arecoline has been researched along with Precancerous Conditions in 13 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral submucous fibrosis (OSF) is known as a potentially malignant disorder, which may result from chemical irritation due to areca nuts (such as arecoline)." | 4.02 | Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis. ( Chang, YC; Hsieh, PL; Liao, YW; Yu, CC, 2021) |
| "Naswar, in addition to oral cancer, causes adverse cardiovascular events by reducing glutathione per oxidase (GPx) and super-oxide dismutase (SOD), serum levels of HDL, whereas, increasing the ratio of cholesterol, LDL, triglycerides and LDL-C/HDL-C." | 2.58 | Molecular Pathogenesis of Chewable Tobacco. ( Baig, S; Farooq, W; Rubab, Z, 2018) |
| "Oral carcinogenesis involves the progression of the normal mucosa into potentially malignant disorders and finally into cancer." | 1.56 | Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model. ( Chiang, WF; Hsieh, YP; Huang, LY; Huang, TT; Huang, WT; Hwang, DY; Jiang, SS; Liu, KJ; Wang, YY, 2020) |
| "Treatment of arecoline in BMFs dose-dependently reduced gene expression of miR-200b, which corresponded with the decreased expression of miR-200b in fBMFs." | 1.48 | miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2. ( Chang, YC; Hsieh, PL; Liao, YW; Yu, CC, 2018) |
| "Arecoline treatment dose-dependently reduced the relative expression of miR-200c in normal BMFs." | 1.48 | miR-200c inhibits the arecoline-associated myofibroblastic transdifferentiation in buccal mucosal fibroblasts. ( Chen, PY; Hsieh, PL; Liao, YW; Lin, KH; Lu, MY; Peng, CY; Yu, CC; Yu, CH, 2018) |
| "Over 80% of OSF-related oral cancers examined had moderate/high αvβ6 expression." | 1.37 | Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. ( Fortune, F; Hart, IR; Jenei, V; Lewis, MP; Marsh, D; Marshall, JF; Moutasim, KA; Sapienza, K; Thomas, GJ; Tilakaratne, WM; Violette, SM; Weinreb, PH, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, LY | 1 |
| Hsieh, YP | 1 |
| Wang, YY | 1 |
| Hwang, DY | 1 |
| Jiang, SS | 1 |
| Huang, WT | 1 |
| Chiang, WF | 1 |
| Liu, KJ | 1 |
| Huang, TT | 1 |
| Yu, CC | 5 |
| Liao, YW | 4 |
| Hsieh, PL | 4 |
| Chang, YC | 3 |
| Yang, HW | 1 |
| Lu, MY | 2 |
| Chiu, YW | 1 |
| Huang, YF | 1 |
| Ju Chueh, P | 1 |
| Baig, S | 1 |
| Rubab, Z | 1 |
| Farooq, W | 1 |
| Chen, PY | 1 |
| Peng, CY | 2 |
| Yu, CH | 2 |
| Lin, KH | 1 |
| Lee, YH | 1 |
| Yang, LC | 1 |
| Hu, FW | 1 |
| Moutasim, KA | 1 |
| Jenei, V | 1 |
| Sapienza, K | 1 |
| Marsh, D | 1 |
| Weinreb, PH | 1 |
| Violette, SM | 1 |
| Lewis, MP | 1 |
| Marshall, JF | 1 |
| Fortune, F | 1 |
| Tilakaratne, WM | 1 |
| Hart, IR | 1 |
| Thomas, GJ | 1 |
| Chang, MC | 1 |
| Lin, LD | 1 |
| Wu, HL | 1 |
| Ho, YS | 1 |
| Hsien, HC | 1 |
| Wang, TM | 1 |
| Jeng, PY | 1 |
| Cheng, RH | 1 |
| Hahn, LJ | 1 |
| Jeng, JH | 1 |
| Yang, SF | 1 |
| Hsieh, YS | 1 |
| Tsai, CH | 1 |
| Chou, MY | 1 |
| Shieh, DH | 1 |
| Chiang, LC | 1 |
| Shieh, TY | 2 |
| Hsu, HJ | 1 |
| Chang, KL | 1 |
| Yang, YH | 1 |
| Awang, MN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of microRNA-29b in the Oral Squamous Cell Carcinoma[NCT02009852] | 100 participants (Anticipated) | Observational [Patient Registry] | 2014-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for arecoline and Precancerous Conditions
| Article | Year |
|---|---|
Molecular Pathogenesis of Chewable Tobacco.
Topics: Areca; Arecoline; Humans; Mouth Mucosa; Mouth Neoplasms; Nicotiana; Pakistan; Pharyngeal Neoplasms; | 2018 |
12 other studies available for arecoline and Precancerous Conditions
| Article | Year |
|---|---|
Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Cell L | 2020 |
Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis.
Topics: Arecoline; Biomarkers; Cell Transdifferentiation; Cells, Cultured; Collagen Type I; Collagen Type I, | 2021 |
Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail.
Topics: Actins; Animals; Areca; Arecoline; Cell Transdifferentiation; Humans; Monoterpenes; Myofibroblasts; | 2018 |
miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2.
Topics: Actins; Apoptosis; Areca; Arecoline; Cell Movement; Cell Transdifferentiation; Dose-Response Relatio | 2018 |
miR-200c inhibits the arecoline-associated myofibroblastic transdifferentiation in buccal mucosal fibroblasts.
Topics: Areca; Arecoline; Cell Transdifferentiation; Humans; MicroRNAs; Mouth Mucosa; Myofibroblasts; Oral S | 2018 |
Elevation of Twist expression by arecoline contributes to the pathogenesis of oral submucous fibrosis.
Topics: Areca; Arecoline; Cells, Cultured; Humans; Mouth Mucosa; Myofibroblasts; Nuclear Proteins; Oral Subm | 2016 |
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.
Topics: Actins; Antigens, Neoplasm; Areca; Arecoline; Carcinoma, Squamous Cell; Cell Differentiation; Cell M | 2011 |
Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
Topics: Areca; Arecoline; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Fibr | 2013 |
The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis.
Topics: Areca; Arecoline; Blotting, Western; Case-Control Studies; Cells, Cultured; Cheek; Humans; Male; Mou | 2003 |
Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis.
Topics: Adult; Aged; Areca; Arecoline; Cells, Cultured; Cheek; Dose-Response Relationship, Drug; Fibroblasts | 2003 |
The effects of arecoline on the release of cytokines using cultured peripheral blood mononuclear cells from patients with oral mucous diseases.
Topics: Arecoline; Carcinoma, Squamous Cell; Cells, Cultured; Cytokines; Fibrosis; Humans; Leukocytes, Monon | 2001 |
Estimation of arecoline contents in commercial areca (betel) nuts and its relation to oral precancerous lesions.
Topics: Areca; Arecoline; Humans; Malaysia; Mouth Neoplasms; Plants, Medicinal; Precancerous Conditions; Ris | 1986 |