arecoline has been researched along with Oral Submucous Fibrosis in 86 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Oral Submucous Fibrosis: Irreversible FIBROSIS of the submucosal tissue of the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to induce oral submucous fibrosis (OSF) in Sprague-Dawley(SD) rat models by arecoline and mechanical stimulation." | 7.91 | [Rat model with oral submucous fibrosis induced by arecoline and mechanical stimulation]. ( Fu, MF; Tang, ZG; Yang, B, 2019) |
| "To explore and analyze the the expression change of miRNA associated with oral submucous fibrosis (OSF) treated by the Salvia combined with law-dose prednisolone." | 7.80 | [Changes of miRNA after oral submucous fibrosis co-cultured with Salvia and low-dose prednisolone]. ( Chen, J; Jian, X; Liu, B, 2014) |
| "Arecoline was found to elevate TIMP-1 expression at the concentration level under 20 microg/ml in a dose-dependent manner." | 5.31 | Increased tissue inhibitor of metalloproteinase-1 expression and inhibition of gelatinase A activity in buccal mucosal fibroblasts by arecoline as possible mechanisms for oral submucous fibrosis. ( Chang, YC; Chou, MY; Hsieh, YS; Tai, KW; Yang, SF, 2002) |
| "Arecoline induced the gradual atrophy and thinning of rat oral mucosal, collagen accumulation, the increase expressions of fibrosis-related proteins and Th17/Treg ratio." | 4.31 | Jiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS). ( Dai, Y; Qin, Y; Tan, J; Tan, Y; Wang, Z; Wu, D; Xiao, Y; Zhou, L; Zhu, K, 2023) |
| "Oral submucous fibrosis (OSF) is known as a potentially malignant disorder, which may result from chemical irritation due to areca nuts (such as arecoline)." | 4.02 | Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis. ( Chang, YC; Hsieh, PL; Liao, YW; Yu, CC, 2021) |
| "Arecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer." | 3.96 | Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression. ( Chen, Q; Chen, Z; He, S; Jiao, J; Li, X; Mai, Z; Ren, J; Wang, Y, 2020) |
| "Arecoline induces oral submucous fibrosis (OSF) via promoting the reactive oxygen species (ROS)." | 3.91 | Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome activation. ( Du, X; Huang, Y; Jin, S; Li, X; Li, Y; Wang, D; Wang, G; Wu, B; You, Y; Zhu, X, 2019) |
| "Oral submucous fibrosis (OSMF) is a pre-malignant condition that is strongly associated with the areca nut alkaloids, arecoline (ARC) and arecaidine (ARD)." | 3.83 | Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression. ( Ali, S; Atif, M; Hassona, Y; James, EL; Lone, MA; Parkinson, EK; Pitiyage, GN; Prime, SS; Rehman, A, 2016) |
| "Arecoline is cytotoxic via necrosis for endothelium, while biochemical assays indicate no appreciable cellular leakage before death and detachment, as well as no clear effect on mitochondrial function in viable cells." | 3.80 | Arecoline is cytotoxic for human endothelial cells. ( Boadle, R; Cox, S; Kelly, E; Ullah, M; Zoellner, H, 2014) |
| "To explore and analyze the the expression change of miRNA associated with oral submucous fibrosis (OSF) treated by the Salvia combined with law-dose prednisolone." | 3.80 | [Changes of miRNA after oral submucous fibrosis co-cultured with Salvia and low-dose prednisolone]. ( Chen, J; Jian, X; Liu, B, 2014) |
| " Arecoline present in betel quid has been proposed as one of the causative factors for oral submucous fibrosis (OSMF)." | 3.75 | Transglutaminase-2 regulation by arecoline in gingival fibroblasts. ( Agarwal, P; Balapure, AK; Khan, I; Kondaiah, P; Rao, SG; Thangjam, GS; Verma, UP, 2009) |
| "Oral submucous fibrosis, a disease of collagen disorder, has been attributed to arecoline present in the saliva of betel quid chewers." | 3.75 | Regulation of extracellular matrix genes by arecoline in primary gingival fibroblasts requires epithelial factors. ( Agarwal, P; Balapure, AK; Kondaiah, P; Rao, SG; Thangjam, GS, 2009) |
| "The differentiation of myofibroblasts from fibroblasts in oral submucous fibrosis might be induced by the interaction of arecoline and keratinocyte." | 3.74 | [Effect of arecoline on the differentiation of myofibroblasts of oral mucosa]. ( Gao, YJ; Li, X; Ling, TY, 2007) |
| "This study aimed to assess the possibility of a direct effect of betel-nut alkaloids arecoline and arecaidine on cell proliferation and interleukin-6 (IL-6) production by cultured fibroblasts from human normal gingiva, buccal mucosa and oral submucous fibrosis (OSF) buccal mucosa in vitro." | 3.69 | In vitro production of interleukin-6 by human gingival, normal buccal mucosa, and oral submucous fibrosis fibroblasts treated with betel-nut alkaloids. ( Chen, CC; Huang, JF; Tsai, CC, 1995) |
| "Fibroblasts cultured in vitro from normal buccal tissue and from tissue from oral submucous fibrosis (OSF) associated with betel-nut chewing showed no significant difference in their rates of proliferation in culture, nor in the rate at which they hydrolysed the betel nut alkaloid arecoline to arecaidine." | 3.67 | An in-vitro comparison of human fibroblasts from normal and oral submucous fibrosis tissue. ( Canniff, JP; Harvey, W; Meghji, S; Scutt, A, 1987) |
| "Arecoline was used to induce human oral keratinocytes (HOKs) senescence." | 1.91 | Senescent epithelial cells remodel the microenvironment for the progression of oral submucous fibrosis through secreting TGF-β1. ( Han, Y; Nie, H; Peng, Y; Shao, S; Su, T; Wang, Z; Xia, K; Xiong, H, 2023) |
| "Treatment of arecoline in BMFs dose-dependently reduced gene expression of miR-200b, which corresponded with the decreased expression of miR-200b in fBMFs." | 1.48 | miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2. ( Chang, YC; Hsieh, PL; Liao, YW; Yu, CC, 2018) |
| "Arecoline treatment dose-dependently reduced the relative expression of miR-200c in normal BMFs." | 1.48 | miR-200c inhibits the arecoline-associated myofibroblastic transdifferentiation in buccal mucosal fibroblasts. ( Chen, PY; Hsieh, PL; Liao, YW; Lin, KH; Lu, MY; Peng, CY; Yu, CC; Yu, CH, 2018) |
| "Arecoline was found to upregulate HIF-1α protein in a dose-dependent manner (P < 0." | 1.42 | Hypoxic regulation of plasminogen activator inhibitor-1 expression in human buccal mucosa fibroblasts stimulated with arecoline. ( Chang, YC; Lee, SS; Tsai, CH, 2015) |
| "In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study." | 1.40 | Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma. ( Chang, YC; Chen, MK; Chien, MH; Chiou, HL; Lin, CW; Su, SC; Yang, JS; Yang, SF, 2014) |
| "Arecoline was found to elevate PAR-1 expression in a dose-dependent and time-dependent manner (p < ." | 1.39 | Regulation of protease-activated receptor-1 expression in human buccal fibroblasts stimulated with arecoline. ( Chang, YC; Huang, FM; Lee, SS; Tsai, CH, 2013) |
| "Over 80% of OSF-related oral cancers examined had moderate/high αvβ6 expression." | 1.37 | Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. ( Fortune, F; Hart, IR; Jenei, V; Lewis, MP; Marsh, D; Marshall, JF; Moutasim, KA; Sapienza, K; Thomas, GJ; Tilakaratne, WM; Violette, SM; Weinreb, PH, 2011) |
| "Arecoline was also found to elevate HO-1 mRNA and protein expression in a dose-dependent manner (P < 0." | 1.35 | Augmented heme oxygenase-1 expression in areca quid chewing-associated oral submucous fibrosis. ( Chang, YC; Lee, SS; Tsai, CH; Yang, SF, 2009) |
| "Arecoline was also found to elevate HSP47 mRNA expression in a dose-dependent manner (P < 0." | 1.35 | The upregulation of heat shock protein 47 expression in human buccal fibroblasts stimulated with arecoline. ( Chang, YC; Tsai, CH; Yang, SF, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.16) | 18.7374 |
| 1990's | 6 (6.98) | 18.2507 |
| 2000's | 20 (23.26) | 29.6817 |
| 2010's | 34 (39.53) | 24.3611 |
| 2020's | 25 (29.07) | 2.80 |
| Authors | Studies |
|---|---|
| Ho, DC | 2 |
| Chen, SH | 1 |
| Fang, CY | 5 |
| Hsieh, CW | 1 |
| Hsieh, PL | 13 |
| Liao, YW | 14 |
| Yu, CC | 18 |
| Tsai, LL | 4 |
| He, C | 1 |
| Wang, W | 5 |
| Wan, W | 1 |
| Liang, J | 1 |
| Hu, J | 1 |
| Yuan, Y | 1 |
| Jiang, C | 2 |
| Li, N | 2 |
| Zhang, P | 1 |
| Chua, NQE | 1 |
| Dang, S | 1 |
| Davis, A | 1 |
| Chong, KW | 1 |
| Prime, SS | 2 |
| Cirillo, N | 1 |
| Li, X | 4 |
| Gao, Y | 2 |
| Chen, W | 3 |
| Gu, Y | 1 |
| Song, J | 1 |
| Zhang, J | 2 |
| Ai, Y | 1 |
| Huang, J | 2 |
| Zhang, H | 1 |
| Fan, X | 1 |
| Guo, J | 2 |
| Xie, C | 1 |
| Li, Z | 2 |
| Hua, Y | 1 |
| Sun, S | 1 |
| Zhong, L | 1 |
| Chen, Q | 3 |
| Feng, H | 1 |
| Ji, N | 1 |
| Li, T | 1 |
| Zhou, X | 1 |
| Zeng, X | 1 |
| Tang, Z | 3 |
| Sun, C | 1 |
| Li, J | 3 |
| Hu, X | 2 |
| Hu, Y | 3 |
| Wang, C | 2 |
| Yang, L | 2 |
| Mao, T | 2 |
| Xia, K | 3 |
| Min, A | 1 |
| Xiong, H | 3 |
| Su, T | 3 |
| Fu, Y | 1 |
| Zhu, Y | 1 |
| Hu, L | 1 |
| Shi, C | 1 |
| Zhang, Y | 1 |
| Zhou, S | 1 |
| Wang, Z | 2 |
| Han, Y | 2 |
| Peng, Y | 1 |
| Shao, S | 1 |
| Nie, H | 1 |
| Wang, L | 1 |
| Zhou, L | 1 |
| Tan, J | 1 |
| Dai, Y | 1 |
| Zhu, K | 1 |
| Xiao, Y | 1 |
| Wu, D | 1 |
| Tan, Y | 1 |
| Qin, Y | 1 |
| Yao, M | 2 |
| Yuan, S | 1 |
| Zhu, X | 3 |
| Hu, Z | 2 |
| Li, Q | 2 |
| Cao, R | 2 |
| Fang, C | 3 |
| Chen, SC | 1 |
| Liu, CM | 2 |
| Lin, YJ | 1 |
| Yu, CH | 8 |
| Wang, YK | 1 |
| Lin, T | 1 |
| Zhu, B | 2 |
| Jiang, Q | 1 |
| Que, G | 1 |
| Dai, Z | 2 |
| Wu, Y | 2 |
| Ohiro, Y | 1 |
| Chu, PM | 3 |
| Huang, YC | 1 |
| Chiang, MH | 1 |
| Lee, KT | 1 |
| Chen, CH | 1 |
| Chen, KK | 1 |
| Wang, YH | 1 |
| Wang, Y | 3 |
| Luo, D | 1 |
| Yuan, X | 1 |
| Luo, Y | 1 |
| Cheng, X | 1 |
| Xie, X | 1 |
| Shen, YW | 1 |
| Shih, YH | 1 |
| Fuh, LJ | 1 |
| Shieh, TM | 1 |
| Jiao, J | 1 |
| Mai, Z | 1 |
| Ren, J | 1 |
| He, S | 1 |
| Chen, Z | 1 |
| Yang, HW | 3 |
| Das, A | 1 |
| Giri, S | 1 |
| Li, L | 1 |
| Gu, L | 1 |
| Yao, Z | 1 |
| Wu, X | 1 |
| Chang, YC | 21 |
| Chen, PY | 2 |
| Lu, KH | 1 |
| Su, SH | 1 |
| Ho, YC | 1 |
| Yang, SF | 10 |
| Lee, SS | 5 |
| Zheng, L | 2 |
| Guan, ZJ | 1 |
| Pan, WT | 1 |
| Du, TF | 1 |
| Zhai, YJ | 1 |
| Hsieh, YP | 2 |
| Wu, KJ | 1 |
| Chen, HM | 3 |
| Deng, YT | 3 |
| Lee, PH | 1 |
| Lin, CY | 2 |
| Lu, MY | 4 |
| Peng, CY | 5 |
| Huang, YF | 2 |
| Chiu, YW | 1 |
| Ju Chueh, P | 1 |
| Zhao, R | 1 |
| Lin, KH | 1 |
| Hsia, SM | 1 |
| Wu, CZ | 1 |
| Lin, KC | 1 |
| You, Y | 1 |
| Huang, Y | 1 |
| Wang, D | 1 |
| Li, Y | 1 |
| Wang, G | 1 |
| Jin, S | 1 |
| Wu, B | 1 |
| Du, X | 1 |
| Yu, H | 1 |
| Jian, X | 3 |
| Peng, J | 1 |
| Yang, B | 1 |
| Fu, MF | 1 |
| Tang, ZG | 1 |
| He, J | 1 |
| Chen, L | 1 |
| Zhu, C | 1 |
| Shen, T | 1 |
| Tsai, CH | 14 |
| Lai, YL | 1 |
| Chi, WY | 1 |
| Li, JJ | 2 |
| Chang, WW | 1 |
| Chang, JZ | 1 |
| Chiang, CP | 2 |
| Kuo, MY | 2 |
| Li, M | 1 |
| Gao, F | 1 |
| Zhou, ZS | 1 |
| Zhang, HM | 1 |
| Zhang, R | 1 |
| Wu, YF | 1 |
| Bai, MH | 1 |
| Lin, SR | 1 |
| Peng, JY | 1 |
| Yang, JS | 1 |
| Chen, MK | 1 |
| Su, SC | 1 |
| Chiou, HL | 1 |
| Chien, MH | 1 |
| Lin, CW | 1 |
| Ullah, M | 1 |
| Cox, S | 1 |
| Kelly, E | 1 |
| Boadle, R | 1 |
| Zoellner, H | 1 |
| Liu, B | 1 |
| Chen, J | 1 |
| Guo, F | 1 |
| Yin, P | 1 |
| Min, AJ | 1 |
| Huang, L | 1 |
| Lee, YH | 1 |
| Yang, LC | 1 |
| Hu, FW | 1 |
| Khan, I | 3 |
| Pant, I | 2 |
| Narra, S | 2 |
| Radhesh, R | 1 |
| Ranganathan, K | 1 |
| Rao, SG | 3 |
| Kondaiah, P | 4 |
| Chen, YJ | 5 |
| Huang, FM | 2 |
| Rehman, A | 1 |
| Ali, S | 1 |
| Lone, MA | 1 |
| Atif, M | 1 |
| Hassona, Y | 1 |
| Pitiyage, GN | 1 |
| James, EL | 1 |
| Parkinson, EK | 1 |
| Adtani, PN | 1 |
| Narasimhan, M | 1 |
| Punnoose, AM | 1 |
| Kambalachenu, HR | 1 |
| Thangjam, GS | 2 |
| Agarwal, P | 2 |
| Verma, UP | 1 |
| Balapure, AK | 2 |
| Cheng, SJ | 1 |
| Moutasim, KA | 1 |
| Jenei, V | 1 |
| Sapienza, K | 1 |
| Marsh, D | 1 |
| Weinreb, PH | 1 |
| Violette, SM | 1 |
| Lewis, MP | 1 |
| Marshall, JF | 1 |
| Fortune, F | 1 |
| Tilakaratne, WM | 2 |
| Hart, IR | 1 |
| Thomas, GJ | 1 |
| Kumar, N | 1 |
| Chang, MC | 1 |
| Lin, LD | 1 |
| Wu, HL | 1 |
| Ho, YS | 1 |
| Hsien, HC | 1 |
| Wang, TM | 1 |
| Jeng, PY | 1 |
| Cheng, RH | 1 |
| Hahn, LJ | 1 |
| Jeng, JH | 1 |
| Hsu, HI | 1 |
| Tai, KW | 3 |
| Yang, SH | 1 |
| Chou, MY | 7 |
| Lii, CK | 1 |
| Hsieh, YS | 4 |
| Shieh, DH | 2 |
| Chiang, LC | 2 |
| Shieh, TY | 3 |
| Lee, CH | 1 |
| Yang, YH | 1 |
| Chu, SC | 1 |
| Klinikowski, MF | 1 |
| Saku, T | 1 |
| Peters, TJ | 1 |
| Warnakulasuriya, S | 1 |
| Chung-Hung, T | 1 |
| Shun-Fa, Y | 1 |
| Yu-Chao, C | 1 |
| Ling, TY | 1 |
| Gao, YJ | 1 |
| Chen, CC | 1 |
| Huang, JF | 1 |
| Tsai, CC | 2 |
| van Wyk, CW | 1 |
| Olivier, A | 1 |
| Hoal-van Helden, EG | 1 |
| Grobler-Rabie, AF | 1 |
| Murti, PR | 1 |
| Bhonsle, RB | 1 |
| Gupta, PC | 1 |
| Daftary, DK | 1 |
| Pindborg, JJ | 1 |
| Mehta, FS | 1 |
| Meghji, S | 3 |
| Haque, MF | 2 |
| Harris, M | 2 |
| Cheng, MH | 1 |
| Chou, LS | 1 |
| Ma, RH | 1 |
| Nazir, R | 1 |
| Shah, B | 1 |
| Lewis, MA | 1 |
| Bedi, R | 1 |
| Scutt, A | 1 |
| Harvey, W | 1 |
| Canniff, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of microRNA-29b in the Oral Squamous Cell Carcinoma[NCT02009852] | 100 participants (Anticipated) | Observational [Patient Registry] | 2014-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for arecoline and Oral Submucous Fibrosis
| Article | Year |
|---|---|
Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents-Does Fibroblast Senescence Play a Role?
Topics: Areca; Arecoline; Carcinoma, Squamous Cell; Disease Progression; Humans; Mouth Neoplasms; Nicotinic | 2022 |
Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments.
Topics: Areca; Arecoline; Biomarkers; Collagen; Humans; Mouth Mucosa; Mouth Neoplasms; Oral Submucous Fibros | 2020 |
A Review on Role of Arecoline and Its Metabolites in the Molecular Pathogenesis of Oral Lesions with an Insight into Current Status of Its Metabolomics.
Topics: Areca; Arecoline; Humans; Metabolomics; Oral Submucous Fibrosis | 2020 |
Oral submucous fibrosis: review on aetiology and pathogenesis.
Topics: Areca; Arecoline; Collagen; Copper; Cytokines; Extracellular Matrix; Humans; Mastication; Mouth Muco | 2006 |
Etiology of oral submucous fibrosis with special reference to the role of areca nut chewing.
Topics: Animals; Areca; Arecoline; Collagen; Cross Reactions; Disease Susceptibility; Fibroblasts; Humans; I | 1995 |
1 trial available for arecoline and Oral Submucous Fibrosis
| Article | Year |
|---|---|
Interferon gamma (IFN-gamma) may reverse oral submucous fibrosis.
Topics: Areca; Arecoline; Cells, Cultured; Cholinergic Agonists; Collagen; Cytokines; Female; Fibroblasts; H | 2001 |
80 other studies available for arecoline and Oral Submucous Fibrosis
| Article | Year |
|---|---|
Paeonol inhibits profibrotic signaling and HOTAIR expression in fibrotic buccal mucosal fibroblasts.
Topics: Acetophenones; Areca; Arecoline; Cell Transdifferentiation; Cells, Cultured; Collagen Type I; Fibrob | 2022 |
Tyrosine sulphation of CXCR4 induces the migration of fibroblast in OSF.
Topics: Areca; Arecoline; ErbB Receptors; Fibroblasts; Humans; Mouth Mucosa; Oral Submucous Fibrosis; Recept | 2023 |
N6-methyladenosine modification contributes to arecoline-mediated oral submucosal fibrosis.
Topics: Adenosine; Arecoline; Humans; Methyltransferases; Oral Submucous Fibrosis; Transforming Growth Facto | 2022 |
Inhibition of miR-497 Attenuates Oral Submucous Fibrosis by Inhibiting Myofibroblast Transdifferentiation in Buccal Mucosal Fibroblasts.
Topics: Areca; Arecoline; Cell Transdifferentiation; Collagen; Fibroblasts; Humans; MicroRNAs; Mouth Mucosa; | 2022 |
Identification of a BRAF/PA28γ/MEK1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis.
Topics: Arecoline; Autoantigens; Carcinoma, Squamous Cell; Epithelial-Mesenchymal Transition; Head and Neck | 2022 |
Overexpression of DEC1 in the epithelium of OSF promotes mesenchymal transition via activating FAK/Akt signal axis.
Topics: Animals; Arecoline; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Collagen; Epithelium; F | 2022 |
Low-dose arecoline regulates distinct core signaling pathways in oral submucous fibrosis and oral squamous cell carcinoma.
Topics: Arecoline; Carcinoma, Squamous Cell; Epigenesis, Genetic; Head and Neck Neoplasms; Humans; Mouth Muc | 2023 |
Senescent epithelial cells remodel the microenvironment for the progression of oral submucous fibrosis through secreting TGF-β1.
Topics: Arecoline; beta-Galactosidase; Humans; Keratinocytes; Oral Submucous Fibrosis; Transforming Growth F | 2023 |
Interleukin-13 contributes to the occurrence of oral submucosal fibrosis.
Topics: Arecoline; Fibroblasts; Fibrosis; Humans; Interleukin-13; Mouth Mucosa; Oral Submucous Fibrosis | 2023 |
Jiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS).
Topics: Animals; Arecoline; Chromatography, High Pressure Liquid; Collagen; Fibroblasts; Fibrosis; Humans; M | 2023 |
Role of the arecoline/YAP1/BMP4 pathway in promoting endothelial-mesenchymal transition in oral submucous fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Antigens, CD; Arecoline; Bone Morphogenetic Protein 4; Cadheri | 2020 |
E3 ligase carboxyl-terminus of Hsp70-interacting protein (CHIP) suppresses fibrotic properties in oral mucosa.
Topics: Actins; Areca; Arecoline; Cell Movement; Cell Transdifferentiation; Down-Regulation; Fibroblasts; GT | 2020 |
Inhibition of HIF1A-AS1 impedes the arecoline-induced migration activity of human oral mucosal fibroblasts.
Topics: Areca; Arecoline; Cell Transdifferentiation; Humans; Mouth Mucosa; Myofibroblasts; Oral Submucous Fi | 2020 |
Role of autophagy and apoptosis in atrophic epithelium in oral submucous fibrosis.
Topics: Apoptosis; Arecoline; Autophagy; Epithelium; Fibroblasts; Humans; Mouth Mucosa; Oral Submucous Fibro | 2020 |
miR-10b regulated by Twist maintains myofibroblasts activities in oral submucous fibrosis.
Topics: Areca; Arecoline; Cell Transdifferentiation; Fibroblasts; Humans; MicroRNAs; Mouth Mucosa; Myofibrob | 2020 |
Photobiomodulation therapy inhibits oral submucous fibrosis in mice.
Topics: Animals; Areca; Arecoline; Collagen; Low-Level Light Therapy; Mice; Oral Submucous Fibrosis | 2020 |
Oxidative-protective effect of nuclear receptor coactivator 7 on arecoline-induced endothelial-to-mesenchymal transition.
Topics: Arecoline; Cells, Cultured; Endothelial Cells; Epithelial-Mesenchymal Transition; Humans; Nuclear Re | 2020 |
Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression.
Topics: Arecoline; Cell Proliferation; Cells, Cultured; Early Growth Response Protein 1; Fibroblasts; Forkhe | 2020 |
Arecoline enhances miR-21 to promote buccal mucosal fibroblasts activation.
Topics: Areca; Arecoline; Cell Transdifferentiation; Fibroblasts; Humans; MicroRNAs; Mouth Mucosa; Oral Subm | 2021 |
Arecoline suppresses epithelial cell viability by upregulating tropomyosin-1 through the transforming growth factor-β/Smad pathway.
Topics: Apoptosis; Arecoline; Cell Survival; Epithelial Cells; HaCaT Cells; Humans; Oral Submucous Fibrosis; | 2020 |
Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis.
Topics: Arecoline; Biomarkers; Cell Transdifferentiation; Cells, Cultured; Collagen Type I; Collagen Type I, | 2021 |
Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor-β/Smad2/3 signaling inhibition.
Topics: Areca; Arecoline; Biphenyl Compounds; Cell Transdifferentiation; Fibroblasts; Humans; Lignans; Mouth | 2021 |
Regulation of hypoxia-inducible factor-1α in human buccal mucosal fibroblasts stimulated with arecoline.
Topics: Arecoline; Case-Control Studies; Cholinergic Agonists; Fibroblasts; Humans; Hypoxia-Inducible Factor | 2017 |
Tanshinone Suppresses Arecoline-Induced Epithelial-Mesenchymal Transition in Oral Submucous Fibrosis by Epigenetically Reactivating the p53 Pathway.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Areca; Arecoline; Cell Proli | 2018 |
Arecoline activates latent transforming growth factor β1 via mitochondrial reactive oxygen species in buccal fibroblasts: Suppression by epigallocatechin-3-gallate.
Topics: Areca; Arecoline; Blotting, Western; Catechin; Cells, Cultured; Connective Tissue Growth Factor; Ear | 2018 |
Inhibitory effect of GMI, an immunomodulatory protein from Ganoderma microsporum, on myofibroblast activity and proinflammatory cytokines in human fibrotic buccal mucosal fibroblasts.
Topics: Actins; Arecoline; Cell Movement; Cells, Cultured; Collagen Type I; Cytokines; Down-Regulation; Enzy | 2018 |
STRO-1 confers myofibroblast transdifferentiation in fibroblasts derived from oral submucous fibrosis.
Topics: Actins; Antigens, Surface; Areca; Arecoline; Biomarkers, Tumor; Cell Transdifferentiation; Collagen | 2018 |
LncRNA GAS5-AS1 inhibits myofibroblasts activities in oral submucous fibrosis.
Topics: Arecoline; Cell Culture Techniques; Cell Movement; Down-Regulation; Humans; Mouth Mucosa; Myofibrobl | 2018 |
Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail.
Topics: Actins; Animals; Areca; Arecoline; Cell Transdifferentiation; Humans; Monoterpenes; Myofibroblasts; | 2018 |
Experimental study on TGF-β1-mediated CD147 expression in oral submucous fibrosis.
Topics: Arecoline; Basigin; Cells, Cultured; Cholinergic Agonists; Humans; Keratinocytes; Mouth Mucosa; Oral | 2018 |
miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2.
Topics: Actins; Apoptosis; Areca; Arecoline; Cell Movement; Cell Transdifferentiation; Dose-Response Relatio | 2018 |
miR-200c inhibits the arecoline-associated myofibroblastic transdifferentiation in buccal mucosal fibroblasts.
Topics: Areca; Arecoline; Cell Transdifferentiation; Humans; MicroRNAs; Mouth Mucosa; Myofibroblasts; Oral S | 2018 |
Slug mediates myofibroblastic differentiation to promote fibrogenesis in buccal mucosa.
Topics: Arecoline; Cell Movement; Cell Transdifferentiation; Collagen Type I; Epithelial-Mesenchymal Transit | 2019 |
Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome activation.
Topics: Angiotensin I; Angiotensin-Converting Enzyme 2; Animals; Anti-Inflammatory Agents; Antioxidants; Are | 2019 |
Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition.
Topics: Areca; Arecoline; Cell Movement; Cell Transdifferentiation; Furans; Gene Expression Regulation; Huma | 2019 |
Role of autophagy induced by arecoline in angiogenesis of oral submucous fibrosis.
Topics: Arecoline; Autophagy; Cell Survival; Human Umbilical Vein Endothelial Cells; Humans; Oral Submucous | 2019 |
[Rat model with oral submucous fibrosis induced by arecoline and mechanical stimulation].
Topics: Animals; Arecoline; Fibroblasts; Mouth Mucosa; Oral Submucous Fibrosis; Rats; Rats, Sprague-Dawley | 2019 |
YAP-Induced Endothelial-Mesenchymal Transition in Oral Submucous Fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Arecoline; Collagen; Epithelial-Mesenchymal Transitio | 2019 |
Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1.
Topics: Actins; Areca; Arecoline; Cell Transdifferentiation; Epithelial-Mesenchymal Transition; Fibroblasts; | 2014 |
Arecoline stimulated early growth response-1 production in human buccal fibroblasts: suppression by epigallocatechin-3-gallate.
Topics: Arecoline; Blotting, Western; Catechin; Cheek; Cholinergic Agonists; Early Growth Response Protein 1 | 2015 |
Arecoline inhibits epithelial cell viability by upregulating the apoptosis pathway: implication for oral submucous fibrosis.
Topics: Apoptosis; Areca; Arecoline; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Cell Line; Cel | 2014 |
Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma.
Topics: Adult; Aged; Antigens, Neoplasm; Areca; Arecoline; Carbonic Anhydrase IX; Carbonic Anhydrases; Carci | 2014 |
Arecoline is cytotoxic for human endothelial cells.
Topics: Arecoline; Autophagy; Cell Count; Cell Culture Techniques; Cell Survival; Cholinergic Agonists; Colo | 2014 |
[Changes of miRNA after oral submucous fibrosis co-cultured with Salvia and low-dose prednisolone].
Topics: Arecoline; Cells, Cultured; Coculture Techniques; Fibroblasts; Humans; MicroRNAs; Mouth Mucosa; Oral | 2014 |
Hypoxic regulation of plasminogen activator inhibitor-1 expression in human buccal mucosa fibroblasts stimulated with arecoline.
Topics: Arecoline; Biomarkers; Cell Hypoxia; Cells, Cultured; Connective Tissue; Epithelial Cells; Fibroblas | 2015 |
miR-203 inhibits arecoline-induced epithelial-mesenchymal transition by regulating secreted frizzled-related protein 4 and transmembrane-4 L six family member 1 in oral submucous fibrosis.
Topics: Antigens, Surface; Arecoline; Cell Line; Cell Proliferation; Epithelial-Mesenchymal Transition; Fibr | 2015 |
Elevation of Twist expression by arecoline contributes to the pathogenesis of oral submucous fibrosis.
Topics: Areca; Arecoline; Cells, Cultured; Humans; Mouth Mucosa; Myofibroblasts; Nuclear Proteins; Oral Subm | 2016 |
Epithelial atrophy in oral submucous fibrosis is mediated by copper (II) and arecoline of areca nut.
Topics: Apoptosis; Areca; Arecoline; Atrophy; Catalase; Cell Proliferation; Cells, Cultured; Copper; DNA Cle | 2015 |
Elevated transglutaminase-2 expression mediates fibrosis in areca quid chewing-associated oral submucocal fibrosis via reactive oxygen species generation.
Topics: Acetylcysteine; Areca; Arecoline; Blotting, Western; Catechin; Dose-Response Relationship, Drug; GTP | 2016 |
Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression.
Topics: Areca; Arecoline; beta-Galactosidase; Cell Cycle; Cell Line; Cellular Senescence; Disease Progressio | 2016 |
Antifibrotic effect of Centella asiatica Linn and asiatic acid on arecoline-induced fibrosis in human buccal fibroblasts.
Topics: Arecoline; Biomarkers; Centella; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Down- | 2017 |
Transglutaminase-2 regulation by arecoline in gingival fibroblasts.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Arecoline; Blotting, Western; Cells, Cultured; Enzyme Induct | 2009 |
Augmented heme oxygenase-1 expression in areca quid chewing-associated oral submucous fibrosis.
Topics: Areca; Arecoline; Blotting, Western; Cells, Cultured; Cholinergic Agonists; Connective Tissue; Dose- | 2009 |
Regulation of extracellular matrix genes by arecoline in primary gingival fibroblasts requires epithelial factors.
Topics: Arecoline; Cell Line; Chelating Agents; Cholinergic Agonists; Collagen; Collagen Type I; Collagen Ty | 2009 |
Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin.
Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Arecoline; Cheek; Cholinergic Agonists; Connec | 2009 |
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.
Topics: Actins; Antigens, Neoplasm; Areca; Arecoline; Carcinoma, Squamous Cell; Cell Differentiation; Cell M | 2011 |
Regulation of protease-activated receptor-1 expression in human buccal fibroblasts stimulated with arecoline.
Topics: Acetylcysteine; Arecoline; Blotting, Western; Cell Culture Techniques; Cholinergic Agonists; Chromon | 2013 |
Activation of TGF-β pathway by areca nut constituents: a possible cause of oral submucous fibrosis.
Topics: Areca; Arecoline; Biomarkers; Cells, Cultured; Collagen; Fibroblasts; Gene Expression Profiling; Gin | 2012 |
Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
Topics: Areca; Arecoline; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Fibr | 2013 |
Elevation of S100A4 expression in buccal mucosal fibroblasts by arecoline: involvement in the pathogenesis of oral submucous fibrosis.
Topics: Arecoline; Collagen; Dose-Response Relationship, Drug; Fibroblasts; Gene Knockdown Techniques; Human | 2013 |
Elevated vimentin expression in buccal mucosal fibroblasts by arecoline in vitro as a possible pathogenesis for oral submucous fibrosis.
Topics: Arecoline; Cell Culture Techniques; Cheek; Cholinergic Agonists; Dose-Response Relationship, Drug; F | 2002 |
The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis.
Topics: Arecoline; Aspirin; Buthionine Sulfoximine; Cell Culture Techniques; Cholinergic Agonists; Cyclooxyg | 2003 |
The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis.
Topics: Areca; Arecoline; Blotting, Western; Case-Control Studies; Cells, Cultured; Cheek; Humans; Male; Mou | 2003 |
Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis.
Topics: Adult; Aged; Areca; Arecoline; Cells, Cultured; Cheek; Dose-Response Relationship, Drug; Fibroblasts | 2003 |
Effects of arecoline, safrole, and nicotine on collagen phagocytosis by human buccal mucosal fibroblasts as a possible mechanism for oral submucous fibrosis in Taiwan.
Topics: Adult; Arecoline; Cell Survival; Cells, Cultured; Cholinergic Agonists; Collagen; Dose-Response Rela | 2004 |
Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels.
Topics: Areca; Arecoline; Buthionine Sulfoximine; Fibroblasts; Glutathione; Humans; Interleukin-6; Male; Ora | 2004 |
Raised keratinocyte growth factor-1 expression in oral submucous fibrosis in vivo and upregulated by arecoline in human buccal mucosal fibroblasts in vitro.
Topics: Arecoline; Cell Culture Techniques; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Fibroblas | 2005 |
The upregulation of insulin-like growth factor-1 in oral submucous fibrosis.
Topics: Arecoline; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Humans; Insulin-Like Growth Factor I; | 2005 |
The upregulation of cystatin C in oral submucous fibrosis.
Topics: Arecoline; Cheek; Cholinergic Agonists; Cystatin C; Cystatins; Enzyme-Linked Immunosorbent Assay; Hu | 2007 |
Increased plasminogen activator inhibitor-1/tissue type plasminogen activator ratio in oral submucous fibrosis.
Topics: Arecoline; Cells, Cultured; Cholinergic Agonists; Fibrinolytic Agents; Fibroblasts; Humans; Mouth Mu | 2007 |
[Effect of arecoline on the differentiation of myofibroblasts of oral mucosa].
Topics: Actins; Arecoline; Cell Differentiation; Cells, Cultured; Coculture Techniques; Fibroblasts; Humans; | 2007 |
The upregulation of heat shock protein 47 expression in human buccal fibroblasts stimulated with arecoline.
Topics: Analysis of Variance; Arecoline; Case-Control Studies; Cells, Cultured; Cholinergic Agonists; Cycloo | 2008 |
In vitro production of interleukin-6 by human gingival, normal buccal mucosa, and oral submucous fibrosis fibroblasts treated with betel-nut alkaloids.
Topics: Adult; Arecoline; Cells, Cultured; Fibroblasts; Gingiva; Humans; Interleukin-6; Middle Aged; Mouth M | 1995 |
Growth of oral and skin fibroblasts from patients with oral submucous fibrosis.
Topics: Adolescent; Adult; Analysis of Variance; Areca; Arecoline; Cell Division; Cells, Cultured; Collagen; | 1995 |
Oral submucous fibrosis and copper.
Topics: Arecoline; Copper; Humans; Oral Submucous Fibrosis; Parasympathomimetics; Up-Regulation | 1997 |
Cytotoxic and non-genotoxic effects of arecoline on human buccal fibroblasts in vitro.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Areca; Arecoline; Cells, Cultured; Coloring Agen | 1998 |
Deficiency in collagen and fibronectin phagocytosis by human buccal mucosa fibroblasts in vitro as a possible mechanism for oral submucous fibrosis.
Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; Areca; Arecoline; Cells, Cultu | 1999 |
Oral submucous fibrosis in a 11-year-old Bangladeshi girl living in the United Kingdom.
Topics: Areca; Arecoline; Bangladesh; Child; Female; Humans; Oral Submucous Fibrosis; Plants, Medicinal; Uni | 2001 |
Increased tissue inhibitor of metalloproteinase-1 expression and inhibition of gelatinase A activity in buccal mucosal fibroblasts by arecoline as possible mechanisms for oral submucous fibrosis.
Topics: Arecoline; Cells, Cultured; Cheek; Dose-Response Relationship, Drug; Fibroblasts; Humans; Matrix Met | 2002 |
An in-vitro comparison of human fibroblasts from normal and oral submucous fibrosis tissue.
Topics: Arecoline; Cell Division; Cells, Cultured; Collagen; Fibroblasts; Humans; Hydrolysis; Mouth Diseases | 1987 |