arginine has been researched along with Acute Confusional Senile Dementia in 104 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.96) | 18.7374 |
| 1990's | 9 (8.65) | 18.2507 |
| 2000's | 38 (36.54) | 29.6817 |
| 2010's | 42 (40.38) | 24.3611 |
| 2020's | 14 (13.46) | 2.80 |
| Authors | Studies |
|---|---|
| Cieślik, P; Kalinowski, L; Wierońska, JM | 1 |
| Dastan, D; Ebadi, A; Fasihi, K; Zhiyani, R | 1 |
| Dubey, A; Dubey, H; Gulati, K; Ray, A | 1 |
| Hashimoto, S; Ishii, A; Kamano, N; Matsuba, Y; Mihira, N; Muramatsu, SI; Saido, TC; Saito, T; Yokosuka, M | 1 |
| Degrush, E; Drachman, D; Gounis, MJ; Henninger, N; Lindsay, C; Shazeeb, MS; Vardar, Z | 1 |
| Lei, Y; Shi, F; Tian, Q; Zhou, X; Zhu, R | 1 |
| Asghari, SM; Eskandari, S; Hashemizadeh, S; Rezayof, A | 1 |
| Aggarwal, N; Chauhan, VS; Kour, A; Kumar, A; Panda, JJ; Sekhar Panda, H; Shukla, S; Tiwari, S; Tiwari, V | 1 |
| Aluko, RE; Asen, ND; Udenigwe, CC | 1 |
| Bansal, G; Bansal, Y; Minhas, R | 1 |
| Altelaar, M; Ferrari, L; Förster, FG; Geerts, WJC; Hoogenraad, CC; Konstantoulea, K; Kos, R; Rüdiger, SGD; Stucchi, R; van Bezouwen, LS; van de Kamp, G | 1 |
| Choi, S; Fica-Contreras, SM; Hedges, JS; Henning, NJ; Shuster, SO | 1 |
| Altiné-Samey, R; Antier, D; Balageas, AC; Beaufils, E; Chalon, S; Dufour-Rainfray, D; Emond, P; Foucault-Fruchard, L; Mavel, S | 1 |
| Adams, KJ; Colton, CA; Gottschalk, WK; Millington, DS; Moseley, MA; Thompson, JW; Wilson, JG | 1 |
| Han, Y; Kong, L; Liu, L; Liu, Z; Sun, H; Wang, X; Yu, J; Zhang, A | 1 |
| Bowe, GJK; Choi, S; Durfee, ND; Fica-Contreras, SM; Henning, NJ; Hill, SA; Sandwick, RK; Shuster, SO; Stillman, DR; Suralik, KM; Vrla, GD | 1 |
| Indeykina, MI; Kozin, SA; Kugaevskaya, EV; Makarov, AA; Mantsyzov, AB; Nikolaev, EN; Popov, IA; Solovyeva, NI; Veselovsky, AV; Zharkova, MS | 1 |
| Adamczyk, A; Cieślik, M; Gąssowska-Dobrowolska, M; Hilgier, W; Jęśko, H; Lukiw, WJ; Murawska, E; Wilkaniec, A | 1 |
| Abraham, WC; Bergin, DH; Jing, Y; Liu, P; Mockett, BG; Zhang, H | 1 |
| Aliès, B; Borghesani, V; Faller, P; Guillon, E; Hureau, C; Noël, S; Sayen, S; Testemale, D | 1 |
| Fülöp, T; Haddad, M; Landri, S; Lepage, A; Perrotte, M; Ramassamy, C | 1 |
| Borghi, R; Monacelli, F; Odetti, P; Pacini, D; Serrati, C; Traverso, N | 1 |
| Goutzourelas, N; Gubandru, M; Ilie, M; Kouretas, D; Margina, D; Tsarouhas, K; Tsatsakis, AM; Tsitsimpikou, C | 1 |
| Alappat, L; Awad, AB; Bradford, PG; Virarkar, M | 1 |
| Coskuner, O; Wise-Scira, O | 1 |
| Gard, PR; Nilforooshan, R; Richardson, C; Tabet, N; Weaving, G | 1 |
| Whiteley, CG | 1 |
| Jiang, B; Shen, X; Tan, L; Wang, W; Wu, X; Yang, L | 1 |
| Cedazo-Mínguez, Á; Cifuentes, A; Ibáñez, C; Lodeiro, M; Simó, C | 1 |
| Abraham, WC; Collie, ND; Curtis, MA; Faull, RL; Fleete, MS; Jing, Y; Liu, P; Waldvogel, HJ; Zhang, H | 1 |
| Aboulkassim, T; Hamel, E; Imboden, H; Lecrux, C; Nicolakakis, N; Ongali, B; Papadopoulos, P; Rosa-Neto, P; Tong, XK | 1 |
| Abdi, Z; Adamson, G; Barnes, J; Beck, JA; Blair, M; Campbell, T; Clegg, SL; Collinge, J; Crutch, SJ; Druyeh, R; Fox, NC; Gambetti, P; Guerreiro, RJ; Harper, L; Kenny, J; Kretzschmar, H; Leung, KK; Lowe, J; Mahoney, CJ; Mead, S; Nicholas, JM; Ponto, C; Rohrer, JD; Rossor, MN; Rowe, JB; Schott, JM; Slattery, CF; Uphill, J; Warren, JD; Zerr, I | 1 |
| Li, J; Lu, N; Peng, YY; Tian, R | 1 |
| Finelli, D; Gerhard, A; Harris, J; Jones, M; Mann, D; Pickering-Brown, S; Richardson, A; Rollinson, S; Snowden, J | 1 |
| Breitinger, HG; El-Sayed, NS; Gad, MZ; Maher, A | 1 |
| Borghi, R; Cammarata, S; Monacelli, F; Nencioni, A; Odetti, P; Piccini, A; Tabaton, M | 1 |
| Lu, Z; Luo, Y; Quan, X; Wang, Y; Yue, W; Zhao, B | 1 |
| Chevallier, OP; Elliott, CT; Graham, SF; Green, BD; Hölscher, C; Johnston, J; Kehoe, PG; McGuinness, B; Passmore, AP | 1 |
| Brown, CM; Colton, CA; Everhart, AL; Gunn, MD; Hoofnagle, AN; Jansen, M; Kan, MJ; Lee, JE; Vitek, MP; Wilson, JG | 1 |
| Georgakis, MK; Latsios, G; Oikonomou, E; Papageorgiou, N; Papaioannou, S; Siasos, G; Tousoulis, D; Zaromitidou, M | 1 |
| Adamczyk, A; Cieślik, M; Gąssowska, M; Hilgier, W; Jęśko, H; Lukiw, WJ; Wilkaniec, A | 1 |
| Bevan, DR; Brown, AM | 1 |
| Cheema, AK; Federoff, HJ; Fiandaca, MS; Lin, F; Mapstone, M; Nalls, MA; Singleton, AB | 1 |
| Arlt, S; Böger, RH; Eichenlaub, M; Jahn, H; Lehmbeck, JT; Maas, R; Schulze, F; Schwedhelm, E | 1 |
| Hovorková, P; Klaschka, J; Kozmiková, I; Kristofiková, Z; Majer, E; Rícný, J; Rípová, D; Zach, P | 1 |
| Delibas, N; Eren, I; Sirin, B; Vural, H; Yilmaz, N | 1 |
| Adame, A; Crews, L; Gage, FH; Hersh, LB; Mante, M; Marr, RA; Masliah, E; Potkar, R; Rockenstein, E; Rose, JB; Spencer, B | 1 |
| Coppus, AM; Fekkes, D; Tuinier, S; van Duijn, CM; Verhoeven, WM | 1 |
| de Bot, ST; Dooijes, D; Kremer, HP; Verbeek, MM | 1 |
| Chang, TY; Huang, CC; Kuo, HC; Lu, CS; Wu-Chou, YH | 1 |
| Cairns, NJ; Chakraverty, S; Galvin, JE; Goate, A; Levitch, D; Norton, JB; Wang, J | 1 |
| Mohlake, P; Whiteley, CG | 1 |
| Bi, L; Chen, W; Guo, L; Qi, H; Qian, Y; Tao, T; Wang, Y; Wu, J; Xu, W | 1 |
| Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Smith, KJ; Soleil, V; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G | 1 |
| Chen, M; Jiang, P; Jiao, BH; Lü, J; Xiang, ZH | 1 |
| Antonell, A; Balasa, M; Bosch, B; Fabregat, N; Fortea, J; Lladó, A; Molinuevo, JL; Oliva, R; Sánchez-Valle, R | 1 |
| Brouwers, N; Funamoto, S; Ihara, Y; Iwata, N; Matsuba, Y; Mihira, N; Nilsson, P; Nishimura, M; Saido, TC; Saito, T; Sleegers, K; Suemoto, T; Takano, J; Van Broeckhoven, C; Yamada, K | 1 |
| Alberici, A; Archetti, S; Bonvicini, C; Borroni, B; Gennarelli, M; Lupi, A; Padovani, A; Pilotto, A | 1 |
| Kokare, DM; Nakhate, KT; Rangani, RJ; Subhedar, NK; Upadhya, MA | 1 |
| Bonvicini, C; Bucossi, S; Manfellotto, D; Mariani, S; Migliore, S; Polimanti, R; Rossini, PM; Salustri, C; Squitti, R; Ventriglia, M; Vernieri, F | 1 |
| Arlt, S; Böger, RH; Jahn, H; Jessen, F; Kölsch, H; Linnebank, M; Popp, J; Schwedhelm, E; Smulders, Y | 1 |
| Levenson, I; Malek-Ahmadi, M; Sabbagh, M; Sparks, DL | 1 |
| Blomberg, M; de Jong, S; Mulder, C; Scheltens, P; Teerlink, T; van Kamp, GJ; Wahlund, LO | 1 |
| Chamson, A; Denis, C; Ferron, C; Frey, J; Gonthier, R; Laurent, B; Meli, M; Parssegny, F; Perier, C; Reynaud, E | 1 |
| Colton, CA; Czapiga, M | 1 |
| Aloi, F; Bernabei, R; Flex, A; Flore, R; Gaetani, E; Gerardino, L; Pola, P; Pola, R; Serricchio, M | 1 |
| Berry, RW; Binder, LI; Gamblin, TC | 1 |
| Hashimoto, Y; Niikura, T; Nishimoto, I; Yamagishi, Y | 1 |
| Selley, ML | 2 |
| Cruts, M; Dermaut, B; Goate, A; Heutink, P; Peeters, K; Rademakers, R; Van Broeckhoven, C | 1 |
| Avila, J; Bhat, R; Hernández, F; Lucas, JJ; Mata, AM; Pérez, M | 1 |
| Elfgren, C; Froelich Fabre, S; Gustafson, L; Lannfelt, L; Nilsson, K; Ostojic, J; Passant, U | 1 |
| Doran, M; Larner, AJ | 1 |
| Chang, GG; Chou, CY; Huang, YC; Lin, TH; Lin, YL; Sheu, SY; Shiao, MS; Tsay, HJ | 1 |
| Abdel-Meguid, SS; Babine, RE; Jin, L; Navaneetham, D; Pandey, P; Strickler, JE; Walsh, PN | 1 |
| DeKosky, ST; Feingold, E; Kamboh, MI; Minster, RL; Sundar, PD | 1 |
| Aykaç-Toker, G; Doğru-Abbasoğlu, S; Emre, M; Gürvit, H; Hanagasi, HA; Uysal, M | 1 |
| Chen, CP; Lee, J; Tan, EK; Wong, MC; Zhao, Y | 1 |
| Elisseeva, YE; Kozin, SA; Kozmin, YP; Kugaevskaya, EV; Makarov, AA; Mirgorodskaya, OA; Nikolaev, EN; Popov, IA; Toropygin, IY | 1 |
| Batbayli, M; Holm, IE; Law, I; Lindquist, SG; Nielsen, JE; Schwartz, M; Stokholm, J; Waldemar, G | 1 |
| Lv, Z; Ma, X; Wang, B; Wang, J; Xie, YC; Yang, Z; Zhang, P; Zheng, C; Zhou, S | 1 |
| Blessed, G; Perry, EK; Perry, RH; Tarbit, I; Tomlinson, BE | 1 |
| Benicourt, C; Junien, JL; Lockhart, BP; Privat, A | 1 |
| Miyata, S; Monnier, VM; Perry, G; Richey, PL; Sayre, LM; Smith, MA; Stern, D; Taneda, S; Yan, SD | 1 |
| De Strooper, B; Umans, L; Van Den Berghe, H; Van Leuven, F | 1 |
| Castaneda, C; Crim, MC; Dawson-Hughes, B; Lammi-Keefe, C; Prior, RL; Rosen, CJ; Spindler, AA | 1 |
| Horie, K; Kurokawa, K; Maeda, K; Miyata, T; Sobue, G; Takeda, A; Yasuda, T; Yasuda, Y | 1 |
| Aldudo, J; Arbizu, T; Bullido, MJ; Oliva, R; Valdivieso, F | 1 |
| Doyu, M; Goto, Y; Horie, K; Inagaki, T; Maeda, K; Miyata, T; Sobue, G; Takeda, A; Wakai, M; Watanabe, M; Yasuda, T; Yasuda, Y | 1 |
| Suzuki, T; Tomita, S | 1 |
| Nakaya, J; Ohtsuka, Y | 1 |
| Bergmans, PL; Kuiper, MA; Scheltens, P; Teerlink, T; Visser, JJ; Wolters, EC | 1 |
| Arthur, JW; Dunbrack, RL; Sauder, JM | 1 |
| Atwood, CS; Bush, AI; Huang, X; Khatri, A; Kim, YS; Moir, RD; Roher, AE; Scarpa, RC; Tanzi, RE | 1 |
| Angelini, G; Garibaldi, S; Marinelli, L; Menini, S; Norese, R; Odetti, P; Perry, G; Siedlak, S; Smith, MA; Tabaton, M; Traverso, N; Valentini, S; Zaccheo, D | 1 |
| Choe, H; Farzan, M; Leung, D; Schnitzler, CE; Vasilieva, N | 1 |
| Cagiano, R; Cassano, T; Cuomo, V; Kendrick, KM; Pietra, C; Steardo, L; Tattoli, M; Trabace, L | 1 |
| Dumitrescu-Ozimek, L; Feinstein, DL; Heneka, MT; Klockgether, T; Riederer, P; Wiesinger, H | 1 |
| Abe, T; Isobe, C; Murata, T; Sato, C; Tohgi, H | 1 |
| Torreilles, F; Touchon, J | 1 |
| Bentley, NM; Getz, GS; Ladu, MJ; Rajan, C; Reardon, CA | 1 |
| Brown, CM; Colton, CA; Czapiga, M; Vitek, MP | 1 |
| Honda, T; Marotta, CA | 1 |
9 review(s) available for arginine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Neurobiochemical characteristics of arginine-rich peptides explain their potential therapeutic efficacy in neurodegenerative diseases.
Topics: Alzheimer Disease; Arginine; Humans; Neurodegenerative Diseases; Nucleic Acids; Oxidative Stress; Peptides | 2023 |
Inducible nitric oxide synthase inhibitors: A comprehensive update.
Topics: Alzheimer Disease; Amidines; Animals; Arginine; Arthritis, Rheumatoid; Catalytic Domain; Chalcones; Chemistry, Pharmaceutical; Drug Design; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Inflammatory Bowel Diseases; Inhibitory Concentration 50; Macrophages; Mice; Multiple Sclerosis; Nitric Oxide; Nitric Oxide Synthase Type II; Parkinson Disease; Steroids | 2020 |
The contributions of metabolomics in the discovery of new therapeutic targets in Alzheimer's disease.
Topics: Alanine; Alzheimer Disease; Animals; Arginine; Aspartic Acid; Biomarkers; Disease Models, Animal; Glutamic Acid; Humans; Metabolomics; Rats | 2021 |
L-arginine and nitric oxide in CNS function and neurodegenerative diseases.
Topics: Alzheimer Disease; Animals; Arginine; Central Nervous System; Central Nervous System Diseases; Diet; Humans; Neurodegenerative Diseases; Nitric Oxide; Nitric Oxide Synthase; Parkinson Disease | 2013 |
Arginine metabolising enzymes as targets against Alzheimers' disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Arginine; Enzyme Inhibitors; Humans; Hydrolases; Molecular Sequence Data; Nitric Oxide Synthase Type I; Peptide Fragments; Thermodynamics | 2014 |
Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches.
Topics: Alzheimer Disease; Animals; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Hypercholesterolemia; Neoplasms; Pre-Eclampsia; Pregnancy; Renal Insufficiency, Chronic | 2015 |
[Structure and function of proteins interacting with the cytoplasmic domain of APP].
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arginine; Cytoplasm; DNA-Binding Proteins; Humans; Phosphorylation; Protein Sorting Signals; Threonine; Ubiquitin-Activating Enzymes | 1999 |
Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Arginine; Biopterins; Brain; Brain Chemistry; Calcium; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Humans; Inflammation; Isoenzymes; Models, Biological; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurofibrillary Tangles; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Protein Processing, Post-Translational; Synaptic Transmission; tau Proteins | 2002 |
Apolipoprotein-E allele-specific regulation of nitric oxide production.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Arginine; Cerebellum; Humans; Neuroglia; Neurons; Nitric Oxide; Protein Isoforms | 2002 |
2 trial(s) available for arginine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Arginine; Enzyme Inhibitors; Female; Homocysteine; Humans; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Reference Values; Statistics as Topic | 2003 |
Effect of oral administration of L-arginine on senile dementia.
Topics: Administration, Oral; Aged; Alzheimer Disease; Arginine; Cognition; Female; Homes for the Aged; Humans; Japan; Learning; Lipid Peroxidation; Lipid Peroxides; Male; Memory; Nitric Oxide; Nursing Homes; Treatment Outcome | 2000 |
93 other study(ies) available for arginine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Procognitive activity of nitric oxide inhibitors and donors in animal models.
Topics: Alzheimer Disease; Animals; Arginine; Cognitive Dysfunction; Dizocilpine Maleate; Enzyme Inhibitors; Male; Mice; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitroso Compounds; Nootropic Agents; Open Field Test; Rotarod Performance Test; Schizophrenia; Scopolamine; Spermine | 2022 |
An arginine-rich peptide inhibits AChE: template-based design, molecular modeling, synthesis, and biological evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation | 2022 |
Protective effects of L-arginine on cognitive deficits and biochemical parameters in an experimental model of type-2 diabetes mellitus induced Alzheimer's disease in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Cognition; Diabetes Mellitus, Type 2; Models, Theoretical; NG-Nitroarginine Methyl Ester; Rats; Streptozocin | 2022 |
Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arginine; Brain; Carrier Proteins; Disease Models, Animal; Mice; Mice, Transgenic; Protein-Arginine N-Methyltransferases; Proteomics; tau Proteins; Vacuoles; Vimentin | 2022 |
Cumulative effect of simvastatin, L-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimer's disease.
Topics: Alzheimer Disease; Arginine; Biopterins; Cerebrovascular Circulation; Cognition; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neuropsychological Tests; Nitric Oxide Synthase Type III; Proof of Concept Study; Simvastatin | 2022 |
Arginine Reduces Glycation in γ
Topics: Alzheimer Disease; AMP-Activated Protein Kinases; Animals; Arginine; Diabetes Mellitus, Type 2; Mice; Plaque, Amyloid | 2022 |
Anti-amyloidogenic amphipathic arginine-dehydrophenylalanine spheres capped selenium nanoparticles as potent therapeutic moieties for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Dipeptides; Humans; Nanoparticles; Neuroblastoma; Peptide Fragments; Phenylalanine; Rats; Selenium; Streptozocin | 2023 |
Quantitative Structure-Activity Relationship Modeling of Pea Protein-Derived Acetylcholinesterase and Butyrylcholinesterase Inhibitory Peptides.
Topics: Acetylcholinesterase; Alzheimer Disease; Arginine; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Oligopeptides; Pea Proteins; Quantitative Structure-Activity Relationship; Structure-Activity Relationship | 2023 |
Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Arginine; Disease Progression; Guanidine; HSP90 Heat-Shock Proteins; Humans; Mass Spectrometry; Molecular Chaperones; Protein Aggregates; Protein Binding; Protein Domains; Protein Folding; Proteome; Rats; Sequence Analysis, Protein; tau Proteins | 2020 |
Comparison of the reaction of methylglyoxal (MGO) with murine and human amyloid beta (Aβ): Insights into a mechanism of Alzheimer's disease (AD).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Humans; Lysine; Mice; Peptide Fragments; Pyruvaldehyde; Superoxides | 2020 |
Capillary Electrophoresis-High Resolution Mass Spectrometry for Measuring In Vivo Arginine Isotope Incorporation in Alzheimer's Disease Mouse Models.
Topics: Alzheimer Disease; Animals; Apolipoprotein E4; Arginine; Brain; Carbon Isotopes; Disease Models, Animal; Electrophoresis, Capillary; Female; Humans; Isotope Labeling; Male; Mass Spectrometry; Mice, Transgenic; Nitric Oxide Synthase Type II; Nitrogen Isotopes; Proof of Concept Study | 2021 |
High-Throughput Metabolomics for Discovering Potential Metabolite Biomarkers and Metabolic Mechanism from the APPswe/PS1dE9 Transgenic Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Cognitive Dysfunction; Dicarboxylic Acids; Disease Models, Animal; Early Diagnosis; Glucuronic Acid; Glyoxylates; Humans; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multivariate Analysis; Pentoses; Proline; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Starch; Sucrose; Tryptophan | 2017 |
Glycation of Lys-16 and Arg-5 in amyloid-β and the presence of Cu
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Arginine; Copper; Cytochromes c; Deoxyguanine Nucleotides; DNA Damage; Glycosylation; Guanosine Monophosphate; Lysine; Models, Molecular; Oxidation-Reduction; Oxidative Stress; Protein Conformation | 2017 |
N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Arginine; Humans; Hydrolysis; Mass Spectrometry; Models, Molecular; Molecular Conformation; Peptidyl-Dipeptidase A; Protein Interaction Domains and Motifs; Proteolysis; Rats; Serine Endopeptidases; Substrate Specificity | 2018 |
Altered Expression of Urea Cycle Enzymes in Amyloid-β Protein Precursor Overexpressing PC12 Cells and in Sporadic Alzheimer's Disease Brain.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arginase; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; CA1 Region, Hippocampal; Gene Expression Regulation; Homeostasis; Humans; Nitric Oxide Synthase; PC12 Cells; Rats; RNA, Messenger; Urea | 2018 |
Altered plasma arginine metabolome precedes behavioural and brain arginine metabolomic profile changes in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Behavior, Animal; Brain; Disease Models, Animal; Female; Humans; Male; Maze Learning; Metabolome; Mice; Mice, Transgenic; Presenilin-1; Spatial Memory | 2018 |
Mutations of Histidine 13 to Arginine and Arginine 5 to Glycine Are Responsible for Different Coordination Sites of Zinc(II) to Human and Murine Peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Binding Sites; Coordination Complexes; Copper; Glycine; Histidine; Humans; Hydrogen-Ion Concentration; Mice; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; X-Ray Absorption Spectroscopy; Zinc | 2018 |
Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Biomarkers; Cell Line; Diagnosis, Differential; Disease Progression; Extracellular Vesicles; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Mental Status and Dementia Tests; Neurons | 2019 |
Pentosidine determination in CSF: a potential biomarker of Alzheimer's disease?
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lysine; Male; Middle Aged; Peptide Fragments | 2014 |
Alzheimer's disease treated patients showed different patterns for oxidative stress and inflammation markers.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Arginine; Biomarkers; Case-Control Studies; Endothelium, Vascular; Female; Glutathione; Homocysteine; Humans; Inflammation; Interleukin-6; Male; Oxidative Stress; Protein Carbonylation; Tumor Necrosis Factor-alpha | 2013 |
Arginine and disordered amyloid-β peptide structures: molecular level insights into the toxicity in Alzheimer's disease.
Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Humans; Models, Theoretical; Molecular Dynamics Simulation; Mutation; Protein Structure, Secondary; Thermodynamics | 2013 |
Impaired renal function and biomarkers of vascular disease in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Biomarkers; Case-Control Studies; Creatinine; Female; Glomerular Filtration Rate; Homocysteine; Humans; Kidney Diseases; Male; Mental Status Schedule; Multivariate Analysis; Risk Factors; Vascular Diseases | 2014 |
Arg972 insulin receptor substrate-1 polymorphism and risk and severity of Alzheimer's disease.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Arginine; China; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Insulin Receptor Substrate Proteins; Male; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Retrospective Studies | 2014 |
Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Arginine; Biomarkers; Carnitine; Cognition Disorders; Cognitive Dysfunction; Creatine; Dicarboxylic Acids; Female; Glycine; Heterozygote; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Sensitivity and Specificity; tau Proteins | 2014 |
Altered arginine metabolism in Alzheimer's disease brains.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Arginase; Arginine; Cerebellum; Disease Progression; Female; Hippocampus; Humans; Male; Middle Aged; Nitric Oxide Synthase; Organ Specificity; Prefrontal Cortex | 2014 |
Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer's disease model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Blood Pressure; Brain; Cerebrovascular Circulation; Cognition Disorders; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Female; Gene Expression Regulation; Humans; Losartan; Male; Mice; Mice, Transgenic; Mutation | 2014 |
R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Brain; Cohort Studies; Creutzfeldt-Jakob Syndrome; Exons; Female; Frontotemporal Dementia; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Genotype; Histidine; Humans; Male; Membrane Glycoproteins; Middle Aged; Phenotype; Receptors, Immunologic; Risk Factors | 2014 |
Key roles of Arg(5), Tyr(10) and his residues in Aβ-heme peroxidase: relevance to Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Arginine; Heme; Histidine; Humans; Mice; Molecular Sequence Data; Mutation; Oxidation-Reduction; Peptide Fragments; Peroxidases; Solutions; Tyrosine | 2014 |
TREM2 analysis and increased risk of Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Amino Acid Substitution; Arginine; Cohort Studies; Cytokines; Female; Genetic Variation; Histidine; Humans; Immunity, Innate; Male; Membrane Glycoproteins; Microglia; Middle Aged; Phagocytosis; Receptors, Immunologic; Risk; United Kingdom | 2015 |
Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: modulation by NOS inhibitors.
Topics: Alzheimer Disease; Amidines; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Benzylamines; Brain; Diflunisal; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Male; Maze Learning; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate | 2014 |
Amnestic mild cognitive impairment and conversion to Alzheimer's disease: insulin resistance and glycoxidation as early biomarker clusters.
Topics: Aged; Alzheimer Disease; Arginine; Blood Glucose; Case-Control Studies; Cognitive Dysfunction; Disease Progression; Female; Humans; Insulin; Insulin Resistance; Lysine; Male; Malondialdehyde; Neuropsychological Tests; Psychiatric Status Rating Scales; Statistics as Topic | 2015 |
Asymmetric dimethylarginine exacerbates Aβ-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Arginine; Caenorhabditis elegans; Disease Models, Animal; Gene Knockdown Techniques; Humans; MAP Kinase Signaling System; Oxidative Stress; Protein-Arginine N-Methyltransferases; Repressor Proteins | 2015 |
Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Arginine; Biomarkers; Case-Control Studies; Cognitive Dysfunction; Female; Humans; Male; Mass Spectrometry; Metabolomics; Polyamines; Predictive Value of Tests | 2015 |
Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Arginine; Brain; Disease Models, Animal; Disease Progression; Eflornithine; Humans; Immunologic Factors; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microarray Analysis; Microglia; Mutation; Nitric Oxide Synthase Type II; Ornithine Decarboxylase Inhibitors | 2015 |
Altered Arginine Metabolism in Cells Transfected with Human Wild-Type Beta Amyloid Precursor Protein (βAPP).
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arginase; Arginine; Brain; Humans; MicroRNAs; Nitric Oxide Synthase; PC12 Cells; Rats; RNA, Messenger; Transfection | 2016 |
Influence of sequence and lipid type on membrane perturbation by human and rat amyloid β-peptide (1-42).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arginine; Cell Membrane; Cholesterol; Humans; Lipid Bilayers; Lipids; Membrane Microdomains; Molecular Dynamics Simulation; Peptide Fragments; Phenotype; Rats; Species Specificity | 2017 |
What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Biomarkers; Cognitive Dysfunction; Female; Humans; Inflammation; Male; Memory; Metabolome; Nitric Oxide; Oxidative Stress; Signal Transduction | 2017 |
Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Arginine; Biomarkers; Body Mass Index; Case-Control Studies; Cognition Disorders; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Risk Factors | 2008 |
Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Citrulline; Dementia, Multi-Infarct; Female; Functional Laterality; Glutamine; Hippocampus; Humans; Isoenzymes; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Schizophrenia; Signal Transduction | 2008 |
The role of arginine-nitric oxide pathway in patients with Alzheimer disease.
Topics: Aged; Alzheimer Disease; Arginase; Arginine; Female; Humans; Magnesium; Male; Nitric Oxide | 2009 |
Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arginine; Benzazepines; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Genetic Vectors; Humans; Mice; Mice, Transgenic; Neprilysin; Nerve Degeneration; Nerve Growth Factors; Neurons; Neuropeptide Y; Peptide Fragments; Receptors, Neuropeptide Y | 2009 |
Plasma levels of nitric oxide related amino acids in demented subjects with Down syndrome are related to neopterin concentrations.
Topics: Alzheimer Disease; Amino Acids; Amino Acids, Aromatic; Amino Acids, Branched-Chain; Arginine; Citrulline; Cohort Studies; Dementia; Depression; Down Syndrome; Epilepsy; Female; Humans; Intellectual Disability; Male; Middle Aged; Neopterin; Nitric Oxide; Oxidative Stress; Severity of Illness Index | 2010 |
CSF studies facilitate DNA diagnosis in familial Alzheimer's disease due to a presenilin-1 mutation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Creutzfeldt-Jakob Syndrome; Dementia; Female; Humans; Leucine; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Peptide Fragments; Presenilin-1; Reference Values; tau Proteins; Young Adult | 2009 |
Analysis of the LRRK2 Gly2385Arg variant in Alzheimer's disease in Taiwan.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glycine; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Taiwan | 2010 |
Presenilin1 G217R mutation linked to Alzheimer disease with cotton wool plaques.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Arginine; Female; Genetic Linkage; Glycine; Humans; Male; Middle Aged; Mutation; Pedigree; Plaque, Amyloid; Presenilin-1 | 2009 |
Arginine metabolising enzymes as therapeutic tools for Alzheimer's disease: peptidyl arginine deiminase catalyses fibrillogenesis of beta-amyloid peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Cattle; Humans; Hydrolases; Neurofibrillary Tangles; Peptide Fragments; Protein-Arginine Deiminases | 2010 |
Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoproteins E; Arginine; Asian People; DNA-Binding Proteins; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Mental Status Schedule; Polymorphism, Genetic; Tryptophan; X-ray Repair Cross Complementing Protein 1 | 2010 |
BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Arginine; Binding Sites; Computer Simulation; Crystallography, X-Ray; Ethylamines; Protease Inhibitors; Rats; Structure-Activity Relationship | 2010 |
[The correlation of asymmetrical dimethylarginine level and oxidative stress to the onset of Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Female; Humans; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peptide Fragments; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2010 |
A novel PSEN1 gene mutation (L235R) associated with familial early-onset Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Arginine; Family Health; Female; Humans; Imaging, Three-Dimensional; Leucine; Magnetic Resonance Imaging; Middle Aged; Mutation; Parietal Lobe; Presenilin-1; Temporal Lobe | 2011 |
Potent amyloidogenicity and pathogenicity of Aβ43.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arginine; Cell Line, Tumor; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Humans; Immunoprecipitation; Isoleucine; L-Lactate Dehydrogenase; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Mutation; Neuroblastoma; Neurons; Peptide Fragments; Presenilin-1 | 2011 |
Atypical presentation of a novel Presenilin 1 R377W mutation: sporadic, late-onset Alzheimer disease with epilepsy and frontotemporal atrophy.
Topics: Aged; Alzheimer Disease; Arginine; Atrophy; Epilepsy; Fluorodeoxyglucose F18; Frontal Lobe; Humans; Male; Mutation; Positron-Emission Tomography; Presenilin-2; Temporal Lobe; Tomography, X-Ray Computed; Tryptophan | 2012 |
Nicotine evoked improvement in learning and memory is mediated through NPY Y1 receptors in rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amygdala; Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Arginine; Colchicine; Dentate Gyrus; Disease Models, Animal; Escape Reaction; Learning; Male; Maze Learning; Memory; Neuropeptide Y; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Septal Nuclei | 2012 |
Association of K832R and R952K SNPs of Wilson's disease gene with Alzheimer's disease.
Topics: Adenosine Triphosphatases; Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Cation Transport Proteins; Copper-Transporting ATPases; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Logistic Models; Lysine; Male; Middle Aged; Polymorphism, Single Nucleotide | 2012 |
Dimethylarginines, homocysteine metabolism, and cerebrospinal fluid markers for Alzheimer's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Biomarkers; Female; Homocysteine; Humans; Male; Middle Aged; S-Adenosylmethionine; Young Adult | 2012 |
KIF6 719Arg allele is associated with statin effects on cholesterol levels in amnestic mild cognitive impairment and Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Amnesia; Arginine; Cholesterol; Cognitive Dysfunction; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinesins; Male; Middle Aged | 2013 |
Alzheimer's disease is not associated with altered concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine in cerebrospinal fluid.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Brain; Cytoskeleton; Dimethylamines; Female; Humans; Male; Middle Aged; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Peptide Fragments; tau Proteins | 2002 |
Serum pentosidine as an indicator of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Female; Humans; Lysine; Male; Predictive Value of Tests; Reference Values; Serum Albumin | 2002 |
Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Arginine; Cationic Amino Acid Transporter 1; Cationic Amino Acid Transporter 2; Cell Division; Cells, Cultured; Cerebral Cortex; Female; Genotype; Humans; Interferon-gamma; Lipopolysaccharides; Male; Mice; Mice, Transgenic; Microglia; Nitric Oxide; RNA, Messenger | 2003 |
Lack of association between Alzheimer's disease and Gln-Arg 192 Q/R polymorphism of the PON-1 gene in an Italian population.
Topics: Aged; Alzheimer Disease; Amino Acid Substitution; Arginine; Aryldialkylphosphatase; Case-Control Studies; Esterases; Female; Genetic Predisposition to Disease; Glycine; Humans; Italy; Male; Polymorphism, Genetic | 2003 |
Tau polymerization: role of the amino terminus.
Topics: Alzheimer Disease; Amino Acid Sequence; Arachidonic Acid; Arginine; Humans; Lasers; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Polymers; Recombinant Proteins; Scattering, Radiation; tau Proteins | 2003 |
Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease-relevant insults.
Topics: Alanine; Alzheimer Disease; Amino Acids; Amyloid beta-Protein Precursor; Animals; Arginine; Culture Media, Conditioned; Dimerization; DNA, Complementary; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Hybrid Cells; Intracellular Signaling Peptides and Proteins; Leucine; Luminescent Proteins; Mice; Mutation; Neurons; Neuroprotective Agents; Peptides; Protein Structure, Tertiary; Proteins; Rats; Structure-Activity Relationship; Time Factors; Transfection | 2003 |
Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe.
Topics: Aged; Alzheimer Disease; Arginine; Europe; Founder Effect; Humans; Microsatellite Repeats; Middle Aged; Mutation; Pedigree; tau Proteins; Tryptophan | 2003 |
Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.
Topics: Alternative Splicing; Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; Cell Nucleus; Cells, Cultured; Exons; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Mutation, Missense; Neurons; Nuclear Proteins; Peptides; Phosphorylation; Precipitin Tests; Protein Isoforms; Ribonucleoproteins; RNA Splicing; RNA, Messenger; Serine; Serine-Arginine Splicing Factors; tau Proteins; Time Factors | 2004 |
The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy.
Topics: Age of Onset; Alzheimer Disease; Arginine; Atrophy; Genes, Dominant; Humans; Memory Disorders; Middle Aged; Mutation; Pedigree; tau Proteins; Temporal Lobe; Time Factors; Tryptophan | 2004 |
Homocysteine increases the production of asymmetric dimethylarginine in cultured neurons.
Topics: Alzheimer Disease; Amidohydrolases; Animals; Antioxidants; Arginine; Brain; Cells, Cultured; Cognition Disorders; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Feedback, Physiological; Homocysteine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Proline; Rats; Thiocarbamates; Up-Regulation | 2004 |
Prominent behavioural and psychiatric symptoms in early-onset Alzheimer's disease in a sib pair with the presenilin-1 gene R269G mutation.
Topics: Alzheimer Disease; Arginine; DNA Mutational Analysis; Family Health; Female; Glycine; Humans; Male; Membrane Proteins; Middle Aged; Mutation; Presenilin-1 | 2004 |
Structural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution.
Topics: Alleles; Alzheimer Disease; Anilino Naphthalenesulfonates; Apolipoprotein E3; Apolipoproteins; Apolipoproteins A; Apolipoproteins E; Arginine; Arteriosclerosis; Biophysics; Brain; Buffers; Circular Dichroism; Cysteine; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; Humans; Light; Microscopy, Fluorescence; Models, Molecular; Models, Statistical; Plasmids; Protein Conformation; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; Scattering, Radiation; Spectrometry, Fluorescence | 2005 |
Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2.
Topics: Alanine; Alzheimer Disease; Arginine; Binding Sites; Carrier Proteins; Catalytic Domain; Crystallography, X-Ray; Disulfides; DNA Mutational Analysis; Dose-Response Relationship, Drug; Factor XIa; Humans; Inhibitory Concentration 50; Kinetics; Lysine; Models, Molecular; Models, Statistical; Mutation; Partial Thromboplastin Time; Phenylalanine; Plasmids; Point Mutation; Proline; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thromboplastin; Time Factors; Vesicular Transport Proteins | 2005 |
Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease.
Topics: Adaptor Proteins, Signal Transducing; Aged; Alzheimer Disease; Apolipoprotein E4; Arginine; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Autophagy-Related Proteins; Carrier Proteins; Cell Cycle Proteins; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Logistic Models; Lysine; Male; Polymorphism, Genetic; Sex Characteristics | 2007 |
The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Case-Control Studies; DNA-Binding Proteins; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Risk; Tryptophan; X-ray Repair Cross Complementing Protein 1 | 2007 |
Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Arginine; Case-Control Studies; Female; Genetic Carrier Screening; Genetic Variation; Glycine; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Mutation; Protein Serine-Threonine Kinases; Risk Factors | 2009 |
The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser desorption/ionization tim
Topics: Alzheimer Disease; Amyloid beta-Peptides; Arginine; Histidine; Humans; Hydrolysis; Isomerism; Peptide Fragments; Peptidyl-Dipeptidase A; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2008 |
Alzheimer disease-like clinical phenotype in a family with FTDP-17 caused by a MAPT R406W mutation.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Chromosomes, Human, Pair 17; Dementia; Denmark; Deoxyglucose; Family Health; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Neurofibrillary Tangles; Neuropsychological Tests; Peptide Fragments; Phenotype; Positron-Emission Tomography; tau Proteins; Tryptophan | 2008 |
Genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G-308A and Saitohin Q7R polymorphisms with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Arginine; Chi-Square Distribution; China; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Glutamine; Humans; Male; Polymorphism, Genetic; tau Proteins; Tumor Necrosis Factor-alpha | 2008 |
Hippocampal free amino acids in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amino Acids; Arginine; Aspartic Acid; Dementia; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Humans; Middle Aged | 1980 |
Inhibitors of free radical formation fail to attenuate direct beta-amyloid25-35 peptide-mediated neurotoxicity in rat hippocampal cultures.
Topics: Allopurinol; Alzheimer Disease; Amino Acid Oxidoreductases; Amyloid beta-Peptides; Animals; Arginine; Catalase; Cell Death; Cells, Cultured; Embryo, Mammalian; Free Radical Scavengers; Free Radicals; Hippocampus; Humans; Indomethacin; Masoprocol; Neurons; Neurotoxins; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Oxypurinol; Peptide Fragments; Quinacrine; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Xanthine Oxidase | 1994 |
Advanced Maillard reaction end products are associated with Alzheimer disease pathology.
Topics: Alzheimer Disease; Arginine; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Hippocampus; Humans; Immunoenzyme Techniques; Lysine; Maillard Reaction; Neurofibrillary Tangles; Norleucine; Pyrroles | 1994 |
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Arginine; Asparagine; Aspartic Acid Endopeptidases; Base Sequence; Cell Compartmentation; Cell Line; Endopeptidases; Methylamines; Mice; Molecular Sequence Data; Mutation; Recombinant Fusion Proteins; Tumor Cells, Cultured | 1993 |
Conditions altering plasma concentrations of urea cycle and other amino acids in elderly human subjects.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids; Arginine; Citrulline; Cohort Studies; Data Collection; Dietary Proteins; Eating; Energy Intake; Fasting; Female; Humans; Middle Aged; Nitrates; Ornithine; Postmenopause; Regression Analysis; Time Factors | 1996 |
Immunohistochemical localization of advanced glycation end products, pentosidine, and carboxymethyllysine in lipofuscin pigments of Alzheimer's disease and aged neurons.
Topics: Adolescent; Aged; Aging; Alzheimer Disease; Arginine; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lipofuscin; Lysine; Nerve Degeneration; Nerve Tissue Proteins; Neurons | 1997 |
Identification of a novel mutation (Leu282Arg) of the human presenilin 1 gene in Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Arginine; Electrophoresis, Polyacrylamide Gel; Female; Genetic Testing; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Pedigree; Point Mutation; Polymorphism, Genetic; Presenilin-1; Risk Factors | 1998 |
Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Astrocytes; Cytoplasmic Granules; Extracellular Space; Glycoconjugates; Hippocampus; Humans; Lysine; Microglia; Staining and Labeling | 1998 |
L-glutamate, L-arginine and L-citrulline levels in cerebrospinal fluid of Parkinson's disease, multiple system atrophy, and Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Arginine; Citrulline; Glutamic Acid; Humans; Middle Aged; Multiple System Atrophy; Neurons; Nitric Oxide; Nitric Oxide Synthase; Parkinson Disease | 2000 |
Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Arginine; Aspartic Acid; Aspartic Acid Endopeptidases; Binding Sites; Crystallography, X-Ray; Endopeptidases; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; Sequence Alignment; Static Electricity; Substrate Specificity | 2000 |
Copper catalyzed oxidation of Alzheimer Abeta.
Topics: Alzheimer Disease; Amino Acids; Amyloid beta-Peptides; Arginine; Catalysis; Chromatography, High Pressure Liquid; Copper; Glutamic Acid; Glutamine; Histidine; Humans; Hydrogen Peroxide; Iron; Oxidation-Reduction; Oxygen; Peptide Fragments; Protein Processing, Post-Translational; Time Factors; Tyrosine | 2000 |
Lipoperoxidation is selectively involved in progressive supranuclear palsy.
Topics: Aged; Aldehydes; Alzheimer Disease; Arginine; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lipid Peroxides; Lysine; Mesencephalon; Middle Aged; Norleucine; Pyrroles; Reference Values; Supranuclear Palsy, Progressive; tau Proteins; Thiobarbituric Acid Reactive Substances | 2000 |
BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Arginine; Aspartic Acid Endopeptidases; Binding Sites; Cell Line; Cloning, Molecular; Endopeptidases; Gene Expression Profiling; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutation, Missense; Nervous System; Netherlands; Peptide Fragments; Phenylalanine; Protein Processing, Post-Translational; Recombinant Fusion Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Sweden | 2000 |
Effects of ENA713 and CHF2819, two anti-Alzheimer's disease drugs, on rat amino acid levels.
Topics: Alzheimer Disease; Animals; Arginine; Aspartic Acid; Carbamates; Cholinesterase Inhibitors; Citrulline; Cyclic N-Oxides; Dose-Response Relationship, Drug; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Neurons; Phenylcarbamates; Rats; Rats, Wistar; Rivastigmine; Synaptic Transmission; Taurine | 2001 |
Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arginine; Argininosuccinate Synthase; Citrulline; Encephalitis; Entorhinal Cortex; Frontal Lobe; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Neuroglia; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments | 2001 |
Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Arginine; Brain; Female; Humans; Male; Middle Aged; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress | 2001 |
Apolipoprotein E structural requirements for the formation of SDS-stable complexes with beta-amyloid-(1-40): the role of salt bridges.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Arginine; Cysteine; DNA, Complementary; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Salts; Sodium Dodecyl Sulfate | 2002 |
Arginine specific endopeptidases modify the aggregation properties of a synthetic peptide derived from Alzheimer beta/A4 amyloid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Arginine; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Endopeptidases; Immunoblotting; Metalloendopeptidases; Molecular Weight; Nerve Growth Factors; Neuropeptides; Serine Endopeptidases; Substrate Specificity | 1992 |