arecoline has been researched along with Mouth Neoplasms in 74 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Mouth Neoplasms: Tumors or cancer of the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "First, the key gene related to oral cancer induced by Arecoline was screened." | 5.91 | MYO1B as a prognostic biomarker and a therapeutic target in Arecoline-associated oral carcinoma. ( Chang, A; Chen, H; Guo, X; Ling, J; Sun, Z; Zhao, H; Zhuo, X, 2023) |
| "The high prevalence of oral squamous cell carcinoma (OSCC) in South Asia is associated with habitual areca nut chewing." | 5.72 | Fat mass and obesity-associated protein regulates arecoline-exposed oral cancer immune response through programmed cell death-ligand 1. ( Ai, Y; Chen, W; Cheng, X; Gao, Y; Gu, Y; Li, X; Song, J; Zhang, J, 2022) |
| "Oral submucous fibrosis (OSMF) is a pre-malignant condition that is strongly associated with the areca nut alkaloids, arecoline (ARC) and arecaidine (ARD)." | 3.83 | Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression. ( Ali, S; Atif, M; Hassona, Y; James, EL; Lone, MA; Parkinson, EK; Pitiyage, GN; Prime, SS; Rehman, A, 2016) |
| "Naswar, in addition to oral cancer, causes adverse cardiovascular events by reducing glutathione per oxidase (GPx) and super-oxide dismutase (SOD), serum levels of HDL, whereas, increasing the ratio of cholesterol, LDL, triglycerides and LDL-C/HDL-C." | 2.58 | Molecular Pathogenesis of Chewable Tobacco. ( Baig, S; Farooq, W; Rubab, Z, 2018) |
| "First, the key gene related to oral cancer induced by Arecoline was screened." | 1.91 | MYO1B as a prognostic biomarker and a therapeutic target in Arecoline-associated oral carcinoma. ( Chang, A; Chen, H; Guo, X; Ling, J; Sun, Z; Zhao, H; Zhuo, X, 2023) |
| "The high prevalence of oral squamous cell carcinoma (OSCC) in South Asia is associated with habitual areca nut chewing." | 1.72 | Fat mass and obesity-associated protein regulates arecoline-exposed oral cancer immune response through programmed cell death-ligand 1. ( Ai, Y; Chen, W; Cheng, X; Gao, Y; Gu, Y; Li, X; Song, J; Zhang, J, 2022) |
| "Melatonin treatment enhanced arecoline-induced ROS production, cytotoxicity, G2/M phase arrest, and cell apoptosis in OSCC cells." | 1.62 | Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma. ( Chiu, KC; Hsia, SM; Lan, WC; Shieh, TM; Shih, YH; Tsai, BH; Wang, TH; Wu, LJ, 2021) |
| "Oral carcinogenesis involves the progression of the normal mucosa into potentially malignant disorders and finally into cancer." | 1.56 | Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model. ( Chiang, WF; Hsieh, YP; Huang, LY; Huang, TT; Huang, WT; Hwang, DY; Jiang, SS; Liu, KJ; Wang, YY, 2020) |
| "Arecoline treatment in vitro at low concentrations and overexpression of HPV16 E6 or E6/E7 in oral cells induced PRDX2 overexpression." | 1.56 | Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation. ( Chuerduangphui, J; Ekalaksananan, T; Heawchaiyaphum, C; Pientong, C; Vatanasapt, P, 2020) |
| "In arecoline-treated OSCC cells, oncostatin M (OSM) expression was significantly upregulated and inversely correlated with miR-22 expression." | 1.48 | Effects of arecoline on proliferation of oral squamous cell carcinoma cells by dysregulating c-Myc and miR-22, directly targeting oncostatin M. ( Chaiyarit, P; Chotiyano, A; Chuerduangphui, J; Ekalaksananan, T; Kongyingyoes, B; Patarapadungkit, N; Pientong, C; Promthet, S, 2018) |
| "Oral squamous cell carcinoma (OSCC), one of the most deadliest malignancies in the world, is caused primarily by areca nut chewing in Southeast Asia." | 1.43 | Acquisition cancer stemness, mesenchymal transdifferentiation, and chemoresistance properties by chronic exposure of oral epithelial cells to arecoline. ( Chang, YC; Chou, MY; Lee, SS; Peng, CY; Wang, TY; Yu, CC, 2016) |
| "Oral squamous cell carcinoma (OSCC) is the sixth most prevalent malignancy worldwide and the third most common cancer in developing nation." | 1.42 | ZEB1 as an indicator of tumor recurrence for areca quid chewing-associated oral squamous cell carcinomas. ( Ho, CM; Hu, FW; Lee, SS; Lin, SS; Shieh, TM; Yu, CC; Yu, CH, 2015) |
| "Arecoline treatment dose dependently induced Lin28B expression in SG and FaDu cells." | 1.42 | Elevated Lin28B expression is correlated with lymph node metastasis in oral squamous cell carcinomas. ( Chou, MY; Lin, WT; Shieh, TM; Wang, TY; Yang, LC; Yu, CC, 2015) |
| "In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study." | 1.40 | Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma. ( Chang, YC; Chen, MK; Chien, MH; Chiou, HL; Lin, CW; Su, SC; Yang, JS; Yang, SF, 2014) |
| "The susceptibility of an individual to oral cancer is mediated by genetic factors and carcinogen-exposure behaviors such as betel quid chewing, tobacco use, and alcohol consumption." | 1.40 | A pilot study evaluating genetic alterations that drive tobacco- and betel quid-associated oral cancer in Northeast India. ( Chattopadhyay, I; Devi, TR; Kapur, S; Kataki, ACh; Saxena, S; Sharma, JD; Singh, LC; Verma, A; Yadav, DS, 2014) |
| "Regarding oral squamous cell carcinoma (OSCC) development, chewing areca is known to be a strong risk factor in many Asian cultures." | 1.40 | Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma. ( Chang, NW; Chen, CM; Chen, HL; Cheng, JC; Fan, SR; Lai, ZL; Tsai, MH; Tsou, YA, 2014) |
| "Arecoline was also found to induced Snail expression in a dose- and time-dependent manner (p<0." | 1.39 | Elevated snail expression mediates tumor progression in areca quid chewing-associated oral squamous cell carcinoma via reactive oxygen species. ( Chang, YC; Lee, SS; Tsai, CH; Yu, CC, 2013) |
| "Arecoline was found to elevate MGMT expression in a dose- and time-dependent manner." | 1.39 | The expression of O(6) -methylguanine-DNA methyltransferase in human oral keratinocytes stimulated with arecoline. ( Chang, YC; Ho, YC; Hsu, HI; Lee, SS; Tsai, CH; Yu, CC, 2013) |
| "Arecoline was found to elevate HSP27 expression in a dose- and time-dependent manner (P < 0." | 1.38 | Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yu, CC, 2012) |
| "Arecoline was found to elevate β-catenin expression in a dose-dependent manner (p < 0." | 1.38 | β-catenin expression in areca quid chewing-associated oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells. ( Chang, YC; Chou, MC; Chou, MY; Lee, SS; Tsai, CH; Tsai, LL, 2012) |
| "0." | 1.37 | Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model. ( Chang, NW; Chiu, CF; Chu, PY; Hsu, HT; Lin, C; Tsai, MH; Yeh, CM; Yeh, KT, 2011) |
| "Over 80% of OSF-related oral cancers examined had moderate/high αvβ6 expression." | 1.37 | Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. ( Fortune, F; Hart, IR; Jenei, V; Lewis, MP; Marsh, D; Marshall, JF; Moutasim, KA; Sapienza, K; Thomas, GJ; Tilakaratne, WM; Violette, SM; Weinreb, PH, 2011) |
| "Arecoline was found to elevate HSP47 expression in a dose- and time-dependent manner (P<0." | 1.37 | Heat shock protein 47 expression in oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells. ( Chang, YC; Lee, SS; Li, YC; Tsai, CH; Tseng, LH, 2011) |
| "Arecoline was found to elevate HIF-1α expression in a dose- and time-dependent manner (P<0." | 1.36 | Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yang, SF, 2010) |
| "Arecoline was found to elevate HSP70 expression in a dose- and time-dependent manner (p<0." | 1.35 | The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH, 2008) |
| "The association between oral squamous cell carcinoma (OSCC) and viral and chemical factors is uncertain." | 1.32 | Involvement of viral and chemical factors with oral cancer in Taiwan. ( Koh, LW; Lin, SJ; Tsai, CH; Tsai, JH; Wong, EF; Yang, CC; Yang, YY, 2004) |
| "However, as the role of IL-8 in oral cancer cells is unclear, this study is thus designed to examine IL-8 secretion in cultured oral epidermoid carcinoma KB CCL17 cells treated with nicotine and/or arecoline." | 1.31 | Interleukin-8 secretion by cultured oral epidermoid carcinoma cells induced with nicotine and/or arecoline treatments. ( Cheng, YA; Hsieh, TY; Shiue, LF; Tsai, CC; Yu, HS, 2000) |
| "Of these, 133 hamsters (80." | 1.31 | Cancer induction in the DMBA hamster cheek pouch: a modified technique using a promoter. ( Ahmed, A; Hengesteg, A; Robbins, KT; Wani, MK; Yarber, RH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.41) | 18.7374 |
| 1990's | 3 (4.05) | 18.2507 |
| 2000's | 14 (18.92) | 29.6817 |
| 2010's | 33 (44.59) | 24.3611 |
| 2020's | 20 (27.03) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, P | 1 |
| Chua, NQE | 1 |
| Dang, S | 1 |
| Davis, A | 1 |
| Chong, KW | 1 |
| Prime, SS | 2 |
| Cirillo, N | 1 |
| Li, X | 5 |
| Chen, W | 4 |
| Gao, Y | 5 |
| Song, J | 2 |
| Gu, Y | 5 |
| Zhang, J | 3 |
| Cheng, X | 2 |
| Ai, Y | 2 |
| Xie, C | 1 |
| Li, Z | 2 |
| Hua, Y | 1 |
| Sun, S | 1 |
| Zhong, L | 1 |
| Chen, Q | 2 |
| Feng, H | 1 |
| Ji, N | 1 |
| Li, T | 1 |
| Zhou, X | 1 |
| Zeng, X | 1 |
| Tang, Z | 1 |
| Sun, C | 1 |
| Li, J | 1 |
| Wang, C | 3 |
| Kadigamuwa, C | 3 |
| Wu, S | 3 |
| Wang, S | 3 |
| Fu, Y | 1 |
| Hu, Y | 1 |
| Zhu, Y | 1 |
| Hu, L | 1 |
| Shi, C | 1 |
| Zhang, Y | 2 |
| Zhou, S | 1 |
| Sun, Z | 1 |
| Guo, X | 1 |
| Chen, H | 1 |
| Ling, J | 1 |
| Zhao, H | 1 |
| Chang, A | 1 |
| Zhuo, X | 1 |
| Ko, AM | 2 |
| Tu, HP | 1 |
| Ko, YC | 5 |
| Ko, HH | 1 |
| Peng, HH | 1 |
| Cheng, AN | 1 |
| Chou, HE | 1 |
| Hou, HH | 1 |
| Kuo, WT | 1 |
| Liu, WW | 1 |
| Kuo, MY | 2 |
| Lee, AY | 1 |
| Cheng, SJ | 2 |
| Islam, S | 1 |
| Uehara, O | 2 |
| Matsuoka, H | 1 |
| Kuramitsu, Y | 1 |
| Adhikari, BR | 2 |
| Hiraki, D | 1 |
| Toraya, S | 1 |
| Jayawardena, A | 1 |
| Saito, I | 1 |
| Muthumala, M | 2 |
| Nagayasu, H | 1 |
| Abiko, Y | 2 |
| Chiba, I | 2 |
| Lee, CH | 2 |
| Shiah, SG | 2 |
| Hsiao, JR | 3 |
| Chang, HJ | 1 |
| Hsu, YM | 2 |
| Wu, GH | 2 |
| Peng, HY | 2 |
| Chou, ST | 2 |
| Kuo, CC | 2 |
| Chang, JY | 2 |
| Shih, YH | 3 |
| Chiu, KC | 1 |
| Wang, TH | 1 |
| Lan, WC | 1 |
| Tsai, BH | 1 |
| Wu, LJ | 1 |
| Hsia, SM | 2 |
| Shieh, TM | 5 |
| Yoshida, K | 1 |
| Paudel, D | 1 |
| Morikawa, T | 1 |
| Sato, J | 1 |
| Amaratunga, P | 1 |
| Arakawa, T | 1 |
| Shen, YW | 1 |
| Fuh, LJ | 1 |
| Huang, LY | 1 |
| Hsieh, YP | 1 |
| Wang, YY | 1 |
| Hwang, DY | 1 |
| Jiang, SS | 1 |
| Huang, WT | 2 |
| Chiang, WF | 1 |
| Liu, KJ | 2 |
| Huang, TT | 1 |
| Wang, X | 1 |
| Han, S | 1 |
| Wang, Y | 1 |
| Liu, R | 1 |
| Meng, F | 1 |
| Su, Z | 1 |
| Huo, F | 1 |
| Chuerduangphui, J | 2 |
| Ekalaksananan, T | 2 |
| Heawchaiyaphum, C | 1 |
| Vatanasapt, P | 1 |
| Pientong, C | 2 |
| Nithiyanantham, S | 2 |
| Arumugam, S | 1 |
| Hsu, HT | 3 |
| Chung, CM | 1 |
| Lee, CP | 2 |
| Tsai, MH | 4 |
| Yeh, KT | 3 |
| Luo, SY | 2 |
| Ren, H | 1 |
| He, G | 1 |
| Lu, Z | 1 |
| He, Q | 1 |
| Li, S | 1 |
| Huang, Z | 1 |
| Chen, Z | 1 |
| Cao, C | 1 |
| Wang, A | 1 |
| Xie, X | 1 |
| Chang, PY | 1 |
| Kuo, TM | 2 |
| Chen, PK | 1 |
| Lin, YZ | 2 |
| Hua, CH | 2 |
| Chen, YC | 2 |
| Chaiyarit, P | 1 |
| Patarapadungkit, N | 1 |
| Chotiyano, A | 1 |
| Kongyingyoes, B | 1 |
| Promthet, S | 1 |
| Baig, S | 1 |
| Rubab, Z | 1 |
| Farooq, W | 1 |
| Tu, HF | 1 |
| Chen, MY | 1 |
| Lai, JC | 1 |
| Chen, YL | 1 |
| Wong, YW | 1 |
| Yang, CC | 2 |
| Chen, HY | 1 |
| Tsai, CY | 1 |
| Fang, HY | 1 |
| Shibu, MA | 3 |
| Lin, YM | 3 |
| Chou, YC | 1 |
| Chen, YH | 1 |
| Day, CH | 2 |
| Shen, CY | 1 |
| Ban, B | 1 |
| Huang, CY | 4 |
| Mo, KC | 1 |
| Lin, SF | 1 |
| Wang, HD | 1 |
| Lee, SS | 9 |
| Tsai, CH | 8 |
| Yu, CC | 6 |
| Chang, YC | 10 |
| Yang, JS | 1 |
| Chen, MK | 1 |
| Yang, SF | 2 |
| Su, SC | 1 |
| Chiou, HL | 1 |
| Chien, MH | 1 |
| Lin, CW | 1 |
| Yadav, DS | 1 |
| Chattopadhyay, I | 1 |
| Verma, A | 1 |
| Devi, TR | 1 |
| Singh, LC | 1 |
| Sharma, JD | 1 |
| Kataki, ACh | 1 |
| Saxena, S | 1 |
| Kapur, S | 1 |
| Chen, PH | 2 |
| Lee, KW | 4 |
| Hsu, CC | 1 |
| Chen, JY | 2 |
| Wang, YH | 2 |
| Chen, KK | 1 |
| Wang, HM | 1 |
| Huang, HW | 1 |
| Huang, B | 2 |
| Lai, ZL | 1 |
| Tsou, YA | 1 |
| Fan, SR | 1 |
| Chen, HL | 1 |
| Chang, NW | 3 |
| Cheng, JC | 1 |
| Chen, CM | 1 |
| Chang, JS | 1 |
| Syu, SH | 1 |
| Wong, TS | 1 |
| Chan, JY | 1 |
| Tang, YC | 1 |
| Yang, ZP | 1 |
| Yang, WC | 1 |
| Chen, CT | 1 |
| Lu, SC | 1 |
| Tang, PH | 1 |
| Yang, TC | 1 |
| Chu, PY | 2 |
| Ho, CM | 1 |
| Hu, FW | 1 |
| Yu, CH | 1 |
| Lin, SS | 1 |
| Shieh, TY | 3 |
| Chen, YK | 2 |
| Wu, JH | 1 |
| Huang, JH | 1 |
| Chen, CC | 1 |
| Lin, WT | 1 |
| Yang, LC | 1 |
| Wang, TY | 2 |
| Chou, MY | 5 |
| Rehman, A | 1 |
| Ali, S | 1 |
| Lone, MA | 1 |
| Atif, M | 1 |
| Hassona, Y | 1 |
| Pitiyage, GN | 1 |
| James, EL | 1 |
| Parkinson, EK | 1 |
| Kuo, WW | 1 |
| Velmurugan, BK | 1 |
| Hsien, HH | 1 |
| Hsieh, YL | 1 |
| Hsu, HH | 3 |
| Tu, CC | 2 |
| Bau, DT | 3 |
| Viswanadha, VP | 2 |
| Lin, KH | 2 |
| Kuo, YH | 1 |
| Chen, MC | 2 |
| Peng, CY | 1 |
| Hsieh, CH | 1 |
| Ho, CC | 1 |
| Wang, SH | 1 |
| Tsai, YS | 2 |
| Huang, JL | 2 |
| Liu, YS | 1 |
| Juo, SH | 1 |
| Kuo, WR | 1 |
| Chang, JG | 1 |
| Lin, CS | 2 |
| Jong, YJ | 2 |
| Sheu, JJ | 1 |
| Wan, L | 1 |
| Lin, YJ | 1 |
| Lai, MT | 1 |
| Tseng, HC | 1 |
| Jinawath, N | 1 |
| Lin, CF | 1 |
| Lin, CC | 1 |
| Hsieh, LJ | 1 |
| Wang, TL | 1 |
| Shih, IeM | 1 |
| Tsai, FJ | 1 |
| Wang, YC | 1 |
| Wang, CS | 1 |
| Huang, AM | 1 |
| Ho, YC | 4 |
| Lin, C | 1 |
| Yeh, CM | 1 |
| Chiu, CF | 1 |
| Moutasim, KA | 1 |
| Jenei, V | 1 |
| Sapienza, K | 1 |
| Marsh, D | 1 |
| Weinreb, PH | 1 |
| Violette, SM | 1 |
| Lewis, MP | 1 |
| Marshall, JF | 1 |
| Fortune, F | 1 |
| Tilakaratne, WM | 1 |
| Hart, IR | 1 |
| Thomas, GJ | 1 |
| Tseng, LH | 1 |
| Li, YC | 1 |
| Deng, YT | 1 |
| Chang, JZ | 1 |
| Yeh, CC | 1 |
| Lin, CY | 1 |
| Liu, CC | 1 |
| Lin, JK | 1 |
| Ji, WT | 1 |
| Yang, SR | 1 |
| Cheng, YP | 1 |
| Lee, YR | 1 |
| Chiang, MK | 1 |
| Chen, HR | 1 |
| Tsai, LL | 1 |
| Chou, MC | 1 |
| Hsu, HI | 1 |
| Chang, MC | 2 |
| Lin, LD | 1 |
| Wu, HL | 2 |
| Ho, YS | 1 |
| Hsien, HC | 1 |
| Wang, TM | 1 |
| Jeng, PY | 1 |
| Cheng, RH | 1 |
| Hahn, LJ | 2 |
| Jeng, JH | 2 |
| Yoganathan, P | 1 |
| Shieh, DH | 1 |
| Chiang, LC | 1 |
| Yang, YY | 1 |
| Koh, LW | 1 |
| Tsai, JH | 1 |
| Wong, EF | 1 |
| Lin, SJ | 1 |
| Lee, JJ | 1 |
| Lee, PH | 1 |
| Chang, HH | 1 |
| Lin, BR | 1 |
| Chen, YJ | 1 |
| Liu, SY | 1 |
| Liu, YC | 1 |
| Huang, GC | 1 |
| Chen, TC | 1 |
| Lin, MH | 1 |
| Gupta, PC | 1 |
| Sugiyama, S | 1 |
| Lin, LM | 1 |
| Lai, DL | 1 |
| Huang, YL | 1 |
| Tai, KW | 1 |
| Cheng, MH | 1 |
| Chou, LS | 1 |
| Cheng, YA | 2 |
| Tsai, CC | 2 |
| Shiue, LF | 1 |
| Yu, HS | 1 |
| Hsieh, TY | 1 |
| Ho, TJ | 1 |
| Chiang, CP | 1 |
| Hong, CY | 1 |
| Kok, SH | 1 |
| Kuo, YS | 1 |
| Yen-Ping Kuo, M | 1 |
| Wani, MK | 1 |
| Yarber, RH | 1 |
| Ahmed, A | 1 |
| Hengesteg, A | 1 |
| Robbins, KT | 1 |
| Hsu, HJ | 1 |
| Chang, KL | 1 |
| Yang, YH | 1 |
| Ashby, J | 1 |
| Styles, JA | 1 |
| Boyland, E | 1 |
| Arjungi, KN | 1 |
| Awang, MN | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of microRNA-29b in the Oral Squamous Cell Carcinoma[NCT02009852] | 100 participants (Anticipated) | Observational [Patient Registry] | 2014-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for arecoline and Mouth Neoplasms
| Article | Year |
|---|---|
Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents-Does Fibroblast Senescence Play a Role?
Topics: Areca; Arecoline; Carcinoma, Squamous Cell; Disease Progression; Humans; Mouth Neoplasms; Nicotinic | 2022 |
Systematic Review of Roles of Arecoline and Arecoline
Topics: Animals; Arecoline; Carcinogenesis; Carcinogens; Humans; Mice; MicroRNAs; Mouth Neoplasms | 2023 |
Betel quid-associated cancer: Prevention strategies and targeted treatment.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Areca; Arecoline; Carcinogens; Cyclic N-Oxi | 2020 |
Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments.
Topics: Areca; Arecoline; Biomarkers; Collagen; Humans; Mouth Mucosa; Mouth Neoplasms; Oral Submucous Fibros | 2020 |
Molecular Pathogenesis of Chewable Tobacco.
Topics: Areca; Arecoline; Humans; Mouth Mucosa; Mouth Neoplasms; Nicotiana; Pakistan; Pharyngeal Neoplasms; | 2018 |
Betel chewing creeps into the New World.
Topics: Areca; Arecoline; Asia; Carcinoma, Squamous Cell; Cariostatic Agents; Cultural Characteristics; Huma | 2002 |
Areca nut: a review.
Topics: Alkaloids; Animals; Areca; Arecoline; Cell Transformation, Neoplastic; Habits; Humans; Indicators an | 1976 |
67 other studies available for arecoline and Mouth Neoplasms
| Article | Year |
|---|---|
Fat mass and obesity-associated protein regulates arecoline-exposed oral cancer immune response through programmed cell death-ligand 1.
Topics: Animals; Apoptosis; Areca; Arecoline; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Immunity; L | 2022 |
Identification of a BRAF/PA28γ/MEK1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis.
Topics: Arecoline; Autoantigens; Carcinoma, Squamous Cell; Epithelial-Mesenchymal Transition; Head and Neck | 2022 |
RNA N6-Methyladenosine (m6A) Methyltransferase-like 3 Facilitates Tumorigenesis and Cisplatin Resistance of Arecoline-Exposed Oral Carcinoma.
Topics: Adenosine; Arecoline; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cis | 2022 |
RNA N6-Methyladenosine (m6A) Methyltransferase-like 3 Facilitates Tumorigenesis and Cisplatin Resistance of Arecoline-Exposed Oral Carcinoma.
Topics: Adenosine; Arecoline; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cis | 2022 |
RNA N6-Methyladenosine (m6A) Methyltransferase-like 3 Facilitates Tumorigenesis and Cisplatin Resistance of Arecoline-Exposed Oral Carcinoma.
Topics: Adenosine; Arecoline; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cis | 2022 |
RNA N6-Methyladenosine (m6A) Methyltransferase-like 3 Facilitates Tumorigenesis and Cisplatin Resistance of Arecoline-Exposed Oral Carcinoma.
Topics: Adenosine; Arecoline; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cis | 2022 |
RNA N6-Methyladenosine (m6A) Methyltransferase-like 3 Facilitates Tumorigenesis and Cisplatin Resistance of Arecoline-Exposed Oral Carcinoma.
Topics: Adenosine; Arecoline; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cis | 2022 |
RNA N6-Methyladenosine (m6A) Methyltransferase-like 3 Facilitates Tumorigenesis and Cisplatin Resistance of Arecoline-Exposed Oral Carcinoma.
Topics: Adenosine; Arecoline; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cis | 2022 |
RNA N6-Methyladenosine (m6A) Methyltransferase-like 3 Facilitates Tumorigenesis and Cisplatin Resistance of Arecoline-Exposed Oral Carcinoma.
Topics: Adenosine; Arecoline; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cis | 2022 |
RNA N6-Methyladenosine (m6A) Methyltransferase-like 3 Facilitates Tumorigenesis and Cisplatin Resistance of Arecoline-Exposed Oral Carcinoma.
Topics: Adenosine; Arecoline; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cis | 2022 |
RNA N6-Methyladenosine (m6A) Methyltransferase-like 3 Facilitates Tumorigenesis and Cisplatin Resistance of Arecoline-Exposed Oral Carcinoma.
Topics: Adenosine; Arecoline; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cis | 2022 |
Low-dose arecoline regulates distinct core signaling pathways in oral submucous fibrosis and oral squamous cell carcinoma.
Topics: Arecoline; Carcinoma, Squamous Cell; Epigenesis, Genetic; Head and Neck Neoplasms; Humans; Mouth Muc | 2023 |
MYO1B as a prognostic biomarker and a therapeutic target in Arecoline-associated oral carcinoma.
Topics: Areca; Arecoline; Biomarkers; Carcinoma; Cell Transformation, Neoplastic; Head and Neck Neoplasms; H | 2023 |
Metastasis and immunosuppression promoted by mtDNA and PD-L1 in extracellular vesicles are reversed by WGP β-glucan in oral squamous cell carcinoma.
Topics: Arecoline; B7-H1 Antigen; beta-Glucans; Carcinoma, Squamous Cell; DNA, Mitochondrial; Extracellular | 2023 |
DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation.
Topics: Adult; Aged; Areca; Arecoline; Biomarkers; Carcinoma, Squamous Cell; Case-Control Studies; Cell Tran | 2020 |
MiR-30a and miR-379 modulate retinoic acid pathway by targeting DNA methyltransferase 3B in oral cancer.
Topics: Alcohol Oxidoreductases; Aldehyde Dehydrogenase 1 Family; Arecoline; Carcinogenesis; Carcinoma, Squa | 2020 |
Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma.
Topics: Areca; Arecoline; Carcinoma, Squamous Cell; DNA Damage; Humans; Melatonin; Mouth Neoplasms; Reactive | 2021 |
Aberrant expression of DUSP4 is a specific phenomenon in betel quid-related oral cancer.
Topics: Areca; Arecoline; Carcinoma, Squamous Cell; DNA Methylation; Dual-Specificity Phosphatases; Gene Exp | 2021 |
Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Cell L | 2020 |
Suppression of miR-886-3p mediated by arecoline (ARE) contributes to the progression of oral squamous cell carcinoma.
Topics: Arecoline; Cell Line, Tumor; Cell Proliferation; Humans; MicroRNAs; Mouth Neoplasms; Squamous Cell C | 2021 |
Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation.
Topics: Aged; Apoptosis; Arecoline; Carcinoma, Squamous Cell; Case-Control Studies; Cell Cycle; Cell Line, T | 2020 |
Arecoline N-oxide initiates oral carcinogenesis and arecoline N-oxide mercapturic acid attenuates the cancer risk.
Topics: Acetylcysteine; Adult; Animals; Arecoline; Cells, Cultured; Cyclic N-Oxides; Female; Free Radical Sc | 2021 |
Arecoline induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression.
Topics: Animals; Arecoline; Cell Line, Tumor; Cell Movement; Cytokines; Epithelial-Mesenchymal Transition; G | 2021 |
Fat mass and obesity-associated protein regulates tumorigenesis of arecoline-promoted human oral carcinoma.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Areca; Arecoline; Carcinogenesis; Case-Control Studie | 2021 |
Arecoline N-Oxide Upregulates Caspase-8 Expression in Oral Hyperplastic Lesions of Mice.
Topics: Animals; Areca; Arecoline; Carcinoma, Squamous Cell; Caspase 3; Caspase 8; Cyclic N-Oxides; Humans; | 2017 |
Effects of arecoline on proliferation of oral squamous cell carcinoma cells by dysregulating c-Myc and miR-22, directly targeting oncostatin M.
Topics: Arecoline; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Inter | 2018 |
Arecoline N-oxide regulates oral squamous cell carcinoma development through NOTCH1 and FAT1 expressions.
Topics: Animals; Arecoline; Biomarkers, Tumor; Body Weight; Cadherins; Carcinogenesis; Carcinoma, Squamous C | 2019 |
Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression.
Topics: Apoptosis; Arecoline; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Squamous Cell; Cell Cycle C | 2019 |
Taiwanin C elicits apoptosis in arecoline and 4-nitroquinoline-1-oxide-induced oral squamous cell carcinoma cells and hinders proliferation via epidermal growth factor receptor/PI3K suppression.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Arecoline; Carcinom | 2019 |
MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1.
Topics: 3' Untranslated Regions; Aged; Ankyrins; Apoptosis; Arecoline; Carcinoma, Squamous Cell; Cell Line, | 2019 |
Elevated snail expression mediates tumor progression in areca quid chewing-associated oral squamous cell carcinoma via reactive oxygen species.
Topics: Adult; Aged; Aged, 80 and over; Areca; Arecoline; Carcinoma, Squamous Cell; Cells, Cultured; Disease | 2013 |
Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma.
Topics: Adult; Aged; Antigens, Neoplasm; Areca; Arecoline; Carbonic Anhydrase IX; Carbonic Anhydrases; Carci | 2014 |
A pilot study evaluating genetic alterations that drive tobacco- and betel quid-associated oral cancer in Northeast India.
Topics: Adult; Aflatoxin B1; Aged; Areca; Arecoline; Chromosome Mapping; DNA, Neoplasm; Genetic Predispositi | 2014 |
Expression of a splice variant of CYP26B1 in betel quid-related oral cancer.
Topics: Alternative Splicing; Areca; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Cell Line, Tumor; Cel | 2014 |
Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Areca; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Cell Lin | 2014 |
IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer.
Topics: Animals; Arecoline; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cells, Cultured; Gene | 2015 |
ZEB1 as an indicator of tumor recurrence for areca quid chewing-associated oral squamous cell carcinomas.
Topics: Areca; Arecoline; Biomarkers, Tumor; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2015 |
The influence of monoamine oxidase variants on the risk of betel quid-associated oral and pharyngeal cancer.
Topics: Areca; Arecoline; Carcinoma, Squamous Cell; Gene Expression; Humans; Monoamine Oxidase; Mouth; Mouth | 2014 |
Elevated Lin28B expression is correlated with lymph node metastasis in oral squamous cell carcinomas.
Topics: Adult; Aged; Arecoline; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement | 2015 |
Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression.
Topics: Areca; Arecoline; beta-Galactosidase; Cell Cycle; Cell Line; Cellular Senescence; Disease Progressio | 2016 |
Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Arecoline; Carcinoma, Squamous Cell; Cell Line, Tumor; C | 2016 |
Taiwanin C selectively inhibits arecoline and 4-NQO-induced oral cancer cell proliferation via ERK1/2 inactivation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents, Phytogenic; Arecoline; Cell Cycle Proteins | 2017 |
Acquisition cancer stemness, mesenchymal transdifferentiation, and chemoresistance properties by chronic exposure of oral epithelial cells to arecoline.
Topics: 3' Untranslated Regions; Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Agents; Arecoline; | 2016 |
Down-regulation of β-catenin and the associated migration ability by Taiwanin C in arecoline and 4-NQO-induced oral cancer cells via GSK-3β activation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; beta Catenin; Cell Line, Tumor; Cell Movement; Cell Pr | 2017 |
Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cells.
Topics: Areca; Arecoline; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Cycle; Cell Cycle | 2008 |
Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Disease Models, | 2009 |
Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: implication for carcinogenesis.
Topics: Areca; Arecoline; Carcinogens; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; G | 2010 |
Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Acetylcysteine; Areca; Arecoline; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; C | 2010 |
Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model.
Topics: 4-Nitroquinoline-1-oxide; Acetyl-CoA Carboxylase; Animals; Anticarcinogenic Agents; Arecoline; Carci | 2011 |
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.
Topics: Actins; Antigens, Neoplasm; Areca; Arecoline; Carcinoma, Squamous Cell; Cell Differentiation; Cell M | 2011 |
Heat shock protein 47 expression in oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells.
Topics: Acetylcysteine; Areca; Arecoline; Carcinoma, Squamous Cell; Case-Control Studies; Cell Line, Tumor; | 2011 |
Arecoline stimulated Cyr61 production in human gingival epithelial cells: inhibition by lovastatin.
Topics: Areca; Arecoline; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cysteine-Rich Prote | 2011 |
Arecoline N-oxide: its mutagenicity and possible role as ultimate carcinogen in areca oral carcinogenesis.
Topics: Areca; Arecoline; Carcinogens; Cyclic N-Oxides; Humans; Mouth Neoplasms; Mutagenicity Tests; Mutagen | 2011 |
Arecoline downregulates levels of p21 and p27 through the reactive oxygen species/mTOR complex 1 pathway and may contribute to oral squamous cell carcinoma.
Topics: Arecoline; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cholin | 2012 |
Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Acetylcysteine; Areca; Arecoline; Carcinoma, Squamous Cell; Case-Control Studies; Catechin; Cyclooxy | 2012 |
β-catenin expression in areca quid chewing-associated oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells.
Topics: Adult; Aged; Areca; Arecoline; beta Catenin; Biopsy; Blotting, Western; Carcinoma, Squamous Cell; Ep | 2012 |
The expression of O(6) -methylguanine-DNA methyltransferase in human oral keratinocytes stimulated with arecoline.
Topics: Areca; Arecoline; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line; Cholinergic Agonists; Dose | 2013 |
Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
Topics: Areca; Arecoline; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Fibr | 2013 |
Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis.
Topics: Adult; Aged; Areca; Arecoline; Cells, Cultured; Cheek; Dose-Response Relationship, Drug; Fibroblasts | 2003 |
Involvement of viral and chemical factors with oral cancer in Taiwan.
Topics: Arecoline; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA, Viral; Herpesvirus 1, Human; Herpesvirus | 2004 |
The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation.
Topics: Apoptosis; Areca; Arecoline; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Cells, | 2004 |
Up-regulation of matrix metalloproteinase-8 by betel quid extract and arecoline and its role in 2D motility.
Topics: Areca; Arecoline; Blotting, Western; Carcinoma, Squamous Cell; Cell Movement; Cells, Cultured; Endop | 2007 |
Areca nut use in India.
Topics: Alkaloids; Areca; Arecoline; Cell Transformation, Neoplastic; Habits; Humans; India; Mouth Neoplasms | 2007 |
[The history of tooth dyeing].
Topics: Arecoline; Coloring Agents; History, 20th Century; History, 21st Century; Humans; India; Mouth Neopl | 2007 |
The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Adult; Aged; Antineoplastic Agents; Areca; Arecoline; Blotting, Western; Carcinoma, Squamous Cell; C | 2008 |
Minimal arecaidine concentrations showing a promotion effect during DMBA-induced hamster cheek pouch carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Cheek; | 1996 |
Cytotoxic and non-genotoxic effects of arecoline on human buccal fibroblasts in vitro.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Areca; Arecoline; Cells, Cultured; Coloring Agen | 1998 |
Nicotine- and arecoline-induced interleukin-1 secretion and intercellular adhesion molecular-1 expression in human oral epidermoid carcinoma cells in vitro.
Topics: Analysis of Variance; Arecoline; Carcinoma, Squamous Cell; Cell Survival; Cholinergic Agonists; Dose | 1999 |
Interleukin-8 secretion by cultured oral epidermoid carcinoma cells induced with nicotine and/or arecoline treatments.
Topics: Antibodies, Monoclonal; Arecoline; Carcinoma, Squamous Cell; Cell Division; Humans; Interleukin-1; I | 2000 |
Induction of the c-jun protooncogene expression by areca nut extract and arecoline on oral mucosal fibroblasts.
Topics: Areca; Arecoline; Carcinoma, Squamous Cell; Fibroblasts; Gene Expression; Humans; Mouth Mucosa; Mout | 2000 |
Cancer induction in the DMBA hamster cheek pouch: a modified technique using a promoter.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Cell Tr | 2001 |
The effects of arecoline on the release of cytokines using cultured peripheral blood mononuclear cells from patients with oral mucous diseases.
Topics: Arecoline; Carcinoma, Squamous Cell; Cells, Cultured; Cytokines; Fibrosis; Humans; Leukocytes, Monon | 2001 |
Betel nuts, arecaidine, and oral cancer.
Topics: Animals; Areca; Arecoline; Carcinogens; Cell Transformation, Neoplastic; Chemical Phenomena; Chemist | 1979 |
Fate of betel nut chemical constituents following nut treatment prior to chewing and its relation to oral precancerous & cancerous lesion.
Topics: Areca; Arecoline; Flavonoids; Humans; Mouth Neoplasms; Phenols; Plants, Medicinal; Polymers; Polyphe | 1988 |
Estimation of arecoline contents in commercial areca (betel) nuts and its relation to oral precancerous lesions.
Topics: Areca; Arecoline; Humans; Malaysia; Mouth Neoplasms; Plants, Medicinal; Precancerous Conditions; Ris | 1986 |