arecoline has been researched along with Muscle Contraction in 46 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to investigate the optimum arecoline content in CAN, using the "target constituent removal combined with bioactivity assay" strategy." | 1.46 | Using the "target constituent removal combined with bioactivity assay" strategy to investigate the optimum arecoline content in charred areca nut. ( Gao, YX; Hu, MB; Liu, YJ; Peng, W; Wu, CJ; Yan, D, 2017) |
| "Mirabegron didn't produce significant inhibitory effects in any of the contractile elements in either species." | 1.43 | The actions of isoprenaline and mirabegron in the isolated whole rat and guinea pig bladder. ( De Wachter, S; Eastham, J; Gillespie, J; Persyn, S; Wyndaele, JJ, 2016) |
| "Tetrodotoxin (TTX) did not inhibit the effects of arecoline." | 1.36 | Arecoline excites the contraction of distal colonic smooth muscle strips in rats via the M3 receptor-extracellular Ca2+ influx - Ca2+ store release pathway. ( Li, CB; Liu, CY; Tang, WB; Xie, DP; Yang, X, 2010) |
| "Atropine did not inhibit the lobeline-induced responses but abolished the muscarinic responses." | 1.32 | Agonist- and nerve-induced phasic activity in the isolated whole bladder of the guinea pig: evidence for two types of bladder activity. ( Drake, MJ; Gillespie, JI; Harvey, IJ, 2003) |
| "Arecoline is an effective component of areca (betel nuts, a Chinese medicine named pinang or binglang)." | 1.32 | Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits. ( Chen, LB; Liu, CY; Liu, KJ; Wang, PS; Xie, DP; Zhang, CL, 2004) |
| " Dose-response curves with either arecoline or histamine on isolated tracheae from these animals display increased maximal contractions, and decreased EC50 values." | 1.28 | Endotoxin-induced hyperreactivity of the guinea-pig isolated trachea coincides with decreased prostaglandin E2 production by the epithelial layer. ( Engels, F; Folkerts, G; Nijkamp, FP, 1989) |
| "Isoarecolone methiodide has been reported previously to be a potent agonist at peripheral nicotinic-cholinergic receptors." | 1.27 | Isoarecolone can inhibit nicotine binding and produce nicotine-like discriminative stimulus effects in rats. ( Reavill, C; Spivak, CE; Stolerman, IP; Waters, JA, 1987) |
| "Pilocarpine which is a well-known partial agonist on muscarinic receptors in most smooth muscles did not cause any contraction in this tissue." | 1.27 | Muscarinic acetylcholine receptors in the rabbit ciliary body smooth muscle: spare receptors and threshold phenomenon. ( Konno, F; Takayanagi, I, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (43.48) | 18.7374 |
| 1990's | 10 (21.74) | 18.2507 |
| 2000's | 10 (21.74) | 29.6817 |
| 2010's | 5 (10.87) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Ward, JS | 1 |
| Merritt, L | 1 |
| Klimkowski, VJ | 1 |
| Lamb, ML | 1 |
| Mitch, CH | 1 |
| Bymaster, FP | 1 |
| Sawyer, B | 1 |
| Shannon, HE | 1 |
| Olesen, PH | 1 |
| Honoré, T | 1 |
| Xu, R | 1 |
| Sim, MK | 1 |
| Go, ML | 1 |
| Chen, Q | 1 |
| Jiang, Z | 1 |
| Zhang, J | 1 |
| Cao, L | 1 |
| Chen, Z | 1 |
| Persyn, S | 1 |
| De Wachter, S | 1 |
| Wyndaele, JJ | 1 |
| Eastham, J | 1 |
| Gillespie, J | 3 |
| Peng, W | 1 |
| Liu, YJ | 1 |
| Hu, MB | 1 |
| Yan, D | 1 |
| Gao, YX | 1 |
| Wu, CJ | 1 |
| Ikeda, Y | 1 |
| Kanai, A | 1 |
| Li, HL | 1 |
| Li, M | 1 |
| Lin, ML | 1 |
| Xie, SB | 1 |
| Zhang, XY | 1 |
| Qiu, SY | 1 |
| Li, CB | 1 |
| Yang, X | 1 |
| Tang, WB | 1 |
| Liu, CY | 2 |
| Xie, DP | 2 |
| Rahnama'i, MS | 1 |
| van Koeveringe, GA | 1 |
| van Kerrebroeck, PE | 1 |
| de Wachter, SG | 1 |
| Drake, MJ | 3 |
| Harvey, IJ | 2 |
| Gillespie, JI | 2 |
| Chen, LB | 1 |
| Zhang, CL | 1 |
| Liu, KJ | 1 |
| Wang, PS | 1 |
| Gevaert, T | 1 |
| Ost, D | 1 |
| De Ridder, D | 1 |
| Lagou, M | 2 |
| Kirkwood, T | 1 |
| Harvey, I | 2 |
| Drake, M | 1 |
| Hedlund, P | 1 |
| Andersson, KE | 1 |
| Höltje, HD | 2 |
| Lambrecht, G | 9 |
| Moser, U | 5 |
| Mutschler, E | 10 |
| Tripathi, ON | 1 |
| Blair, KL | 1 |
| Bennett, JL | 1 |
| Pax, RA | 1 |
| Masuda, Y | 1 |
| Yamahara, NS | 1 |
| Tanaka, M | 1 |
| Ryang, S | 1 |
| Kawai, T | 1 |
| Imaizumi, Y | 1 |
| Watanabe, M | 1 |
| Toja, E | 1 |
| Parini, C | 1 |
| Bonetti, C | 1 |
| Hunt, P | 1 |
| Fortin, M | 1 |
| Barzaghi, F | 1 |
| Cesana, R | 1 |
| Maggioni, A | 1 |
| Nencioni, A | 1 |
| Galliani, G | 1 |
| Chaudhuri, L | 1 |
| Ganguly, DK | 2 |
| Brundage, L | 1 |
| Avery, L | 1 |
| Katz, A | 1 |
| Kim, UJ | 1 |
| Mendel, JE | 1 |
| Sternberg, PW | 2 |
| Simon, MI | 1 |
| Gross, J | 1 |
| Tumiatti, V | 1 |
| Wehrle, J | 1 |
| Hildebrandt, C | 1 |
| Dannhardt, G | 1 |
| Lluel, P | 1 |
| Palea, S | 1 |
| Barras, M | 1 |
| Grandadam, F | 1 |
| Heudes, D | 1 |
| Bruneval, P | 1 |
| Corman, B | 1 |
| Martin, DJ | 1 |
| Garcia, LR | 1 |
| Mehta, P | 1 |
| Beleslin, D | 1 |
| Samardzić, R | 1 |
| Malobabić, Z | 1 |
| Katsuragi, T | 1 |
| Furukawa, T | 1 |
| Jaiswal, N | 1 |
| Tacke, R | 1 |
| Malik, KU | 1 |
| Hong, SJ | 1 |
| Chang, CC | 1 |
| Folkerts, G | 1 |
| Engels, F | 1 |
| Nijkamp, FP | 1 |
| Riotte, J | 1 |
| Wagner, M | 1 |
| Wess, J | 2 |
| Waters, JA | 2 |
| Spivak, CE | 2 |
| Hermsmeier, M | 1 |
| Yadav, JS | 1 |
| Liang, RF | 1 |
| Gund, TM | 1 |
| Reavill, C | 1 |
| Stolerman, IP | 1 |
| Barlow, RB | 1 |
| Weston-Smith, P | 1 |
| Konno, F | 1 |
| Takayanagi, I | 1 |
| Labrid, C | 1 |
| Dureng, G | 1 |
| Streichenberger, G | 1 |
| Chaudhuri, SK | 1 |
| Phan, DV | 1 |
| György, L | 2 |
| Gellén, B | 1 |
| Dóda, M | 1 |
| Prozorovskiĭ, VB | 1 |
| Gladysheva, NI | 1 |
46 other studies available for arecoline and Muscle Contraction
| Article | Year |
|---|---|
Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore.
Topics: Animals; Hippocampus; In Vitro Techniques; Male; Models, Molecular; Molecular Conformation; Muscle C | 1992 |
Synthesis and pharmacological characterization of O-alkynyloximes of tropinone and N-methylpiperidinone as muscarinic agonists.
Topics: Animals; Aorta; Binding, Competitive; Drug Design; Escape Reaction; In Vitro Techniques; Male; Maze | 1998 |
Arecoline hydrobromide enhances jejunum smooth muscle contractility via voltage-dependent potassium channels in W/Wv mice.
Topics: Animals; Arecoline; Atropine; Dose-Response Relationship, Drug; Gastrointestinal Motility; Jejunum; | 2021 |
The actions of isoprenaline and mirabegron in the isolated whole rat and guinea pig bladder.
Topics: Acetanilides; Animals; Arecoline; Carbachol; Female; Guinea Pigs; In Vitro Techniques; Isoproterenol | 2016 |
Using the "target constituent removal combined with bioactivity assay" strategy to investigate the optimum arecoline content in charred areca nut.
Topics: Animals; Apoptosis; Areca; Arecoline; Cell Line; Gastric Emptying; Gastrointestinal Tract; Humans; M | 2017 |
Urotheliogenic modulation of intrinsic activity in spinal cord-transected rat bladders: role of mucosal muscarinic receptors.
Topics: Animals; Arecoline; Calcium Channel Blockers; Disease Models, Animal; Female; Mucous Membrane; Musca | 2008 |
[Effects of arecoline on contractile activity of isolated antral circular muscle strips in guinea pigs].
Topics: Animals; Arecoline; Cholinergic Agonists; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Con | 2010 |
Arecoline excites the contraction of distal colonic smooth muscle strips in rats via the M3 receptor-extracellular Ca2+ influx - Ca2+ store release pathway.
Topics: Animals; Arecoline; Calcium; Cholinergic Agonists; Colon; Constipation; Dose-Response Relationship, | 2010 |
The effect of indomethacin on the muscarinic induced contractions in the isolated normal guinea pig urinary bladder.
Topics: Animals; Arecoline; Cyclooxygenase Inhibitors; Dinoprostone; Guinea Pigs; Indomethacin; Male; Muscar | 2013 |
Autonomous activity in the isolated guinea pig bladder.
Topics: Animals; Arecoline; Atropine; Female; Guinea Pigs; Homeostasis; In Vitro Techniques; Movement; Muscl | 2003 |
Agonist- and nerve-induced phasic activity in the isolated whole bladder of the guinea pig: evidence for two types of bladder activity.
Topics: Anesthetics, Local; Animals; Arecoline; Atropine; Carbachol; Cholinergic Agonists; Electric Stimulat | 2003 |
Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits.
Topics: Animals; Arecoline; Atropine; Colon; Dose-Response Relationship, Drug; Female; Ganglionic Stimulants | 2004 |
Comparison study of autonomous activity in bladders from normal and paraplegic rats.
Topics: Animals; Arecoline; Carbachol; Cholinergic Agonists; Female; Muscarinic Agonists; Muscle Contraction | 2006 |
Muscarinic stimulation of the mouse isolated whole bladder: physiological responses in young and ageing mice.
Topics: Age Factors; Aging; Animals; Arecoline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; | 2006 |
Muscarinic stimulation of the rat isolated whole bladder: pathophysiological models of detrusor overactivity.
Topics: Animals; Arecoline; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypertension; | 2006 |
[Structure- and conformation-activity relationships of heterocyclic acetylcholine analogues. 16. Conformational behaviour and cholinergic properties of isoarecaidine and sulfoisoarecaidine esters].
Topics: Acetylcholine; Acetylcholinesterase; Animals; Arecoline; Behavior, Animal; Blood Pressure; Chemical | 1983 |
[Structure- and conformation-activity relationships of heterocyclic acetylcholine analogs. 17. Conformational behavior and cholinergic properties of arecaidine and sulfoarecaidine esters].
Topics: Acetylcholinesterase; Animals; Arecoline; Atropine Derivatives; Blood Pressure; Chemical Phenomena; | 1983 |
Arecoline induced nicotinic and muscarinic stimulation of the superior cervical ganglion of cat.
Topics: Animals; Arecoline; Cats; Dimethylphenylpiperazinium Iodide; Drug Synergism; Female; Ganglia, Sympat | 1983 |
Serotonin and acetylcholine: further analysis of praziquantel-induced contraction of magnesium-paralysed Schistosoma mansoni.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Amifampridine; Animals; Arecoline; Carbachol; Colforsi | 1993 |
Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Alkaloids; Anim | 1995 |
New classes of antimuscarinic agents endowed with selective antispasmodic properties. 1-Arylsulfonyl pyrrolidin-2-ones and 2-thiones, 1-arylsulfonyl piperidin-2-ones and 2-thiones and 1-arylsulfonyl hexahydro-2H-azepin-2-one.
Topics: Animals; Arecoline; Atropine; Azepines; Butylscopolammonium Bromide; Carbachol; Gastric Acid; Gastro | 1994 |
Involvement of gamma-aminobutyric acid in the stimulatory effect of metoclopramide on gastrointestinal motility.
Topics: Aminobutyrates; Animals; Arecoline; Bicuculline; Drug Interactions; Ethylenediamines; gamma-Aminobut | 1994 |
Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability.
Topics: Amino Acid Sequence; Animals; Arecoline; Base Sequence; Caenorhabditis elegans; DNA Primers; Female; | 1996 |
Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Arecoline; Binding, Competitive; Digestive System; Electric S | 1999 |
Muscarinic properties of compounds related to arecaidine propargyl ester.
Topics: Animals; Arecoline; Cholinergic Agents; Female; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Male | 2000 |
Functional and morphological modifications of the urinary bladder in aging female rats.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aging; Animals; Arecoli | 2000 |
Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating.
Topics: Acetylcholine; Aldicarb; Animals; Antinematodal Agents; Arecoline; Caenorhabditis elegans; Caenorhab | 2001 |
[Pharmacological analysis of the inhibition of peristalsis of the isolated guinea-pig ileum by tetramethylammonium].
Topics: Acetylcholine; Animals; Arecoline; Carbachol; Female; Gastrointestinal Motility; Guinea Pigs; Histam | 1976 |
Cholinergic potentiation by ouabain in the contraction of guinea-pig vas deferens through pre- and post-synaptic mechanism.
Topics: Animals; Arecoline; Drug Interactions; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; M | 1979 |
Quaternary isoarecoline: a potent muscarine-like and nicotine-like acting agonist.
Topics: Acetylcholine; Animals; Arecoline; Atropine; Cold Temperature; Dose-Response Relationship, Drug; Gan | 1975 |
Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Antihy | 1991 |
Nicotinic actions of oxotremorine on murine skeletal muscle. Evidence against muscarinic modulation of acetylcholine release.
Topics: Acetylcholine; Action Potentials; Animals; Arecoline; Calcium; Diaphragm; Evoked Potentials; In Vitr | 1990 |
Endotoxin-induced hyperreactivity of the guinea-pig isolated trachea coincides with decreased prostaglandin E2 production by the epithelial layer.
Topics: Airway Resistance; Animals; Arachidonic Acid; Arachidonic Acids; Arecoline; Dinoprostone; Drug Inter | 1989 |
[The spasmolytic activity of propiverine and some of its structural analogs].
Topics: Adrenergic alpha-Antagonists; Animals; Arecoline; Barium; Barium Compounds; Benzilates; Chlorides; I | 1987 |
Structure-activity relationships of new analogues of arecaidine propargyl ester at muscarinic M1 and M2 receptor subtypes.
Topics: Animals; Arecoline; Chemical Phenomena; Chemistry, Physical; Decerebrate State; Female; Guinea Pigs; | 1989 |
Synthesis, pharmacology, and molecular modeling studies of semirigid, nicotinic agonists.
Topics: Animals; Arecoline; Computer Simulation; Ganglionic Stimulants; In Vitro Techniques; Models, Molecul | 1988 |
Stimulation of ganglionic muscarinic M1 receptors by a series of tertiary arecaidine and isoarecaidine esters in the pithed rat.
Topics: Animals; Arecoline; Decerebrate State; Hemodynamics; Male; Muscle Contraction; Muscle, Smooth; Piloc | 1987 |
Isoarecolone can inhibit nicotine binding and produce nicotine-like discriminative stimulus effects in rats.
Topics: Animals; Anura; Arecoline; Brain; Carbachol; Discrimination, Psychological; Male; Muscle Contraction | 1987 |
The relative potencies of some agonists at M2 muscarinic receptors in guinea-pig ileum, atria and bronchi.
Topics: Acetylcholine; Animals; Arecoline; Atrial Function; Bronchi; Carbachol; Choline; Guinea Pigs; Heart | 1985 |
Muscarinic acetylcholine receptors in the rabbit ciliary body smooth muscle: spare receptors and threshold phenomenon.
Topics: Animals; Arecoline; Atropine; Carbachol; Ciliary Body; In Vitro Techniques; Male; Muscle Contraction | 1985 |
[Interaction of N-methyl and N-butyl scopolammonium and some parasympathomimetics on cholinergic receptors in the jejunum of the rat].
Topics: Acetylcholine; Animals; Arecoline; Carbachol; Dose-Response Relationship, Drug; Furans; Humans; In V | 1974 |
Neuromuscular pharmacology of harmine and arecoline.
Topics: Alkaloids; Animals; Arecoline; Chickens; Convulsants; In Vitro Techniques; Indoles; Muscle Contracti | 1974 |
Effect of oxotremorine and arecoline on the inferior eyelid of the rat.
Topics: Adrenal Glands; Adrenalectomy; Animals; Arecoline; Atropine; Eyelids; Female; Guanethidine; Hyperten | 1972 |
Influence of the surgical isolation of the hypothalamus on oxotremorine-induced rage reaction and sympathetic response in the cat.
Topics: Anger; Animals; Arecoline; Behavior, Animal; Cats; Female; Gallamine Triethiodide; Hypothalamus; Mal | 1972 |
[Effect of changes in temperature on muscle reactivity to acetylcholine].
Topics: Acetylcholine; Animals; Anura; Arecoline; Barium; Caffeine; Electric Stimulation; Gastrointestinal M | 1973 |
[Structure-activity relationships of isoarecaidine esters].
Topics: Animals; Arecoline; Atropine; Blood Pressure; Carbachol; Depression, Chemical; Dose-Response Relatio | 1973 |