arecoline has been researched along with Disease Exacerbation in 8 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral submucous fibrosis (OSMF) is a pre-malignant condition that is strongly associated with the areca nut alkaloids, arecoline (ARC) and arecaidine (ARD)." | 3.83 | Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression. ( Ali, S; Atif, M; Hassona, Y; James, EL; Lone, MA; Parkinson, EK; Pitiyage, GN; Prime, SS; Rehman, A, 2016) |
| "Our results indicate that arecoline attenuates the progression of atherosclerosis and inhibits endothelial cells activation and adherence by stimulating endothelial NNMR." | 3.80 | Stimulation of endothelial non-neuronal muscarinic receptor attenuates the progression of atherosclerosis via inhibiting endothelial cells activation. ( Cui, WY; Long, CL; Pan, ZY; Wang, H; Zhang, YF; Zhou, JH, 2014) |
| "Regarding oral squamous cell carcinoma (OSCC) development, chewing areca is known to be a strong risk factor in many Asian cultures." | 1.40 | Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma. ( Chang, NW; Chen, CM; Chen, HL; Cheng, JC; Fan, SR; Lai, ZL; Tsai, MH; Tsou, YA, 2014) |
| "Arecoline was also found to induced Snail expression in a dose- and time-dependent manner (p<0." | 1.39 | Elevated snail expression mediates tumor progression in areca quid chewing-associated oral squamous cell carcinoma via reactive oxygen species. ( Chang, YC; Lee, SS; Tsai, CH; Yu, CC, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, P | 1 |
| Chua, NQE | 1 |
| Dang, S | 1 |
| Davis, A | 1 |
| Chong, KW | 1 |
| Prime, SS | 2 |
| Cirillo, N | 1 |
| Tu, HF | 1 |
| Chen, MY | 1 |
| Lai, JC | 1 |
| Chen, YL | 1 |
| Wong, YW | 1 |
| Yang, CC | 1 |
| Chen, HY | 1 |
| Hsia, SM | 1 |
| Shih, YH | 1 |
| Shieh, TM | 1 |
| Lee, SS | 1 |
| Tsai, CH | 1 |
| Yu, CC | 1 |
| Chang, YC | 1 |
| Lai, ZL | 1 |
| Tsou, YA | 1 |
| Fan, SR | 1 |
| Tsai, MH | 2 |
| Chen, HL | 1 |
| Chang, NW | 2 |
| Cheng, JC | 1 |
| Chen, CM | 1 |
| Zhou, JH | 1 |
| Pan, ZY | 1 |
| Zhang, YF | 1 |
| Cui, WY | 1 |
| Long, CL | 1 |
| Wang, H | 1 |
| Rehman, A | 1 |
| Ali, S | 1 |
| Lone, MA | 1 |
| Atif, M | 1 |
| Hassona, Y | 1 |
| Pitiyage, GN | 1 |
| James, EL | 1 |
| Parkinson, EK | 1 |
| Wu, IC | 1 |
| Chen, YK | 1 |
| Wu, CC | 1 |
| Cheng, YJ | 1 |
| Chen, WC | 1 |
| Ko, HJ | 1 |
| Liu, YP | 1 |
| Chai, CY | 1 |
| Lin, HS | 1 |
| Wu, DC | 1 |
| Wu, MT | 1 |
| Pei, RJ | 1 |
| Tseng, HC | 1 |
| Yeh, KT | 1 |
| Chan, HC | 1 |
| Lee, MR | 1 |
| Lin, C | 1 |
| Hsieh, WT | 1 |
| Kao, MC | 1 |
| Lin, CF | 1 |
1 review available for arecoline and Disease Exacerbation
| Article | Year |
|---|---|
Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents-Does Fibroblast Senescence Play a Role?
Topics: Areca; Arecoline; Carcinoma, Squamous Cell; Disease Progression; Humans; Mouth Neoplasms; Nicotinic | 2022 |
7 other studies available for arecoline and Disease Exacerbation
| Article | Year |
|---|---|
Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression.
Topics: Apoptosis; Arecoline; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Squamous Cell; Cell Cycle C | 2019 |
Elevated snail expression mediates tumor progression in areca quid chewing-associated oral squamous cell carcinoma via reactive oxygen species.
Topics: Adult; Aged; Aged, 80 and over; Areca; Arecoline; Carcinoma, Squamous Cell; Cells, Cultured; Disease | 2013 |
Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Areca; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Cell Lin | 2014 |
Stimulation of endothelial non-neuronal muscarinic receptor attenuates the progression of atherosclerosis via inhibiting endothelial cells activation.
Topics: Animals; Aorta; Apolipoproteins E; Arecoline; Atherosclerosis; Cell Adhesion Molecules; Chemokine CC | 2014 |
Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression.
Topics: Areca; Arecoline; beta-Galactosidase; Cell Cycle; Cell Line; Cellular Senescence; Disease Progressio | 2016 |
Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
Topics: Animals; Arecoline; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; D | 2016 |
Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; alpha-Crystallin B Chain; Animals; Arecoline; Carcinogens; Disease Models, | 2010 |