arecoline has been researched along with Substance Withdrawal Syndrome in 6 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arecoline treatment partly decreased the self-administration of morphine, it prevented the abstinence-induced decrease in body weight, and it reduced lever responding after protracted withdrawal (by 56%)." | 1.34 | A 24-h access I.V. self-administration schedule of morphine reinforcement and the estimation of recidivism: Pharmacological modification by arecoline. ( Bain, JN; Buccafusco, JJ, 2007) |
| "Mice were given several atropine injections at a high dosage level." | 1.25 | Sensitivity changes to morphine and other drugs induced by cholinergic blockade. ( Contreras, E; Quijada, L; Tamayo, L, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhat, SJ | 1 |
| Blank, MD | 1 |
| Balster, RL | 1 |
| Nichter, M | 2 |
| Buccafusco, JJ | 2 |
| Bain, JN | 1 |
| Zhang, LC | 1 |
| Shuster, LC | 1 |
| Jonnala, RR | 1 |
| Gattu, M | 1 |
| Iwamoto, ET | 1 |
| Loh, HH | 1 |
| Way, EL | 1 |
| Contreras, E | 1 |
| Tamayo, L | 1 |
| Quijada, L | 1 |
| Gothoni, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NIH-NCI U54 University of Guam/Cancer Center of Hawaii Partnership Full Project II: The Betel Nut Intervention Trial[NCT02942745] | 276 participants (Actual) | Interventional | 2016-08-31 | Completed | |||
| Cross-Cultural Adaptation of a Betel Quid Cessation Program and Evaluation of Its Effectiveness in a Malaysian High-Risk Community[NCT05782166] | 92 participants (Anticipated) | Interventional | 2024-01-02 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for arecoline and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Areca nut dependence among chewers in a South Indian community who do not also use tobacco.
Topics: Adolescent; Adult; Aged; Areca; Arecoline; Behavior, Addictive; Child; Female; Health Knowledge, Att | 2010 |
Areca nut dependence among chewers in a South Indian community who do not also use tobacco.
Topics: Adolescent; Adult; Aged; Areca; Arecoline; Behavior, Addictive; Child; Female; Health Knowledge, Att | 2010 |
Areca nut dependence among chewers in a South Indian community who do not also use tobacco.
Topics: Adolescent; Adult; Aged; Areca; Arecoline; Behavior, Addictive; Child; Female; Health Knowledge, Att | 2010 |
Areca nut dependence among chewers in a South Indian community who do not also use tobacco.
Topics: Adolescent; Adult; Aged; Areca; Arecoline; Behavior, Addictive; Child; Female; Health Knowledge, Att | 2010 |
A 24-h access I.V. self-administration schedule of morphine reinforcement and the estimation of recidivism: Pharmacological modification by arecoline.
Topics: Analgesics, Opioid; Animals; Arecoline; Dose-Response Relationship, Drug; Infusions, Intravenous; Ma | 2007 |
Prevention of precipitated withdrawal symptoms by activating central cholinergic systems during a dependence-producing schedule of morphine in rats.
Topics: Acetylcholinesterase; Animals; Arecoline; Blood Pressure; Brain; Cardiovascular System; Cholinergic | 2000 |
Dopaminergic-cholinergic interactions in naloxone-induced circling in morphine-dependent rats with nigral lesions.
Topics: Animals; Apomorphine; Arecoline; Atropine; Behavior; Dopamine; Humans; Hydroxydopamines; Male; Morph | 1976 |
Sensitivity changes to morphine and other drugs induced by cholinergic blockade.
Topics: Amphetamine; Analgesics; Animals; Arecoline; Atropine; Drug Tolerance; Female; Hexobarbital; Humans; | 1975 |
Ethanol withdrawal tremor does not interact with physostigmine-induced tremor in rat.
Topics: Animals; Arecoline; Atropine; Ethanol; Male; Physostigmine; Rats; Rats, Inbred Strains; Substance Wi | 1985 |