arenastatin-a and Carcinoma--Lewis-Lung

arenastatin-a has been researched along with Carcinoma--Lewis-Lung* in 1 studies

Other Studies

1 other study(ies) available for arenastatin-a and Carcinoma--Lewis-Lung

ArticleYear
New analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, with anti-tumor activity.
    Bioorganic & medicinal chemistry letters, 2004, May-17, Volume: 14, Issue:10

    Two analogues possessing steric hindered substituents on C-15 of arenastatin A (1), a potent cytotoxic spongean depsipeptide, were synthesized and shown to enhance stability in mouse serum. Notably, 15-tert-butylanalogue (6) with higher cytotoxicity exhibited in vivo anti-tumor activity through iv administration different from 1. Additionally, conformation analysis among the two analogues and arenastatin A (1) indicated that the torsion angle from C-14 to C-20 is a conclusive factor for the potent cytotoxicity of 1.

    Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cytotoxins; Depsipeptides; Dose-Response Relationship, Drug; Drug Stability; Mice; Molecular Conformation; Porifera; Structure-Activity Relationship; Treatment Outcome

2004