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arecoline and Seizures

arecoline has been researched along with Seizures in 8 studies

Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"A tropane ester, three tropane ethers, atropine and mecamylamine were compared in mice for their anti-muscarinic and anti-nicotinic activity against arecoline-induced tremor and nicotine-induced convulsions, respectively."3.69Anticholinergic activity in mice and receptor-binding properties in rats of a series of synthetic tropane derivatives. ( Cui, WY; Gao, ZG; Liu, BY; Liu, CG; Wang, L, 1997)
"In an attempt to know the relation of seizure and gastric mucosal damage, we challenged arecoline (ACL) centrally to induce seizure and investigated gastric hemorrhagic injury in acid-irrigated stomachs of rats."1.31Gastric mucosal damage induced by arecoline seizure in rats. ( Cheng, JT; Hung, CR; Shih, CS, 2000)
"Haloperidol-induced catalepsy was potentiated in DSP-4 treated rats, while arecoline-induced catalepsy was attenuated."1.26Alterations in drug induced catalepsy and post-decapitation convulsions following brain and spinal cord depletion of norepinephrine by the neurotoxin DSP-4. ( Asin, KE; Fibiger, HC; Wirtshafter, D, 1982)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19905 (62.50)18.7374
1990's1 (12.50)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Basselin, M1
Chang, L1
Seemann, R1
Bell, JM1
Rapoport, SI1
Asin, KE1
Wirtshafter, D1
Fibiger, HC1
Gao, ZG1
Cui, WY1
Liu, BY1
Liu, CG1
Wang, L1
Hung, CR1
Cheng, JT1
Shih, CS1
Lazarova, M2
Roussinov, K2
Lodge, D1
Johnston, GA1
Curtis, DR1
Brand, SJ1
Witkin, JM1
Alvarado-Garcia, R1
Lee, MA1
Witkin, KM1

Other Studies

8 other studies available for arecoline and Seizures

ArticleYear
Chronic lithium administration potentiates brain arachidonic acid signaling at rest and during cholinergic activation in awake rats.
    Journal of neurochemistry, 2003, Volume: 85, Issue:6

    Topics: Animals; Arachidonic Acid; Arecoline; Autoradiography; Body Weight; Brain; Carbon Radioisotopes; Cho

2003
Alterations in drug induced catalepsy and post-decapitation convulsions following brain and spinal cord depletion of norepinephrine by the neurotoxin DSP-4.
    Life sciences, 1982, May-03, Volume: 30, Issue:18

    Topics: Amines; Animals; Arecoline; Benzylamines; Brain; Catalepsy; Drug Interactions; Haloperidol; Humans;

1982
Anticholinergic activity in mice and receptor-binding properties in rats of a series of synthetic tropane derivatives.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:3

    Topics: Animals; Arecoline; Brain; Drug Antagonism; Female; Male; Mice; Muscarinic Agonists; Muscarinic Anta

1997
Gastric mucosal damage induced by arecoline seizure in rats.
    Life sciences, 2000, May-05, Volume: 66, Issue:24

    Topics: Animals; Arecoline; Cholinergic Agonists; Cholinergic Antagonists; Dose-Response Relationship, Drug;

2000
On some relationships between gamma-aminobutyric acid (GABA) and the cholinergic mechanisms in electric convulsions.
    Acta physiologica et pharmacologica Bulgarica, 1977, Volume: 3, Issue:4

    Topics: Aminobutyrates; Animals; Arecoline; Diphenylacetic Acids; Electric Stimulation; gamma-Aminobutyric A

1977
On some relationships between gamma-aminobutyric acid (GABA) and the cholinergic mechanisms in pentylenetetrazol convulsions.
    Acta physiologica et pharmacologica Bulgarica, 1977, Volume: 3, Issue:4

    Topics: Aminobutyrates; Animals; Arecoline; gamma-Aminobutyric Acid; Male; Mice; Parasympathetic Nervous Sys

1977
Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system.
    Brain research, 1977, Nov-18, Volume: 136, Issue:3

    Topics: Action Potentials; Alanine; Aminobutyrates; Animals; Areca; Arecoline; Bicuculline; Cats; Cerebellum

1977
Nonmuscarinic neurotoxicity of oxotremorine.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: Animals; Arecoline; Atropine; Atropine Derivatives; Benactyzine; Benztropine; Crying; Diazepam; Dose

1987