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arecoline and Neuroblastoma

arecoline has been researched along with Neuroblastoma in 7 studies

Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"Electrically permeabilized SH-SY5Y neuroblastoma cells have been used to examine the relationship between receptor occupation by muscarinic agonists, inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) accumulation and Ca2+ mobilization from intracellular stores."7.69A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells. ( Nahorski, SR; Safrany, ST, 1994)
"This study reports increased intracellular Ca2+ and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] in response to muscarinic-cholinergic stimulation of human neuroblastoma (SH-SY5Y) cells."7.68Muscarinic-receptor-mediated changes in intracellular Ca2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y. ( Lambert, DG; Nahorski, SR, 1990)
"Electrically permeabilized SH-SY5Y neuroblastoma cells have been used to examine the relationship between receptor occupation by muscarinic agonists, inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) accumulation and Ca2+ mobilization from intracellular stores."3.69A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells. ( Nahorski, SR; Safrany, ST, 1994)
"This study reports increased intracellular Ca2+ and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] in response to muscarinic-cholinergic stimulation of human neuroblastoma (SH-SY5Y) cells."3.68Muscarinic-receptor-mediated changes in intracellular Ca2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y. ( Lambert, DG; Nahorski, SR, 1990)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19902 (28.57)18.7374
1990's4 (57.14)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Lucianò, AM1
Perciballi, E1
Fiore, M1
Del Bufalo, D1
Tata, AM1
Shifrin, GS1
Klein, WL1
Safrany, ST1
Nahorski, SR3
Lahiri, DK1
Farlow, MR1
Szekeres, PG1
Koenig, JA1
Edwardson, JM1
Lambert, DG2
Ghataorre, AS1

Other Studies

7 other studies available for arecoline and Neuroblastoma

ArticleYear
The Combination of the M2 Muscarinic Receptor Agonist and Chemotherapy Affects Drug Resistance in Neuroblastoma Cells.
    International journal of molecular sciences, 2020, Nov-10, Volume: 21, Issue:22

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arecoline; ATP-Binding Cassette Transporters; Cell C

2020
Regulation of muscarinic acetylcholine receptor concentration in cloned neuroblastoma cells.
    Journal of neurochemistry, 1980, Volume: 34, Issue:4

    Topics: Acetylcholine; Animals; Arecoline; Carbachol; Cell Line; Clone Cells; Dose-Response Relationship, Dr

1980
A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells.
    Neuropharmacology, 1994, Volume: 33, Issue:7

    Topics: Arecoline; Brain Neoplasms; Calcium; Calcium Radioisotopes; Carbachol; Guanine Nucleotides; Humans;

1994
Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines.
    Journal of molecular neuroscience : MN, 1996,Spring, Volume: 7, Issue:1

    Topics: Amyloid beta-Protein Precursor; Animals; Arecoline; Astrocytes; Atropine; Calcimycin; Carbachol; Cho

1996
The relationship between agonist intrinsic activity and the rate of endocytosis of muscarinic receptors in a human neuroblastoma cell line.
    Molecular pharmacology, 1998, Volume: 53, Issue:4

    Topics: Arecoline; Bethanechol; Carbachol; Endocytosis; Humans; Kinetics; Ligands; Methacholine Chloride; Mu

1998
Muscarinic-receptor-mediated changes in intracellular Ca2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y.
    The Biochemical journal, 1990, Jan-15, Volume: 265, Issue:2

    Topics: Arecoline; Atropine; Benzofurans; Calcium; Carbachol; Cell Line; Fluorescent Dyes; Fura-2; Humans; I

1990
Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1.
    European journal of pharmacology, 1989, Jun-08, Volume: 165, Issue:1

    Topics: Arecoline; Atropine; Carbachol; Cell Membrane; Humans; Neuroblastoma; Piperidines; Pirenzepine; Rece

1989