis; Glucose; Glucose Tolerance Test; Glycogen Storage Disease; Growth Hormone; Humans; Hypoglycemia; Insulin; Insulin Secretion; Lactates; Liver Neoplasms; Male; Muscles; Phentolamine; Phosphates; Rats; Tolbutamide

1971
[Penetration of canavanine in different types of cells].
    Archives des sciences physiologiques, 1972, Volume: 26, Issue:1

    Topics: Animals; Arginine; Biological Transport, Active; Canavanine; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Membrane Permeability; Erythrocytes; Escherichia coli; Kinetics; Liver Neoplasms; Methods; Rabbits; Rats; Reticulocytes; Structure-Activity Relationship

1972
In vivo turnover and distribution of radio-N-methyl in arginine-rich histones from rat tissues.
    Archives of biochemistry and biophysics, 1972, Volume: 152, Issue:2

    Topics: Animals; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography, Ion Exchange; Histones; Kinetics; Liver; Liver Neoplasms; Lysine; Male; Methionine; Methylation; Neoplasms, Experimental; Rats; Spleen

1972
Isolation of arginine acceptor-proteins from normal rat liver and Novikoff hepatoma supernatant.
    British journal of cancer, 1973, Volume: 27, Issue:1

    Topics: Animals; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Liver; Liver Neoplasms; Neoplasm Proteins; Neoplasms, Experimental; Proteins; Rats

1973
[Comparative study of transfer ribonucleic acids extracted from rat liver and Zajdela hepatoma. I. Study of the acceptor properties of tRNA].
    Biochimie, 1972, Volume: 54, Issue:10

    Topics: Acylation; Alanine; Animals; Arginine; Ascites; Carcinoma, Hepatocellular; Cell Differentiation; Cell Transformation, Neoplastic; Isoleucine; Kinetics; Liver; Liver Neoplasms; Neoplasms, Experimental; Rats; RNA, Transfer; Serine; Transfer RNA Aminoacylation; Valine

1972
Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply.
    Journal of cellular physiology, 1974, Volume: 83, Issue:3

    Topics: Amino Acids; Animals; Arginine; Asparagine; Carbon Radioisotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Culture Media; Cycloheximide; Drug Synergism; Glutamine; Glycine; Immune Sera; Leucine; Liver Neoplasms; Neoplasm Proteins; Ornithine; Proline; Pyridoxal; Rats; Serine; Stimulation, Chemical; Time Factors

1974
Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC.
    Journal for immunotherapy of cancer, 2022, Volume: 10, Issue:8

    Topics: Animals; Antibodies; Carcinoma, Hepatocellular; Humans; Hyperbaric Oxygenation; Hypoxia; Liver Neoplasms; Membrane Proteins; Mice; Nucleotidyltransferases; Oxaliplatin; Oxygen; Teniposide; Tumor Microenvironment; United States

2022
Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC.
    Journal for immunotherapy of cancer, 2023, Volume: 11, Issue:1

    Topics: Antibodies; Carcinoma, Hepatocellular; Humans; Hyperbaric Oxygenation; Liver Neoplasms; Membrane Proteins; Nucleotidyltransferases; Programmed Cell Death 1 Receptor; Teniposide

2023
Response to 'Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC' by Yang
    Journal for immunotherapy of cancer, 2023, Volume: 11, Issue:3

    Topics: Antibodies; Carcinoma, Hepatocellular; Humans; Hyperbaric Oxygenation; Liver Neoplasms; Oxygen; Programmed Cell Death 1 Receptor; Radiation-Sensitizing Agents; Teniposide

2023
Characterization of the metabolic alteration-modulated tumor microenvironment mediated by TP53 mutation and hypoxia.
    Computers in biology and medicine, 2023, Volume: 163

    Topics: Carcinoma, Hepatocellular; Humans; Hypoxia; Liver Neoplasms; Mutation; Teniposide; Tumor Microenvironment; Tumor Suppressor Protein p53

2023
Caspase-dependent and independent cell death in rat hepatoma 5123tc cells.
    Apoptosis : an international journal on programmed cell death, 2000, Volume: 5, Issue:3

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspase 3; Caspase Inhibitors; Caspases; Cell Nucleus; Culture Media, Serum-Free; Cysteine Proteinase Inhibitors; DNA Fragmentation; Electrophoresis, Gel, Pulsed-Field; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Humans; Lamins; Microscopy, Fluorescence; Nuclear Proteins; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Rats; Teniposide; Tumor Cells, Cultured

2000