arecoline has been researched along with Huntington Disease in 3 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arecoline did produce significant alterations of blood pressure, heart rate, and body temperature, probably by central cholinergic stimulation." | 2.64 | Treatment of Huntington disease with a cholinergic agonist. ( Chase, TN; Nutt, JG; Rosin, A, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nutt, JG | 2 |
| Durso, R | 1 |
| Tamminga, CA | 1 |
| Denaro, A | 1 |
| Ruggeri, S | 1 |
| Chase, TN | 2 |
| Rosin, A | 1 |
1 trial available for arecoline and Huntington Disease
| Article | Year |
|---|---|
Treatment of Huntington disease with a cholinergic agonist.
Topics: Adult; Arecoline; Clinical Trials as Topic; Female; Hemodynamics; Humans; Huntington Disease; Male; | 1978 |
2 other studies available for arecoline and Huntington Disease
| Article | Year |
|---|---|
Effect of cholinergic agents in Huntington's disease: a reappraisal.
Topics: Arecoline; Benztropine; Humans; Huntington Disease; Parasympatholytics; Parasympathomimetics; Physos | 1983 |
Plasma growth hormone and prolactin response to dopaminergic GABAmimetic and cholinergic stimulation in Huntington's disease.
Topics: Adult; Apomorphine; Arecoline; Dopamine; Female; gamma-Aminobutyric Acid; Growth Hormone; Humans; Hu | 1983 |