arecoline has been researched along with Disease Models, Animal in 24 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "AEBN and arecoline induced dyslipidemia by downregulating AMPK (Thr-172) and activating ACC (Ser-79); they also downregulated tumor suppressor p53 (Ser-15)." | 7.91 | Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model. ( Choudhury, Y; Laskar, J; Sengupta, M, 2019) |
| "Cerebral demyelination is possibly one of the main pathological factors involved in the development of schizophrenia." | 5.51 | Arecoline attenuates memory impairment and demyelination in a cuprizone-induced mouse model of schizophrenia. ( Adilijiang, A; He, J; Li, X; Lin, D; Wang, W; Xu, Z; You, P, 2019) |
| "AEBN and arecoline induced dyslipidemia by downregulating AMPK (Thr-172) and activating ACC (Ser-79); they also downregulated tumor suppressor p53 (Ser-15)." | 3.91 | Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model. ( Choudhury, Y; Laskar, J; Sengupta, M, 2019) |
| "Arecoline induces oral submucous fibrosis (OSF) via promoting the reactive oxygen species (ROS)." | 3.91 | Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome activation. ( Du, X; Huang, Y; Jin, S; Li, X; Li, Y; Wang, D; Wang, G; Wu, B; You, Y; Zhu, X, 2019) |
| "Two lines of rats that were selectively bred to vary in their sensitivity to the anticholinesterase DFP exhibited different degrees of behavioral depression after injection of the muscarinic agonist arecoline (2 mg/kg)." | 3.67 | Selective breeding for increased cholinergic function: development of a new animal model of depression. ( Overstreet, DH, 1986) |
| "Oral carcinogenesis involves the progression of the normal mucosa into potentially malignant disorders and finally into cancer." | 1.56 | Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model. ( Chiang, WF; Hsieh, YP; Huang, LY; Huang, TT; Huang, WT; Hwang, DY; Jiang, SS; Liu, KJ; Wang, YY, 2020) |
| "Cerebral demyelination is possibly one of the main pathological factors involved in the development of schizophrenia." | 1.51 | Arecoline attenuates memory impairment and demyelination in a cuprizone-induced mouse model of schizophrenia. ( Adilijiang, A; He, J; Li, X; Lin, D; Wang, W; Xu, Z; You, P, 2019) |
| "Regarding oral squamous cell carcinoma (OSCC) development, chewing areca is known to be a strong risk factor in many Asian cultures." | 1.40 | Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma. ( Chang, NW; Chen, CM; Chen, HL; Cheng, JC; Fan, SR; Lai, ZL; Tsai, MH; Tsou, YA, 2014) |
| "The discovery of cholinergic deficit in Alzheimer's disease (AD) patient's brain has triggered research efforts, using cholinomimetic approaches for their efficacy in AD therapy." | 1.35 | Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models. ( Chandra, JN; Malviya, M; Rangappa, KS; Sadashiva, CT; Subhash, MN, 2008) |
| "Of these, 133 hamsters (80." | 1.31 | Cancer induction in the DMBA hamster cheek pouch: a modified technique using a promoter. ( Ahmed, A; Hengesteg, A; Robbins, KT; Wani, MK; Yarber, RH, 2001) |
| "3, 1, 3, 10, or 30 mg/kg/day sc for 14 days) attenuated the AF64A-induced cognitive impairment in a dose-dependent manner, producing an inverted U-shaped dose-response function which was optimal at 1." | 1.30 | Arecoline via miniosmotic pump improves AF64A-impaired radial maze performance in rats: a possible model of Alzheimer's disease. ( Bartolomeo, AC; Boast, CA; Morris, H, 1997) |
| "Glutamatergic hypofunction occurs in Alzheimer's disease (AD)." | 1.30 | 5HT antagonists attenuate MK801-impaired radial arm maze performance in rats. ( Bartolomeo, AC; Boast, C; Morris, H; Moyer, JA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.50) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, YC | 1 |
| Malviya, M | 2 |
| Chandra, JN | 3 |
| Sadashiva, CT | 3 |
| Kumar, CS | 1 |
| Prasad, SB | 1 |
| Prasanna, DS | 1 |
| Subhash, MN | 3 |
| Rangappa, KS | 3 |
| Kavitha, CV | 1 |
| Thimmegowda, A | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Laskar, J | 1 |
| Sengupta, M | 1 |
| Choudhury, Y | 1 |
| Huang, LY | 1 |
| Hsieh, YP | 1 |
| Wang, YY | 1 |
| Hwang, DY | 1 |
| Jiang, SS | 1 |
| Huang, WT | 1 |
| Chiang, WF | 1 |
| Liu, KJ | 1 |
| Huang, TT | 1 |
| You, Y | 1 |
| Huang, Y | 1 |
| Wang, D | 1 |
| Li, Y | 1 |
| Wang, G | 1 |
| Jin, S | 1 |
| Zhu, X | 1 |
| Wu, B | 1 |
| Du, X | 1 |
| Li, X | 2 |
| Xu, Z | 1 |
| Adilijiang, A | 1 |
| Wang, W | 1 |
| You, P | 1 |
| Lin, D | 1 |
| He, J | 1 |
| Lai, ZL | 1 |
| Tsou, YA | 1 |
| Fan, SR | 1 |
| Tsai, MH | 3 |
| Chen, HL | 1 |
| Chang, NW | 3 |
| Cheng, JC | 1 |
| Chen, CM | 1 |
| Wu, IC | 1 |
| Chen, YK | 1 |
| Wu, CC | 1 |
| Cheng, YJ | 1 |
| Chen, WC | 1 |
| Ko, HJ | 1 |
| Liu, YP | 1 |
| Chai, CY | 1 |
| Lin, HS | 1 |
| Wu, DC | 1 |
| Wu, MT | 1 |
| Ikeda, Y | 1 |
| Kanai, A | 1 |
| Lee, LM | 1 |
| Chang, CK | 1 |
| Cheng, KC | 1 |
| Kou, DH | 1 |
| Liu, IM | 1 |
| Cheng, JT | 1 |
| Sheu, JJ | 1 |
| Hua, CH | 1 |
| Wan, L | 1 |
| Lin, YJ | 1 |
| Lai, MT | 1 |
| Tseng, HC | 2 |
| Jinawath, N | 1 |
| Lin, CF | 2 |
| Lin, CC | 1 |
| Hsieh, LJ | 1 |
| Wang, TL | 1 |
| Shih, IeM | 1 |
| Tsai, FJ | 1 |
| Pei, RJ | 1 |
| Yeh, KT | 1 |
| Chan, HC | 1 |
| Lee, MR | 1 |
| Lin, C | 1 |
| Hsieh, WT | 1 |
| Kao, MC | 1 |
| Drake, M | 1 |
| Gillespie, J | 1 |
| Hedlund, P | 1 |
| Harvey, I | 1 |
| Lagou, M | 1 |
| Andersson, KE | 1 |
| Shoaib, M | 1 |
| Magazanik, LG | 1 |
| Tikhonov, DB | 1 |
| Tikhonova, TB | 1 |
| Lukomskaya, NY | 1 |
| Andreas, K | 1 |
| Fischer, HD | 1 |
| Schmidt, J | 1 |
| Sitaram, N | 1 |
| Gillin, JC | 1 |
| Bartolomeo, AC | 2 |
| Morris, H | 2 |
| Boast, CA | 1 |
| Boast, C | 1 |
| Moyer, JA | 1 |
| Wani, MK | 1 |
| Yarber, RH | 1 |
| Ahmed, A | 1 |
| Hengesteg, A | 1 |
| Robbins, KT | 1 |
| Overstreet, DH | 1 |
24 other studies available for arecoline and Disease Models, Animal
| Article | Year |
|---|---|
Effect of novel N-aryl sulfonamide substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer's dementia models.
Topics: Alzheimer Disease; Animals; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship | 2008 |
Synthesis and pharmacological evaluation of novel N-alkyl/aryl substituted thiazolidinone arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models.
Topics: Alzheimer Disease; Animals; Arecoline; Brain; Disease Models, Animal; Male; Memory; Molecular Struct | 2009 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model.
Topics: AMP-Activated Protein Kinases; Animals; Areca; Arecoline; Carcinogenesis; Disease Models, Animal; Dy | 2019 |
Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Cell L | 2020 |
Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome activation.
Topics: Angiotensin I; Angiotensin-Converting Enzyme 2; Animals; Anti-Inflammatory Agents; Antioxidants; Are | 2019 |
Arecoline attenuates memory impairment and demyelination in a cuprizone-induced mouse model of schizophrenia.
Topics: Animals; Arecoline; Chelating Agents; Cholinergic Agonists; Cuprizone; Demyelinating Diseases; Disea | 2019 |
Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Areca; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Cell Lin | 2014 |
Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
Topics: Animals; Arecoline; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; D | 2016 |
Urotheliogenic modulation of intrinsic activity in spinal cord-transected rat bladders: role of mucosal muscarinic receptors.
Topics: Animals; Arecoline; Calcium Channel Blockers; Disease Models, Animal; Female; Mucous Membrane; Musca | 2008 |
Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats.
Topics: Animals; Arecoline; Blood Pressure; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Mo | 2008 |
Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Disease Models, | 2009 |
Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; alpha-Crystallin B Chain; Animals; Arecoline; Carcinogens; Disease Models, | 2010 |
Muscarinic stimulation of the rat isolated whole bladder: pathophysiological models of detrusor overactivity.
Topics: Animals; Arecoline; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypertension; | 2006 |
Effects of isoarecolone, a nicotinic receptor agonist in rodent models of nicotine dependence.
Topics: Animals; Arecoline; Behavior, Animal; Disease Models, Animal; Male; Nicotine; Nicotinic Agonists; Ra | 2006 |
Mechanisms of the blockade of glutamate channel receptors: significance for structural and physiological investigations.
Topics: Animals; Animals, Newborn; Arecoline; Diamines; Disease Models, Animal; Drug Interactions; Excitator | 2007 |
Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models.
Topics: Acetylcholine; Alzheimer Disease; Animals; Arecoline; Binding, Competitive; Brain; Disease Models, A | 2008 |
[Effect of central effective substances on alcohol preference].
Topics: Alcohol Drinking; Alcoholism; Animals; Arecoline; Atropine; Central Nervous System Stimulants; Cypro | 1983 |
Development and use of pharmacological probes of the CNS in man: evidence of cholinergic abnormality in primary affective illness.
Topics: Acetylcholine; Arecoline; Central Nervous System; Choline; Disease Models, Animal; Dose-Response Rel | 1980 |
Arecoline via miniosmotic pump improves AF64A-impaired radial maze performance in rats: a possible model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Arecoline; Aziridines; Brain; Brain Mapping; Cerebral Cortex; Choline; D | 1997 |
5HT antagonists attenuate MK801-impaired radial arm maze performance in rats.
Topics: Alzheimer Disease; Animals; Arecoline; Cognition Disorders; Disease Models, Animal; Dizocilpine Male | 1999 |
Cancer induction in the DMBA hamster cheek pouch: a modified technique using a promoter.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Cell Tr | 2001 |
Selective breeding for increased cholinergic function: development of a new animal model of depression.
Topics: Animals; Arecoline; Breeding; Depression; Depressive Disorder; Disease Models, Animal; Electroshock; | 1986 |