arginine and Acute Myelogenous Leukemia

arginine has been researched along with Acute Myelogenous Leukemia in 34 studies

Research

Studies (34)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (17.65)	18.7374
1990's	7 (20.59)	18.2507
2000's	2 (5.88)	29.6817
2010's	12 (35.29)	24.3611
2020's	7 (20.59)	2.80

Authors

Authors	Studies
Almowaled, M; Barlow, J; Bartnik, A; Booth, S; Cheng, P; Craddock, C; De Santo, C; De Simone, D; Dunn, W; Endou, H; Fultang, L; Gneo, L; Jankevics, A; Keeshan, K; Lloyd, G; Mussai, F; Panetti, S; Platt, F; Potluri, S; Priestman, DA; Scarpa, U; Southam, A; Stavrou, V	1
Cheng, Y; Huang, B; Jiang, JY; Li, MY; Li, SQ; Liu, J; Wang, XZ; Xu, S; Yao, FY; Zhang, N; Zhong, FM	1
Gritsman, K	1
Gorshkov, V; Grinev, V; Helin, K; Hendrickson, RC; Jensen, ON; Kovalchuk, S; Lorenzini, E; Radzisheuskaya, A; Shliaha, PV; Shlyueva, D	1
Dirks, WG; Drexler, HG; Fähnrich, S; Hauer, V; Pommerenke, C; Quentmeier, H; Uphoff, CC; Zaborski, M	1
Gusachenko, I; Lymanets, T; Maslova, G; Skrypnyk, I	1
AlAbdi, L; Chen, T; Forstoffer, NE; Gowher, H; Liu, B; Michie, AR; Norvil, AB; Tu, YH	1
Booth, S; Chesler, L; De Santo, C; Dunn, WB; Fultang, L; Jankevics, A; Lee, SP; Lloyd, G; Martins da Costa, B; Mussai, F; Panetti, S; Scarpa, U; Southam, A; Stavrou, V; Tubb, V; Yogev, O	1
Bomalaski, JS; Chen, TY; Cho, SF; Feng, X; Hsiao, HH; Hsu, YT; Johnston, A; Kao, HW; Kuo, MC; Liu, TC; Liu, YC; Tsai, HJ	1
Cai, Y; Chau, KC; Chow, DTL; Chow, JPH; Chung, SHK; Kwok, SY; Lam, JYT; Lee, WL; Leung, YC; Leung, YO; Lu, X; Wong, RMH; Yang, LL; Yuen, CH	1
Biedroń, M; Butrym, A; Chachaj, A; Fleszar, MG; Gamian, A; Karczewski, M; Krzystek-Korpacka, M; Mazur, G; Rybka, J; Szuba, A; Wiśniewski, J; Wróbel, T	1
Abi-Habib, RJ; Bekdash, A; Frankel, AE; Georgiou, G; Kassab, E; Stone, E; Tanios, R	1
Bari, R; Gan, K; Kang, G; Leung, W; Rujkijyanont, P; Sullivan, E; Turner, V	1
Gao, C; Gao, L; Guan, L; Li, M; Wang, L; Yin, Y; Yu, L	1
Beggs, A; Cheng, P; De Santo, C; Egan, S; Higginbotham-Jones, J; Kearns, P; Lo, A; Loke, J; Mussai, F; Ng, M; Odintsova, E; Perry, T; Pratt, G; U, KP	1
Anjos-Afonso, F; Ariza-McNaughton, L; Bomalaski, JS; Bonnet, D; Cavenagh, J; Clear, A; Ghazaly, E; Grantham, M; Gribben, JG; Hodby, KA; Liapis, K; Miraki-Moud, F; Sohrabi, F; Szlosarek, PW; Taussig, DC	1
Alinari, L; Anghelina, M; Baiocchi, RA; Caligiuri, MA; Croce, CM; Frankhouser, D; Garzon, R; Huang, X; Lai, H; Li, C; Li, L; Marcucci, G; Radomska, HS; Santhanam, R; Tarighat, SS; Walker, A; Wang, H	1
Abdel-Wahab, O; Chen, WY; Chrysovergis, K; Lu, R; Parton, T; Rockowitz, S; Wade, PA; Wang, GG; Wang, P; Zheng, D; Zhou, Y	1
Hämäläinen, S; Jantunen, E; Juutilainen, A; Koivula, I; Lappalainen, M; Pulkki, K	1
Jing, N; Shao, H; Tweardy, DJ; Xu, X	1
Doppler, W; Fuchs, D; Goossen, B; Grünewald, K; Hentze, MW; Pantopoulos, K; Wachter, H; Weiss, G; Werner-Felmayer, G	1
Hansz, J	1
Kass, L	1
Becker, Y; Haspel, O; Kotler, M; Olshevsky, U; Weinberg, E	1
Higashino, K; Izumi, K; Kobayashi, S; Kodama, J; Satani, M	1
Hirschfeld, S; Ho, PT; Pazdur, R; Smith, M	1
Crist, WM; Pratt, CB; Pui, CH; Rivera, GK; Santana, VM	1
Herngren, L; Liliemark, E; Liliemark, J; Peterson, C; Pettersson, B	1
Sullivan, MP; Sutow, WW	1
Anderson, GR; Beerman, TA; Russo, CA; Spina, AM; Stoler, DL	1
Castel, V; Esquembre, C; Fernandez, JM; Ferris, J; Prieto, F; Ruiz, JG; Tasso, MJ; Verdeguer, A	1
Evans, WE; Mirro, J; Petros, WP; Rodman, JH	1
Björkholm, M	1
Dahl, GV; Grier, HE; Kalwinsky, DK; Mason, C; Mirro, J; Murphy, SB; Santana, VM	1

Reviews

3 review(s) available for arginine and Acute Myelogenous Leukemia

Article	Year
Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-15, Volume: 21, Issue:6 Topics: Antineoplastic Agents; Azacitidine; Child; Child, Preschool; Drug Approval; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neuroblastoma; Osteosarcoma; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide; United States; United States Food and Drug Administration; Vindesine	2003
Epipodophyllotoxins in the treatment of childhood cancer. Cancer chemotherapy and pharmacology, 1994, Volume: 34 Suppl Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cytarabine; Etoposide; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Neoplasms; Neoplasms, Second Primary; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide	1994
Etoposide and teniposide in the treatment of acute leukemia. Medical oncology and tumor pharmacotherapy, 1990, Volume: 7, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Etoposide; Humans; Leukemia, Myeloid, Acute; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide	1990

Trials

1 trial(s) available for arginine and Acute Myelogenous Leukemia

Article	Year
Phase I study of ADI-PEG20 plus low-dose cytarabine for the treatment of acute myeloid leukemia. Cancer medicine, 2021, Volume: 10, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Anemia; Antineoplastic Combined Chemotherapy Protocols; Arginine; Argininosuccinate Synthase; Cytarabine; Drug Administration Schedule; Female; Humans; Hydrolases; Injections, Intramuscular; Injections, Subcutaneous; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Neutropenia; Polyethylene Glycols; Thrombocytopenia; Treatment Outcome	2021

Article

Year

Phase I study of ADI-PEG20 plus low-dose cytarabine for the treatment of acute myeloid leukemia.

Cancer medicine, 2021, Volume: 10, Issue:9

Topics: Adult; Aged; Aged, 80 and over; Anemia; Antineoplastic Combined Chemotherapy Protocols; Arginine; Argininosuccinate Synthase; Cytarabine; Drug Administration Schedule; Female; Humans; Hydrolases; Injections, Intramuscular; Injections, Subcutaneous; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Neutropenia; Polyethylene Glycols; Thrombocytopenia; Treatment Outcome

2021

Other Studies

30 other study(ies) available for arginine and Acute Myelogenous Leukemia

Article	Year
Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment. Cancer immunology, immunotherapy : CII, 2023, Volume: 72, Issue:3 Topics: Arginine; Cell Proliferation; Humans; Leukemia, Myeloid, Acute; Myeloid-Derived Suppressor Cells; Natural Killer T-Cells	2023
Splicing factor-mediated regulation patterns reveals biological characteristics and aid in predicting prognosis in acute myeloid leukemia. Journal of translational medicine, 2023, 01-07, Volume: 21, Issue:1 Topics: Alternative Splicing; Arginine; Cell Cycle Proteins; Humans; Leukemia, Myeloid, Acute; Prognosis; Repressor Proteins; RNA Splicing; RNA Splicing Factors; Serine-Arginine Splicing Factors; Tumor Microenvironment	2023
FLT3-ITD gets by with a little help from PRMT1. Blood, 2019, 08-08, Volume: 134, Issue:6 Topics: Arginine; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Methylation; Methyltransferases; Mutation; Protein-Arginine N-Methyltransferases; Repressor Proteins	2019
PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia. Nature structural & molecular biology, 2019, Volume: 26, Issue:11 Topics: Animals; Antineoplastic Agents; Arginine; Catalysis; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Methylation; Mice; Molecular Targeted Therapy; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Oncogene Proteins, Fusion; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteomics; RNA Splicing; Serine-Arginine Splicing Factors	2019
DNMT3A R882H mutation in acute myeloid leukemia cell line SET-2. Leukemia research, 2020, Volume: 88 Topics: Amino Acid Substitution; Arginine; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA Mutational Analysis; Histidine; Humans; Leukemia, Myeloid, Acute; Mutation, Missense	2020
How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy. Experimental oncology, 2019, Volume: 41, Issue:4 Topics: Adult; Anthracyclines; Antibiotics, Antineoplastic; Arginine; Cardiotoxicity; Comorbidity; Cryoprotective Agents; Female; Humans; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Myocardial Ischemia; Quality of Life	2019
The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme. Nucleic acids research, 2020, 04-17, Volume: 48, Issue:7 Topics: Amino Acid Substitution; Animals; Arginine; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA, Satellite; Embryonic Stem Cells; Humans; Kinetics; Leukemia, Myeloid, Acute; Mice; Mutation; Myeloid Ecotropic Viral Integration Site 1 Protein; Substrate Specificity	2020
Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity. Blood, 2020, 09-03, Volume: 136, Issue:10 Topics: Animals; Apoptosis; Arginine; Argininosuccinate Synthase; Cell Proliferation; Humans; Immunotherapy, Adoptive; Leukemia, Myeloid, Acute; Metabolic Engineering; Mice; Mice, Nude; Neuroblastoma; Ornithine Carbamoyltransferase; Receptors, Chimeric Antigen; T-Lymphocytes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2020
NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both Molecular cancer therapeutics, 2021, Volume: 20, Issue:11 Topics: Animals; Arginine; Disease Models, Animal; Humans; Hypothalamic Hormones; Leukemia, Myeloid, Acute; Mice; Peptide Fragments	2021
Asymmetric and symmetric dimethylarginines and mortality in patients with hematological malignancies-A prospective study. PloS one, 2018, Volume: 13, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers, Tumor; Case-Control Studies; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Middle Aged; Prognosis; Prospective Studies; Survival Rate; Young Adult	2018
Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells. Leukemia research, 2013, Volume: 37, Issue:11 Topics: Apoptosis; Arginase; Arginine; Argininosuccinate Synthase; Autophagy; Blotting, Western; Cell Cycle; Cell Proliferation; Flow Cytometry; Humans; Leukemia, Myeloid, Acute; Polyethylene Glycols; Recombinant Proteins; Tumor Cells, Cultured	2013
Effect of donor KIR2DL1 allelic polymorphism on the outcome of pediatric allogeneic hematopoietic stem-cell transplantation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Oct-20, Volume: 31, Issue:30 Topics: Adolescent; Alleles; Analysis of Variance; Arginine; Child; Child, Preschool; Cysteine; Disease Progression; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; HLA-C Antigens; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, KIR2DL1; Transplantation, Homologous	2013
The Frequency and clinical significance of IDH1 mutations in Chinese acute myeloid leukemia patients. PloS one, 2013, Volume: 8, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Asian People; Child; Female; Humans; Isocitrate Dehydrogenase; Karyotyping; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation Rate; Survival Analysis	2013
Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target. Blood, 2015, Apr-09, Volume: 125, Issue:15 Topics: Adolescent; Aged; Animals; Antimetabolites, Antineoplastic; Arginase; Arginine; Child; Child, Preschool; Cytarabine; Enzyme Therapy; Female; Humans; Infant; Leukemia, Myeloid, Acute; Male; Mice, SCID; Middle Aged; Recombinant Proteins; Tumor Cells, Cultured; Young Adult	2015
Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo. Blood, 2015, Jun-25, Volume: 125, Issue:26 Topics: Animals; Antineoplastic Agents; Arginine; Argininosuccinate Synthase; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Humans; Hydrolases; Immunohistochemistry; Leukemia, Myeloid, Acute; Mass Spectrometry; Mice; Mice, Inbred NOD; Mice, SCID; Polyethylene Glycols; Real-Time Polymerase Chain Reaction; Xenograft Model Antitumor Assays	2015
The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. Leukemia, 2016, Volume: 30, Issue:4 Topics: Animals; Apoptosis; Arginine; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Epigenomics; Flow Cytometry; Gene Expression Regulation, Leukemic; Histones; Humans; Immunoenzyme Techniques; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; MicroRNAs; Protein-Arginine N-Methyltransferases; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Transcriptional Activation; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2016
Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development. Cancer cell, 2016, 07-11, Volume: 30, Issue:1 Topics: Animals; Arginine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Genes, ras; Homeodomain Proteins; Humans; Leukemia, Myeloid, Acute; Methyltransferases; Mice; Mutation; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Neoplasms, Experimental; Promoter Regions, Genetic; Stem Cells; Tumor Cells, Cultured	2016
Asymmetric dimethylarginine in the assessment of febrile neutropenia in hematological patients. Scandinavian journal of clinical and laboratory investigation, 2017, Volume: 77, Issue:2 Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Arginine; Bacteremia; Biomarkers; C-Reactive Protein; Febrile Neutropenia; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Prospective Studies; Shock, Septic; Stem Cell Transplantation; Transplantation, Autologous	2017
Unique structural determinants for Stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744. Journal of immunology (Baltimore, Md. : 1950), 2006, Mar-01, Volume: 176, Issue:5 Topics: Arginine; Cell Line; Computational Biology; Glutamic Acid; Humans; Leukemia, Myeloid, Acute; Ligands; Lysine; Models, Molecular; Phosphopeptides; Phosphotyrosine; Protein Binding; Receptors, Granulocyte Colony-Stimulating Factor; STAT3 Transcription Factor	2006
Stimulation of IRE-BP activity of IRF by tetrahydrobiopterin and cytokine dependent induction of nitric oxide synthase. Advances in experimental medicine and biology, 1994, Volume: 356 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cell Line; Chloramphenicol O-Acetyltransferase; Deferoxamine; Humans; Interferon-gamma; Iron; Iron-Regulatory Proteins; Kinetics; Leukemia, Myeloid, Acute; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; RNA Probes; RNA-Binding Proteins; Transfection; Tumor Cells, Cultured	1994
[Metabolic utilization of arginine by leukemic cells in acute myeloid leukemia]. Polskie Archiwum Medycyny Wewnetrznej, 1979, Volume: 61, Issue:2 Topics: Adolescent; Adult; Arginine; Blood Proteins; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged	1979
Histone abnormalities in adult acute leukemias. Blood, 1975, Volume: 45, Issue:4 Topics: Adult; Arginine; Electrophoresis, Disc; Esterases; Hematopoietic Stem Cells; Histones; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lysine; Monocytes	1975
Particles released from arginine deprived human leukaemic cells. Nature: New biology, 1973, Aug-15, Volume: 244, Issue:137 Topics: Arginine; Cells, Cultured; Centrifugation, Density Gradient; Culture Media; DNA, Viral; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Microscopy, Electron; Oncogenic Viruses; Ribonucleases; RNA-Directed DNA Polymerase; RNA, Ribosomal; Templates, Genetic; Tritium; Uridine; Virus Cultivation	1973
[Developing mechanism of the adverse effects of L-asparaginase and their control]. Blut, 1974, Volume: 28, Issue:1 Topics: Ammonia; Arginine; Asparaginase; Glutamates; Humans; Injections, Intravenous; Leukemia, Myeloid, Acute; Nausea; Renal Dialysis; Seizures; Shock; Unconsciousness; Vomiting	1974
Ultrafiltration and subsequent high performance liquid chromatography for in vivo determinations of the protein binding of etoposide. Cancer letters, 1996, Aug-23, Volume: 106, Issue:1 Topics: Antineoplastic Agents; Blood Proteins; Chromatography, High Pressure Liquid; Dialysis; Etoposide; Humans; Leukemia, Myeloid, Acute; Reference Values; Teniposide; Ultrafiltration	1996
Childhood cancer: the improving prognosis. Postgraduate medicine, 1976, Volume: 59, Issue:2 Topics: Asparaginase; Child; Cyclophosphamide; Cytosine; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Hodgkin Disease; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Osteosarcoma; Prednisone; Procarbazine; Prognosis; Remission, Spontaneous; Rhabdomyosarcoma; Teniposide; Thioguanine; Vincristine; Wilms Tumor	1976
Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells. Cancer research, 1992, Aug-15, Volume: 52, Issue:16 Topics: Animals; Cell Hypoxia; Cell Survival; DNA Probes; DNA, Neoplasm; Endonucleases; Enzyme Induction; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Liver Neoplasms, Experimental; Molecular Weight; Neoplasms; Plasmids; Rats; Teniposide; Tumor Cells, Cultured; Tumor Stem Cell Assay	1992
Acute nonlymphoblastic leukemia in children treated for acute lymphoblastic leukemia with an intensive regimen including teniposide. Medical and pediatric oncology, 1992, Volume: 20, Issue:1 Topics: Child, Preschool; Female; Humans; Immunophenotyping; Leukemia, Myeloid, Acute; Male; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide	1992
Pharmacokinetics of continuous-infusion amsacrine and teniposide for the treatment of relapsed childhood acute nonlymphocytic leukemia. Cancer chemotherapy and pharmacology, 1991, Volume: 27, Issue:5 Topics: Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Infant; Leukemia, Myeloid, Acute; Teniposide	1991
Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine. Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:2 Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Child; Child, Preschool; Drug Evaluation; Female; Humans; Infant; Infusions, Intravenous; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukopenia; Male; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Stomatitis; Teniposide; Thrombocytopenia	1989